MA51606A - Inhibition de synthase d'acide gras (fasn) - Google Patents

Inhibition de synthase d'acide gras (fasn)

Info

Publication number
MA51606A
MA51606A MA051606A MA51606A MA51606A MA 51606 A MA51606 A MA 51606A MA 051606 A MA051606 A MA 051606A MA 51606 A MA51606 A MA 51606A MA 51606 A MA51606 A MA 51606A
Authority
MA
Morocco
Prior art keywords
fasn
fatty acid
acid synthase
synthase inhibition
inhibition
Prior art date
Application number
MA051606A
Other languages
English (en)
Inventor
Christopher Dinsmore
Matthew W Martin
Scot Mente
Zhongguo Wang
Mary-Margaret Zablocki
Xiaozhang Zheng
Original Assignee
Forma Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forma Therapeutics Inc filed Critical Forma Therapeutics Inc
Publication of MA51606A publication Critical patent/MA51606A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MA051606A 2018-10-10 2019-10-10 Inhibition de synthase d'acide gras (fasn) MA51606A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862744071P 2018-10-10 2018-10-10
TW108136774A TWI767148B (zh) 2018-10-10 2019-10-09 抑制脂肪酸合成酶(fasn)

Publications (1)

Publication Number Publication Date
MA51606A true MA51606A (fr) 2020-11-25

Family

ID=70159790

Family Applications (1)

Application Number Title Priority Date Filing Date
MA051606A MA51606A (fr) 2018-10-10 2019-10-10 Inhibition de synthase d'acide gras (fasn)

Country Status (14)

Country Link
US (3) US10875848B2 (fr)
JP (1) JP2022504730A (fr)
KR (1) KR20210075120A (fr)
CN (1) CN113329748A (fr)
AR (1) AR116626A1 (fr)
AU (1) AU2019357592A1 (fr)
BR (1) BR112021005836A2 (fr)
CA (1) CA3116045A1 (fr)
EA (1) EA202190902A1 (fr)
IL (1) IL282065A (fr)
MA (1) MA51606A (fr)
MX (1) MX2021003992A (fr)
SG (1) SG11202103454SA (fr)
TW (1) TWI767148B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018300980A1 (en) 2017-07-12 2020-01-02 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
ES3064093T3 (en) 2017-10-20 2026-04-22 Univ Vanderbilt Antagonists of the muscarinic acetylcholine receptor m4
TWI767148B (zh) * 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
WO2021091751A1 (fr) * 2019-11-05 2021-05-14 Merck Sharp & Dohme Corp. Modulateurs allostériques de spiropipéridine de récepteurs nicotiniques de l'acétylcholine
US20230183218A1 (en) * 2020-04-24 2023-06-15 Vanderbilt University Condensed substituted hydropyrroles as antagonists of the muscarinic acetylcholine receptor m4

Family Cites Families (276)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4888268A (en) 1985-09-11 1989-12-19 Fuji Photo Film Co., Ltd. Silver halide photographic materials comprising blocked photographic reagants releasing plug groups
JPH06509069A (ja) 1991-06-27 1994-10-13 バージニア・コモンウェルス・ユニバーシティ シグマレセプターリガンドおよびその用途
US5376664A (en) 1992-07-27 1994-12-27 The Du Pont Merck Pharmaceutical Company Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents
IL117580A0 (en) 1995-03-29 1996-07-23 Merck & Co Inc Inhibitors of farnesyl-protein transferase and pharmaceutical compositions containing them
US6235878B1 (en) 1996-07-19 2001-05-22 Takeda Chemical Industries, Ltd. Fas ligand-like protein, its production and use
DE19743435A1 (de) 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidinderivate
DE69932712T2 (de) 1998-04-23 2007-09-06 Duke University Vorhersage über die rezeptor-modulierende wirkung von verbindungen
PL344749A1 (en) 1998-06-11 2001-11-19 Dimensional Pharmaceuticals 3 Pyrazinone protease inhibitors
CA2346396C (fr) 1998-10-09 2009-04-28 Janssen Pharmaceutica N.V. Derives de 4-5-dihydro-isoxazole et leur utilisation pharmaceutique
WO2000022909A2 (fr) 1998-10-19 2000-04-27 Biotech Australia Pty. Limited Systemes d'administration orale
CO5180605A1 (es) 1999-06-23 2002-07-30 Smithkline Beecham Corp Compuestos de indol
CO5190665A1 (es) 1999-06-23 2002-08-29 Smithkline Beecham Corp Compuestos de indol
AU748949B2 (en) 1999-06-23 2002-06-13 Merck & Co., Inc. Integrin receptor antagonists
EP1206463A4 (fr) 1999-08-23 2003-01-29 Smithkline Beecham Corp Inhibiteurs de synthase d'acide gras
AR029001A1 (es) 1999-08-23 2003-06-04 Smithkline Beecham Corp Derivados de bencil-3,4-metilendioxicinamico y el uso de los mismos para la manufactura de un medicamento
US6498187B1 (en) 1999-08-23 2002-12-24 Smithkline Beecham Corporation Fatty acid synthase inhibitors
JP2003508509A (ja) 1999-09-04 2003-03-04 アストラゼネカ アクチボラグ ピルビン酸デヒドロゲナーゼの阻害剤としてのアミド
