MA54567A - Pyridine et composés de pyridimine en tant qu'inhibiteurs de pi3k-gamma - Google Patents
Pyridine et composés de pyridimine en tant qu'inhibiteurs de pi3k-gammaInfo
- Publication number
- MA54567A MA54567A MA054567A MA54567A MA54567A MA 54567 A MA54567 A MA 54567A MA 054567 A MA054567 A MA 054567A MA 54567 A MA54567 A MA 54567A MA 54567 A MA54567 A MA 54567A
- Authority
- MA
- Morocco
- Prior art keywords
- pyridimine
- pi3k
- pyridine
- compounds
- gamma inhibitors
- Prior art date
Links
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 2
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662274942P | 2016-01-05 | 2016-01-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA54567A true MA54567A (fr) | 2021-10-27 |
Family
ID=57868380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA054567A MA54567A (fr) | 2016-01-05 | 2017-01-04 | Pyridine et composés de pyridimine en tant qu'inhibiteurs de pi3k-gamma |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20170190689A1 (fr) |
| EP (2) | EP3792256B1 (fr) |
| AR (1) | AR107293A1 (fr) |
| ES (2) | ES2995198T3 (fr) |
| MA (1) | MA54567A (fr) |
| TW (1) | TW201734003A (fr) |
| WO (1) | WO2017120194A1 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016130501A1 (fr) | 2015-02-09 | 2016-08-18 | Incyte Corporation | Composés aza-hétéroaryle en tant qu'inhibiteurs de pi3k-gamma |
| RS63359B1 (sr) | 2015-11-06 | 2022-07-29 | Incyte Corp | Heterociklična jedinjenja kao inhibitori pi3k-gama |
| ES2995198T3 (en) | 2016-01-05 | 2025-02-07 | Incyte Corp | Pyridine compounds as pi3k-gamma inhibitors |
| TW201803871A (zh) | 2016-06-24 | 2018-02-01 | 英塞特公司 | 作為ＰＩ３Ｋ-γ抑制劑之雜環化合物 |
| KR102717072B1 (ko) | 2017-10-18 | 2024-10-15 | 인사이트 코포레이션 | Pi3k-감마 저해제로서의 3차 하이드록시기로 치환된 축합된 이미다졸 유도체 |
| US12133852B2 (en) | 2017-11-15 | 2024-11-05 | Epivario, Inc. | ACSS2 inhibitors and methods of use thereof |
| WO2019099203A1 (fr) * | 2017-11-17 | 2019-05-23 | Hepagene Therapeutics, Inc. | Dérivés d'oxazole et de thiazole utilisés en tant qu'inhibiteurs d'ask1 |
| WO2019119206A1 (fr) * | 2017-12-18 | 2019-06-27 | Merck Sharp & Dohme Corp. | Inhibiteurs puriques de la phosphatidylinositol 3-kinase delta humaine |
| CR20200464A (es) | 2018-03-08 | 2021-04-14 | Incyte Corp | Compuestos diólicos de aminopirazina como inhibidores de pi3k-y |
| WO2020010003A1 (fr) | 2018-07-02 | 2020-01-09 | Incyte Corporation | DÉRIVÉS D'AMINOPYRAZINE UTILISÉS EN TANT QU'INHIBITEURS DE PI3K-γ |
| CR20250050A (es) | 2018-09-05 | 2025-03-19 | Incyte Corp | Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165) |
| WO2020210379A1 (fr) * | 2019-04-10 | 2020-10-15 | Hangzhou Zhengxiang Pharmaceuticals Co., Ltd. | Inhibiteur de la phosphatidylinositol 3-kinase |
| EP3983386A4 (fr) * | 2019-05-14 | 2023-01-11 | Metabomed Ltd | Inhibiteurs d'acss2 et leurs procédés d'utilisation |
| CN111718310B (zh) * | 2019-08-19 | 2021-06-11 | 中国药科大学 | 苯基取代的五元杂环类化合物及其制备方法、用途和药物组合物 |
| EP4157281A4 (fr) * | 2020-05-27 | 2024-11-27 | Duke University | Compositions et procédés pour sensibiliser des leucémies myéloïdes aiguës à une chimiothérapie |
| AU2022345071A1 (en) * | 2021-09-14 | 2024-05-02 | Vanderbilt University | Heteroaryl-linked analogs as mglu5 negative allosteric modulators and methods of making and using the same |
| JP7843071B2 (ja) * | 2021-11-12 | 2026-04-09 | バイオポーラー ヨータン（グァンドン） ファーマシューティカル カンパニー，リミテッド | Ｄｒａｋ２阻害剤およびその製造方法と使用 |
