MA48459A - Méthodes d'utilisation de dérivés de benzotriazole trisubstitués en tant qu'inhibiteurs de dihydroorotate oxygénase - Google Patents

Méthodes d'utilisation de dérivés de benzotriazole trisubstitués en tant qu'inhibiteurs de dihydroorotate oxygénase

Info

Publication number: MA48459A
Authority: MA; Morocco
Prior art keywords: methods; benzotriazole derivatives; oxygenase inhibitors; trisubstituted benzotriazole; dihydroorotate oxygenase
Prior art date: 2017-04-24

Application number

MA048459A

Other languages

English (en)

Other versions

MA48459B1 (fr

Inventor

Subramanya Hosahalli

Kavitha Nellore

Original Assignee

Aurigene Discovery Tech Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-04-24

Filing date

2018-04-19

Publication date

2020-03-04

2017-04-24 Priority claimed from US15/494,820 external-priority patent/US9937155B2/en

2018-02-20 Priority claimed from US15/899,707 external-priority patent/US20180369206A1/en

2018-04-19 Application filed by Aurigene Discovery Tech Ltd filed Critical Aurigene Discovery Tech Ltd

2020-03-04 Publication of MA48459A publication Critical patent/MA48459A/fr

2021-09-30 Publication of MA48459B1 publication Critical patent/MA48459B1/fr

Links

150000001565 benzotriazoles Chemical class 0.000 title 1
UFIVEPVSAGBUSI-UHFFFAOYSA-N dihydroorotic acid Chemical compound OC(=O)C1CC(=O)NC(=O)N1 UFIVEPVSAGBUSI-UHFFFAOYSA-N 0.000 title 1
239000003650 oxygenase inhibitor Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

MA48459A 2017-04-24 2018-04-19 Méthodes d'utilisation de dérivés de benzotriazole trisubstitués en tant qu'inhibiteurs de dihydroorotate oxygénase MA48459B1 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US15/494,820 US9937155B2 (en)	2013-02-25	2017-04-24	Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors
US15/899,707 US20180369206A1 (en)	2017-04-24	2018-02-20	Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors
PCT/IB2018/052710 WO2018197997A1 (fr)	2017-04-24	2018-04-19	Méthodes d'utilisation de dérivés de benzotriazole trisubstitués en tant qu'inhibiteurs de dihydroorotate oxygénase

Publications (2)

Publication Number	Publication Date
MA48459A true MA48459A (fr)	2020-03-04
MA48459B1 MA48459B1 (fr)	2021-09-30

Family

ID=65803213

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA48459A MA48459B1 (fr)	2017-04-24	2018-04-19	Méthodes d'utilisation de dérivés de benzotriazole trisubstitués en tant qu'inhibiteurs de dihydroorotate oxygénase

Country Status (28)

Country	Link
US (1)	US12290507B2 (fr)
EP (2)	EP3615027B1 (fr)
JP (3)	JP7225114B2 (fr)
KR (2)	KR102756047B1 (fr)
CN (1)	CN110662539B (fr)
AU (2)	AU2018260390B2 (fr)
CA (1)	CA3060390A1 (fr)
CY (1)	CY1124702T1 (fr)
DK (1)	DK3615027T3 (fr)
EA (1)	EA201992528A1 (fr)
ES (1)	ES2889100T3 (fr)
HR (1)	HRP20211462T1 (fr)
HU (1)	HUE056485T2 (fr)
IL (1)	IL270066B2 (fr)
LT (1)	LT3615027T (fr)
MA (1)	MA48459B1 (fr)
MD (1)	MD3615027T2 (fr)
MX (1)	MX2019012640A (fr)
NZ (1)	NZ758333A (fr)
PH (1)	PH12019502402A1 (fr)
PL (1)	PL3615027T3 (fr)
PT (1)	PT3615027T (fr)
RS (1)	RS62519B1 (fr)
SG (1)	SG11201909718QA (fr)
SI (1)	SI3615027T1 (fr)
SM (1)	SMT202100553T1 (fr)
TW (1)	TWI821180B (fr)
UA (1)	UA129244C2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MA48459B1 (fr)	2017-04-24	2021-09-30	Aurigene Discovery Tech Ltd	Méthodes d'utilisation de dérivés de benzotriazole trisubstitués en tant qu'inhibiteurs de dihydroorotate oxygénase
MX2020008678A (es) *	2018-02-20	2020-09-25	Servier Lab	Metodos de uso para derivados de benzotriazol trisustituidos.
CN116847874A (zh) *	2020-08-27	2023-10-03	瑟维尔实验室	Dhodh抑制剂化合物在组合癌症疗法中的用途
KR102514860B1 (ko) *	2020-12-01	2023-03-29	한국과학기술연구원	5-ht7 세로토닌 수용체 활성 저해용 바이페닐 피롤리딘 및 바이페닐 다이하이드로이미다졸 유도체 및 이를 유효성분으로 포함하는 약학 조성물