US6486211B1 (en) 1999-10-22 2002-11-26 Smithkline Beecham Corporation Indole compounds
AU1607501A (en) 1999-11-15 2001-05-30 Drug Innovation & Design, Inc. Selective cellular targeting: multifunctional delivery vehicles
EP1255567A1 (fr) 1999-11-15 2002-11-13 Drug Innovation & Design, Inc. Ciblage cellulaire selectif: vecteurs d'administration multifonctionnels
JP2003534340A (ja) 2000-05-24 2003-11-18 スミスクライン・ビーチャム・コーポレイション 脂肪酸シンターゼ阻害剤
AU2001266070A1 (en) 2000-06-16 2001-12-24 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Method for identifying apoptosis-modified proteins
EP1164374A1 (fr) 2000-06-16 2001-12-19 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Procédé pour l'identification de protéines modifiées durant l'apoptose
WO2002000647A1 (fr) 2000-06-23 2002-01-03 Bristol-Myers Squibb Pharma Company Inhibiteurs du facteur xa a substitution heteroaryl-phenyle
WO2002000646A1 (fr) 2000-06-27 2002-01-03 Smithkline Beecham Corporation Inhibiteurs de synthase d'acide gras
WO2002000620A1 (fr) 2000-06-27 2002-01-03 Smithkline Beecham Corporation Inhibiteurs de synthase d'acide gras
AU2001271718A1 (en) 2000-06-29 2002-01-14 Smith Kline Beecham Corporation Fatty acid synthase inhibitors
US6723749B2 (en) 2000-08-02 2004-04-20 Smithkline Beecham Corporation Fatty acid synthase inhibitors
AU2001284705A1 (en) 2000-08-02 2002-02-13 Smith Kline Beecham Corporation Fatty acid synthase inhibitors
JP2004513887A (ja) 2000-09-22 2004-05-13 スミスクライン・ビーチャム・コーポレイション 脂肪酸合成酵素阻害剤
EP1329454A1 (fr) 2000-09-29 2003-07-23 Nippon Soda Co., Ltd. Composes de thienopyrimidine et leurs sels et procede de preparation
JP2002201193A (ja) 2000-10-25 2002-07-16 Takeda Chem Ind Ltd 三環性化合物、その製造法および剤
WO2002055661A2 (fr) 2000-11-17 2002-07-18 Smithkline Beecham Corporation Inhibiteurs de la synthase des acides gras
JP2004534743A (ja) 2001-04-09 2004-11-18 ロランティス リミテッド ヘッジホッグ
WO2002083071A2 (fr) 2001-04-17 2002-10-24 Sepracor, Inc. Composes analgesiques heterocycliques et leurs methodes d'utilisation
WO2002095007A2 (fr) 2001-05-23 2002-11-28 Dendreon San Diego Llc Conjugues actives par des proteases de surface cellulaire et leurs utilisations therapeutiques
GB0115109D0 (en) 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
FR2829766A1 (fr) 2001-09-14 2003-03-21 Lipha Derives d'oxamates comportant un heterocycle azote diversement substitue
MXPA04002653A (es) 2001-09-21 2004-07-08 Boryung Pharm Metodo para preparar compuestos de pirimidinona y sales farmaceuticamente aceptables del mismo.
AU2002360561A1 (en) 2001-12-11 2003-06-23 Sepracor, Inc. 4-substituted piperidines, and methods of use thereof
BR0215202A (pt) 2001-12-20 2004-10-13 Osi Pharm Inc Compostos antagonistas seletivos a2b de pirimidina, sua sìntese e uso
JP4201716B2 (ja) 2002-03-05 2008-12-24 メルク フロスト カナダ リミテツド カテプシンシステインプロテアーゼ阻害剤
US6995144B2 (en) 2002-03-14 2006-02-07 Eisai Co., Ltd. Nitrogen containing heterocyclic compounds and medicines containing the same
ES2315494T3 (es) * 2002-04-26 2009-04-01 Schering Corporation Antagonistas muscarinicos.
EP1534074A4 (fr) 2002-07-18 2008-01-09 Merck & Co Inc Polytherapie pour le traitement de l'obesite
TW200424183A (en) 2002-08-09 2004-11-16 Nps Pharma Inc New compounds
JP3897662B2 (ja) 2002-08-26 2007-03-28 三井化学株式会社 光記録媒体
AU2003262023A1 (en) 2002-09-10 2004-04-30 Takeda Pharmaceutical Company Limited Five-membered heterocyclic compounds
WO2004030637A2 (fr) 2002-10-01 2004-04-15 Merck & Co., Inc. Traitement de l'obesite et d'autres troubles associes a une consommation alimentaire excessive
EP1554260A1 (fr) 2002-10-22 2005-07-20 Glaxo Group Limited Derives d'aryloxyalkylamine tels que des ligands du recepteur h3
AU2003297564A1 (en) 2002-12-04 2004-06-23 Merck & Co., Inc. Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
US7144911B2 (en) 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
CA2514547A1 (fr) 2003-01-28 2004-08-12 Takeda Pharmaceutical Company Limited Agonistes de recepteurs
EP1628666B1 (fr) 2003-05-14 2015-09-23 NeuroGenetic Pharmaceuticals, Inc. Composes et leurs utilisations pour la modulation de l'amyloide-beta
EP1635832A2 (fr) 2003-06-06 2006-03-22 Merck & Co., Inc. Polytherapie permettant de traiter le diabete
US20060160834A1 (en) 2003-06-06 2006-07-20 Fong Tung M Combination therapy for the treatment of hypertension
WO2005000217A2 (fr) 2003-06-06 2005-01-06 Merck & Co., Inc. Polytherapie permettant de traiter la dyslipidemie
