MA50402A - Composés hétéroaryle utilisés en tant que modulateurs allostériques positifs du récepteur muscarinique m1 - Google Patents
Composés hétéroaryle utilisés en tant que modulateurs allostériques positifs du récepteur muscarinique m1Info
- Publication number
- MA50402A MA50402A MA050402A MA50402A MA50402A MA 50402 A MA50402 A MA 50402A MA 050402 A MA050402 A MA 050402A MA 50402 A MA50402 A MA 50402A MA 50402 A MA50402 A MA 50402A
- Authority
- MA
- Morocco
- Prior art keywords
- muscarinic
- receptor
- compounds used
- positive allosteric
- allosteric modulators
- Prior art date
Links
- 102000007207 Muscarinic M1 Receptor Human genes 0.000 title 1
- 108010008406 Muscarinic M1 Receptor Proteins 0.000 title 1
- 230000003281 allosteric effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201741037090 | 2017-10-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA50402A true MA50402A (fr) | 2021-05-19 |
Family
ID=64277732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA050402A MA50402A (fr) | 2017-10-18 | 2018-10-17 | Composés hétéroaryle utilisés en tant que modulateurs allostériques positifs du récepteur muscarinique m1 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US11234979B2 (fr) |
| EP (1) | EP3697790B1 (fr) |
| JP (1) | JP7104783B2 (fr) |
| KR (1) | KR102438588B1 (fr) |
| CN (1) | CN111212840B (fr) |
| AU (1) | AU2018353544B2 (fr) |
| BR (1) | BR112020007606A2 (fr) |
| CA (1) | CA3076757C (fr) |
| EA (1) | EA039781B1 (fr) |
| IL (1) | IL273748B (fr) |
| MA (1) | MA50402A (fr) |
| MX (1) | MX2020003832A (fr) |
| NZ (1) | NZ764004A (fr) |
| SG (1) | SG11202003284RA (fr) |
| WO (1) | WO2019077517A1 (fr) |
| ZA (1) | ZA202002034B (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7110338B2 (ja) * | 2017-10-27 | 2022-08-01 | スヴェン・ライフ・サイエンシーズ・リミテッド | ムスカリンｍ１受容体陽性アロステリックモジュレーターである多環式アミド類 |
| EA202191046A1 (ru) * | 2018-10-17 | 2021-07-12 | Сувен Лайф Сайенсиз Лимитед | Производные пирролопиридазина, как позитивные аллостерические модуляторы мускаринового рецептора m1 |
| KR102765208B1 (ko) * | 2021-08-10 | 2025-02-11 | 연세대학교 산학협력단 | 1,3-치환된 인돌리진의 원팟 합성 방법 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2501231B1 (fr) | 2009-11-20 | 2016-12-21 | Merck Sharp & Dohme Corp. | Modulateurs allostériques positifs du récepteur m1 de type quinolizidinone-carboxamide |
| TW201512197A (zh) * | 2013-08-30 | 2015-04-01 | Hoffmann La Roche | 吡咯并吡啶或吡唑并吡啶衍生物 |
| CA2918925A1 (fr) * | 2013-09-27 | 2015-04-02 | F. Hoffmann-La Roche Ag | Derives d'indoles et indazoles |
| GB201317363D0 (en) * | 2013-10-01 | 2013-11-13 | Eisai Ltd | Novel compounds |
| US10221175B2 (en) | 2015-04-24 | 2019-03-05 | Vanderbilt University | Substituted pyrrolo[3,4-e]indolizines, imidazo[1,2-a]pyrrolo[3,4-e]pyridines, pyrrolo[3,4-e][1,2,4]triazolo[1,5-a]pyridines and pyrrolo[3,4-e][1,2,4]triazolo[4,3-a]pyridines as positive allosteric modulators of muscarinic acetylcholine receptor M1 |
| CA2987843C (fr) | 2015-06-08 | 2020-07-14 | Suven Life Sciences Limited | Modulateurs allosteriques positifs du recepteur muscarinique m1 |
| AU2016320645B2 (en) | 2015-09-10 | 2019-02-28 | Suven Life Sciences Limited | Fluoroindole derivatives as muscarinic M1 receptor positive allosteric modulators |
-
2018
- 2018-10-17 WO PCT/IB2018/058047 patent/WO2019077517A1/fr not_active Ceased
- 2018-10-17 BR BR112020007606-6A patent/BR112020007606A2/pt unknown
- 2018-10-17 JP JP2020520490A patent/JP7104783B2/ja active Active
- 2018-10-17 MX MX2020003832A patent/MX2020003832A/es unknown
- 2018-10-17 MA MA050402A patent/MA50402A/fr unknown
- 2018-10-17 NZ NZ764004A patent/NZ764004A/en unknown
- 2018-10-17 EP EP18801031.8A patent/EP3697790B1/fr active Active
- 2018-10-17 CN CN201880066720.4A patent/CN111212840B/zh active Active
- 2018-10-17 EA EA202090925A patent/EA039781B1/ru unknown
- 2018-10-17 CA CA3076757A patent/CA3076757C/fr active Active
- 2018-10-17 AU AU2018353544A patent/AU2018353544B2/en active Active
- 2018-10-17 SG SG11202003284RA patent/SG11202003284RA/en unknown
- 2018-10-17 KR KR1020207013222A patent/KR102438588B1/ko active Active
- 2018-10-17 US US16/753,183 patent/US11234979B2/en active Active
-
2020
- 2020-04-01 IL IL273748A patent/IL273748B/en unknown
- 2020-05-04 ZA ZA2020/02034A patent/ZA202002034B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US11234979B2 (en) | 2022-02-01 |
| KR20200069330A (ko) | 2020-06-16 |
| AU2018353544A1 (en) | 2020-04-16 |
| EA202090925A1 (ru) | 2020-07-13 |
| EA039781B1 (ru) | 2022-03-14 |
| BR112020007606A2 (pt) | 2020-09-29 |
| US20200237761A1 (en) | 2020-07-30 |
| JP2021500323A (ja) | 2021-01-07 |
| IL273748B (en) | 2022-06-01 |
| NZ764004A (en) | 2023-03-31 |
| CN111212840A (zh) | 2020-05-29 |
| AU2018353544B2 (en) | 2020-09-17 |
| IL273748A (en) | 2020-05-31 |
| CA3076757A1 (fr) | 2019-04-25 |
| CN111212840B (zh) | 2022-07-22 |
| JP7104783B2 (ja) | 2022-07-21 |
| KR102438588B1 (ko) | 2022-08-31 |
| SG11202003284RA (en) | 2020-05-28 |
| WO2019077517A1 (fr) | 2019-04-25 |
| ZA202002034B (en) | 2021-05-26 |
| EP3697790B1 (fr) | 2023-01-18 |
| CA3076757C (fr) | 2022-10-11 |
| EP3697790A1 (fr) | 2020-08-26 |
| MX2020003832A (es) | 2020-08-06 |
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