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2142937C1 (ru)	1990-05-18	1999-12-20	Хехст АГ	Амиды органических кислот, способ их получения и фармацевтическая композиция
FI974171A7 (fi)	1995-05-10	1997-11-07	Pfizer	Metotreksaatin ja tenidapin yhdistelmä nivelreuman hoitoon
US5904937A (en)	1997-10-03	1999-05-18	Fmc Corporation	Taste masked pharmaceutical compositions
JP2003510352A (ja)	1999-10-01	2003-03-18	インスティチュートオブモレキュラーアンドセルバイオロジー	ウイルス媒介性疾病の治療用化合物
US6841561B1 (en) *	1999-10-01	2005-01-11	Institute Of Molecular And Cell Biology	Dihydroorotate dehydrogenase inhibitors for the treatment of viral-mediated diseases
WO2003006424A1 (fr)	2001-07-10	2003-01-23	4Sc Ag	Nouveaux composes utilises comme agents anti-inflammatoires, immunomodulateurs et anti-proliferatoires
MX2007002208A (es)	2004-08-25	2007-05-08	Targegen Inc	Compuestos hetrociclicos y metodos de uso.
HRP20100561T1 (hr)	2004-09-22	2010-11-30	Janssen Pharmaceutica Nv	Inhibitori interakcije između mdm2 i p53
JP2007015952A (ja)	2005-07-06	2007-01-25	Shionogi & Co Ltd	ナフタレン誘導体
DE102005049953A1 (de)	2005-10-19	2007-04-26	Sanofi-Aventis Deutschland Gmbh	Carbamoylbenzotriazol-derivate als Inhibitoren von Lipasen und Phospholipasen
KR101177729B1 (ko)	2006-09-08	2012-09-07	에프. 호프만-라 로슈 아게	벤조트리아졸 키나아제 조절제
EP2387568A1 (fr)	2009-01-19	2011-11-23	NeuroSearch A/S	Nouveaux dérivés de benzotriazole utiles pour le traitement de troubles du snc
EP2230232A1 (fr)	2009-03-13	2010-09-22	Almirall, S.A.	Sels adjuvants de trométhamine dotés de dérivés d'acide azabiphénylaminobenzoïque en tant qu'inhibiteurs de la DHOD
EP2228367A1 (fr)	2009-03-13	2010-09-15	Almirall, S.A.	Sels adjuvants d'amines contenant des groupes hydroxyle et/ou carbonyle avec des dérivés d'acides aminonicotiques en tant qu'inhibiteurs de la DHODH
US9316632B2 (en)	2009-03-17	2016-04-19	Marshall University Research Corporation	Methods of screening chemotherapeutic agents and treating cancer
NZ595819A (en)	2009-04-02	2013-02-22	Merck Serono Sa	DIHYDROOROTATE DEHYDROGENASE INHIBITORS; benzimidazole-4-carboxylic acid
EP2509600B1 (fr)	2009-12-09	2017-08-02	Agios Pharmaceuticals, Inc.	Composés thérapeutiquement actifs destinés au traitement d'un cancer caractérisé par une mutation idh
WO2011143160A2 (fr) *	2010-05-10	2011-11-17	The Johns Hopkins University	Inhibiteur métabolique contre des tumeurs ayant une mutation de l'idh
US9012464B2 (en)	2010-11-25	2015-04-21	Ratiopharm Gmbh	Salts and polymorphic forms of Afatinib
WO2013049112A1 (fr)	2011-09-27	2013-04-04	Emory University	Détection de biomarqueurs à l'aide de résonance magnétique
CN103965133B (zh)	2013-01-31	2018-11-30	华东理工大学	一种具有dhodh抑制活性的含n、s杂环化合物及其制备和用途
US9630932B2 (en) *	2013-02-25	2017-04-25	Um Pharmauji Sdn. Bhd.	Trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors
US9603927B2 (en)	2014-02-28	2017-03-28	Janssen Biotech, Inc.	Combination therapies with anti-CD38 antibodies
ES2960598T3 (es)	2014-05-08	2024-03-05	Kiora Pharmaceuticals Gmbh	Compuestos para el tratamiento de enfermedades y trastornos oftálmicos
CA2996632C (fr)	2015-09-01	2023-10-17	Bayer Pharma Aktiengesellschaft	Composes et methodes utiles pour le traitement ou la prevention de cancers hematologiques
KR20180102105A (ko)	2015-12-30	2018-09-14	아지오스 파마슈티컬스 아이엔씨.	돌연변이체 이소시트레이트 데히드로게나제를 포함하고 있는 종양의 치료
JOP20190094A1 (ar)	2016-10-27	2019-04-25	Broad Inst Inc	مركبات 1، 2، 4-تريازولون تحمل ثلاثة بدائل عند المواقع 2، 4، 5 مفيدة كمثبطات لديهيدروجيناز ثنائي هيدرو أوروتات (dhodh)
WO2018136009A1 (fr)	2017-01-20	2018-07-26	Aslan Pharmaceuticals Pte Ltd	Polythérapie
US11311548B2 (en)	2017-03-02	2022-04-26	Aslan Pharmaceuticals Pte. Ltd.	Cancer therapy
MA48459B1 (fr)	2017-04-24	2021-09-30	Aurigene Discovery Tech Ltd	Méthodes d'utilisation de dérivés de benzotriazole trisubstitués en tant qu'inhibiteurs de dihydroorotate oxygénase
US20180369206A1 (en)	2017-04-24	2018-12-27	Aurigene Discovery Technologies Limited	Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors
WO2019012030A1 (fr)	2017-07-13	2019-01-17	INSERM (Institut National de la Santé et de la Recherche Médicale)	Inhibiteur de dhodh et inhibiteur de chk1 pour le traitement du cancer
MX2020008678A (es)	2018-02-20	2020-09-25	Servier Lab	Metodos de uso para derivados de benzotriazol trisustituidos.
EP3858361B1 (fr)	2018-09-28	2025-10-08	FUJIFILM Corporation	Agent antitumoral contenant de la cytarabine, activateur d'effet antitumoral utilisé en combinaison avec la cytarabine, kit antitumoral, et agent antitumoral utilisé en combinaison avec le cytarabine
WO2020109625A1 (fr)	2018-11-30	2020-06-04	Fondazione Centro San Raffaele	Traitement combiné du lymphome primaire du système nerveux central
JP2022515239A (ja)	2018-12-21	2022-02-17	レラボラトワールセルヴィエソシエテ・パール・アクシオンス・サンプリフィエ	有機化合物の結晶および塩形態およびその医薬組成物
US12582667B2 (en)	2019-09-27	2026-03-24	The Rockefeller University	Compositions and methods to treat metastatic gastrointestinal cancer
JP2023533489A (ja)	2020-06-24	2023-08-03	レラボラトワールセルビエ	癌併用療法におけるｄｈｏｄｈ阻害剤化合物の利用
WO2021262874A1 (fr)	2020-06-24	2021-12-30	Servier Pharmaceuticals , Llc	Utilisation d'un composé inhibiteur de dhodh en polythérapie anticancéreuse
CN116847874A (zh)	2020-08-27	2023-10-03	瑟维尔实验室	Dhodh抑制剂化合物在组合癌症疗法中的用途