US7419990B2 (en) 2003-07-22 2008-09-02 Merck & Co., Inc. Piperidine derivatives as melanocortin-4 receptor agonists
BRPI0413469A (pt) 2003-08-14 2006-10-17 Pfizer derivados de piperazina para o tratamento de infecções por hiv
TWI290140B (en) 2003-08-25 2007-11-21 Schering Corp 2-Substituted benzimidazole derivatives as selective melanin concentrating hormone receptor antagonists for thr treatment of obesity and related disorders
WO2005033090A1 (fr) 2003-10-06 2005-04-14 Sumitomo Chemical Company, Limited Compose aromatique
WO2005035534A1 (fr) 2003-10-08 2005-04-21 Ono Pharmaceutical Co., Ltd. Composes a anneau bicyclique heterocyclique et a anneau tricyclique heterocyclique et medicaments les contenant
GB0324886D0 (en) 2003-10-24 2003-11-26 Glaxo Group Ltd Medicinal compounds
GB0325956D0 (en) 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
GB0326029D0 (en) 2003-11-07 2003-12-10 Astrazeneca Ab Chemical compounds
WO2005073186A1 (fr) 2004-01-29 2005-08-11 Ono Pharmaceutical Co., Ltd. Dérivés de pyrrolidine
JP4846709B2 (ja) 2004-03-10 2011-12-28 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ５員複素環で置換されているｍｔｐ阻害性アリールピペリジン若しくはピペラジン
PE20060285A1 (es) 2004-03-30 2006-05-08 Aventis Pharma Inc Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp)
CN1960969B (zh) 2004-04-01 2012-03-28 伊莱利利公司 组胺h3受体药物、其制备方法及治疗用途
JP4790704B2 (ja) 2004-04-12 2011-10-12 トレント・ファーマシューティカルズ・リミテッド Ｈｓｐ７０誘発因子としての２−プロペン−１−オン
AU2005247906B2 (en) 2004-05-18 2011-08-25 Merck Sharp & Dohme Corp. Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors
CN1997370B (zh) 2004-05-19 2011-06-01 索尔瓦药物有限公司 N-氨磺酰-n＇-芳基哌嗪类化合物在制备用于预防或治疗肥胖和相关疾病的药物中的用途
EP1767532A4 (fr) 2004-05-28 2009-04-01 Riken Procédé servant à produire un dérivé de fullerène
WO2006006490A1 (fr) 2004-07-08 2006-01-19 Ono Pharmaceutical Co., Ltd. Composé spirocyclique
EP1791827A1 (fr) 2004-08-26 2007-06-06 Kudos Pharmaceuticals Limited Derives de phtalazinone substitues par un groupe 4-heteroarylmethyle
BRPI0516958A (pt) 2004-09-20 2008-03-25 4Sc Ag inibidores da nf-capab heterocìclicos
MX2007003319A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como agentes terapeuticos.
US20080200376A1 (en) 2004-10-29 2008-08-21 Maccoss Malcolm Compositions and Methods For the Treatment Of Obesity and Sexual Dysfunction
FR2877667B1 (fr) 2004-11-05 2007-03-23 Sod Conseils Rech Applic Derives de 4,7-dioxobenzothiazole-2-carboxamides, leur preparation et leurs applications therapeutiques
CA2588517A1 (fr) 2004-12-01 2006-06-08 Devgen N.V. Derives de thiazole substitue par du 5-carboxamido qui interagissent avec des canaux ioniques, en particulier avec des canaux ioniques de la famille de kv
WO2006060461A1 (fr) 2004-12-03 2006-06-08 Schering Corporation Piperazines substituees en tant qu'antagonistes de cb1
KR100637951B1 (ko) 2004-12-09 2006-10-26 엘지전자 주식회사 댁내의 전력 사용량 관리 시스템
WO2006061094A1 (fr) 2004-12-11 2006-06-15 Merck Patent Gmbh Composes a cristaux liquides, milieu a cristaux liquides et ecran a cristaux liquides
FR2879598B1 (fr) 2004-12-17 2007-03-30 Sod Conseils Rech Applic Inhibiteurs de phosphatases cdc25
GB0510141D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B3
GB0510139D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
CA2609394A1 (fr) 2005-05-23 2006-11-30 Masaki Takagi Compose de pyrazole et agent therapeutique pour le diabete comprenant celui-ci
EP1896453B1 (fr) 2005-06-20 2009-12-02 Schering Corporation Pipéridines substituées liées à un atome de carbone et leurs dérivés utiles en tant qu antagonistes de l'histamine h3
NZ564759A (en) 2005-06-30 2011-08-26 Prosidion Ltd GPCR agonists
GB0518237D0 (en) 2005-09-07 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds
US7473688B2 (en) 2005-09-13 2009-01-06 Bristol-Myers Squibb Company Indolobenzazepine HCV NS5B inhibitors
JP5335426B2 (ja) 2005-09-27 2013-11-06 アイアールエム・リミテッド・ライアビリティ・カンパニー ジアリールアミン含有化合物および組成物、ならびにｃ−ｋｉｔ受容体のモジュレーターとしてのそれらの使用
EP2612854B1 (fr) 2005-10-25 2015-04-29 Shionogi&Co., Ltd. Dérivés d'aminothiazolidine et d'aminotétrahydrothiazepine comme inhibiteurs de BACE 1
WO2007092065A2 (fr) 2005-11-14 2007-08-16 Irm Llc Composés et compositions servant de modulateurs du lxr
WO2007068620A1 (fr) 2005-12-15 2007-06-21 F. Hoffmann-La Roche Ag Derives de pyrrolo[2,3-c]pyridine
JP2009519293A (ja) 2005-12-16 2009-05-14 エフ．ホフマン−ラ ロシュ アーゲー Ｈ３レセプター調節剤としてのピロロ［２，３−ｂ］ピリジン誘導体