Family Cites Families (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4269846A (en) | 1979-10-29 | 1981-05-26 | Usv Pharmaceutical Corporation | Heterocyclic compounds useful as anti-allergy agents |
| US5521184A (en) | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| ES2342240T3 (es) | 1998-08-11 | 2010-07-02 | Novartis Ag | Derivados de isoquinolina con actividad que inhibe la angiogenia. |
| US6133031A (en) | 1999-08-19 | 2000-10-17 | Isis Pharmaceuticals Inc. | Antisense inhibition of focal adhesion kinase expression |
| GB9905075D0 (en) | 1999-03-06 | 1999-04-28 | Zeneca Ltd | Chemical compounds |
| GB0004890D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0011092D0 (en) | 2000-05-08 | 2000-06-28 | Black James Foundation | Gastrin and cholecystokinin receptor ligands (III) |
| EP1294358B1 (fr) | 2000-06-28 | 2004-08-18 | Smithkline Beecham Plc | Procede de broyage par voie humide |
| CN100391958C (zh) | 2001-09-19 | 2008-06-04 | 安万特医药股份有限公司 | 化合物 |
| FR2831536A1 (fr) | 2001-10-26 | 2003-05-02 | Aventis Pharma Sa | Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr |
| IL161576A0 (en) | 2001-10-26 | 2004-09-27 | Aventis Pharma Inc | Benzimidazoles and analogues and their use as protein kinases inhibitors |
| PT1441737E (pt) | 2001-10-30 | 2006-12-29 | Dana Farber Cancer Inst Inc | Derivados de estrutura como inibidores da actividade do receptor de tirosina cinase flt3 |
| DE10207843A1 (de) | 2002-02-15 | 2003-09-04 | Schering Ag | Mikrolia-Inhibitoren zur Unterbrechung von Interleukin 12 und IFN-gamma vermittelten Immunreaktionen |
| PE20040522A1 (es) | 2002-05-29 | 2004-09-28 | Novartis Ag | Derivados de diarilurea dependientes de la cinasa de proteina |
| GB0215676D0 (en) | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| AR042052A1 (es) | 2002-11-15 | 2005-06-08 | Vertex Pharma | Diaminotriazoles utiles como inhibidores de proteinquinasas |
| UA80767C2 (en) | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| US7186832B2 (en) | 2003-02-20 | 2007-03-06 | Sugen Inc. | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors |
| WO2004078943A2 (fr) | 2003-03-04 | 2004-09-16 | California Institute Of Technology | Nouveaux heterocycles pour reconnaissance d'adn |
| GB0305929D0 (en) | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| BRPI0413234A (pt) | 2003-08-01 | 2006-10-03 | Genelabs Tech Inc | derivados de imidazola bicìclica contra flaviviridae |
| PE20050952A1 (es) | 2003-09-24 | 2005-12-19 | Novartis Ag | Derivados de isoquinolina como inhibidores de b-raf |
| WO2005118580A2 (fr) | 2004-05-12 | 2005-12-15 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health | Composes tricycliques utiles comme inhibiteurs du mecanisme de signalisation hypoxique |
| RU2007123675A (ru) | 2004-11-24 | 2008-12-27 | Новартис АГ (CH) | Комбинации ингибиторов jak |
| US7345178B2 (en) | 2005-08-04 | 2008-03-18 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| EP1928237A4 (fr) | 2005-09-02 | 2011-03-09 | Abbott Lab | Nouveaux heterocycles a base imidazo |
| PT2404919E (pt) | 2005-11-08 | 2013-10-22 | Vertex Pharma | Composto heterocíclico útil como um modulador de transportadores de cassete de ligação a atp |
| DE602007004618D1 (de) | 2006-06-22 | 2010-03-18 | Biovitrum Ab Publ | Pyridin- und pyrazinderivate als mnk-kinaseinhibitoren |
| EP2139474A2 (fr) | 2007-03-27 | 2010-01-06 | Paratek Pharmaceuticals, Inc. | Composés modulant le facteur de transcription et leurs procédés d'utilisation |
| DE102007035333A1 (de) | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| GB0716292D0 (en) | 2007-08-21 | 2007-09-26 | Biofocus Dpi Ltd | Imidazopyrazine compounds |
