MA52286A - Dérivés de pyrazo-tétrahydroisoquinoléine en tant que modulateurs positifs du récepteur d1 de la dopamine - Google Patents

Dérivés de pyrazo-tétrahydroisoquinoléine en tant que modulateurs positifs du récepteur d1 de la dopamine

Info

Publication number
MA52286A
MA52286A MA052286A MA52286A MA52286A MA 52286 A MA52286 A MA 52286A MA 052286 A MA052286 A MA 052286A MA 52286 A MA52286 A MA 52286A MA 52286 A MA52286 A MA 52286A
Authority
MA
Morocco
Prior art keywords
tetrahydroisoquinolein
pyrazo
dopamine
receptor
derivatives
Prior art date
Application number
MA052286A
Other languages
English (en)
Inventor
David Andrew Coates
Junliang Hao
Darryl Wayne Hilliard
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MA52286A publication Critical patent/MA52286A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
MA052286A 2018-04-20 2019-04-17 Dérivés de pyrazo-tétrahydroisoquinoléine en tant que modulateurs positifs du récepteur d1 de la dopamine MA52286A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862660622P 2018-04-20 2018-04-20

Publications (1)

Publication Number Publication Date
MA52286A true MA52286A (fr) 2021-05-12

Family

ID=66324031

Family Applications (1)

Application Number Title Priority Date Filing Date
MA052286A MA52286A (fr) 2018-04-20 2019-04-17 Dérivés de pyrazo-tétrahydroisoquinoléine en tant que modulateurs positifs du récepteur d1 de la dopamine

Country Status (29)

Country Link
US (1) US10611751B2 (fr)
EP (1) EP3781560B1 (fr)
JP (1) JP7083916B2 (fr)
KR (1) KR102520872B1 (fr)
CN (1) CN111971282B (fr)
AR (1) AR114467A1 (fr)
AU (1) AU2019256350B2 (fr)
BR (1) BR112020019934A2 (fr)
CA (1) CA3097692C (fr)
CL (1) CL2020002697A1 (fr)
CO (1) CO2020012678A2 (fr)
CR (1) CR20200481A (fr)
EA (1) EA202092146A1 (fr)
EC (1) ECSP20066271A (fr)
ES (1) ES2927142T3 (fr)
IL (1) IL278045B2 (fr)
JO (1) JOP20200263B1 (fr)
MA (1) MA52286A (fr)
MX (1) MX2020010914A (fr)
MY (1) MY197645A (fr)
NZ (1) NZ767900A (fr)
PE (1) PE20201151A1 (fr)
PH (1) PH12020551713A1 (fr)
SA (1) SA520420382B1 (fr)
SG (1) SG11202009938TA (fr)
TW (1) TWI725408B (fr)
UA (1) UA125271C2 (fr)
WO (1) WO2019204418A1 (fr)
ZA (1) ZA202006439B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020131671A1 (fr) 2018-12-18 2020-06-25 Eli Lilly And Company Schémas posologiques pour l'utilisation de ly3154207 dans le traitement de troubles du système nerveux central dopaminergiques
MX2021015872A (es) 2019-07-01 2022-02-03 UCB Biopharma SRL Un derivado de tetrahidroisoquinolina sustituido como modulador alosterico positivo de d1.
PH12021552825A1 (en) 2019-07-01 2022-10-03 UCB Biopharma SRL A substituted tetrahydroisoquinoline derivative as a d1 positive allosteric modulator
EP4200280B1 (fr) * 2020-10-07 2024-02-21 Eli Lilly And Company Dérivés de la phényl-3,4-dihydroisoquinoléine-2(1h)-yl-éthan-1-one comme modulateurs allostériques positifs du récepteur d1 de la dopamine
EP4267555A1 (fr) * 2020-12-03 2023-11-01 UCB Biopharma SRL Dérivés d'octahydroisoquinolinyle
CA3202106A1 (fr) * 2020-12-18 2022-06-23 Adrian Hall Derives de dihydroisoquinolinyle

