MA54829A - Composés et leurs utilisations - Google Patents

Composés et leurs utilisations

Info

Publication number
MA54829A
MA54829A MA054829A MA54829A MA54829A MA 54829 A MA54829 A MA 54829A MA 054829 A MA054829 A MA 054829A MA 54829 A MA54829 A MA 54829A MA 54829 A MA54829 A MA 54829A
Authority
MA
Morocco
Prior art keywords
compounds
Prior art date
Application number
MA054829A
Other languages
English (en)
Inventor
Bourdonnec Bertrand Le
Matthew Lucas
Kerem Ozboya
Bhaumik Pandya
Iwona Wrona
Original Assignee
Yumanity Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yumanity Therapeutics Inc filed Critical Yumanity Therapeutics Inc
Publication of MA54829A publication Critical patent/MA54829A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA054829A 2019-01-24 2020-01-24 Composés et leurs utilisations MA54829A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962796411P 2019-01-24 2019-01-24
US201962822353P 2019-03-22 2019-03-22
US201962934900P 2019-11-13 2019-11-13

Publications (1)

Publication Number Publication Date
MA54829A true MA54829A (fr) 2021-12-01

Family

ID=71735919

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054829A MA54829A (fr) 2019-01-24 2020-01-24 Composés et leurs utilisations

Country Status (13)

Country Link
US (3) US12098146B2 (fr)
EP (1) EP3914593A4 (fr)
JP (1) JP7742775B2 (fr)
KR (1) KR20220007845A (fr)
CN (1) CN113906019A (fr)
AU (1) AU2020212034A1 (fr)
BR (1) BR112021014583A2 (fr)
CA (1) CA3127791A1 (fr)
IL (1) IL285118A (fr)
MA (1) MA54829A (fr)
MX (3) MX2021008903A (fr)
SG (1) SG11202108079RA (fr)
WO (1) WO2020154571A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA46589A (fr) 2016-10-24 2019-08-28 Yumanity Therapeutics Inc Composés et utilisations de ces derniers
EP3566055B1 (fr) 2017-01-06 2025-03-12 Janssen Pharmaceutica NV Inhibiteurs de la scd pour le traitement de troubles neurologiques
CA3083000A1 (fr) 2017-10-24 2019-05-02 Yumanity Therapeutics, Inc. Composes et utilisations de ces composes
ES3043183T3 (en) 2018-03-23 2025-11-25 Janssen Pharmaceutica Nv Compounds and uses thereof
MX2021008903A (es) 2019-01-24 2021-11-04 Yumanity Therapeutics Inc Compuestos y usos de los mismos.
EA202192047A1 (ru) 2019-11-13 2021-12-08 Юманити Терапьютикс, Инк. Соединения и их применение