| EP2234487A4 (fr) | 2007-12-19 | 2011-09-07 | Scripps Research Inst | Anilides et analogues utilisés comme inhibiteurs de la rho kinase |
| JP5795714B2 (ja) | 2008-01-15 | 2015-10-14 | シガ・テクノロジーズ・インコーポレーテッド | アレナウイルス感染症の治療のための抗ウイルス薬 |
| WO2009133127A1 (fr) | 2008-04-30 | 2009-11-05 | Merck Serono S.A. | Composés bicycliques fusionnés et utilisations de ceux-ci comme inhibiteurs de p13k |
| WO2009158118A2 (fr) | 2008-05-30 | 2009-12-30 | University Of Notre Dame Du Lac | Agents antibactériens produits à partir d'échafaudages benzo[d]hétérocycliques utilisés pour prévenir et traiter une bactérie multirésistante aux antibiotiques |
| US8470819B2 (en) | 2008-11-03 | 2013-06-25 | Merck Sharp & Dohme Corp. | Benzimidazole and aza-benzimidazole carboxamides |
| WO2010061903A1 (fr) * | 2008-11-27 | 2010-06-03 | 塩野義製薬株式会社 | Dérivé de pyrimidine et dérivé de pyridine présentant tous deux une activité inhibitrice de pi3k |
| GB0822981D0 (en) | 2008-12-17 | 2009-01-21 | Summit Corp Plc | Compounds for treatment of duchenne muscular dystrophy |
| EP2401273A1 (fr) | 2009-02-27 | 2012-01-04 | Vertex Pharmaceuticals Incorporated | Inhibiteurs tricycliques de pyrazolopyridine kinase |
| NZ596479A (en) | 2009-05-22 | 2014-01-31 | Incyte Corp | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| EP2448938B9 (fr) | 2009-06-29 | 2015-06-10 | Incyte Corporation | Pyrimidinones comme inhibiteurs de pi3k |
| TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| WO2011075643A1 (fr) | 2009-12-18 | 2011-06-23 | Incyte Corporation | Dérivés condensés d'hétéroaryles substitués à titre d'inhibiteurs de pi3k |
| WO2011075630A1 (fr) | 2009-12-18 | 2011-06-23 | Incyte Corporation | Dérivés substitués d'aryles et d'hétéroaryles fusionnés au titre d'inhibiteurs de pi3k |
| WO2011099832A2 (fr) | 2010-02-12 | 2011-08-18 | Crystalgenomics, Inc. | Nouveau composé de benzimidazole, son procédé de préparation et composition pharmaceutique le contenant |
| CA2792508C (fr) | 2010-03-10 | 2018-01-16 | Incyte Corporation | Derives de piperidin-4-yl azetidine en tant qu'inhibiteurs de jak1 |
| JP2013523766A (ja) | 2010-03-31 | 2013-06-17 | グラクソ グループ リミテッド | キナーゼ阻害剤としてのイミダゾリル‐イミダゾール |
| EP2558463A1 (fr) | 2010-04-14 | 2013-02-20 | Incyte Corporation | Dérivés condensés en tant qu'inhibiteurs de i3 |
| CA2800509A1 (fr) | 2010-05-24 | 2011-12-01 | Presidio Pharmaceuticals, Inc. | Inhibiteurs de ns5a du vhc |
| EP2627650A2 (fr) * | 2010-05-26 | 2013-08-21 | Merck Sharp & Dohme Corp. | Inhibiteurs n-phénylimidazolecarboxamides de la protéine kinase 3-phosphoinositide-dépendante de type 1 |
| US9062055B2 (en) | 2010-06-21 | 2015-06-23 | Incyte Corporation | Fused pyrrole derivatives as PI3K inhibitors |
| MX2013004003A (es) | 2010-10-13 | 2013-10-01 | Millenium Pharmaceuticals Inc | Heteroarilos y usos de los mismos. |
| ES2536415T3 (es) | 2010-11-19 | 2015-05-25 | Incyte Corporation | Pirrolopiridinas y pirrolopirimidinas sustituidas heterocíclicas como inhibidores de JAK |
| CA2818542A1 (fr) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Derives pyrrolopyridine et pyrrolopyrimidine a substitution cyclobutyle utilises comme inhibiteurs des jak |
| US8729102B2 (en) | 2010-11-30 | 2014-05-20 | Takeda Pharmaceutical Company Limited | Bicyclic compound |
| JP5961187B2 (ja) | 2010-12-20 | 2016-08-02 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｐｉ３ｋ阻害剤としてのｎ−（１−（置換フェニル）エチル）−９ｈ−プリン−６−アミン |
