MA43251B1 - Utilisation de dérivés d'indole n-substitués comme modulateurs des récepteurs des pge2 - Google Patents
Utilisation de dérivés d'indole n-substitués comme modulateurs des récepteurs des pge2Info
- Publication number
- MA43251B1 MA43251B1 MA43251A MA43251A MA43251B1 MA 43251 B1 MA43251 B1 MA 43251B1 MA 43251 A MA43251 A MA 43251A MA 43251 A MA43251 A MA 43251A MA 43251 B1 MA43251 B1 MA 43251B1
- Authority
- MA
- Morocco
- Prior art keywords
- modulators
- indole derivatives
- substituted indole
- pge2 receptors
- receptors
- Prior art date
Links
- 102000008866 Prostaglandin E receptors Human genes 0.000 title 1
- 108010088540 Prostaglandin E receptors Proteins 0.000 title 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- 150000001875 compounds Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne des dérivés de formule (i), r1)n, r2, r3, r4a, r4b, r5a, r5b et ar1 étant tels que définis dans la description, leur préparation, leurs sels pharmaceutiquement acceptables et leur utilisation en tant que produits pharmaceutiques, des compositions pharmaceutiques contenant au moins un composé de formule (i), et en particulier leur utilisation comme modulateurs des récepteurs ep2 et/ou ep4 de prostaglandine 2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2015077269 | 2015-11-20 | ||
| PCT/EP2016/078028 WO2017085198A1 (fr) | 2015-11-20 | 2016-11-17 | Utilisation de dérivés d'indole n-substitués comme modulateurs des récepteurs des pge2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA43251A MA43251A (fr) | 2021-04-28 |
| MA43251B1 true MA43251B1 (fr) | 2021-11-30 |
Family
ID=57326428
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA43251A MA43251B1 (fr) | 2015-11-20 | 2016-11-17 | Utilisation de dérivés d'indole n-substitués comme modulateurs des récepteurs des pge2 |
| MA55046A MA55046B1 (fr) | 2015-11-20 | 2016-11-17 | Utilisation de dérivés d'indole n-substitués comme modulateurs des récepteurs des pge2 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA55046A MA55046B1 (fr) | 2015-11-20 | 2016-11-17 | Utilisation de dérivés d'indole n-substitués comme modulateurs des récepteurs des pge2 |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US11241431B2 (fr) |
| EP (2) | EP3377483B9 (fr) |
| JP (2) | JP2018534328A (fr) |
| KR (1) | KR102352022B1 (fr) |
| CN (1) | CN108349949B (fr) |
| AU (1) | AU2016358242B2 (fr) |
| BR (1) | BR112018010291B1 (fr) |
| CA (1) | CA3002610C (fr) |
| CL (1) | CL2018001325A1 (fr) |
| CO (1) | CO2018005715A2 (fr) |
| CR (1) | CR20180323A (fr) |
| CY (1) | CY1124913T1 (fr) |
| DK (2) | DK3928836T3 (fr) |
| EA (1) | EA037953B1 (fr) |
| ES (2) | ES2994636T3 (fr) |
| FI (1) | FI3928836T3 (fr) |
| HR (2) | HRP20241521T1 (fr) |
| HU (2) | HUE056679T2 (fr) |
| IL (1) | IL259424B (fr) |
| LT (2) | LT3377483T (fr) |
| MA (2) | MA43251B1 (fr) |
| MX (1) | MX375978B (fr) |
| MY (1) | MY195888A (fr) |
| PE (1) | PE20181304A1 (fr) |
| PH (1) | PH12018501077B1 (fr) |
| PL (2) | PL3928836T3 (fr) |
| PT (2) | PT3928836T (fr) |
| RS (2) | RS62598B1 (fr) |
| SA (1) | SA518391588B1 (fr) |
| SG (1) | SG11201803627XA (fr) |
| SI (2) | SI3377483T1 (fr) |
| TW (2) | TWI719078B (fr) |
| UA (1) | UA123441C2 (fr) |
| WO (1) | WO2017085198A1 (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20180323A (es) * | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| WO2018176134A1 (fr) | 2017-03-27 | 2018-10-04 | HYDRO-QUéBEC | Sels destinés à être utilisés dans des compositions d'électrolyte ou en tant qu'additifs d'électrode |
