MA49047A - Composés inhibiteurs d'ask1 et utilisations associées - Google Patents

Composés inhibiteurs d'ask1 et utilisations associées

Info

Publication number
MA49047A
MA49047A MA049047A MA49047A MA49047A MA 49047 A MA49047 A MA 49047A MA 049047 A MA049047 A MA 049047A MA 49047 A MA49047 A MA 49047A MA 49047 A MA49047 A MA 49047A
Authority
MA
Morocco
Prior art keywords
inhibitor compounds
ask1 inhibitor
associated uses
ask1
compounds
Prior art date
Application number
MA049047A
Other languages
English (en)
Inventor
Samuel David Brown
Original Assignee
Seal Rock Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seal Rock Therapeutics Inc filed Critical Seal Rock Therapeutics Inc
Publication of MA49047A publication Critical patent/MA49047A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
MA049047A 2017-04-05 2018-04-04 Composés inhibiteurs d'ask1 et utilisations associées MA49047A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762482085P 2017-04-05 2017-04-05

Publications (1)

Publication Number Publication Date
MA49047A true MA49047A (fr) 2020-02-12

Family

ID=63712299

Family Applications (1)

Application Number Title Priority Date Filing Date
MA049047A MA49047A (fr) 2017-04-05 2018-04-04 Composés inhibiteurs d'ask1 et utilisations associées

Country Status (34)

Country Link
US (3) US20210087167A1 (fr)
EP (1) EP3606519B1 (fr)
JP (1) JP7196093B2 (fr)
KR (1) KR102665145B1 (fr)
CN (1) CN110730661B (fr)
AR (1) AR111407A1 (fr)
AU (1) AU2018250217B2 (fr)
CA (1) CA3059107A1 (fr)
CL (1) CL2019002810A1 (fr)
CO (1) CO2019011708A2 (fr)
CR (1) CR20190503A (fr)
CU (1) CU20190080A7 (fr)
DK (1) DK3606519T3 (fr)
DO (1) DOP2019000255A (fr)
EA (1) EA201992299A1 (fr)
EC (1) ECSP19078393A (fr)
ES (1) ES2992084T3 (fr)
FI (1) FI3606519T3 (fr)
HU (1) HUE068103T2 (fr)
IL (1) IL269711B (fr)
JO (1) JOP20190221A1 (fr)
MA (1) MA49047A (fr)
MX (1) MX394098B (fr)
NI (1) NI201900102A (fr)
NZ (1) NZ758345A (fr)
PE (1) PE20200009A1 (fr)
PH (1) PH12019502288A1 (fr)
PL (1) PL3606519T3 (fr)
PT (1) PT3606519T (fr)
RU (1) RU2019134679A (fr)
SG (1) SG11201909155VA (fr)
SI (1) SI3606519T1 (fr)
TW (1) TWI779022B (fr)
WO (1) WO2018187506A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109071448B (zh) * 2017-01-22 2020-03-17 福建广生堂药业股份有限公司 Ask1抑制剂及其制备方法和应用
ES2971098T3 (es) 2017-05-12 2024-06-03 Enanta Pharm Inc Inhibidores de la quinasa 1 que regula la señal de apoptosis y métodos de uso de los mismos
CN111801314B (zh) 2018-01-02 2023-10-31 西尔洛克治疗公司 Ask1抑制剂化合物及其用途
CN110407806B (zh) * 2018-04-28 2021-08-17 深圳微芯生物科技股份有限公司 甲酰胺类化合物、其制备方法及其应用
EP3787621B1 (fr) 2018-05-02 2024-12-18 Enanta Pharmaceuticals, Inc. Inhibiteurs de la kinase 1 régulant le signal d'apoptose contenant des tétrazoles et leurs méthodes d'utilisation
US10654833B2 (en) 2018-06-28 2020-05-19 Hepatikos Therapeutics, Llc ASK1 isoindolin-1-one inhibitors and methods of use thereof
US10968199B2 (en) 2018-08-22 2021-04-06 Enanta Pharmaceuticals, Inc. Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
US11345699B2 (en) 2018-11-19 2022-05-31 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2020198214A1 (fr) * 2019-03-25 2020-10-01 Enanta Pharmaceuticals, Inc. Inhibiteurs de la kinase 1 régulant le signal d'apoptose et leurs procédés d'utilisation
CN112409332B (zh) * 2019-08-23 2023-12-08 广东东阳光药业股份有限公司 三氮唑衍生物及其在药物中的应用
MX2022008066A (es) 2019-12-27 2022-08-15 Lupin Ltd Compuestos triciclicos sustituidos.
JP7303948B2 (ja) 2020-05-01 2023-07-05 ファイザー・インク Ｈｐｋ１阻害薬としてのアザラクタム化合物
WO2021224818A1 (fr) * 2020-05-08 2021-11-11 Pfizer Inc. Composés d'isoindolone en tant qu'inhibiteurs de hpk1
US20230271940A1 (en) * 2020-08-03 2023-08-31 Novartis Ag Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
US20260021084A1 (en) * 2022-07-20 2026-01-22 Seal Rock Therapeutics, Inc. Method of treating organ diseases or disorders with ask1 inhibitors
WO2025233319A1 (fr) 2024-05-06 2025-11-13 Genfit (1,2,4-triazol-3-yl)-2-pyridyl-1-isoindolinone destinée à être utilisée dans le traitement de la septicémie
WO2026057806A1 (fr) 2024-09-13 2026-03-19 Genfit Forme posologique injectable de 2-[6-(4-cyclopropyl-4h-1,2,4-triazol-3-yl)-2-pyridyl]-5-morpholinocarbonyl-1-isoindolinone