| US9108984B2 (en) | 2011-03-14 | 2015-08-18 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors |
| US8673905B2 (en) | 2011-03-17 | 2014-03-18 | Hoffmann-La Roche Inc. | Imidazo pyrazines |
| US9126948B2 (en) | 2011-03-25 | 2015-09-08 | Incyte Holdings Corporation | Pyrimidine-4,6-diamine derivatives as PI3K inhibitors |
| WO2012143796A2 (fr) | 2011-04-21 | 2012-10-26 | Institut Pasteur Korea | Composés anti-inflammatoires |
| KR101913619B1 (ko) | 2011-06-09 | 2018-12-28 | 리젠 파마슈티컬스 소시에떼 아노님 | Gpr-119의 조절제로서의 신규한 화합물 |
| US8691807B2 (en) | 2011-06-20 | 2014-04-08 | Incyte Corporation | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors |
| TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物 |
| MX389479B (es) | 2011-09-02 | 2025-03-20 | Incyte Holdings Corp | Heterociclilaminas como inhibidores de fosfoinositida 3-cinasas (pi3k) |
| WO2013129674A1 (fr) | 2012-03-01 | 2013-09-06 | 学校法人兵庫医科大学 | Nouveau dérivé de benzimidazole et son utilisation |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| TW201406761A (zh) | 2012-05-18 | 2014-02-16 | Incyte Corp | 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物 |
| WO2013180193A1 (fr) | 2012-05-31 | 2013-12-05 | 住友化学株式会社 | Composé hétérocyclique condensé |
| ES2689429T3 (es) | 2012-07-13 | 2018-11-14 | Ucb Biopharma Sprl | Derivados de imidazopiridina como moduladores de actividad de TNF |
| CA2888816A1 (fr) | 2012-11-01 | 2014-05-08 | Incyte Corporation | Derives de thiophene condenses tricycliques a titre d'inhibiteurs de jak |
| TWI736135B (zh) | 2013-03-01 | 2021-08-11 | 美商英塞特控股公司 | 吡唑并嘧啶衍生物治療PI3Kδ相關病症之用途 |
| WO2014149207A2 (fr) | 2013-03-15 | 2014-09-25 | Dow Agrosciences Llc | Compositions insecticides à base de benzimidazole et procédés apparentés |
| EP2976077A4 (fr) | 2013-03-22 | 2016-11-30 | Scripps Research Inst | Benzimidazoles substitués en tant que modulateurs d'un récepteur de nociceptine |
| EP2994142A4 (fr) | 2013-05-08 | 2017-03-29 | Colorado Seminary, Which Owns and Operates The University of Denver | Agents antibiotiques et antiparasitaires qui modulent la fructose 1,6-bisphosphate aldolase de classe ii |
| CR20190156A (es) | 2013-05-17 | 2019-05-16 | Incyte Corp | Derivados de bipirazol como inhibidores jak |
| TWI641595B (zh) | 2013-07-17 | 2018-11-21 | 日商大塚製藥股份有限公司 | 氰基三唑化合物類 |
| WO2015051241A1 (fr) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Composés hétérocycliques et leurs utilisations |
| CA3158254C (fr) | 2014-04-08 | 2024-05-21 | Incyte Corporation | Traitement des malignites de cellules b par une combinaison d'inhibiteurs de jak et de pi3k |
| EP2930048A1 (fr) | 2014-04-10 | 2015-10-14 | Johnson Controls Automotive Electronics SAS | Dispositif d'affichage tête haute projetant des informations visuelles sur un écran |
| US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
| CA2961525A1 (fr) * | 2014-09-16 | 2016-03-24 | Celgene Quanticel Research, Inc. | Inhibiteurs de l'histone demethylase |
| WO2016054491A1 (fr) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Composés hétérocycliques et leurs utilisations |
| MA40933A (fr) * | 2014-11-11 | 2017-09-19 | Piqur Therapeutics Ag | Difluorométhyl-aminopyridines et difluorométhyl-aminopyrimidines |
| WO2016130501A1 (fr) | 2015-02-09 | 2016-08-18 | Incyte Corporation | Composés aza-hétéroaryle en tant qu'inhibiteurs de pi3k-gamma |
| RS63359B1 (sr) | 2015-11-06 | 2022-07-29 | Incyte Corp | Heterociklična jedinjenja kao inhibitori pi3k-gama |
| ES2995198T3 (en) | 2016-01-05 | 2025-02-07 | Incyte Corp | Pyridine compounds as pi3k-gamma inhibitors |