JP2009521451A (ja) 2005-12-21 2009-06-04 シェーリング コーポレイション ヒスタミンｈ３アンタゴニストとして有用な置換アニリン誘導体
EP1963276B9 (fr) 2005-12-21 2012-09-26 Decode Genetics EHF Inhibiteurs aryle heteroaryle a liaison azote de lta4h utilises dans le traitement de l'inflammation
EP1976848A2 (fr) 2005-12-21 2008-10-08 Schering Corporation Phenoxypiperidines et leurs analogues utilisables en tant qu'antagonistes de l'histamine h3
CA2635719A1 (fr) 2006-01-13 2007-07-19 F. Hoffmann-La Roche Ag Derives de methanone de type cyclohexyle et piperazinyle et leur application en tant que modulateurs du recepteur h3 de l'histamine
KR20080091814A (ko) 2006-01-20 2008-10-14 쉐링 코포레이션 지질혈증장애의 치료를 위한 니코틴산 수용체 효능제로서의헤테로사이클
DE602007008831D1 (de) 2006-01-23 2010-10-14 Hoffmann La Roche Cyclohexyl-sulfonamid-derivate mit h3-rezeptoraktivität
WO2007089634A2 (fr) 2006-01-30 2007-08-09 Merck & Co., Inc. Inhibiteurs de la synthase d'acides gras (fas)
US7601716B2 (en) 2006-05-01 2009-10-13 Cephalon, Inc. Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors
US7902184B2 (en) 2006-05-30 2011-03-08 Hoffmann-La Roche Inc. Piperazinyl pyrimidine derivatives
US7834015B2 (en) 2006-05-31 2010-11-16 Instituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Pyrrolo[1,2-a] pyrazin-1(2H)-one and pyrrolo[1,2-d][1,2,4]triazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose)polymerase (PARP)
GB0610680D0 (en) 2006-05-31 2006-07-12 Istituto Di Ricerche D Biolog Therapeutic compounds
AU2007275301A1 (en) 2006-07-20 2008-01-24 Amgen Inc. Substituted azole aromatic heterocycles as inhibitors of 11-beta-HSD-1
WO2008023720A1 (fr) 2006-08-23 2008-02-28 Astellas Pharma Inc. COMPOSÉ D'URÉE OU SEL DUDIT COMPOSé
CA2662337A1 (fr) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition de la synthese d'acides gras au moyen d'inhibiteurs parp et methodes de traitement associees
JO2653B1 (en) 2006-10-24 2012-06-17 شركة جانسين فارماسوتيكا ان. في Tetrahydroflavin 1-carboxylic acid substituted with pyridine or pyrazine inhibit MTB
WO2008052658A1 (fr) 2006-11-02 2008-05-08 Sanofi-Aventis Deutschland Gmbh Nouvelle diphénylazétidinone substituée par l'acide pipérazin-1-sulfonique présentant des propriétés pharmacologiques améliorées
WO2008059214A1 (fr) 2006-11-13 2008-05-22 Astrazeneca Ab Dérivés de bisamide et utilisation de ceux-ci en tant qu'inhibiteurs de l'acide gras synthase
CN101190894A (zh) 2006-11-23 2008-06-04 中国人民解放军军事医学科学院毒物药物研究所 脂肪酸合成酶抑制剂及其制药用途
CA2670636A1 (fr) 2006-11-27 2008-06-05 H. Lundbeck A/S Derives d'heteroaryl-amides
WO2008073825A1 (fr) 2006-12-08 2008-06-19 Exelixis, Inc. Modulateurs lxr et fxr
DE102006060598A1 (de) 2006-12-21 2008-06-26 Merck Patent Gmbh Tetrahydrobenzoisoxazole
TW200831092A (en) 2006-12-21 2008-08-01 Astrazeneca Ab Therapeutic agents
TW200833663A (en) 2006-12-21 2008-08-16 Astrazeneca Ab Therapeutic agents
WO2008075077A1 (fr) 2006-12-21 2008-06-26 Astrazeneca Ab Dérivés de pipéridine destinés au traitement de l'obésité
JP2010513357A (ja) 2006-12-22 2010-04-30 ノバルティス アーゲー Ｄｐｐ−ｉｖ阻害剤としての１−アミノメチル−１−フェニル−シクロヘキサン誘導体
DE102007007751A1 (de) 2007-02-16 2008-08-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel
WO2008106202A1 (fr) 2007-02-27 2008-09-04 Housey Gerard M Modulateurs de théramutéine
BRPI0808089A2 (pt) 2007-02-28 2014-07-15 Conatus Pharmaceuticals Inc Método para tratar uma doença do fígado, para diminuir um nível elevado de uma enzima do fígado, para inibir uma cascata de sinalização de tnf-alfa e uma cascata de sinalização de alfa-faz, para reduzir um dano ao fígado, para suprimir a apoptose excessiva em uma célula de fígado, e para inibir a replicação do vírus da hepatite c.
WO2008106167A1 (fr) 2007-02-28 2008-09-04 Conatus Pharmaceuticals, Inc. Polythérapie incluant des inhibiteurs de métalloprotéinases matricielles et des inhibiteurs de caspases pour le traitement de maladies hépatiques
CN101668520A (zh) 2007-02-28 2010-03-10 科内图斯医药公司 使用特定基质金属蛋白酶(mmp)抑制剂治疗肝脏疾病的方法
JP2010520291A (ja) 2007-03-07 2010-06-10 コンサート ファーマシューティカルズ インコーポレイテッド 抗狭心症化合物としての重水素化ピペラジン誘導体
CN101641348B (zh) 2007-03-30 2014-09-10 霍夫曼-拉罗奇有限公司 咪唑烷酮衍生物
GB0707051D0 (en) 2007-04-12 2007-05-30 Istituto Di Ricerche D Biolog Antiviral agents
WO2008133273A1 (fr) 2007-04-24 2008-11-06 Shionogi & Co., Ltd. Composition pharmaceutique pour le traitement de la maladie d'alzheimer
MX2009011578A (es) 2007-04-25 2009-11-11 Exelixis Inc 6-fenilpirimidinonas como moduladores de pim.
