MA32173B1 - Derives de pyridin-2-yle utilises comme agents immunomodulateurs - Google Patents

Derives de pyridin-2-yle utilises comme agents immunomodulateurs

Info

Publication number
MA32173B1
MA32173B1 MA33209A MA33209A MA32173B1 MA 32173 B1 MA32173 B1 MA 32173B1 MA 33209 A MA33209 A MA 33209A MA 33209 A MA33209 A MA 33209A MA 32173 B1 MA32173 B1 MA 32173B1
Authority
MA
Morocco
Prior art keywords
pyridine
immunomodulatory agents
derivatives used
derivatives
immunomodulatory
Prior art date
Application number
MA33209A
Other languages
Arabic (ar)
English (en)
Inventor
Martin Bolli
Cyrille Lescop
Boris Mathys
Claus Mueller
Oliver Nayler
Beat Steiner
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40584746&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32173(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MA32173B1 publication Critical patent/MA32173B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

L'invention concerne des dérivés de pyridine de la formule (i), dans laquelle a, r1, r2, r3, r4, r5, r6 et r7 sont tels que décrits dans la description, ainsi que leur préparation et leur utilisation comme composés pharmaceutiquement actifs. Lesdits composés agissent en particulier comme des agents immunomodulateurs.
MA33209A 2008-03-07 2010-09-29 Derives de pyridin-2-yle utilises comme agents immunomodulateurs MA32173B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2008050848 2008-03-07
PCT/IB2009/050749 WO2009109872A1 (fr) 2008-03-07 2009-02-25 Dérivés de pyridin-2-yle utilisés comme agents immunomodulateurs

Publications (1)

Publication Number Publication Date
MA32173B1 true MA32173B1 (fr) 2011-03-01

Family

ID=40584746

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33209A MA32173B1 (fr) 2008-03-07 2010-09-29 Derives de pyridin-2-yle utilises comme agents immunomodulateurs

Country Status (26)

Country Link
US (1) US8575200B2 (fr)
EP (1) EP2252609B1 (fr)
JP (1) JP5435745B2 (fr)
KR (1) KR101615779B1 (fr)
CN (1) CN102015695B (fr)
AR (1) AR070858A1 (fr)
AU (1) AU2009220861B2 (fr)
BR (1) BRPI0909055A2 (fr)
CA (1) CA2715437C (fr)
CL (1) CL2009000532A1 (fr)
CY (1) CY1114096T1 (fr)
DK (1) DK2252609T3 (fr)
ES (1) ES2414533T3 (fr)
HR (1) HRP20130641T1 (fr)
IL (1) IL207972A (fr)
MA (1) MA32173B1 (fr)
MX (1) MX2010009644A (fr)
MY (1) MY183039A (fr)
NZ (1) NZ588438A (fr)
PL (1) PL2252609T3 (fr)
PT (1) PT2252609E (fr)
RU (1) RU2494099C2 (fr)
SI (1) SI2252609T1 (fr)
TW (1) TWI444377B (fr)
WO (1) WO2009109872A1 (fr)
ZA (1) ZA201007136B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2069336E (pt) * 2006-09-07 2013-03-07 Actelion Pharmaceuticals Ltd Derivados de piridin-4-ilo como agentes imunomoduladores
PL2069335T3 (pl) * 2006-09-08 2013-05-31 Actelion Pharmaceuticals Ltd Pochodne pirydyn-3-ylu jako środki immunomodulujące
ES2393412T3 (es) * 2006-09-21 2012-12-21 Actelion Pharmaceuticals Ltd. Derivados de fenilo y su uso como inmunomoduladores
BRPI0808789A2 (pt) * 2007-03-16 2014-08-12 Actelion Pharmaceuticals Ltd Compostos e composição farmacêutica de derivados aminopiridina e uso destes
PT2195311E (pt) * 2007-08-17 2011-05-25 Actelion Pharmaceuticals Ltd Derivados de piridina como moduladores do receptor s1p1/edg1
KR20100092473A (ko) * 2007-11-01 2010-08-20 액테리온 파마슈티칼 리미티드 신규한 피리미딘 유도체
CA2767585C (fr) 2009-07-16 2017-09-26 Actelion Pharmaceuticals Ltd Derives pyridin-4-yliques
EP2558433B1 (fr) * 2010-04-15 2014-06-18 Merck Patent GmbH Procédé pour la préparation d'hydroquinones
MA34910B1 (fr) 2011-01-19 2014-02-01 Actelion Pharmaceuticals Ltd Dérivés de 2-methoxy-pyridin-4-yl
NZ713080A (en) * 2013-03-15 2020-06-26 Idorsia Pharmaceuticals Ltd Pyridin-4-yl derivatives
PH12017502097B1 (en) 2015-05-20 2023-05-05 Idorsia Pharmaceuticals Ltd Crystalline form of the compound (s)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol

Family Cites Families (40)