| MX388257B (es) | 2017-05-18 | 2025-03-19 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina como moduladores del receptor de pge2. |
| JP7093791B2 (ja) | 2017-05-18 | 2022-06-30 | イドーシア ファーマシューティカルズ リミテッド | Pge2レセプター調節剤としてのベンゾフラン及びベンゾチオフェン誘導体 |
| AR111941A1 (es) | 2017-05-18 | 2019-09-04 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina como moduladores del receptor de pge2 |
| EP3625223B1 (fr) | 2017-05-18 | 2021-08-11 | Idorsia Pharmaceuticals Ltd | Dérivés de pyrimidine |
| CN109678780A (zh) * | 2017-10-19 | 2019-04-26 | 中国石油化工股份有限公司 | 一种制备3-烷基吲哚衍生物的方法 |
| US11547712B2 (en) | 2017-11-20 | 2023-01-10 | Icahn School Of Medicine At Mount Sinai | Kinase inhibitor compounds and compositions and methods of use |
| CN111819193A (zh) | 2018-01-05 | 2020-10-23 | 西奈山伊坎医学院 | 增加胰腺β细胞增殖的方法、治疗方法以及组合物 |
| AU2019240065A1 (en) | 2018-03-20 | 2020-09-24 | Icahn School Of Medicine At Mount Sinai | Kinase inhibitor compounds and compositions and methods of use |
| CA3124353A1 (fr) * | 2018-12-31 | 2020-07-09 | Icahn School Of Medicine At Mount Sinai | Composes inhibiteurs de kinase, compositions et methodes d'utilisation |
| EP3693359A1 (fr) * | 2019-02-08 | 2020-08-12 | Medibiofarma, S.L. | Nouveaux dérivés de n-benzyl-2-phénoxybenzamide en tant que modulateurs des récepteurs de la prostaglandine e2 (pge2) |
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| CR20230165A (es) | 2020-09-15 | 2023-06-02 | Revolution Medicines Inc | Derivados indólicos como inhibidores de ras en el tratamiento del cáncer |
| EP4245301A4 (fr) | 2020-11-13 | 2024-08-21 | ONO Pharmaceutical Co., Ltd. | Traitement du cancer par utilisation combinée d'un antagoniste d'ep4 et d'un inhibiteur de point de contrôle immunitaire |
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| WO2025229177A1 (fr) | 2024-05-02 | 2025-11-06 | Idorsia Pharmaceuticals Ltd | Formes cristallines d'un dérivé d'indole n-substitué |
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| EA028921B1 (ru) | 2013-12-17 | 2018-01-31 | Эли Лилли Энд Компани | Феноксиэтилы |
| DK3083554T3 (da) | 2013-12-17 | 2019-05-13 | Lilly Co Eli | Dimethylbenzoesyreforbindelser |
| TW201607943A (zh) | 2013-12-19 | 2016-03-01 | 拜耳製藥公司 | 作為ep4配體之新穎苯并咪唑衍生物 |
| TW201623277A (zh) | 2014-03-26 | 2016-07-01 | 安斯泰來製藥股份有限公司 | 醯胺化合物 |
| US10052332B2 (en) | 2014-04-29 | 2018-08-21 | Emory University | Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto |
| US20170182003A1 (en) | 2014-05-23 | 2017-06-29 | Eisai R&D Management Co., Ltd. | Combination therapies for the treatment of cancer |
| RU2016151390A (ru) | 2014-06-04 | 2018-07-17 | Томас Хелледайс Стифтелсе Фёр Медисинск Форскнинг | Ингибиторы мтн1 для лечения воспалительных и аутоиммунных заболеваний |
| WO2016021742A1 (fr) | 2014-08-07 | 2016-02-11 | Takeda Pharmaceutical Company Limited | Composés hétérocycliques utilisés en tant qu'antagonistes des récepteurs ccr4 |
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| MX390051B (es) | 2015-10-16 | 2025-03-20 | Eisai R&D Man Co Ltd | Antagonistas de ep4. |
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| EP3625223B1 (fr) | 2017-05-18 | 2021-08-11 | Idorsia Pharmaceuticals Ltd | Dérivés de pyrimidine |
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