BRPI0812504B8 (pt) 2007-06-21 2021-05-25 Cara Therapeutics Inc composto para profilaxia ou tratamento de doença ou condição associada a receptor de canabinoides em sujeito mamífero
EP2019091A1 (fr) 2007-06-25 2009-01-28 Fundació Privada Institut d'Investigació Biomédica de Girona - Dr. Josep Trueta Nouveaux composés polyhydroxydés en tant qu'inhibiteurs de l'acide gras synthase (FASN)
US20090023727A1 (en) 2007-07-05 2009-01-22 Muhammad Hashim Javaid Phthalazinone derivatives
WO2009030318A1 (fr) 2007-08-29 2009-03-12 Merck Patent Gmbh Affichage à cristaux liquides
ES2474165T3 (es) 2007-10-30 2014-07-08 Janssen Pharmaceutica N.V. Proceso enantioselectivo para preparar un ácido alcanoico sustituido
JP2011503620A (ja) 2007-11-13 2011-01-27 ファスゲン ダイアグノスティクス，リミティド ライアビリティ カンパニー リン酸化脂肪酸シンターゼ及び癌
WO2009099736A2 (fr) 2008-02-06 2009-08-13 Lead Therapeutics, Inc. Inhibiteurs à base de composés benzoxazole-carboxamide de l’activité poly(adp-ribose)polymérase (parp)
WO2009098282A1 (fr) 2008-02-06 2009-08-13 Novasaid Ab Dérivés de thiophène 2,5-disubstitués de faible poids moléculaire et leur utilisation en thérapie
KR20100134680A (ko) 2008-03-20 2010-12-23 포레스트 래보러토리즈 홀딩스 리미티드 스테아로일-ｃｏａ 불포화효소의 저해물질로서 신규한 피페리딘 유도체
CA2722326A1 (fr) 2008-04-24 2009-10-29 Incyte Corporation Composes macrocycliques et leur utilisation a titre d'inhibiteurs de kinase
US20090325964A1 (en) 2008-05-23 2009-12-31 Wyeth Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression
WO2009151910A2 (fr) 2008-05-25 2009-12-17 Wyeth Produit de combinaison d'un inhibiteur de tyrosine kinase de récepteur et d'un inhibiteur d'acide gras synthase pour le traitement du cancer
US8349210B2 (en) 2008-06-27 2013-01-08 Transitions Optical, Inc. Mesogenic stabilizers
US8012976B2 (en) 2008-08-06 2011-09-06 Biomarin Pharmaceutical Inc. Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP)
US20100113465A1 (en) * 2008-10-30 2010-05-06 Pfizer Inc. 7-azaspiro[3.5]nonane-7-carboxamide compounds
US8815875B2 (en) 2008-11-12 2014-08-26 Merck Sharp & Dohme Corp. Inhibitors of fatty acid binding protein (FABP)
US8772318B2 (en) 2008-11-14 2014-07-08 The Scripps Research Institute Methods and compositions related to targeting monoacylglycerol lipase
US20100130477A1 (en) * 2008-11-25 2010-05-27 Astrazeneca Ab Spirocyclobutyl Piperidine Derivatives
US20100168080A1 (en) 2008-12-17 2010-07-01 Khamrai Uttam Novel compounds useful as cc chemokine receptor ligands
CN102264866B (zh) 2008-12-22 2014-06-18 默克专利股份有限公司 液晶显示器
WO2010075273A1 (fr) 2008-12-23 2010-07-01 Schering Corporation Dérivés d'hétérocycles bicycliques et leurs procédés d'utilisation
DE102010006691A1 (de) 2009-02-06 2010-10-28 Merck Patent Gmbh Flüssigkristallines Medium und Flüssigkristallanzeige
TW201038569A (en) 2009-02-16 2010-11-01 Abbott Gmbh & Co Kg Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
TW201041868A (en) 2009-03-20 2010-12-01 Intervet Int Bv Anthelmintic agents and their use
WO2010114957A1 (fr) 2009-04-03 2010-10-07 Schering Corporation Dérivés de pipéridine et de pipérazine bicycliques en tant que modulateurs de rcpg pour le traitement de l'obésité, du diabète et d'autres troubles métaboliques
WO2010120262A1 (fr) 2009-04-14 2010-10-21 Smith Holdings, Llc Méthodes et compositions pour le traitement d'états médicaux impliquant une programmation cellulaire
JP5918693B2 (ja) 2009-05-05 2016-05-18 ダナ ファーバー キャンサー インスティテュート インコーポレイテッド Ｅｇｆｒ阻害剤及び疾患の治療方法
SG175708A1 (en) 2009-05-27 2011-12-29 Genentech Inc Bicyclic pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use
EP2445506B1 (fr) 2009-06-24 2014-12-31 Entarco SA Utlisation de spinosynes ou du preparation contenant de spinosyne pour combattre les infection à protozoaires, les infections virals et le cancer.
