MA49250A - Nouveaux anticorps anti-cd3 - Google Patents

Nouveaux anticorps anti-cd3

Info

Publication number: MA49250A
Authority: MA; Morocco
Prior art keywords: antibodies; new anti; new
Prior art date: 2017-06-05

Application number

MA049250A

Other languages

English (en)

Inventor

Teddy Beltrametti

Tea Gunde

Christian Hess

Sebastian Meyer

Alexandre Simonin

David Urech

Original Assignee

Numab Therapeutics AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-06-05

Filing date

2018-06-04

Publication date

2021-04-14

2018-06-04 Application filed by Numab Therapeutics AG filed Critical Numab Therapeutics AG

2021-04-14 Publication of MA49250A publication Critical patent/MA49250A/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Oncology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

MA049250A 2017-06-05 2018-06-04 Nouveaux anticorps anti-cd3 MA49250A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201762515293P	2017-06-05	2017-06-05
EP17203832		2017-11-27

Publications (1)

Publication Number	Publication Date
MA49250A true MA49250A (fr)	2021-04-14

Family

ID=62555064

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA049250A MA49250A (fr)	2017-06-05	2018-06-04	Nouveaux anticorps anti-cd3

Country Status (10)

Country	Link
US (2)	US11319371B2 (fr)
EP (2)	EP3634998B8 (fr)
JP (1)	JP7247110B2 (fr)
KR (1)	KR102651965B1 (fr)
CN (1)	CN110691789A (fr)
AU (2)	AU2018280681B2 (fr)
CA (1)	CA3064163A1 (fr)
ES (1)	ES3015105T3 (fr)
IL (1)	IL271128B2 (fr)
MA (1)	MA49250A (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US12098203B2 (en) *	2017-06-05	2024-09-24	Numab Therapeutics AG	Hetero-dimeric multi-specific antibody format targeting at least CD3 and HSA
US11319371B2 (en) *	2017-06-05	2022-05-03	Numab Therapeutics AG	Anti-CD3 antibodies
CN120554509A (zh) *	2020-09-27	2025-08-29	嘉和生物药业有限公司	靶向CD3e/g的抗体或其抗原结合片段、其制备和应用
TW202317639A (zh) *	2021-09-13	2023-05-01	大陸商江蘇先聲藥業有限公司	抗人cd3抗體及其應用
EP4416182A4 (fr) *	2021-10-12	2025-09-17	Lepu Biopharma Co Ltd	Anticorps anti-cd3 avec réactivité croisée vis-à-vis des protéines humaines et de cynomolgus
CN118974087A (zh) *	2022-03-09	2024-11-15	德琪(杭州)生物有限公司	新颖的抗cd3抗体以及其用途
CN115286715B (zh) *	2022-05-18	2023-05-23	上海百英生物科技股份有限公司	一种抗cd3的纳米抗体或其抗原结合部分及其制备方法
CN116284391B (zh) *	2022-11-16	2023-08-08	艾可泰科(浙江)控股有限公司	使用胰岛干细胞和抗体治疗糖尿病
GB2645024A (en) *	2023-01-19	2026-07-15	Henry M Jackson Found Advancement Military Medicine Inc	ETV1 monoclonal antibodies
CN120958019A (zh) *	2023-03-29	2025-11-14	南京金斯瑞生物科技有限公司	针对人分化簇3蛋白的抗体及其变体

