MA52411B1 - Dérivés de 2,4-diaminoquinazoline et leurs utilisations dans le traitement des infections virales, cancer et des allergies - Google Patents

Dérivés de 2,4-diaminoquinazoline et leurs utilisations dans le traitement des infections virales, cancer et des allergies

Info

Publication number
MA52411B1
MA52411B1 MA52411A MA52411A MA52411B1 MA 52411 B1 MA52411 B1 MA 52411B1 MA 52411 A MA52411 A MA 52411A MA 52411 A MA52411 A MA 52411A MA 52411 B1 MA52411 B1 MA 52411B1
Authority
MA
Morocco
Prior art keywords
fluorine
methyl
deuterium
cyclopropyl
formula
Prior art date
Application number
MA52411A
Other languages
English (en)
Other versions
MA52411A (fr
Inventor
Werner EMBRECHTS
Tim Jonckers
Pierre Raboisson
Gowan David Mc
Ludwig Cooymans
Jérôme Guillemont
Original Assignee
Janssen Sciences Ireland Unlimited Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Unlimited Co filed Critical Janssen Sciences Ireland Unlimited Co
Publication of MA52411A publication Critical patent/MA52411A/fr
Publication of MA52411B1 publication Critical patent/MA52411B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La présente invention concerne des dérivés de quinazoline de formule (i), des compositions pharmaceutiques comprenant les composés de formule (i), et l'utilisation des composés de formule (i) dans le traitement ou la prévention d'une infection virale, d'une maladie induite par un virus, du cancer ou d'une allergie. Dans la formule (i), r1 représente un alkyle en c3-8, éventuellement substitué par un ou plusieurs substituants choisis indépendamment parmi le fluor, hydroxyle, amino, nitrile, ester, amide, alkyle en c1-3, ou alcoxy en c1-3, le carbone de r1 lié à l'amine en position 4 de la quinazoline est dans la configuration (r), r2 représente l'hydrogène, deutérium, fluor, chlore, méthyle, méthoxy, cyclopropyle, trifluorométhyle, ou amide carboxylique, chacun parmi le méthyle, méthoxy et cyclopropyle étant éventuellement substitué par un ou plusieurs substituants indépendamment choisis parmi le fluor et le nitrile, r3 représente l'hydrogène ou le deutérium, r4 représente l'hydrogène, deutérium, fluor, méthyle, ester carboxylique, amide carboxylique, nitrile, cyclopropyle, hétérocycle en c4-7, ou un groupe hétéroaryle à 5 chaînons, chacun des groupes méthyle, cyclopropyle, hétérocycle en c4-7 et hétéroaryle à 5 chaînons étant éventuellement substitué par un ou plusieurs substituants indépendamment choisis parmi le fluor, hydroxyle, ou méthyle, r5 représente un atome d'hydrogène, de deutérium, de fluor, de chlore, de méthyle ou de méthoxy, à condition qu'au moins l'un de r2, r3, r4 et r5 ne représentent pas de l'hydrogène.
MA52411A 2018-03-01 2019-02-28 Dérivés de 2,4-diaminoquinazoline et leurs utilisations dans le traitement des infections virales, cancer et des allergies MA52411B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18159583 2018-03-01
PCT/EP2019/054941 WO2019166532A1 (fr) 2018-03-01 2019-02-28 Dérivés de 2,4-diaminoquinazoline et leurs utilisations médicales

Publications (2)

Publication Number Publication Date
MA52411A MA52411A (fr) 2021-01-06
MA52411B1 true MA52411B1 (fr) 2022-12-30

Family

ID=61557126

Family Applications (1)

Application Number Title Priority Date Filing Date
MA52411A MA52411B1 (fr) 2018-03-01 2019-02-28 Dérivés de 2,4-diaminoquinazoline et leurs utilisations dans le traitement des infections virales, cancer et des allergies

Country Status (32)

Country Link
US (2) US11597704B2 (fr)
EP (2) EP4059924A1 (fr)
JP (1) JP2021514981A (fr)
KR (1) KR20200128394A (fr)
CN (1) CN111868040A (fr)
AR (1) AR114420A1 (fr)
AU (1) AU2019226342B2 (fr)
BR (1) BR112020017702A2 (fr)
CA (1) CA3091076A1 (fr)
CL (3) CL2020002253A1 (fr)
CY (1) CY1125489T1 (fr)
DK (1) DK3759083T3 (fr)
EA (1) EA202092052A1 (fr)
ES (1) ES2923579T3 (fr)
HR (1) HRP20220781T1 (fr)
HU (1) HUE059149T2 (fr)
IL (2) IL276952B2 (fr)
JO (2) JOP20200208B1 (fr)
LT (1) LT3759083T (fr)
MA (1) MA52411B1 (fr)
MD (1) MD3759083T2 (fr)
MX (2) MX2020009071A (fr)
PH (1) PH12020551345A1 (fr)
PL (1) PL3759083T3 (fr)
PT (1) PT3759083T (fr)
RS (1) RS63401B1 (fr)
SG (1) SG11202008293YA (fr)
SI (1) SI3759083T1 (fr)
SM (1) SMT202200315T1 (fr)
TW (2) TW201945003A (fr)
UA (1) UA127590C2 (fr)
WO (1) WO2019166532A1 (fr)

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Publication number Priority date Publication date Assignee Title
AU2016306275A1 (en) 2015-08-07 2018-02-08 Arrowhead Pharmaceuticals, Inc. RNAi therapy for Hepatitis B virus infection
JOP20190015A1 (ar) 2016-08-04 2019-02-04 Arrowhead Pharmaceuticals Inc عوامل (ار ان ايه آي) لعدوى فيروس الالتهاب الكبدي الوبائي ب
TW201945003A (zh) * 2018-03-01 2019-12-01 愛爾蘭商健生科學愛爾蘭無限公司 ２，４－二胺基喹唑啉衍生物及其醫學用途
CN113301963A (zh) * 2019-01-14 2021-08-24 先天肿瘤免疫公司 用于治疗癌症的作为nlrp3调节剂的取代的喹唑啉类
CA3140707A1 (fr) * 2019-06-18 2020-12-24 Helen Horton Association de vaccins contre le virus de l'hepatite b (vhb) et de derives de quinazoline
JP2022545872A (ja) 2019-08-19 2022-11-01 シャンハイ ジムン バイオファーマ，インコーポレーテッド ２―アミノピリミジン化合物ならびにその医薬組成物および用途
CN114555565B (zh) * 2019-12-13 2024-03-05 四川科伦博泰生物医药股份有限公司 含氮并环化合物、其制备方法及用途
KR20220123437A (ko) 2020-01-02 2022-09-06 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 피리도피리미딘 유도체의 결정형 및 이의 제조 방법

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