KR101732205B1 (ko) 2009-08-28 2017-05-02 주식회사 쿠라레 Ｎ-아실-β-락탐 유도체, 고분자 화합물 및 포토레지스트 조성물
WO2011035018A2 (fr) 2009-09-18 2011-03-24 Fate Therapeutics, Inc. Cellules cytotoxiques
AU2010299820A1 (en) 2009-09-28 2012-04-19 F. Hoffmann-La Roche Ag Benzoxepin PI3K inhibitor compounds and methods of use
US8865704B2 (en) 2009-10-07 2014-10-21 Siena Biotech S.P.A. Wnt pathway antagonists
EP2485735B1 (fr) 2009-10-08 2015-07-29 Merck Sharp & Dohme Corp. Inhibiteurs de protéines de liaison aux acides gras (fabp)
JP2013508461A (ja) 2009-10-27 2013-03-07 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 脂肪酸シンターゼ阻害剤としてのベンズイミダゾール
JP2013509434A (ja) 2009-10-30 2013-03-14 トランザイム・ファーマ，インコーポレイテッド 大環状グレリン受容体アンタゴニストおよびインバースアゴニストならびにその使用方法
WO2011066211A1 (fr) 2009-11-24 2011-06-03 Glaxosmithkline Llc Azabenzamidazoles comme inhibiteurs d'acide gras synthase
WO2011094890A1 (fr) 2010-02-02 2011-08-11 Argusina Inc. Dérivés phénylalanines et leur utilisation comme modulateurs non peptidiques du récepteur de glp-1
DE102010008644A1 (de) 2010-02-15 2011-08-18 Bayer Schering Pharma Aktiengesellschaft, 13353 Zyklische Ketoenole zur Therapie
ES2509951T3 (es) 2010-02-22 2014-10-20 Glaxosmithkline Llc Triazolonas como inhibidores de sintasa de ácidos grasos
WO2011123681A1 (fr) 2010-03-31 2011-10-06 Rigel Pharmaceuticals, Inc. Procédés d'utilisation de composés de carboxamides, sulfonamides et amines
WO2011140190A1 (fr) 2010-05-05 2011-11-10 Infinity Pharmaceuticals Tétrazolones utilisés en tant qu'inhibiteurs d'acide gras synthase (fasn)
US8450350B2 (en) 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
US20110312996A1 (en) 2010-05-17 2011-12-22 Intermune, Inc. Novel inhibitors of hepatitis c virus replication
US8450316B2 (en) 2010-06-24 2013-05-28 Trustees Of Tufts College Niacin mimetics, and methods of use thereof
WO2011163612A1 (fr) 2010-06-24 2011-12-29 Trustees Of Tufts College Mimétiques de niacine et leurs procédés d'utilisation
KR101764952B1 (ko) 2010-07-29 2017-08-03 리겔 파마슈티칼스, 인크. Ａｍｐｋ-활성화 헤테로시클릭 화합물 및 그의 사용 방법
WO2012016133A2 (fr) 2010-07-29 2012-02-02 President And Fellows Of Harvard College Inhibiteurs de la ros1 kinase pour le traitement de glioblastome et d'autres cancers déficients en p53
CN102372698A (zh) 2010-08-10 2012-03-14 江苏恒瑞医药股份有限公司 酞嗪酮类衍生物、其制备方法及其在医药上的应用
JP2013537233A (ja) 2010-09-17 2013-09-30 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド 脂肪酸合成酵素阻害剤
JP2014508097A (ja) 2010-09-17 2014-04-03 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド 脂肪酸合成酵素阻害剤
CN102432598A (zh) 2010-09-29 2012-05-02 江苏恒瑞医药股份有限公司 三环化合物、其制备方法及其在医药上的应用
JP2013542960A (ja) 2010-11-08 2013-11-28 グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー２、リミテッド 脂肪酸シンターゼ阻害剤
US20130345270A1 (en) 2010-11-12 2013-12-26 Waake Forest University Health Sciences Methods of treating cancer and other disorders
US20140243401A1 (en) 2010-11-24 2014-08-28 The Johns Hopkins University Methods of screening compounds that are cytotoxic to tumor cells and methods of treating tumor cells using such compound
JP2012123282A (ja) 2010-12-10 2012-06-28 Nikon Corp 電子機器
US20150232455A1 (en) 2010-12-15 2015-08-20 Allan C. Krueger Anti-viral compounds
US20150158909A1 (en) 2010-12-15 2015-06-11 Abbevie Inc. Anti-viral compounds
EP2651928A4 (fr) 2010-12-15 2014-06-18 Abbvie Inc Composés anti-viraux
TWI549947B (zh) 2010-12-29 2016-09-21 阿吉歐斯製藥公司 治療化合物及組成物
WO2012096928A2 (fr) 2011-01-10 2012-07-19 Glaxosmithkline Llc Dérivés de pyrimidinone en tant qu'inhibiteurs de l'acide gras synthase
JP5959537B2 (ja) 2011-01-28 2016-08-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換ピリジニル−ピリミジン及び医薬としてのその使用
EP2675789A1 (fr) 2011-02-17 2013-12-25 Bayer Intellectual Property GmbH 3-(biphényle-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4,5]dec-3-en-2-ones substituées pour la thérapie et des cétoénols spirocycliques substitués par des halogènes
EP2683244B1 (fr) 2011-03-08 2017-02-01 3-V Biosciences, Inc. Modulateurs hétérocycliques de la synthèse des lipides
EP2686305B1 (fr) 2011-03-14 2020-09-16 Impact Therapeutics, Inc. Quinazolinediones et leur utilisation
DE102012003796A1 (de) 2011-03-18 2012-09-20 Merck Patent Gmbh Flüssigkristallines Medium
WO2012129562A2 (fr) 2011-03-24 2012-09-27 The Scripps Research Institute Composés et procédés pour l'induction de la chondrogenèse
