MA48943A - Dérivés d'indoline substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue - Google Patents

Dérivés d'indoline substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue

Info

Publication number
MA48943A
MA48943A MA048943A MA48943A MA48943A MA 48943 A MA48943 A MA 48943A MA 048943 A MA048943 A MA 048943A MA 48943 A MA48943 A MA 48943A MA 48943 A MA48943 A MA 48943A
Authority
MA
Morocco
Prior art keywords
substitute
dengue virus
virus replication
derivatives used
replication inhibitors
Prior art date
Application number
MA048943A
Other languages
English (en)
Inventor
Dorothée Alice Marie-Eve Bardiot
Jean-François Bonfanti
Erwin Coesemans
Jérôme Michel Claude Fortin
Bart Rudolf Romanie Kesteleyn
Arnaud Didier M Marchand
Guillaume Jean Maurice Mercey
Pierre Jean-Marie Bernard Raboisson
Original Assignee
Janssen Pharmaceuticals Inc
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc, Univ Leuven Kath filed Critical Janssen Pharmaceuticals Inc
Publication of MA48943A publication Critical patent/MA48943A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA048943A 2017-05-22 2018-05-18 Dérivés d'indoline substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue MA48943A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17172237 2017-05-22

Publications (1)

Publication Number Publication Date
MA48943A true MA48943A (fr) 2021-04-28

Family

ID=58745157

Family Applications (1)

Application Number Title Priority Date Filing Date
MA048943A MA48943A (fr) 2017-05-22 2018-05-18 Dérivés d'indoline substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue

Country Status (25)

Country Link
US (2) US11407715B2 (fr)
EP (1) EP3630723B1 (fr)
JP (1) JP7203764B2 (fr)
KR (1) KR102625988B1 (fr)
CN (1) CN110691773B (fr)
AR (1) AR111878A1 (fr)
AU (1) AU2018274100B2 (fr)
BR (1) BR112019024195A2 (fr)
CA (1) CA3060583C (fr)
CL (1) CL2019003294A1 (fr)
CO (1) CO2019012035A2 (fr)
CR (1) CR20190530A (fr)
EA (1) EA201992782A1 (fr)
EC (1) ECSP19083640A (fr)
ES (1) ES2929667T3 (fr)
IL (1) IL270726B2 (fr)
MA (1) MA48943A (fr)
MX (1) MX393586B (fr)
NI (1) NI201900119A (fr)
PE (1) PE20200604A1 (fr)
PH (1) PH12019502559A1 (fr)
TW (1) TWI758480B (fr)
UA (1) UA125407C2 (fr)
UY (1) UY37742A (fr)
WO (1) WO2018215315A1 (fr)

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GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
JOP20160086B1 (ar) 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar) 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CR20180496A (es) 2016-03-31 2018-12-06 Univ Leuven Kath Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
WO2017167950A1 (fr) 2016-03-31 2017-10-05 Janssen Pharmaceuticals, Inc. Dérivés d'indole substitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue
JOP20170069B1 (ar) 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CN109069482B (zh) 2016-04-01 2022-04-05 杨森制药公司 作为登革热病毒复制抑制剂的经取代的吲哚化合物衍生物
JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180026A1 (ar) 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
PE20200342A1 (es) 2017-05-22 2020-02-14 Janssen Pharmaceuticals Inc Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue
CN121358711A (zh) * 2023-06-05 2026-01-16 载度思生命科学有限公司 治疗病毒感染的新的化合物
WO2025248536A1 (fr) * 2024-05-29 2025-12-04 Zydus Lifesciences Limited Nouveaux dérivés d'oxime pour traiter des infections virales

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JOP20160198B1 (ar) 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
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JOP20170069B1 (ar) 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
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CN109069482B (zh) 2016-04-01 2022-04-05 杨森制药公司 作为登革热病毒复制抑制剂的经取代的吲哚化合物衍生物
JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180026A1 (ar) 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
PE20200342A1 (es) 2017-05-22 2020-02-14 Janssen Pharmaceuticals Inc Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue

Also Published As

Publication number Publication date
KR20200009027A (ko) 2020-01-29
ES2929667T3 (es) 2022-11-30
WO2018215315A1 (fr) 2018-11-29
KR102625988B1 (ko) 2024-01-16
US20200255376A1 (en) 2020-08-13
CR20190530A (es) 2020-01-24
CN110691773B (zh) 2023-06-23
CL2019003294A1 (es) 2020-03-20
EA201992782A1 (ru) 2020-03-24
TW201908291A (zh) 2019-03-01
PE20200604A1 (es) 2020-03-10
CO2019012035A2 (es) 2020-01-17
US20220340522A1 (en) 2022-10-27
IL270726B1 (en) 2023-01-01
US11407715B2 (en) 2022-08-09
AR111878A1 (es) 2019-08-28
MX393586B (es) 2025-03-24
UY37742A (es) 2018-11-30
CA3060583C (fr) 2024-06-04
PH12019502559A1 (en) 2021-01-25
MX2019013893A (es) 2020-01-20
US11795149B2 (en) 2023-10-24
ECSP19083640A (es) 2019-11-30
AU2018274100A1 (en) 2019-11-21
CN110691773A (zh) 2020-01-14
TWI758480B (zh) 2022-03-21
JP7203764B2 (ja) 2023-01-13
EP3630723B1 (fr) 2022-08-24
UA125407C2 (uk) 2022-03-02
AU2018274100B2 (en) 2022-06-23
EP3630723A1 (fr) 2020-04-08
JP2020520946A (ja) 2020-07-16
IL270726B2 (en) 2023-05-01
NI201900119A (es) 2020-03-23
BR112019024195A2 (pt) 2020-06-23
IL270726A (en) 2020-01-30
CA3060583A1 (fr) 2018-11-29

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