MA53219B1 - Nouveaux composés hétérocycliques en tant qu'inhibiteurs de monoacylglycérol lipase - Google Patents

Nouveaux composés hétérocycliques en tant qu'inhibiteurs de monoacylglycérol lipase

Info

Publication number
MA53219B1
MA53219B1 MA53219A MA53219A MA53219B1 MA 53219 B1 MA53219 B1 MA 53219B1 MA 53219 A MA53219 A MA 53219A MA 53219 A MA53219 A MA 53219A MA 53219 B1 MA53219 B1 MA 53219B1
Authority
MA
Morocco
Prior art keywords
heterocyclic compounds
novel heterocyclic
lipase inhibitors
monoacylglycerol lipase
compounds
Prior art date
Application number
MA53219A
Other languages
English (en)
Other versions
MA53219A (fr
Inventor
Bernd Kuhn
Katrin Groebke Zbinden
Luca Gobbi
Buelent Kocer
Fionn O`HARA
Carsten KROLL
Uwe Grether
Didier Rombach
Hans Richter
Joerg Benz
Charles Bell
Benoit Hornsperger
Martin Ritter
Marius Daniel Rinaldo LUTZ
Martin KURATLI
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of MA53219A publication Critical patent/MA53219A/fr
Publication of MA53219B1 publication Critical patent/MA53219B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne de nouveaux composés hétérocycliques de formule générale (I), dans laquelle A, L, X, m, n, R1 et R2 sont tels que décrits dans la description, des compositions comprenant les composés, des procédés de fabrication des composés et des procédés d'utilisation des composés.
MA53219A 2018-08-13 2019-08-12 Nouveaux composés hétérocycliques en tant qu'inhibiteurs de monoacylglycérol lipase MA53219B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18188681 2018-08-13
PCT/EP2019/071520 WO2020035424A1 (fr) 2018-08-13 2019-08-12 Nouveaux composés hétérocycliques en tant qu'inhibiteurs de monoacylglycérol lipase
EP19755855.4A EP3837263B1 (fr) 2018-08-13 2019-08-12 Nouveaux composés hétérocycliques en tant qu'inhibiteurs de monoacylglycérol lipase

Publications (2)

Publication Number Publication Date
MA53219A MA53219A (fr) 2021-11-17
MA53219B1 true MA53219B1 (fr) 2024-09-30

Family

ID=63244467

Family Applications (1)

Application Number Title Priority Date Filing Date
MA53219A MA53219B1 (fr) 2018-08-13 2019-08-12 Nouveaux composés hétérocycliques en tant qu'inhibiteurs de monoacylglycérol lipase

Country Status (33)