EP3260518B1 (fr) 2011-03-29 2019-12-25 Merck Patent GmbH Milieu cristallin liquide
TWI527800B (zh) 2011-04-01 2016-04-01 南京英派藥業有限公司 作為聚（二磷酸腺苷酸－核醣）聚合酶（ｐａｒｐ）之抑制劑之１－（芳基甲基）喹唑啉－２，４（１ｈ，３ｈ）－二酮及其應用
JP6272754B2 (ja) 2011-05-03 2018-01-31 アジオス ファーマシューティカルズ， インコーポレイテッド ピルビン酸キナーゼ活性化剤の使用方法
AU2012250690B2 (en) 2011-05-03 2017-06-08 Agios Pharmaceuticals, Inc Pyruvate kinase activators for use in therapy
CN103702961A (zh) 2011-05-23 2014-04-02 赛诺菲 含有n-烷基的氘代化合物的制备方法
CN103619993B (zh) 2011-07-07 2016-10-12 默克专利股份有限公司 液晶介质
DE102011080406A1 (de) 2011-08-04 2013-02-07 Bayer Pharma AG Substituierte 3-(Biphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro8[4.5]dec-3-en-2-one
CA2844982A1 (fr) 2011-08-15 2013-02-21 Intermune, Inc. Antagonistes des recepteurs d'acide lysophosphatidique
WO2013028447A1 (fr) * 2011-08-19 2013-02-28 Glaxosmithkline Llc Inhibiteurs d'acide gras synthase
WO2013028445A1 (fr) 2011-08-19 2013-02-28 Glaxosmithkline Llc Inhibiteurs d'acide gras synthase
WO2013028495A1 (fr) 2011-08-19 2013-02-28 Biomarin Pharmaceutical Inc. Inhibiteurs dihydropyridophthalazinone de poly (adp-ribose) polymérase (parp) pour le traitement du myélome multiple
AU2012300246A1 (en) 2011-08-30 2014-03-06 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
WO2013045413A1 (fr) 2011-09-27 2013-04-04 Sanofi Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase
WO2013060636A1 (fr) 2011-10-25 2013-05-02 Sanofi Dérivés d'amide de l'acide 6-(4-hydroxy-phényl)-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinases
US9102631B2 (en) 2011-11-01 2015-08-11 Impact Therapeutics, Inc. 1-(arylmethyl)-5,6,7,8-tetrahydroquinazoline-2,4-diones and analogs and the use thereof
CN103130723B (zh) 2011-11-30 2015-01-14 成都地奥制药集团有限公司 一种多聚(adp-核糖)聚合酶抑制剂
CN104080789B (zh) * 2012-01-31 2016-05-11 南京奥昭生物科技有限公司 作为布鲁顿酪氨酸激酶抑制剂的环状分子
CN104136576B (zh) 2012-02-22 2020-10-16 默克专利股份有限公司 液晶介质
DK2820008T3 (en) * 2012-03-02 2017-03-27 Genentech Inc AMIDO-SPIROCYCLIC AMIDE AND SULPHONAMIDE DERIVATIVES
CN102627610B (zh) 2012-04-11 2014-06-25 江苏先声药物研究有限公司 一类苯并咪唑类衍生物及其应用
WO2013157021A1 (fr) 2012-04-20 2013-10-24 Advinus Therapeutics Limited Composés bicycliques, compositions et applications médicinales de ceux-ci
US9096579B2 (en) 2012-04-20 2015-08-04 Boehringer Ingelheim International Gmbh Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
CN103420890B (zh) 2012-05-15 2015-06-24 天津药物研究院 3-吡咯甲酸衍生物及其制备方法和用途
US9013997B2 (en) 2012-06-01 2015-04-21 Broadcom Corporation System for performing distributed data cut-through
US9056860B2 (en) * 2012-06-05 2015-06-16 Gilead Pharmasset Llc Synthesis of antiviral compound
MA37830B1 (fr) * 2012-08-10 2018-09-28 Boehringer Ingelheim Int Composés hétéroromatiques en tant qu'inhibiteurs de la tyrosine kinase de bruton (btk)
US9526720B2 (en) 2012-08-17 2016-12-27 The Broad Institute, Inc. Modulators of hepatic lipoprotein metabolism
WO2014039769A1 (fr) 2012-09-07 2014-03-13 Janssen Pharmaceutica Nv Dérivés d'imidazoline—5-one utiles en tant qu'inhibiteurs de l'acide gras synthase (fasn) pour le traitement du cancer
AR092211A1 (es) 2012-09-24 2015-04-08 Merck Patent Ges Mit Beschränkter Haftung Derivados de hidropirrolopirrol
EP2931836B1 (fr) 2012-12-12 2020-03-18 Merck Patent GmbH Support à cristaux liquides
JP2014118368A (ja) 2012-12-14 2014-06-30 Taisho Pharmaceutical Co Ltd アザスピロアルカン化合物を有効成分として含有する血糖低下作用薬
HRP20191860T1 (hr) 2013-03-13 2019-12-27 Forma Therapeutics, Inc. Derivati 2-hidroksi-1-{4-[(4-fenilfenil)karbonil]piperazin-1-il}etan-1-ona i srodni spojevi kao inhibitori sintaze masnih kiselina (fasn) za liječenje raka
EP2970300B1 (fr) * 2013-03-15 2018-05-16 Boehringer Ingelheim International GmbH Composés hétéroaromatiques en tant qu'inhibiteurs btk
ES2634875T3 (es) 2013-03-21 2017-09-29 Merck Patent Gmbh Derivados de piperazina como inhibidores de FASN
US20160093812A1 (en) 2013-04-08 2016-03-31 Merck Patent Gmbh Organic electroluminescent device
WO2014166584A1 (fr) 2013-04-08 2014-10-16 Merck Patent Gmbh Dispositif électroluminescent organique comportant une matière à fluorescence retardée thermiquement activée
CA2919552C (fr) 2013-07-29 2022-03-15 Merck Patent Gmbh Derives de cyclopentane 1,3-disubstitutes
KR102252761B1 (ko) 2013-08-02 2021-05-18 메르크 파텐트 게엠베하 액정 매질
KR101628288B1 (ko) 2013-09-30 2016-06-08 주식회사 엘지화학 음성 광학 분산도를 갖는 광학 소자 제조용 조성물 및 이로부터 제조된 광학 이방체