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3920358A1 (de)	1989-06-22	1991-01-17	Behringwerke Ag	Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
GB9114948D0 (en)	1991-07-11	1991-08-28	Pfizer Ltd	Process for preparing sertraline intermediates
WO1993011794A1 (fr)	1991-12-13	1993-06-24	Xoma Corporation	Procedes et matieres de preparation de domaines variables d'anticorps modifies et leurs utilisations therapeutiques
JP3614866B2 (ja)	1997-06-12	2005-01-26	リサーチコーポレイションテクノロジーズ，インコーポレイティド	人工抗体ポリペプチド
CA2326389C (fr)	1998-04-21	2007-01-23	Micromet Gesellschaft Fur Biomedizinische Forschung Mbh	Polypeptides specifiques a cd19 et cd3 et leurs utilisations
DE19819846B4 (de)	1998-05-05	2016-11-24	Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts	Multivalente Antikörper-Konstrukte
US8236308B2 (en)	2005-10-11	2012-08-07	Micromet Ag	Composition comprising cross-species-specific antibodies and uses thereof
WO2008119565A2 (fr)	2007-04-03	2008-10-09	Micromet Ag	Domaine de liaison spécifique d'espèces croisées
WO2008119567A2 (fr)	2007-04-03	2008-10-09	Micromet Ag	Domaine de liaison spécifique d'espèces croisées
KR101837053B1 (ko)	2008-10-01	2018-03-12	암젠 리서치 (뮌헨) 게엠베하	종간 특이적 ＰＳＣＡｘＣＤ３, ＣＤ19ｘＣＤ3, ｃ-ＭＥＴｘＣＤ3, 엔도시알린ｘＣＤ3, ＥｐＣＡＭｘＣＤ3, ＩＧＦ-1ＲｘＣＤ3 또는 ＦＡＰαｘＣＤ3 이중특이적 단일쇄 항체
WO2012143524A2 (fr)	2011-04-20	2012-10-26	Genmab A/S	Anticorps bispécifiques contre her2 et cd3
HK1217023A1 (zh)	2013-05-28	2016-12-16	Numab Innovation Ag	新型抗体
HK1218549A1 (zh)	2013-06-26	2017-02-24	Numab Therapeutics AG	新型抗体框架
AP2016009222A0 (en)	2013-11-04	2016-05-31	Glenmark Pharmaceuticals Sa	Production of t cell retargeting hetero-dimeric immunoglobulins
CN106459201A (zh) *	2014-05-28	2017-02-22	豪夫迈·罗氏有限公司	结合人和食蟹猴CD3ε的抗体
CA2955947A1 (fr) *	2014-07-25	2016-01-28	Cytomx Therapeutics, Inc.	Anticorps anti-cd3, anticorps anti-cd3 activables, anticorps anti-cd3 multispecifiques, anticorps anti-cd3 activables multispecifiques et procedes d'utilisation de ces anticorps
EP2982693A1 (fr) *	2014-08-07	2016-02-10	Affimed Therapeutics AG	Domaine de liaison CD3
MA40894A (fr) *	2014-11-04	2017-09-12	Glenmark Pharmaceuticals Sa	Immunoglobulines hétéro-dimères reciblant des lymphocytes t cd3/cd38 et leurs procédés de production
WO2016184570A1 (fr) *	2015-05-18	2016-11-24	Numab Ag	Nouvelles méthodes de traitement sur la base de molécules multifonctionnelles
KR20250091329A (ko)	2015-06-15	2025-06-20	누맙 세러퓨틱스 아게	이종 이량체 다중 특이적 항체 포맷
JOP20160154B1 (ar) *	2015-07-31	2021-08-17	Regeneron Pharma	أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها
US11319371B2 (en) *	2017-06-05	2022-05-03	Numab Therapeutics AG	Anti-CD3 antibodies
US12098203B2 (en) *	2017-06-05	2024-09-24	Numab Therapeutics AG	Hetero-dimeric multi-specific antibody format targeting at least CD3 and HSA
EP3816185A1 (fr) *	2019-11-04	2021-05-05	Numab Therapeutics AG	Anticorps multi-spécifique contra pd-l1 et antigène associé à une tumeur
MX2022014768A (es) *	2020-05-29	2023-01-11	Numab Therapeutics AG	Anticuerpo multiespecifico.
EP3915580A1 (fr) *	2020-05-29	2021-12-01	Numab Therapeutics AG	Anticorps multi-spécifique

2018
- 2018-06-04 US US16/619,121 patent/US11319371B2/en active Active
- 2018-06-04 JP JP2019566606A patent/JP7247110B2/ja active Active
- 2018-06-04 MA MA049250A patent/MA49250A/fr unknown
- 2018-06-04 CA CA3064163A patent/CA3064163A1/fr active Pending
- 2018-06-04 EP EP18729644.7A patent/EP3634998B8/fr active Active
- 2018-06-04 EP EP25159929.6A patent/EP4541819A3/fr active Pending
- 2018-06-04 CN CN201880036701.7A patent/CN110691789A/zh active Pending
- 2018-06-04 KR KR1020197035542A patent/KR102651965B1/ko active Active
- 2018-06-04 ES ES18729644T patent/ES3015105T3/es active Active
- 2018-06-04 IL IL271128A patent/IL271128B2/en unknown
- 2018-06-04 AU AU2018280681A patent/AU2018280681B2/en active Active
2022
- 2022-04-22 US US17/727,449 patent/US20220403028A1/en not_active Abandoned
2025
- 2025-04-16 AU AU2025202700A patent/AU2025202700A1/en active Pending

Also Published As

Publication number	Publication date
IL271128A (en)	2020-01-30
JP2020522260A (ja)	2020-07-30
CN110691789A (zh)	2020-01-14
KR20200013233A (ko)	2020-02-06
AU2025202700A1 (en)	2025-05-08
EP4541819A2 (fr)	2025-04-23
AU2018280681A1 (en)	2019-12-05
KR102651965B1 (ko)	2024-03-28
AU2018280681B2 (en)	2025-01-23
IL271128B1 (en)	2024-06-01
EP3634998B8 (fr)	2025-04-09
US20220403028A1 (en)	2022-12-22
EP3634998A1 (fr)	2020-04-15
CA3064163A1 (fr)	2018-12-13
EP4541819A3 (fr)	2025-07-09
US11319371B2 (en)	2022-05-03
US20200115449A1 (en)	2020-04-16
EP3634998C0 (fr)	2025-02-26
EP3634998B1 (fr)	2025-02-26
ES3015105T3 (en)	2025-04-29
IL271128B2 (en)	2024-10-01
JP7247110B2 (ja)	2023-03-28

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