MA48987A - Dérivés d'indoline substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue - Google Patents

Dérivés d'indoline substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue

Info

Publication number
MA48987A
MA48987A MA048987A MA48987A MA48987A MA 48987 A MA48987 A MA 48987A MA 048987 A MA048987 A MA 048987A MA 48987 A MA48987 A MA 48987A MA 48987 A MA48987 A MA 48987A
Authority
MA
Morocco
Prior art keywords
substitute
dengue virus
virus replication
derivatives used
replication inhibitors
Prior art date
Application number
MA048987A
Other languages
English (en)
Inventor
Dorothée Alice Marie-Eve Bardiot
Jean-François Bonfanti
Bart Rudolf Romanie Kesteleyn
Arnaud Didier M Marchand
Pierre Jean-Marie Bernard Raboisson
Original Assignee
Janssen Pharmaceuticals Inc
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc, Univ Leuven Kath filed Critical Janssen Pharmaceuticals Inc
Publication of MA48987A publication Critical patent/MA48987A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MA048987A 2017-03-31 2018-03-29 Dérivés d'indoline substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue MA48987A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17164045 2017-03-31

Publications (1)

Publication Number Publication Date
MA48987A true MA48987A (fr) 2020-02-05

Family

ID=58464339

Family Applications (1)

Application Number Title Priority Date Filing Date
MA048987A MA48987A (fr) 2017-03-31 2018-03-29 Dérivés d'indoline substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue

Country Status (31)

Country Link
US (1) US11179368B2 (fr)
EP (1) EP3601225B1 (fr)
JP (1) JP7038733B2 (fr)
KR (1) KR102556222B1 (fr)
CN (1) CN110612284B (fr)
AR (1) AR111315A1 (fr)
AU (1) AU2018246299A1 (fr)
BR (1) BR112019019928A2 (fr)
CA (1) CA3055260A1 (fr)
CL (1) CL2019002744A1 (fr)
CO (1) CO2019010292A2 (fr)
CR (1) CR20190447A (fr)
DK (1) DK3601225T3 (fr)
EA (1) EA201992334A1 (fr)
EC (1) ECSP19070413A (fr)
ES (1) ES2887673T3 (fr)
HR (1) HRP20211102T1 (fr)
HU (1) HUE055576T2 (fr)
IL (1) IL269657A (fr)
JO (1) JOP20180026A1 (fr)
LT (1) LT3601225T (fr)
MA (1) MA48987A (fr)
MX (1) MX2019011608A (fr)
NI (1) NI201900098A (fr)
PE (1) PE20191652A1 (fr)
PH (1) PH12019502095A1 (fr)
SG (1) SG11201908465QA (fr)
SI (1) SI3601225T1 (fr)
TW (1) TW201900610A (fr)
UY (1) UY37646A (fr)
WO (1) WO2018178238A1 (fr)

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JOP20160198B1 (ar) 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
BR112018069601A2 (pt) 2016-03-31 2019-01-29 Janssen Pharmaceuticals Inc derivados de indolina substituídos como inibidores da replicação viral da dengue
BR112018068676A2 (pt) 2016-03-31 2019-01-15 Janssen Pharmaceuticals Inc derivados de indol substituídos como inibidores da replicação viral do dengue
BR112018068956A2 (pt) 2016-04-01 2019-01-22 Janssen Pharmaceuticals Inc derivados do composto indol substituídos como inibidores da replicação viral da dengue
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UA125970C2 (uk) 2017-05-22 2022-07-20 Янссен Фармасьютікалз, Інк. Заміщені похідні індоліну як інгібітори реплікації вірусів денге
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WO2025248536A1 (fr) * 2024-05-29 2025-12-04 Zydus Lifesciences Limited Nouveaux dérivés d'oxime pour traiter des infections virales
CN119306651B (zh) * 2024-10-11 2025-12-05 山东大学 一种吲哚3-酰胺类衍生物及其制备方法与应用

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Also Published As

Publication number Publication date
AR111315A1 (es) 2019-06-26
CN110612284B (zh) 2023-10-31
LT3601225T (lt) 2021-08-10
US11179368B2 (en) 2021-11-23
US20200054606A1 (en) 2020-02-20
KR102556222B1 (ko) 2023-07-14
JP2020512374A (ja) 2020-04-23
HUE055576T2 (hu) 2021-12-28
JOP20180026A1 (ar) 2019-01-30
PH12019502095A1 (en) 2020-03-09
ES2887673T3 (es) 2021-12-27
NI201900098A (es) 2020-03-11
AU2018246299A1 (en) 2019-09-19
EP3601225B1 (fr) 2021-06-02
IL269657A (en) 2019-11-28
EA201992334A1 (ru) 2020-02-20
CO2019010292A2 (es) 2019-10-09
KR20190135496A (ko) 2019-12-06
HRP20211102T1 (hr) 2021-10-29
JP7038733B2 (ja) 2022-03-18
TW201900610A (zh) 2019-01-01
PE20191652A1 (es) 2019-11-07
BR112019019928A2 (pt) 2020-04-22
SG11201908465QA (en) 2019-10-30
SI3601225T1 (sl) 2021-09-30
WO2018178238A1 (fr) 2018-10-04
DK3601225T3 (da) 2021-08-16
MX2019011608A (es) 2019-11-08
CL2019002744A1 (es) 2019-12-27
ECSP19070413A (es) 2019-10-31
CR20190447A (es) 2019-11-13
EP3601225A1 (fr) 2020-02-05
CN110612284A (zh) 2019-12-24
UY37646A (es) 2018-09-28
CA3055260A1 (fr) 2018-10-04

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