Country Link
US (4) US20200308190A1 (fr)
EP (2) EP3837263B1 (fr)
JP (2) JP7637049B2 (fr)
KR (1) KR102879259B1 (fr)
CN (1) CN112867720A (fr)
AR (1) AR116666A1 (fr)
AU (1) AU2019322538B2 (fr)
BR (1) BR112021002298A2 (fr)
CA (1) CA3104928A1 (fr)
CL (1) CL2021000362A1 (fr)
CO (1) CO2021002382A2 (fr)
CR (1) CR20210077A (fr)
DK (1) DK3837263T3 (fr)
ES (1) ES2986417T3 (fr)
FI (1) FI3837263T3 (fr)
HR (1) HRP20241201T1 (fr)
HU (1) HUE067912T2 (fr)
IL (1) IL279173B2 (fr)
LT (1) LT3837263T (fr)
MA (1) MA53219B1 (fr)
MX (1) MX2021001433A (fr)
MY (1) MY210507A (fr)
PE (1) PE20211089A1 (fr)
PH (1) PH12021500013A1 (fr)
PL (1) PL3837263T3 (fr)
PT (1) PT3837263T (fr)
RS (1) RS65912B1 (fr)
RU (1) RU2769507C1 (fr)
SG (1) SG11202013064WA (fr)
SI (1) SI3837263T1 (fr)
TW (1) TWI812770B (fr)
UA (1) UA127629C2 (fr)
WO (1) WO2020035424A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR114136A1 (es) 2017-10-10 2020-07-29 Hoffmann La Roche Compuestos heterocíclicos
WO2019105915A1 (fr) 2017-11-28 2019-06-06 F. Hoffmann-La Roche Ag Nouveaux composés hétérocycliques
WO2019134985A1 (fr) 2018-01-08 2019-07-11 F. Hoffmann-La Roche Ag Octahydropyrido[1,2-alpha]pyrazines en tant qu'inhibiteurs de magl
BR122023024273A2 (pt) 2018-02-27 2024-02-20 Incyte Corporation Compostos imidazopirimidinas e triazolopirimidinas, seus usos, método para inibir uma atividade de um receptor de adenosina e composição farmacêutica dos mesmos
EP3810610A1 (fr) 2018-05-18 2021-04-28 Incyte Corporation Dérivés de pyrimidine fusionnés utilisés en tant qu'inhibiteurs de a2a/a2b
AU2019297361B2 (en) 2018-07-05 2024-06-27 Incyte Corporation Fused pyrazine derivatives as A2A / A2B inhibitors
AU2019322538B2 (en) * 2018-08-13 2021-09-30 F. Hoffmann-La Roche Ag New heterocyclic compounds as monoacylglycerol lipase inhibitors
PL3883936T3 (pl) 2018-11-22 2023-11-20 F. Hoffmann-La Roche Ag Nowe związki heterocykliczne
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
AU2020343737A1 (en) * 2019-09-05 2022-03-31 Lunan Pharmaceutical Group Corporation MAGL inhibitor, preparation method therefor and use thereof
US20210094971A1 (en) * 2019-09-09 2021-04-01 Hoffmann-La Roche Inc. Heterocyclic compounds
MX2022002311A (es) 2019-09-12 2022-03-25 Hoffmann La Roche Compuestos de 4,4a,5,7,8,8a-hexapirido[4,3-b][1,4]oxazin-3-ona como inhibidores de monoacilglicerol lipasa (magl).
EP4034239A1 (fr) * 2019-09-23 2022-08-03 F. Hoffmann-La Roche AG Composés hétérocycliques
AU2020354414A1 (en) * 2019-09-24 2022-02-17 F. Hoffmann-La Roche Ag New heterocyclic monoacylglycerol lipase (MAGL) inhibitors
BR112022003357A2 (pt) * 2019-09-24 2022-05-17 Hoffmann La Roche Compostos heterocíclicos
EP4041229A4 (fr) * 2019-10-07 2023-10-25 D.E. Shaw Research, LLC Composés hétérocycliques d'arylméthylène utilisés en tant que bloqueurs des canaux potassiques kv1.3 de type shaker
CA3176113A1 (fr) * 2020-03-26 2021-09-30 Janssen Pharmaceutica Nv Aminocyclobutanes servant de modulateurs de la monoacylglycerol lipase
CR20230115A (es) 2020-09-03 2023-04-11 Hoffmann La Roche Compuestos heterocíclicos
IL313987A (en) 2021-12-29 2024-08-01 Psy Therapeutics Inc Inhibiting monoacylglycerol lipase (magl)
KR20250060956A (ko) 2022-08-05 2025-05-07 컴쿼트 바이오사이언시즈 인크. 헤테로환 화합물 및 이의 용도
WO2024168426A1 (fr) 2023-02-13 2024-08-22 Apogee Pharmaceuticals, Inc. Petites molécules utilisées en tant qu'inhibiteurs de monoacylglycérol lipase (magl), compositions et utilisation associées

