MA43251A - Utilisation de dérivés d'indole n-substitués comme modulateurs des récepteurs des pge2 - Google Patents

Utilisation de dérivés d'indole n-substitués comme modulateurs des récepteurs des pge2

Info

Publication number
MA43251A
MA43251A MA043251A MA43251A MA43251A MA 43251 A MA43251 A MA 43251A MA 043251 A MA043251 A MA 043251A MA 43251 A MA43251 A MA 43251A MA 43251 A MA43251 A MA 43251A
Authority
MA
Morocco
Prior art keywords
receptor modulators
indole derivatives
substituted indole
pge2 receptor
pge2
Prior art date
Application number
MA043251A
Other languages
English (en)
Other versions
MA43251B1 (fr
Inventor
Olivier Corminboeuf
Heinz Fretz
Isabelle Lyothier
Julien Pothier
Davide Pozzi
Sylvia Richard-Bildstein
Thierry Sifferlen
Peters Lorenza Wyder
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of MA43251A publication Critical patent/MA43251A/fr
Publication of MA43251B1 publication Critical patent/MA43251B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA43251A 2015-11-20 2016-11-17 Utilisation de dérivés d'indole n-substitués comme modulateurs des récepteurs des pge2 MA43251B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2015077269 2015-11-20
PCT/EP2016/078028 WO2017085198A1 (fr) 2015-11-20 2016-11-17 Utilisation de dérivés d'indole n-substitués comme modulateurs des récepteurs des pge2

Publications (2)

Publication Number Publication Date
MA43251A true MA43251A (fr) 2021-04-28
MA43251B1 MA43251B1 (fr) 2021-11-30

Family

ID=57326428

Family Applications (2)

Application Number Title Priority Date Filing Date
MA43251A MA43251B1 (fr) 2015-11-20 2016-11-17 Utilisation de dérivés d'indole n-substitués comme modulateurs des récepteurs des pge2
MA55046A MA55046B1 (fr) 2015-11-20 2016-11-17 Utilisation de dérivés d'indole n-substitués comme modulateurs des récepteurs des pge2

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA55046A MA55046B1 (fr) 2015-11-20 2016-11-17 Utilisation de dérivés d'indole n-substitués comme modulateurs des récepteurs des pge2

Country Status (34)

Country Link
US (2) US11241431B2 (fr)
EP (2) EP3377483B9 (fr)
JP (2) JP2018534328A (fr)
KR (1) KR102352022B1 (fr)
CN (1) CN108349949B (fr)
AU (1) AU2016358242B2 (fr)
BR (1) BR112018010291B1 (fr)
CA (1) CA3002610C (fr)
CL (1) CL2018001325A1 (fr)
CO (1) CO2018005715A2 (fr)
CR (1) CR20180323A (fr)
CY (1) CY1124913T1 (fr)
DK (2) DK3928836T3 (fr)
EA (1) EA037953B1 (fr)
ES (2) ES2994636T3 (fr)
FI (1) FI3928836T3 (fr)
HR (2) HRP20241521T1 (fr)
HU (2) HUE056679T2 (fr)
IL (1) IL259424B (fr)
LT (2) LT3377483T (fr)
MA (2) MA43251B1 (fr)
MX (1) MX375978B (fr)
MY (1) MY195888A (fr)
PE (1) PE20181304A1 (fr)
PH (1) PH12018501077B1 (fr)
PL (2) PL3928836T3 (fr)
PT (2) PT3928836T (fr)
RS (2) RS62598B1 (fr)
SA (1) SA518391588B1 (fr)
SG (1) SG11201803627XA (fr)
SI (2) SI3377483T1 (fr)
TW (2) TWI719078B (fr)
UA (1) UA123441C2 (fr)
WO (1) WO2017085198A1 (fr)

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AR111941A1 (es) 2017-05-18 2019-09-04 Idorsia Pharmaceuticals Ltd Derivados de pirimidina como moduladores del receptor de pge2
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CR20230165A (es) 2020-09-15 2023-06-02 Revolution Medicines Inc Derivados indólicos como inhibidores de ras en el tratamiento del cáncer
EP4245301A4 (fr) 2020-11-13 2024-08-21 ONO Pharmaceutical Co., Ltd. Traitement du cancer par utilisation combinée d'un antagoniste d'ep4 et d'un inhibiteur de point de contrôle immunitaire
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WO2025229177A1 (fr) 2024-05-02 2025-11-06 Idorsia Pharmaceuticals Ltd Formes cristallines d'un dérivé d'indole n-substitué

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