2018
- 2018-04-19 MA MA48459A patent/MA48459B1/fr unknown
- 2018-04-19 SM SM20210553T patent/SMT202100553T1/it unknown
- 2018-04-19 EP EP18723602.1A patent/EP3615027B1/fr active Active
- 2018-04-19 MD MDE20200226T patent/MD3615027T2/ro unknown
- 2018-04-19 HU HUE18723602A patent/HUE056485T2/hu unknown
- 2018-04-19 HR HRP20211462TT patent/HRP20211462T1/hr unknown
- 2018-04-19 EP EP21184786.8A patent/EP3915557A1/fr active Pending
- 2018-04-19 IL IL270066A patent/IL270066B2/en unknown
- 2018-04-19 CN CN201880027155.0A patent/CN110662539B/zh active Active
- 2018-04-19 PL PL18723602T patent/PL3615027T3/pl unknown
- 2018-04-19 MX MX2019012640A patent/MX2019012640A/es unknown
- 2018-04-19 EA EA201992528A patent/EA201992528A1/ru unknown
- 2018-04-19 SG SG11201909718Q patent/SG11201909718QA/en unknown
- 2018-04-19 DK DK18723602.1T patent/DK3615027T3/da active
- 2018-04-19 JP JP2019557358A patent/JP7225114B2/ja active Active
- 2018-04-19 SI SI201830423T patent/SI3615027T1/sl unknown
- 2018-04-19 PT PT187236021T patent/PT3615027T/pt unknown
- 2018-04-19 ES ES18723602T patent/ES2889100T3/es active Active
- 2018-04-19 AU AU2018260390A patent/AU2018260390B2/en active Active
- 2018-04-19 LT LTEPPCT/IB2018/052710T patent/LT3615027T/lt unknown
- 2018-04-19 UA UAA201911329A patent/UA129244C2/uk unknown
- 2018-04-19 KR KR1020247020497A patent/KR102756047B1/ko active Active
- 2018-04-19 CA CA3060390A patent/CA3060390A1/fr active Pending
- 2018-04-19 KR KR1020197034384A patent/KR102678263B1/ko active Active
- 2018-04-19 RS RS20211150A patent/RS62519B1/sr unknown
- 2018-04-19 NZ NZ758333A patent/NZ758333A/en unknown
- 2018-04-23 TW TW107113690A patent/TWI821180B/zh active
2019
- 2019-10-23 PH PH12019502402A patent/PH12019502402A1/en unknown
2021
- 2021-10-04 CY CY20211100855T patent/CY1124702T1/el unknown
- 2021-10-14 US US17/501,701 patent/US12290507B2/en active Active
2022
- 2022-12-02 JP JP2022193406A patent/JP2023022252A/ja active Pending
2024
- 2024-07-25 AU AU2024205090A patent/AU2024205090A1/en active Pending
2025
- 2025-07-31 JP JP2025128059A patent/JP2025156453A/ja active Pending