US9562035B2 (en) 2013-12-03 2017-02-07 Janssen Pharmaceutica Nv Benzamide derivative useful as FASN inhibitors for the treatment of cancer
US10131841B2 (en) 2013-12-16 2018-11-20 Merck Patent Gmbh Liquid-crystalline medium
WO2015103583A1 (fr) 2014-01-06 2015-07-09 President And Fellows Of Harvard College Monobactames et procédés de synthèse et d'utilisation de ces derniers
US9828364B2 (en) * 2014-01-29 2017-11-28 Boehringer Ingelheim International Gmbh Pyrazole compounds as BTK inhibitors
RU2016141934A (ru) 2014-04-04 2018-05-07 Сирос Фармасьютикалз, Инк. Ингибиторы циклин-зависимой киназы 7 (cdk7)
EP3805218A1 (fr) 2014-04-05 2021-04-14 Syros Pharmaceuticals, Inc. Inhibiteurs de la kinase cycline-dépendante 7 (cdk7)
WO2015175171A1 (fr) 2014-04-23 2015-11-19 X-Rx Discovery, Inc. N-(2-amino)-2-oxoétriylbenzamides substitués en tant qu'inhibiteurs d'autotaxine
SI3143011T1 (sl) 2014-05-13 2021-08-31 F. Hoffmann-La Roche Ag Devterirane heterociklične spojine in njihova uporaba kot kontrastna sredstva
EP3166605A1 (fr) 2014-07-11 2017-05-17 Intervet International B.V. Utilisation d'agents anthelmintiques contre dirofilaria immitis
EP2985334B1 (fr) 2014-08-15 2018-06-20 Merck Patent GmbH Milieu liquide cristallin
WO2016034262A1 (fr) 2014-09-05 2016-03-10 Merck Patent Gmbh Formulations et dispositifs électroniques
WO2016040449A1 (fr) 2014-09-10 2016-03-17 Raze Therapeutics, Inc. Inhibiteurs de la 3-phosphoglycérate déshydrogénase) et leurs utilisations
EP3195182B1 (fr) 2014-09-16 2021-09-29 Verifone, Inc. Lecteur de carte à puce sécurisé
MX2017005484A (es) * 2014-10-31 2017-10-20 Indivior Uk Ltd Compuestos antagonistas del receptor de dopamina d3.
EP3247701B1 (fr) 2015-01-20 2021-09-22 Boehringer Ingelheim Animal Health USA Inc. Composés anthelmintiques, compositions et leur procédé d'utilisation
CN104876912B (zh) 2015-04-08 2017-07-21 苏州云轩医药科技有限公司 Wnt信号通路抑制剂及其应用
MX379846B (es) 2015-06-18 2025-03-11 89Bio Ltd Derivados de 4-bencil y 4-benzoil piperidina sustituidos.
WO2016205633A1 (fr) 2015-06-18 2016-12-22 Cephalon, Inc. Dérivés de pipéridine 1,4-substitués
EP3112440B1 (fr) 2015-07-02 2019-07-24 Merck Patent GmbH Milieu cristallin liquide
WO2017019817A1 (fr) 2015-07-29 2017-02-02 Medivation Technologies, Inc. Méthodes et compositions pour une thérapeutique ciblée
WO2017019822A1 (fr) 2015-07-29 2017-02-02 Medivation Technologies, Inc. Composition aggrégée contenant des cellules réparatrices
CN114395405B (zh) 2015-09-09 2024-10-29 默克专利股份有限公司 液晶介质
US20180305334A1 (en) 2015-10-14 2018-10-25 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules
CN107925481A (zh) 2015-12-21 2018-04-17 三菱电机株式会社 光中继装置、控制方法以及光传输系统
KR102419178B1 (ko) 2015-12-29 2022-07-11 삼성디스플레이 주식회사 유기 발광 소자
KR20170097820A (ko) 2016-02-18 2017-08-29 삼성디스플레이 주식회사 유기 발광 소자
EP3429591B1 (fr) 2016-03-16 2023-03-15 Kura Oncology, Inc. Composés thiéno[2,3-d]pyrimidiniques substitués en tant qu'inhibiteurs de ménine-mll et méthodes d'utilisation
WO2017189613A1 (fr) 2016-04-25 2017-11-02 Forma Therapeutics, Inc. Procédés d'utilisation d'inhibiteurs de fasn
US11883381B2 (en) 2016-05-12 2024-01-30 The Regents Of The University Of Michigan ASH1L inhibitors and methods of treatment therewith
CA2939286A1 (fr) * 2016-08-17 2018-02-17 Pharmascience Inc. Spirocyclique contenant des composes et usages pharmaceutiques dudit spirocyclique
KR102673813B1 (ko) 2016-11-04 2024-06-10 삼성전자주식회사 유기금속 화합물, 이를 포함한 유기 발광 소자 및 이를 포함한 진단용 조성물
JP7668509B2 (ja) 2016-11-11 2025-04-25 サギメット バイオサイエンシーズ インコーポレイテッド 脂質合成の複素環式モジュレーター
WO2018106820A1 (fr) 2016-12-07 2018-06-14 Kura Oncology, Inc. Procédés de promotion de la prolifération de cellules bêta
WO2018106818A1 (fr) 2016-12-07 2018-06-14 Kura Oncology, Inc. Procédés de promotion de la prolifération de cellules bêta
WO2018112204A1 (fr) 2016-12-14 2018-06-21 Cephalon, Inc. Dérivés de spiropipéridine
CN106831787B (zh) * 2017-01-20 2018-10-23 成都倍特药业有限公司 用作布鲁顿酪氨酸激酶抑制剂的化合物及其制备方法和应用
CN109384790B (zh) * 2017-08-08 2022-05-10 药捷安康(南京)科技股份有限公司 成纤维细胞生长因子受体抑制剂及其用途
WO2020013752A1 (fr) 2018-07-12 2020-01-16 Suncarbon Ab Purification de lignine
TWI767148B (zh) * 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)

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AR116626A1 (es) 2021-05-26
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