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5214038A (en) 1991-04-15 1993-05-25 Hoechst-Roussel Pharmaceuticals Inc. 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
US7579495B2 (en) 2003-12-19 2009-08-25 Momentive Performance Materials Inc. Active-releasing cyclic siloxanes
US7842810B2 (en) 2005-03-31 2010-11-30 Janssen Pharmaceutica, Nv Bicyclic pyrazole compounds as antibacterial agents
EP1896453B1 (fr) 2005-06-20 2009-12-02 Schering Corporation Pipéridines substituées liées à un atome de carbone et leurs dérivés utiles en tant qu antagonistes de l'histamine h3
JP5116687B2 (ja) 2005-11-02 2013-01-09 バイエル・ファルマ・アクチェンゲゼルシャフト がんおよび他の過剰増殖性疾患の処置のためのピロロ［２，１−ｆ］［１，２，４］トリアジン−４−イルアミンＩＧＦ−１Ｒキナーゼ阻害剤
WO2007098418A1 (fr) 2006-02-17 2007-08-30 Memory Pharmaceuticals Corporation Composes ayant une affinite pour le recepteur 5-ht6
WO2007117557A2 (fr) 2006-04-05 2007-10-18 Vitae Pharmaceuticals, Inc. Diaminopropanols inhibiteurs de rénine
CA2679754C (fr) 2007-03-12 2018-08-07 Intra-Cellular Therapies, Inc. Synthese de gamma-carbolines fusionnees a heterocycles substitues
FR2915197B1 (fr) * 2007-04-18 2009-06-12 Sanofi Aventis Sa Derives de triazolopyridine-carboxamides, leur preparation et leur application therapeutique.
TW200942537A (en) 2008-02-01 2009-10-16 Irm Llc Compounds and compositions as kinase inhibitors
US8394792B2 (en) 2008-03-31 2013-03-12 C&C Research Laboratories Heterocyclic derivatives
CA2741153A1 (fr) 2008-10-29 2010-05-06 F. Hoffmann-La Roche Ag Nouveaux derives d'amides phenyliques ou d'amides pyridyliques et leur utilisation en tant agonistes de gpbar1
CA2773182A1 (fr) 2009-09-10 2011-03-17 F. Hoffmann-La Roche Ag Inhibiteurs de jak
WO2011059118A1 (fr) 2009-11-10 2011-05-19 Kim Hyun Jeen Système de test de perception olfactive
US9051296B2 (en) * 2009-11-16 2015-06-09 Raqualia Pharma Inc. Aryl carboxamide derivatives as TTX-S blockers
US8420661B2 (en) 2010-04-13 2013-04-16 Hoffmann-La Roche Inc. Arylethynyl derivatives
JP6254075B2 (ja) 2011-05-16 2017-12-27 バイオノミックス リミテッド カリウムチャネル遮断剤としてのアミン誘導体
WO2013059118A1 (fr) 2011-10-19 2013-04-25 The Trustees Of Columbia University In The City Of New York Compositions catalytiques à base de cyclopropénimine et procédés
EP2785721A1 (fr) 2011-11-30 2014-10-08 Actelion Pharmaceuticals Ltd. Antibiotiques d'octahydro-2h-pyrido[4,3-e][1,3]oxazin-2-one 3,7-disubstituée
MY170922A (en) 2011-12-22 2019-09-18 Novartis Ag Dihydro-benzo-oxazine and dihydro-pyrido-oxazine derivatives
MX350788B (es) 2012-01-06 2017-09-13 Abide Therapeutics Inc Compuestos de carbamato y preparación y uso de los mismos.
GB201209587D0 (en) 2012-05-30 2012-07-11 Takeda Pharmaceutical Therapeutic compounds
TW201422625A (zh) 2012-11-26 2014-06-16 Novartis Ag 二氫－吡啶并－□衍生物之固體形式
TWI599567B (zh) 2013-03-14 2017-09-21 健生藥品公司 Ｐ２ｘ７調節劑
EA029361B1 (ru) 2013-04-16 2018-03-30 Идорсиа Фармасьютиклз Лтд Антибактериальные биароматические производные
WO2016109501A1 (fr) 2014-12-30 2016-07-07 Karos Pharmaceuticals, Inc. Composés amides utilisés en tant qu'inhibiteurs de la tryptophane hydroxylase
WO2016158956A1 (fr) 2015-03-30 2016-10-06 武田薬品工業株式会社 Composé hétérocyclique
CN107635986A (zh) 2015-05-13 2018-01-26 赛尔维他股份公司 取代的喹喔啉衍生物
CA2986199C (fr) 2015-05-21 2023-07-18 Glaxosmithkline Intellectual Property Development Limited Derives de benzoimidazole comme inhibiteurs pad4