Also Published As

Publication number	Publication date
UA129244C2 (uk)	2025-02-26
MA48459B1 (fr)	2021-09-30
CN110662539A (zh)	2020-01-07
CN110662539B (zh)	2023-08-15
SMT202100553T1 (it)	2021-11-12
HRP20211462T1 (hr)	2021-12-24
DK3615027T3 (da)	2021-08-30
SI3615027T1 (sl)	2021-12-31
CA3060390A1 (fr)	2018-11-01
IL270066A (fr)	2019-12-31
US12290507B2 (en)	2025-05-06
IL270066B1 (en)	2023-06-01
JP2020517654A (ja)	2020-06-18
PT3615027T (pt)	2021-09-24
JP2025156453A (ja)	2025-10-14
LT3615027T (lt)	2021-10-25
TW201902880A (zh)	2019-01-16
BR112019022331A2 (pt)	2020-05-26
EP3615027A1 (fr)	2020-03-04
EA201992528A1 (ru)	2020-02-28
KR102678263B1 (ko)	2024-06-24
MD3615027T2 (ro)	2021-11-30
IL270066B2 (en)	2023-10-01
JP2023022252A (ja)	2023-02-14
EP3615027B1 (fr)	2021-07-14
US20220241246A1 (en)	2022-08-04
AU2018260390A1 (en)	2019-11-07
KR20240105481A (ko)	2024-07-05
KR20190140005A (ko)	2019-12-18
JP7225114B2 (ja)	2023-02-20
CY1124702T1 (el)	2022-07-22
TWI821180B (zh)	2023-11-11
AU2024205090A1 (en)	2024-08-15
NZ758333A (en)	2025-10-31
PL3615027T3 (pl)	2022-01-03
HUE056485T2 (hu)	2022-02-28
KR102756047B1 (ko)	2025-01-15
PH12019502402A1 (en)	2021-01-25
SG11201909718QA (en)	2019-11-28
RS62519B1 (sr)	2021-11-30
MX2019012640A (es)	2020-12-11
AU2018260390B2 (en)	2024-05-02
ES2889100T3 (es)	2022-01-11
EP3915557A1 (fr)	2021-12-01