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4229447A (en) 1979-06-04 1980-10-21 American Home Products Corporation Intraoral methods of using benzodiazepines
US4596795A (en) 1984-04-25 1986-06-24 The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives
US4755386A (en) 1986-01-22 1988-07-05 Schering Corporation Buccal formulation
US5739136A (en) 1989-10-17 1998-04-14 Ellinwood, Jr.; Everett H. Intraoral dosing method of administering medicaments
TWI491606B (zh) 2009-07-13 2015-07-11 Gilead Sciences Inc 調節細胞凋亡信號之激酶的抑制劑
WO2011097079A1 (fr) * 2010-02-03 2011-08-11 Takeda Pharmaceutical Company Limited Inhibiteurs de kinase 1 régulant le signal d'apoptose
WO2012079022A1 (fr) * 2010-12-10 2012-06-14 Concert Pharmaceuticals, Inc. Dérivés de dioxopipéridinylphtalimide substitué
JP5927201B2 (ja) * 2010-12-16 2016-06-01 カルチャン リミテッド Ａｓｋ１阻害ピロロピリミジン誘導体
SG11201701723XA (en) * 2014-09-24 2017-04-27 Gilead Sciences Inc Methods of treating liver disease
US10669242B2 (en) * 2016-06-10 2020-06-02 Venenum Biodesign, LLC Clostridium difficile toxin inhibitors
PH12019501688B1 (en) 2017-01-22 2023-08-04 Fujian Akeylink Biotechnology Co Ltd Pyridine derivative as ask1 inhibitor and preparation method and use thereof
CN109071448B (zh) 2017-01-22 2020-03-17 福建广生堂药业股份有限公司 Ask1抑制剂及其制备方法和应用
EP3580224B1 (fr) 2017-02-07 2022-07-13 Biogen MA Inc. Agents inhibiteurs d'ask1
CN109071498B (zh) 2017-02-16 2021-03-30 四川科伦博泰生物医药股份有限公司 激酶抑制剂及其制备方法和用途
WO2018151830A1 (fr) 2017-02-17 2018-08-23 Fronthera U.S. Pharmaceuticals Llc Inhibiteurs de kinase de régulation du signal apoptotique à base de pyridinyle
WO2018157277A1 (fr) 2017-02-28 2018-09-07 Eli Lilly And Company Composés d'isoquinoléine et de naphtydrine
WO2018157856A1 (fr) 2017-03-03 2018-09-07 江苏豪森药业集团有限公司 Inhibiteur de dérivé d'amide, son procédé de préparation et son application
US11345676B2 (en) 2017-03-27 2022-05-31 Pharmakea, Inc. Apoptosis signal-regulating kinase 1 (ASK 1) inhibitor compounds
WO2019055540A1 (fr) * 2017-09-13 2019-03-21 D.E. Shaw Research, Llc Composés utilisés comme inhibiteurs de ras et leur utilisation
US10654833B2 (en) 2018-06-28 2020-05-19 Hepatikos Therapeutics, Llc ASK1 isoindolin-1-one inhibitors and methods of use thereof

Also Published As

Publication number Publication date
JP7196093B2 (ja) 2022-12-26
IL269711B (en) 2021-12-01
US20180291002A1 (en) 2018-10-11
CA3059107A1 (fr) 2018-10-11
JP2020515589A (ja) 2020-05-28
MX394098B (es) 2025-03-24
NZ758345A (en) 2022-02-25
CN110730661A (zh) 2020-01-24
NI201900102A (es) 2020-05-15
DK3606519T3 (da) 2024-08-12
CR20190503A (es) 2020-02-28
EP3606519B1 (fr) 2024-06-05
WO2018187506A1 (fr) 2018-10-11
SG11201909155VA (en) 2019-10-30
BR112019021021A2 (pt) 2020-05-05
JOP20190221A1 (ar) 2019-09-23
US10150755B2 (en) 2018-12-11
RU2019134679A (ru) 2021-05-05
EP3606519A1 (fr) 2020-02-12
US20210087167A1 (en) 2021-03-25
CU20190080A7 (es) 2020-10-20
PL3606519T3 (pl) 2024-10-28
US20250304552A1 (en) 2025-10-02
CL2019002810A1 (es) 2020-03-27
DOP2019000255A (es) 2019-12-15
MX2019012013A (es) 2019-12-18
KR102665145B1 (ko) 2024-05-09
FI3606519T3 (fi) 2024-08-09
TW201838983A (zh) 2018-11-01
AR111407A1 (es) 2019-07-10
AU2018250217B2 (en) 2022-05-19
EP3606519A4 (fr) 2020-12-02
CO2019011708A2 (es) 2020-01-17
IL269711A (en) 2019-11-28
CN110730661B (zh) 2023-06-13
SI3606519T1 (sl) 2024-10-30
HUE068103T2 (hu) 2024-12-28
AU2018250217A1 (en) 2019-11-07
ES2992084T3 (es) 2024-12-09
TWI779022B (zh) 2022-10-01
PT3606519T (pt) 2024-08-06
PE20200009A1 (es) 2020-01-06
ECSP19078393A (es) 2019-12-27
EA201992299A1 (ru) 2020-03-26
PH12019502288A1 (en) 2020-07-13
KR20190141166A (ko) 2019-12-23

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