| TW201803871A (zh) | 2016-06-24 | 2018-02-01 | 英塞特公司 | 作為ＰＩ３Ｋ-γ抑制劑之雜環化合物 |
-
2017
- 2017-01-04 ES ES20187907T patent/ES2995198T3/es active Active
- 2017-01-04 EP EP20187907.9A patent/EP3792256B1/fr active Active
- 2017-01-04 MA MA054567A patent/MA54567A/fr unknown
- 2017-01-04 TW TW106100143A patent/TW201734003A/zh unknown
- 2017-01-04 ES ES17701205T patent/ES2833955T3/es active Active
- 2017-01-04 AR ARP170100017A patent/AR107293A1/es unknown
- 2017-01-04 US US15/398,121 patent/US20170190689A1/en not_active Abandoned
- 2017-01-04 EP EP17701205.1A patent/EP3400221B1/fr active Active
- 2017-01-04 WO PCT/US2017/012135 patent/WO2017120194A1/fr not_active Ceased
-
2019
- 2019-03-29 US US16/369,541 patent/US11352340B2/en active Active
-
2022
- 2022-03-25 US US17/705,079 patent/US11952367B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3792256A1 (fr) | 2021-03-17 |
| EP3792256B1 (fr) | 2024-10-23 |
| US11352340B2 (en) | 2022-06-07 |
| EP3400221B1 (fr) | 2020-08-26 |
| WO2017120194A1 (fr) | 2017-07-13 |
| US20170190689A1 (en) | 2017-07-06 |
| AR107293A1 (es) | 2018-04-18 |
| ES2995198T3 (en) | 2025-02-07 |
| US20220227736A1 (en) | 2022-07-21 |
| ES2833955T3 (es) | 2021-06-16 |
| TW201734003A (zh) | 2017-10-01 |
| US20190359592A1 (en) | 2019-11-28 |
| US11952367B2 (en) | 2024-04-09 |
| EP3400221A1 (fr) | 2018-11-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA43862A (fr) | Spiroheptane salicylamides et composés associés en tant qu' inhibiteurs de rock | |
| MA45244A (fr) | Pyridines substituées utilisées en tant qu'inhibiteurs de dnmt1 | |
| MA43169A (fr) | Composés hétérocycliques utilisés en tant qu'inhibiteurs de pi3k-gamma | |
| MA51878A (fr) | Composés d'aminothiazole en tant qu'inhibiteurs de c-kit | |
| MA53150A (fr) | Composés de benzimidazole en tant qu'inhibiteurs de c-kit | |
| EP3533787A4 (fr) | Composé de pyridone en tant qu'inhibiteur de c-met | |
| MA49903A (fr) | Sulfonylureés et sulfonylthioureés en tant qu'inhibiteurs de nlrp3 | |
| MA55194A (fr) | Composés hétérocycliques en tant qu'immunomodulateurs | |
| MA42990A (fr) | Composés utiles en tant qu'immunomodulateurs | |
| MA47120A (fr) | Dérivés pyridine utilisés en tant qu'immunomodulateurs | |
| MA40587A (fr) | Composés d'aminopyrimidinyle en tant qu'inhibiteurs de jak | |
| MA51438A (fr) | Composés hétérocycliques utilisés en tant qu'inhibiteurs de lsd1 | |
| ME03574B (fr) | Composés hétéroaryle utiles en tant qu'inhibiteurs de l'enzyme d'activation sumo | |
| EP3386981A4 (fr) | Hétérocycles utiles en tant qu'agents anticancereux | |
| MA42659A (fr) | Dérivés hétéroaryle utilisés en tant qu'inhibiteurs de parp | |
| MA45377A (fr) | Composés hétérocycliques en tant qu'agents antibacteriens | |
| MA41551A (fr) | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 | |
| MA46091A (fr) | Composés biaryles utiles en tant qu'immunomodulateurs | |
| MA47013A (fr) | Composés benzolactames utilisés en tant qu'inhibiteurs de protéine kinase | |
| EP3464275A4 (fr) | Composés inhibiteurs de l'egfr | |
| MA52063A (fr) | Composés de n-((hét)arylméthyl)hétéroaryle-carboxamides en tant qu'inhibiteurs de la kallicréine plasmatique | |
| MA40774A (fr) | Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38 | |
| EP3416964A4 (fr) | Dérivés de carboxamide utiles en tant qu'inhibiteurs de rsk | |
| EP3380101A4 (fr) | Composés inhibiteurs d'eif4-a et procédés associés | |
| EP3359164A4 (fr) | Composés et procédés pour moduler l'expression de l'angiotensinogène |