Family Cites Families (277)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4782071A (en) 1986-11-03 1988-11-01 Warner-Lambert Company Tetrasubstituted urea cholinergic agents
US5780472A (en) 1995-01-11 1998-07-14 Samjin Pharmaceuticazl Co., Ltd. Piperazine derivatives and methods for the preparation thereof and compositions containing the same
TW360653B (en) 1995-03-01 1999-06-11 Janssen Pharmaceutica Nv A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition
AU4414999A (en) 1998-06-08 1999-12-30 Sambasiva R. Chavali Inhibition of delta-9-desaturase activity by saponins
US6107313A (en) 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
US20070087363A1 (en) 1998-12-22 2007-04-19 Myriad Genetics, Incorporated Therapeutic methods, compounds and compositions
CA2377771A1 (fr) 1999-07-01 2001-01-11 Ajinomoto Co., Inc. Composes heterocycliques et leurs applications en medecine
HUP0301764A3 (en) 1999-07-20 2004-06-28 Dow Agrosciences Llc Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation
BR0013469B1 (pt) 1999-08-20 2011-01-25 amidas aromáticas heterocìclicas fungicidas, composição fungicida compreendendo as mesmas, bem como método para o controle ou a prevenção de infestação fúngica.
PT1315831E (pt) 2000-02-24 2010-11-04 Xenon Pharmaceuticals Inc Estearoil-coa dessaturase para identificar agentes terapêuticos que reduzem triglicéridos
MXPA02012314A (es) 2000-06-12 2004-09-06 Eisai Co Ltd Compuestos de 1,2-dihidropiridina, metodo de fabricacion y utilizacion de los mismos.
WO2001095856A2 (fr) 2000-06-15 2001-12-20 Chaconne Nsi Co., Ltd. Derive d'uree en tant qu'agent anticancereux et son procede de preparation
EP1346042A2 (fr) 2000-11-17 2003-09-24 Xenon Genetics, Inc. Genes a regulation lipidique, utilisations de ces genes et composes permettant leur modulation
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
US20050256068A1 (en) 2001-05-18 2005-11-17 Sirna Therapeutics, Inc. RNA interference mediated inhibition of stearoyl-CoA desaturase (SCD) gene expression using short interfering nucleic acid (siNA)
US20050043256A1 (en) 2001-07-30 2005-02-24 Isis Pharmaceuticals, Inc. Antisense modulation of stearoyl-CoA desaturase expression
US6727247B2 (en) 2001-12-10 2004-04-27 Hoffman-La Roche Inc. Substituted benzothiazole amide derivatives
EP1499628A4 (fr) 2002-02-20 2005-06-15 Sirna Therapeutics Inc Inhibition mediee de l'interference d'arn de l'expression du gene de la stearoyl-coa desaturase (scd) au moyen d'acides nucleiques d'interference courts
US6995144B2 (en) 2002-03-14 2006-02-07 Eisai Co., Ltd. Nitrogen containing heterocyclic compounds and medicines containing the same
US7105505B2 (en) 2002-04-18 2006-09-12 Schering Corporation Benzimidazole derivatives useful as histamine H3 antagonists
AU2003264018A1 (en) 2002-08-09 2004-02-25 Astrazeneca Ab Compounds having an activity at metabotropic glutamate receptors
EP1537098A1 (fr) 2002-08-13 2005-06-08 Warner-Lambert Company LLC Derives monocycliques en tant qu'inhibiteurs de metalloproteinases matricielles
US7144876B2 (en) 2002-12-18 2006-12-05 Cytovia, Inc. 3,5-Disubstituted-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof
CA2528003A1 (fr) 2003-06-10 2004-12-23 Kalypsys, Inc. Composes carbonyle utilises comme inhibiteurs de l'histone desacetylase a des fins therapeutiques
SG145695A1 (en) 2003-07-29 2008-09-29 Xenon Pharmaceuticals Inc Pyridyl derivatives and their use as therapeutic agents
EP2316825A1 (fr) 2003-07-30 2011-05-04 Xenon Pharmaceuticals Inc. Dérivés de pyridyle et utilisation de ceux-ci en tant qu'agents thérapeutiques
US7759348B2 (en) 2003-07-30 2010-07-20 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
NZ545265A (en) 2003-07-30 2009-11-27 Xenon Pharmaceuticals Inc Pyridazine derivatives and their use for treating diseases mediated by stearoyl-CoA desaturase (SCD) enzymes
US7754711B2 (en) 2003-07-30 2010-07-13 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
KR20060037409A (ko) 2003-07-30 2006-05-03 제논 파마슈티칼스 인크. 피페라진 유도체 및 그의 치료제로서의 용도
EP1653952A4 (fr) 2003-08-06 2007-04-04 Pfizer Prod Inc Composes d'oxazole destines au traitement de troubles neurodegenerescents