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE97893T1 (de) 1988-02-19 1993-12-15 Smithkline Beecham Farma 1,2,3,4-tetrahydroisoquinoline, verfharen zu ihrer herstellung und ihre verwendung als kappa- rezeptor agonisten.
US5236934A (en) 1992-08-26 1993-08-17 E. I. Du Pont De Nemours And Company 1,2,3,4-tetrahydroisoquinolines useful in the treatment of CNS disorders
JP2004507456A (ja) 2000-05-11 2004-03-11 ブリストル−マイヤーズ　スクイブ　カンパニー 成長ホルモン分泌促進薬として有用なテトラヒドロイソキノリン類縁体
US7601739B2 (en) 2003-08-08 2009-10-13 Virgina Commonwealth University Compounds having antiestrogenic and tissue selective estrogenic properties, and compounds with anti-androgenic properties for treatment of prostate cancer and androgen receptor dependent diseases
AR095883A1 (es) 2013-04-18 2015-11-18 Astellas Pharma Inc Compuestos de acetamida heterocíclica
JO3316B1 (ar) * 2013-05-30 2019-03-13 Lilly Co Eli مركبات 3، 4-داي هيدرو أيزو كوينولين -2(1h)-يل
ES2729490T3 (es) 2014-10-08 2019-11-04 Ucb Biopharma Sprl Derivados de isoindolina
EA035544B1 (ru) * 2014-10-08 2020-07-03 Юсб Байофарма Спрл Производные тетрагидроизохинолина
AR105025A1 (es) 2015-06-19 2017-08-30 Astellas Pharma Inc Compuesto de imidazodiazepina
AR106332A1 (es) * 2015-10-23 2018-01-03 Lilly Co Eli Forma cristalina de 2-(2,6-diclorofenil)-1-[(1s,3r)-3-(hidroximetil)-5-(3-hidroxi-3-metilbutil)-1-metil-3,4-dihidroisoquinolin-2(1h)-il]etanona
CN108884050B (zh) 2016-04-13 2022-07-05 Ucb生物制药私人有限公司 四氢异喹啉衍生物
EP3418270A1 (fr) 2017-06-19 2018-12-26 Universidad Complutense De Madrid Nouveaux biphénylsulfoximines comme modulateurs allostériques du récepteur de la dopamine d1
WO2019173437A1 (fr) 2018-03-06 2019-09-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Modulateurs allostériques positifs du récepteur de la dopamine 1 et procédé d'utilisation associé

Also Published As

Publication number Publication date
MX2020010914A (es) 2021-01-08
WO2019204418A1 (fr) 2019-10-24
SA520420382B1 (ar) 2022-08-04
JOP20200263A1 (ar) 2020-10-15
ZA202006439B (en) 2024-06-26
SG11202009938TA (en) 2020-11-27
JOP20200263B1 (ar) 2024-04-18
UA125271C2 (uk) 2022-02-09
KR102520872B1 (ko) 2023-04-13
JP2021518853A (ja) 2021-08-05
NZ767900A (en) 2023-06-30
CN111971282A (zh) 2020-11-20
ECSP20066271A (es) 2020-11-30
BR112020019934A2 (pt) 2021-01-05
IL278045B1 (en) 2023-05-01
AU2019256350A1 (en) 2020-09-24
IL278045B2 (en) 2023-09-01
EP3781560A1 (fr) 2021-02-24
AR114467A1 (es) 2020-09-09
CL2020002697A1 (es) 2021-02-19
EA202092146A1 (ru) 2021-01-25
PH12020551713A1 (en) 2021-07-26
TWI725408B (zh) 2021-04-21
PE20201151A1 (es) 2020-10-26
US20190322639A1 (en) 2019-10-24
MY197645A (en) 2023-06-30
IL278045A (en) 2020-11-30
EP3781560B1 (fr) 2022-08-24
JP7083916B2 (ja) 2022-06-13
TW202003486A (zh) 2020-01-16
US10611751B2 (en) 2020-04-07
CA3097692A1 (fr) 2019-10-24
KR20200132948A (ko) 2020-11-25
CA3097692C (fr) 2024-02-20
CR20200481A (es) 2020-11-18
CO2020012678A2 (es) 2020-10-30
CN111971282B (zh) 2024-03-19
ES2927142T3 (es) 2022-11-02
AU2019256350B2 (en) 2021-04-22

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