MA52856B1 - Composés bicycliques hétéroaryle ou aryle fusionnés et leur utilisation en tant qu'inhibiteurs irak4 - Google Patents

Composés bicycliques hétéroaryle ou aryle fusionnés et leur utilisation en tant qu'inhibiteurs irak4

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Publication number
MA52856B1
MA52856B1 MA52856A MA52856A MA52856B1 MA 52856 B1 MA52856 B1 MA 52856B1 MA 52856 A MA52856 A MA 52856A MA 52856 A MA52856 A MA 52856A MA 52856 B1 MA52856 B1 MA 52856B1
Authority
MA
Morocco
Prior art keywords
heteroaryl
fused aryl
compounds
bicyclic compounds
aryl bicyclic
Prior art date
Application number
MA52856A
Other languages
English (en)
Other versions
MA52856A (fr
Inventor
Akshay Patny
Seungil Han
Eddine Saiah
Christoph Wolfgang Zapf
Joseph Walter Strohbach
John David Trzupek
Xiaolun Wang
David Hepworth
Christoph Martin Dehnhardt
David Randolph Anderson
Mark Edward Bunnage
Kevin Joseph Curran
Lori Krim Gavrin
Joel Adam Goldberg
Horng-Chih Huang
Arthur Lee
Katherine Lin Lee
Frank Eldridge Lovering
Michael Dennis Lowe
John Paul Mathias
Nikolaos Papaioannou
Betsy Susan Pierce
Richard Vargas
Stephen Wayne Wright
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA52856A publication Critical patent/MA52856A/fr
Publication of MA52856B1 publication Critical patent/MA52856B1/fr

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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Abstract

L'invention concerne des composés, des tautomères et des sels pharmaceutiquement acceptables des composés, les composés ayant la structure de ia formule, tel que défini dans le cahier des charges. Des compositions pharmaceutiques correspondantes, des procédés de traitement de maladies auto-immunes et inflammatoires associées à la kinase associée au récepteur de l'interleukine-1 (irak), des procédés de synthèse et des intermédiaires sont également décrits
MA52856A 2014-04-04 2015-03-26 Composés bicycliques hétéroaryle ou aryle fusionnés et leur utilisation en tant qu'inhibiteurs irak4 MA52856B1 (fr)

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