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AU653957B2 (en) 1990-09-20 1994-10-20 Merrell Dow Pharmaceuticals Inc. 1-aryl-3-pyridinyl-2-propene-1-ones
DE4429465A1 (de) * 1994-08-19 1996-02-22 Bayer Ag Verfahren zur Herstellung von 2-Halogenpyridinaldehyden und neue 2-Halogenpyridinaldehyde
JP2003034684A (ja) * 2001-06-29 2003-02-07 Biofor Inc 新規な種類の抗真菌剤
JP2005533058A (ja) * 2002-06-17 2005-11-04 メルク　エンド　カムパニー　インコーポレーテッド Ｅｄｇ受容体アゴニストとしての１−（（５−アリール−１，２，４−オキサジアゾール−３−イル）ベンジル）アゼチジン−３−カルボキシラートおよび１−（（５−アリール−１，２，４−オキサジアゾール−３−イル）ベンジル）ピロリジン−３−カルボキシラート
DE10237883A1 (de) 2002-08-19 2004-03-04 Merckle Gmbh Chem.-Pharm. Fabrik Substituierte Isoxazolderivate und ihre Verwendung in der Pharmazie
WO2004035538A1 (fr) * 2002-10-15 2004-04-29 Merck & Co., Inc. Procede de fabrication de l'acide azetidine-3-carboxylique
US20070043014A1 (en) * 2003-10-01 2007-02-22 Merck & Co., Inc. 3,5-Aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists
EP1697333A4 (fr) * 2003-12-17 2009-07-08 Merck & Co Inc Carboxylates propanoiques 3,4-disusbstitues utilises en tant qu'agonistes du recepteur s1p (edg)
JP5315611B2 (ja) * 2004-06-23 2013-10-16 小野薬品工業株式会社 Ｓ１ｐ受容体結合能を有する化合物およびその用途
WO2006010379A1 (fr) * 2004-07-29 2006-02-02 Actelion Pharmaceuticals Ltd. Nouveaux derives du thiophene utilises comme agents immunosupresseurs
BRPI0519012A2 (pt) * 2004-12-13 2008-12-23 Ono Pharmaceutical Co derivado do Ácido aminocarboxÍlico e seu uso medicinal
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AR057894A1 (es) * 2005-11-23 2007-12-26 Actelion Pharmaceuticals Ltd Derivados de tiofeno
TWI404706B (zh) * 2006-01-11 2013-08-11 Actelion Pharmaceuticals Ltd 新穎噻吩衍生物
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EP2258700A1 (fr) * 2006-05-09 2010-12-08 Pfizer Products Inc. Dérivés d'acides aminés cycloalkyles et compositions pharmaceutiques les contenant
PT2069336E (pt) * 2006-09-07 2013-03-07 Actelion Pharmaceuticals Ltd Derivados de piridin-4-ilo como agentes imunomoduladores
AR061841A1 (es) * 2006-09-07 2008-09-24 Actelion Pharmaceuticals Ltd Derivados de tiofen-oxadiazoles, agonistas del receptor s1p1/edg1, composiciones farmaceuticas que los contienen y usos como agentes inmunomoduladores.
PL2069335T3 (pl) * 2006-09-08 2013-05-31 Actelion Pharmaceuticals Ltd Pochodne pirydyn-3-ylu jako środki immunomodulujące
ES2393412T3 (es) * 2006-09-21 2012-12-21 Actelion Pharmaceuticals Ltd. Derivados de fenilo y su uso como inmunomoduladores
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BRPI0808789A2 (pt) * 2007-03-16 2014-08-12 Actelion Pharmaceuticals Ltd Compostos e composição farmacêutica de derivados aminopiridina e uso destes
PT2195311E (pt) * 2007-08-17 2011-05-25 Actelion Pharmaceuticals Ltd Derivados de piridina como moduladores do receptor s1p1/edg1
KR20100092473A (ko) * 2007-11-01 2010-08-20 액테리온 파마슈티칼 리미티드 신규한 피리미딘 유도체
MX2010005889A (es) * 2007-12-10 2010-06-22 Actelion Pharmaceuticals Ltd Derivados de tiofeno como agonistas de s1p1/edg1.
WO2009109907A1 (fr) * 2008-03-06 2009-09-11 Actelion Pharmaceuticals Ltd Nouveaux dérivés de pyrimidine-pyridine
EP2262799B1 (fr) * 2008-03-06 2012-07-04 Actelion Pharmaceuticals Ltd. Composés de pyridine
CA2715317A1 (fr) * 2008-03-07 2009-09-11 Actelion Pharmaceuticals Ltd Nouveaux derives d'aminomethylbenzene
CA2767585C (fr) * 2009-07-16 2017-09-26 Actelion Pharmaceuticals Ltd Derives pyridin-4-yliques

Also Published As

Publication number Publication date
CL2009000532A1 (es) 2010-04-09
KR101615779B1 (ko) 2016-04-26
AR070858A1 (es) 2010-05-12
WO2009109872A1 (fr) 2009-09-11
RU2010140854A (ru) 2012-04-20
JP5435745B2 (ja) 2014-03-05
TWI444377B (zh) 2014-07-11
IL207972A (en) 2016-03-31
CY1114096T1 (el) 2016-07-27
PT2252609E (pt) 2013-06-24
PL2252609T3 (pl) 2013-09-30
ES2414533T3 (es) 2013-07-19
TW200940532A (en) 2009-10-01
MX2010009644A (es) 2010-09-22
SI2252609T1 (sl) 2013-07-31
EP2252609A1 (fr) 2010-11-24
BRPI0909055A2 (pt) 2019-02-26
IL207972A0 (en) 2010-12-30
KR20100137493A (ko) 2010-12-30
NZ588438A (en) 2012-05-25
US20100331372A1 (en) 2010-12-30
AU2009220861A1 (en) 2009-09-11
CA2715437C (fr) 2016-05-24
RU2494099C2 (ru) 2013-09-27
AU2009220861B2 (en) 2014-05-29
JP2011513381A (ja) 2011-04-28
CA2715437A1 (fr) 2009-09-11
CN102015695A (zh) 2011-04-13
EP2252609B1 (fr) 2013-04-17
ZA201007136B (en) 2014-03-26
DK2252609T3 (da) 2013-06-24
HK1150601A1 (en) 2012-01-06
US8575200B2 (en) 2013-11-05
CN102015695B (zh) 2014-08-27
HRP20130641T1 (en) 2013-08-31
MY183039A (en) 2021-02-08

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