MX379846B (es) 2015-06-18 2025-03-11 89Bio Ltd Derivados de 4-bencil y 4-benzoil piperidina sustituidos.
HK1249101A1 (zh) 2015-07-31 2018-10-26 辉瑞公司 作为magl抑制剂的1，1，1-三氟-3-羟基丙-2-基氨基甲酸酯衍生物及1，1，1-三氟-4-羟基丁-2-基氨基甲酸酯衍生物
WO2017087863A1 (fr) 2015-11-20 2017-05-26 Abide Therapeutics, Inc. Composés de pyrazole, procédés de production et utilisation
WO2017087858A1 (fr) 2015-11-20 2017-05-26 Abide Therapeutics, Inc. Composés de pyrazole, procédés de production et utilisation
MY194647A (en) 2016-03-31 2022-12-09 Takeda Pharmaceuticals Co Heterocyclic compound
US10610520B2 (en) 2016-03-31 2020-04-07 Takeda Pharmaceutical Company Limited Heterocyclic compound
KR20190022728A (ko) 2016-06-30 2019-03-06 바실리어 파마슈티카 인터내셔널 리미티드 증식 장애의 치료를 위한 미토콘드리아 억제제
PE20191239A1 (es) 2016-11-16 2019-09-16 Abide Therapeutics Inc Formas cristalinas de un inhibidor de magl
JOP20190107A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
MX394645B (es) 2017-06-12 2025-03-21 Boehringer Ingelheim Int Compuestos heteroaromáticos como inhibidores de vanina.
JP7189143B2 (ja) 2017-09-29 2022-12-13 武田薬品工業株式会社 複素環化合物
AR114136A1 (es) 2017-10-10 2020-07-29 Hoffmann La Roche Compuestos heterocíclicos
WO2019105915A1 (fr) 2017-11-28 2019-06-06 F. Hoffmann-La Roche Ag Nouveaux composés hétérocycliques
TW201930300A (zh) 2017-12-15 2019-08-01 瑞士商赫孚孟拉羅股份公司 新雜環化合物
WO2019134985A1 (fr) 2018-01-08 2019-07-11 F. Hoffmann-La Roche Ag Octahydropyrido[1,2-alpha]pyrazines en tant qu'inhibiteurs de magl
MX2020008894A (es) 2018-03-22 2020-10-12 Hoffmann La Roche Inhibidores de oxazin monoacilglicerol lipasa (magl).
AU2019322538B2 (en) 2018-08-13 2021-09-30 F. Hoffmann-La Roche Ag New heterocyclic compounds as monoacylglycerol lipase inhibitors
WO2020035425A1 (fr) 2018-08-13 2020-02-20 F. Hoffmann-La Roche Ag Nouveaux composés hétérocycliques utilisés en tant qu'inhibiteurs de monoacylglycérol lipase
PL3883936T3 (pl) 2018-11-22 2023-11-20 F. Hoffmann-La Roche Ag Nowe związki heterocykliczne
CU20210042A7 (es) 2018-11-22 2022-01-13 Qilu Regor Therapeutics Inc Compuestos agonistas de glp-1r y composiciones farmacéuticas que lo contienen
WO2020207941A1 (fr) 2019-04-09 2020-10-15 F. Hoffmann-La Roche Ag Composés hétérocycliques en tant qu'inhibiteurs de la monoacylglycérol lipase (magl)
JP7669299B2 (ja) 2019-07-03 2025-04-28 エフ． ホフマン－ラ ロシュ アーゲー 複素環モノアシルグリセロールリパーゼ（ｍａｇｌ）阻害剤
JP7649283B2 (ja) 2019-07-09 2025-03-19 エフ． ホフマン－ラ ロシュ アーゲー 新規複素環化合物
US20210094971A1 (en) 2019-09-09 2021-04-01 Hoffmann-La Roche Inc. Heterocyclic compounds
JP2022548018A (ja) 2019-09-12 2022-11-16 エフ．ホフマン－ラ ロシュ アーゲー 放射性標識化合物
MX2022002311A (es) 2019-09-12 2022-03-25 Hoffmann La Roche Compuestos de 4,4a,5,7,8,8a-hexapirido[4,3-b][1,4]oxazin-3-ona como inhibidores de monoacilglicerol lipasa (magl).
EP4034239A1 (fr) 2019-09-23 2022-08-03 F. Hoffmann-La Roche AG Composés hétérocycliques
BR112022003357A2 (pt) 2019-09-24 2022-05-17 Hoffmann La Roche Compostos heterocíclicos
EP4034602A1 (fr) 2019-09-24 2022-08-03 F. Hoffmann-La Roche AG Sondes fluorescentes pour la monoacylglycérol lipase (magl)
AU2020354414A1 (en) 2019-09-24 2022-02-17 F. Hoffmann-La Roche Ag New heterocyclic monoacylglycerol lipase (MAGL) inhibitors
CN116096723A (zh) 2020-08-26 2023-05-09 豪夫迈·罗氏有限公司 用作magl抑制剂的杂环化合物
CR20230115A (es) 2020-09-03 2023-04-11 Hoffmann La Roche Compuestos heterocíclicos
KR20240000574A (ko) 2021-04-23 2024-01-02 에프. 호프만-라 로슈 아게 헤테로시클릭 화합물