Publication	Publication Date	Title
MA53150A (fr)	2021-05-26	Composés de benzimidazole en tant qu'inhibiteurs de c-kit
MA51290A (fr)	2021-03-31	Nouvelles pyridopyrimidinones à substitution benzylamino et dérivés à utiliser en tant qu'inhibiteurs de sos1
MA51878A (fr)	2020-12-30	Composés d'aminothiazole en tant qu'inhibiteurs de c-kit
MA47125A (fr)	2021-04-28	Dérivés de pyrazole en tant qu'inhibiteurs de malt1
MA51438A (fr)	2021-04-14	Composés hétérocycliques utilisés en tant qu'inhibiteurs de lsd1
MA45244A (fr)	2019-04-17	Pyridines substituées utilisées en tant qu'inhibiteurs de dnmt1
MA43169A (fr)	2018-09-12	Composés hétérocycliques utilisés en tant qu'inhibiteurs de pi3k-gamma
MA42659A (fr)	2018-06-27	Dérivés hétéroaryle utilisés en tant qu'inhibiteurs de parp
MA45189A (fr)	2019-04-10	Nouveaux dérivés hétérocycliques utiles en tant qu'inhibiteurs de shp2
MA47086A (fr)	2021-04-28	Dérivés de dihydropyrimidine-carboxamide bicycliques utilisés en tant qu'inhibiteurs de rho-kinase
MA53352A (fr)	2021-09-15	Dérivés de pyridin-2-(1h)-one-quinolinone en tant qu'inhibiteurs d'isocitrate déshydrogénase
EP3755311A4 (fr)	2021-11-10	Indane-amines utiles en tant qu'antagonistes de pd-l1
MA46981A (fr)	2019-10-09	Dérivés de benzimidazole en tant qu'inhibiteurs de bromodomaine
MA42592A (fr)	2018-06-20	Utilisation de dérivés de 2-(pyrazolopyridin-3-yl) pyrimidine en tant qu'inhibiteurs de jak
EP3416964A4 (fr)	2019-09-18	Dérivés de carboxamide utiles en tant qu'inhibiteurs de rsk
MA52063A (fr)	2021-05-26	Composés de n-((hét)arylméthyl)hétéroaryle-carboxamides en tant qu'inhibiteurs de la kallicréine plasmatique
MA40774A (fr)	2017-08-08	Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38
MA54567A (fr)	2021-10-27	Pyridine et composés de pyridimine en tant qu'inhibiteurs de pi3k-gamma
MA42919A (fr)	2018-08-01	Composés bicycliques utilisés en tant qu'inhibiteurs d'atx
MA43864A (fr)	2018-11-21	Utilisation de dérivés de thiohydantoin substitué en tant qu'antagonistes des récepteurs d'androgènes
MA42918A (fr)	2018-08-01	Composés bicycliques utilisés en tant qu'inhibiteurs d'atx
MA46878A (fr)	2019-10-02	Composés de benzodiazolium en tant qu'inhibiteurs d'enac
MA47593A (fr)	2020-01-01	Dérivés de 1, 4, 6-trisubstitué-2-alkyl-1h-benzo[d]imidazole en tant qu'inhibiteurs de dihydroorotate oxygénase
MA49374A (fr)	2021-04-21	Composés hétéroaromatiques utilisés en tant qu'inhibiteurs de vanine
MA51897A (fr)	2020-12-30	Procédés d'utilisation de dérivés de benzotriazole trisubstitués