MA52074A - Nouveaux systèmes d'endonucléase à arn programmable et leurs utilisations - Google Patents

Nouveaux systèmes d'endonucléase à arn programmable et leurs utilisations

Info

Publication number
MA52074A
MA52074A MA052074A MA52074A MA52074A MA 52074 A MA52074 A MA 52074A MA 052074 A MA052074 A MA 052074A MA 52074 A MA52074 A MA 52074A MA 52074 A MA52074 A MA 52074A
Authority
MA
Morocco
Prior art keywords
programmable rna
rna endonuclease
endonuclease systems
new programmable
new
Prior art date
Application number
MA052074A
Other languages
English (en)
Inventor
Christopher Cheng
Wayne Coco
Andre Cohnen
Michael Biag Gamalinda
Ashish Gupta
Christian Pitzler
Caroline W Reiss
Florian Richter
Moritz Schmidt
Ryo Takeuchi
Jan Tebbe
Original Assignee
Bayer Healthcare Llc
Crispr Therapeutics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Llc, Crispr Therapeutics Ag filed Critical Bayer Healthcare Llc
Publication of MA52074A publication Critical patent/MA52074A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA052074A 2018-03-19 2019-03-19 Nouveaux systèmes d'endonucléase à arn programmable et leurs utilisations MA52074A (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP18162681 2018-03-19
EP18162683 2018-03-19
EP18172625 2018-05-16
EP18174707 2018-05-29
EP18181680 2018-07-04
US201862745240P 2018-10-12 2018-10-12
US201862745238P 2018-10-12 2018-10-12
US201862745239P 2018-10-12 2018-10-12
US201862745246P 2018-10-12 2018-10-12

Publications (1)

Publication Number Publication Date
MA52074A true MA52074A (fr) 2021-01-27

Family

ID=65895066

Family Applications (1)

Application Number Title Priority Date Filing Date
MA052074A MA52074A (fr) 2018-03-19 2019-03-19 Nouveaux systèmes d'endonucléase à arn programmable et leurs utilisations

Country Status (8)

Country Link
US (2) US12203110B2 (fr)
EP (1) EP3768834B1 (fr)
JP (1) JP7550648B2 (fr)
CN (1) CN112424348B (fr)
AU (1) AU2019239957A1 (fr)
CA (1) CA3092497A1 (fr)
MA (1) MA52074A (fr)
WO (1) WO2019183150A1 (fr)

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WO2018119010A1 (fr) 2016-12-19 2018-06-28 Editas Medicine, Inc. Évaluation du clivage de nucléases
WO2018129368A2 (fr) 2017-01-06 2018-07-12 Editas Medicine, Inc. Procédés d'évaluation de la coupure par les nucléases
EP3615672A1 (fr) 2017-04-28 2020-03-04 Editas Medicine, Inc. Procédés et systèmes d'analyse de molécules d'arn
EP3635104A1 (fr) 2017-06-09 2020-04-15 Editas Medicine, Inc. Nucléases cas9 modifiées
WO2019014564A1 (fr) 2017-07-14 2019-01-17 Editas Medicine, Inc. Systèmes et procédés d'intégration ciblée et d'édition du génome et détection de celle-ci à l'aide de sites d'amorçage intégrés
WO2019165168A1 (fr) 2018-02-23 2019-08-29 Pioneer Hi-Bred International, Inc. Nouveaux orthologues de cas9
CA3092497A1 (fr) 2018-03-19 2019-09-26 Crispr Therapeutics Ag Nouveaux systemes d'endonuclease a arn programmable et leurs utilisations
AU2019291918B2 (en) 2018-06-29 2025-06-12 Editas Medicine, Inc. Synthetic guide molecules, compositions and methods relating thereto
CA3121191A1 (fr) * 2018-11-28 2020-06-04 Crispr Therapeutics Ag Cas9 de codage d'arnm optimise destine a etre utilise dans des lnp
US12365888B2 (en) 2018-12-14 2025-07-22 Pioneer Hi-Bred International, Inc. CRISPR-Cas systems for genome editing
SG11202109741VA (en) * 2019-03-12 2021-10-28 Crispr Therapeutics Ag Novel high fidelity rna-programmable endonuclease systems and uses thereof
US12173290B2 (en) * 2019-06-28 2024-12-24 Crispr Therapeutics Ag Materials and methods for controlling gene editing
CA3170123A1 (fr) * 2020-02-24 2021-09-02 Pioneer Hi-Bred International, Inc. Nouveaux systemes crispr-cas d'edition du genome
WO2022018638A1 (fr) 2020-07-21 2022-01-27 Crispr Therapeutics Ag Méthodes et compositions d'édition génomique pour moduler la faah pour le traitement de troubles neurologiques
EP4211242A1 (fr) * 2020-09-09 2023-07-19 Vertex Pharmaceuticals Incorporated Compositions et méthodes de traitement de la dystrophie musculaire de duchenne
US20230392134A1 (en) 2020-09-30 2023-12-07 Crispr Therapeutics Ag Materials and methods for treatment of amyotrophic lateral sclerosis
WO2022098933A1 (fr) 2020-11-06 2022-05-12 Vertex Pharmaceuticals Incorporated Compositions et méthodes pour le traitement de la dm1 avec slucas9 et sacas9
WO2022133246A1 (fr) 2020-12-17 2022-06-23 Vertex Pharmaceuticals Incorporated Compositions et procédés pour l'édition de bêta-globine pour le traitement d'hémoglobinopathies
WO2022229851A1 (fr) * 2021-04-26 2022-11-03 Crispr Therapeutics Ag Compositions et procédés d'utilisation de séquences d'échafaudage slucas9
WO2022238958A1 (fr) 2021-05-12 2022-11-17 Crispr Therapeutics Ag Édition génétique multiplex
EP4512403A1 (fr) 2023-08-22 2025-02-26 Friedrich-Schiller-Universität Jena Neuropeptide b et récepteur w comme cible pour le traitement des troubles de l'humeur et/ou du stress chronique

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US20250320477A1 (en) 2025-10-16
EP3768834C0 (fr) 2025-08-13
US20210054353A1 (en) 2021-02-25
CN112424348B (zh) 2024-12-31
US12203110B2 (en) 2025-01-21
WO2019183150A1 (fr) 2019-09-26
EP3768834A1 (fr) 2021-01-27
AU2019239957A1 (en) 2020-09-10
CN112424348A (zh) 2021-02-26

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