MA54567A - Pyridine et composés de pyridimine en tant qu'inhibiteurs de pi3k-gamma - Google Patents

Pyridine et composés de pyridimine en tant qu'inhibiteurs de pi3k-gamma

Info

Publication number
MA54567A
MA54567A MA054567A MA54567A MA54567A MA 54567 A MA54567 A MA 54567A MA 054567 A MA054567 A MA 054567A MA 54567 A MA54567 A MA 54567A MA 54567 A MA54567 A MA 54567A
Authority
MA
Morocco
Prior art keywords
pyridimine
pi3k
pyridine
compounds
gamma inhibitors
Prior art date
Application number
MA054567A
Other languages
English (en)
Inventor
Andrew W Buesking
Andrew P Combs
Nikoo Falahatpisheh
Lixin Shao
Stacey Shepard
Richard B Sparks
Haisheng Wang
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of MA54567A publication Critical patent/MA54567A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA054567A 2016-01-05 2017-01-04 Pyridine et composés de pyridimine en tant qu'inhibiteurs de pi3k-gamma MA54567A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662274942P 2016-01-05 2016-01-05

Publications (1)

Publication Number Publication Date
MA54567A true MA54567A (fr) 2021-10-27

Family

ID=57868380

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054567A MA54567A (fr) 2016-01-05 2017-01-04 Pyridine et composés de pyridimine en tant qu'inhibiteurs de pi3k-gamma

Country Status (7)

Country Link
US (3) US20170190689A1 (fr)
EP (2) EP3400221B1 (fr)
AR (1) AR107293A1 (fr)
ES (2) ES2995198T3 (fr)
MA (1) MA54567A (fr)
TW (1) TW201734003A (fr)
WO (1) WO2017120194A1 (fr)

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JP2024535825A (ja) * 2021-09-14 2024-10-02 ヴァンダービルト ユニバーシティー ｍＧｌｕ５ネガティブアロステリックモジュレーターとしてのヘテロアリール結合アナログ並びにこの製造方法及び使用方法
WO2023083330A1 (fr) * 2021-11-12 2023-05-19 百极优棠(广东)医药科技有限公司 Inhibiteur de drak2, son procédé de préparation et son utilisation

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Also Published As

Publication number Publication date
EP3400221A1 (fr) 2018-11-14
AR107293A1 (es) 2018-04-18
ES2833955T3 (es) 2021-06-16
US11952367B2 (en) 2024-04-09
WO2017120194A1 (fr) 2017-07-13
EP3792256A1 (fr) 2021-03-17
US11352340B2 (en) 2022-06-07
US20190359592A1 (en) 2019-11-28
EP3400221B1 (fr) 2020-08-26
ES2995198T3 (en) 2025-02-07
US20170190689A1 (en) 2017-07-06
US20220227736A1 (en) 2022-07-21
TW201734003A (zh) 2017-10-01
EP3792256B1 (fr) 2024-10-23

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