Also Published As

Publication number Publication date
AR116666A1 (es) 2021-06-02
RS65912B1 (sr) 2024-10-31
MA53219A (fr) 2021-11-17
CA3104928A1 (fr) 2020-02-20
JP2021534139A (ja) 2021-12-09
WO2020035424A1 (fr) 2020-02-20
PE20211089A1 (es) 2021-06-14
FI3837263T3 (fi) 2024-09-03
US20260022130A1 (en) 2026-01-22
TW202021970A (zh) 2020-06-16
JP7637049B2 (ja) 2025-02-27
US12281124B2 (en) 2025-04-22
SI3837263T1 (sl) 2024-10-30
US20230050901A1 (en) 2023-02-16
US20200308190A1 (en) 2020-10-01
TWI812770B (zh) 2023-08-21
AU2019322538A1 (en) 2021-01-07
HUE067912T2 (hu) 2024-11-28
JP2024174966A (ja) 2024-12-17
DK3837263T3 (da) 2024-09-09
CL2021000362A1 (es) 2021-07-09
EP4474017A3 (fr) 2025-02-26
AU2019322538B2 (en) 2021-09-30
SG11202013064WA (en) 2021-01-28
US20240150373A1 (en) 2024-05-09
UA127629C2 (uk) 2023-11-08
PH12021500013A1 (en) 2021-09-13
PL3837263T3 (pl) 2024-10-14
KR102879259B1 (ko) 2025-10-31
ES2986417T3 (es) 2024-11-11
US11802133B2 (en) 2023-10-31
KR20210045992A (ko) 2021-04-27
HRP20241201T1 (hr) 2024-11-22
MX2021001433A (es) 2021-04-12
EP3837263A1 (fr) 2021-06-23
LT3837263T (lt) 2024-09-25
CO2021002382A2 (es) 2021-03-08
RU2769507C1 (ru) 2022-04-01
CR20210077A (es) 2021-03-11
PT3837263T (pt) 2024-08-30
EP3837263B1 (fr) 2024-07-03
MY210507A (en) 2025-09-28
IL279173A (en) 2021-01-31
EP4474017A2 (fr) 2024-12-11
IL279173B1 (en) 2025-01-01
BR112021002298A2 (pt) 2021-05-04
IL279173B2 (en) 2025-05-01
CN112867720A (zh) 2021-05-28

Similar Documents

Publication Publication Date Title
MA55131B1 (fr) Nouveaux composés hétérocycliques
MA64323B1 (fr) Inhibiteurs de nlrp3
MA42109B1 (fr) Amides hétérocycliques utilisés en tant qu'inhibiteurs de kinase
MA48594B1 (fr) Nouveaux dérivés d'éther d'isoxazolyle en tant que pam alpha5 gaba a
MA32391B1 (fr) Activateurs de la glucokinase
MA31597B1 (fr) Nouveaux herbicides
WO2019035863A8 (fr) Activateurs de la pyruvate kinase destinés à être utilisés dans le traitement de troubles hématologiques
MA46325B1 (fr) Composés dinucléotidiques cycliques
MA31763B1 (fr) Inhibiteurs de kinase de type polo
MA30784B1 (fr) Derives phenyliques et utilisation de ceux-ci en tant qu'immunomodulateurs.
MA33275B1 (fr) Inhibiteurs de la replication du virus de l'immunodeficience humaine
MA31586B1 (fr) Dérivés d'alcools alkyliques de 1-phényl-2-pyridinyle en tant qu'inhibiteurs de la phosphodiestérase
MA30912B1 (fr) Nouveaux derives de phenylsulfamoyl-benzamide en tant qu'antagonistes de la bradykinine
MA34359B1 (fr) Dérivés de carbamate d'hexafluoroisopropyle, leur préparation et leur application thérapeutique
MX2022012676A (es) Compuestos y metodos para modular el empalme.
MA30717B1 (fr) Derives de pyridin-3-yle en tant qu'agents immunomodulateurs
MA30718B1 (fr) Derives de pyridin-4-yle en tant qu'agents immunomodulateurs.
MA32729B1 (fr) Derives d'acide 1-amino-2-cyclobutylethylboronique
MA30911B1 (fr) Nouveaux derives de sulfonamide en tant qu'antagonistes de bradykinine
MA45222B1 (fr) Nouveaux dérivés de pipéridinyle, procédé de préparation de ceux-ci et compositions pharmaceutiques les contenant
MA39193B1 (fr) Modulateurs du gpr6 à base de tétrahydropyridopyrazines
MA35434B1 (fr) Amino-quinazolines en tant qu'inhibiteurs de kinase
MA63458B1 (fr) Nouveaux dérivés de sulfonamide pyrimidin-2-yl
MA31596B1 (fr) Nouveaux herbicides
MA31782B1 (fr) Antagonistes du cgrp