US7504401B2 (en) 2003-08-29 2009-03-17 Locus Pharmaceuticals, Inc. Anti-cancer agents and uses thereof
CA2537844A1 (fr) 2003-09-05 2005-03-17 Cellzome Ag Traitement de maladies neurodegeneratives
MXPA06002567A (es) 2003-09-06 2006-09-04 Vertex Pharma Moduladores de transportadores con casete de union de atp.
US8188064B2 (en) 2003-11-25 2012-05-29 Wisconsin Alumni Research Foundation Vitamin D analogs for obesity prevention and treatment
CN1898235A (zh) 2003-12-24 2007-01-17 普罗西迪恩有限公司 作为gpcr受体激动剂的杂环衍生物
JP2005213233A (ja) 2004-02-02 2005-08-11 Fuji Oil Co Ltd 肝臓ステアロイル‐ＣｏＡ不飽和化酵素１合成抑制剤
US7459562B2 (en) 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
BRPI0512481A (pt) 2004-06-25 2008-03-11 Du Pont polinucleotìdeo isolado, polipeptìdeo, construção recombinante, célula, yarrowia sp.transformada, métodos para transformar uma célula, produzir uma planta transformada, produzir levedura, produzir ácidos graxos poliinsaturados e produzir pelo menos um ácido graxo poliinsaturados, sementes, óleos, plantas de sementes oleaginosa e alimentos ou rações
BRPI0418939A (pt) 2004-07-06 2008-04-08 Xenon Pharmaceuticals Inc derivados de nicotinamida e sua utilização como agentes terapêuticos
ES2325836T3 (es) 2004-07-26 2009-09-21 Merck Serono Sa Derivados de la n.hidroxiamida y uso de los mismos.
PT1778837E (pt) 2004-08-09 2008-07-11 Cellzome Ag Tratamento de doenças neurodegenerativas por utilização de inibidores de scd4
WO2006022442A1 (fr) 2004-08-24 2006-03-02 Santen Pharmaceutical Co., Ltd. Nouveaux derives d’amides heterocycliques ayant une activite d’inhibition de la dihydroorotate deshydrogenase
CA2580855A1 (fr) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Derives heterocycliques et leur utilisation en tant qu'agents therapeutiques
JP4958787B2 (ja) 2004-09-20 2012-06-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド ヒトステアロイル−ＣｏＡデサチュラーゼを阻害するためのピリジン誘導体
US8071603B2 (en) 2004-09-20 2011-12-06 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
MX2007003329A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y biciclicos y su uso como inhibidores de estearoil-coa-desaturasa (scd).
MX2007003327A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa.
TW200626138A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
WO2006034341A2 (fr) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Derives heterocycliques et leur utilisation en tant qu'agents therapeutiques
AR051026A1 (es) 2004-09-20 2006-12-13 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
AU2005304560C1 (en) 2004-11-10 2013-05-09 Incyte Holdings Corporation Lactam compounds and their use as pharmaceuticals
EP1838667A2 (fr) 2004-11-22 2007-10-03 Wisconsin Alumni Research Foundation 2alpha-methyl-19-nor-1alpha-hydroxy-homopregnacalciferol et ses utilisations
GT200500375A (es) 2004-12-20 2006-11-28 Derivados de piperidina y su uso como agentes antiinflamatorios
NZ556017A (en) 2004-12-24 2009-10-30 Prosidion Ltd G-protein coupled receptor (gpr116) agonists and use thereof for treating obesity and diabetes
MX2007007220A (es) 2004-12-27 2007-08-20 Astrazeneca Ab Compuestos de pirazolona como agonistas de receptor de glutamato metabotropico para el tratamiento de trastornos neurologicos y psiquiatricos.
RS56194B1 (sr) 2004-12-30 2017-11-30 Janssen Pharmaceutica Nv Derivativi fenilamida 4-(benzil)-piperazin-1-karboksilne kiseline i slična jedinjenja kao modulatori hidrolaze amida masnih kiselina (faah) za lečenje anksioznosti, bola i ostalih stanja
RU2396270C2 (ru) 2005-01-07 2010-08-10 Ф.Хоффманн-Ля Рош Аг Производные [4-(гетероарил)пиперазин-1-ил]-(2,5-замещенный фенил)метанона в качестве ингибиторов переносчика глицина-1 (glyt-1) для лечения неврологических и психоневрологических заболеваний
GT200600046A (es) 2005-02-09 2006-09-25 Terapia de combinacion
JO2787B1 (en) 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
WO2006125181A2 (fr) 2005-05-19 2006-11-23 Xenon Pharmaceuticals Inc. Derives piperidiniques: utilisation comme agents therapeutiques
WO2006125179A1 (fr) 2005-05-19 2006-11-23 Xenon Pharmaceuticals Inc. Composes tricycliques: utilisation comme agents therapeutiques
WO2007046868A2 (fr) 2005-05-19 2007-04-26 Xenon Pharmaceuticals Inc. Derives de thiazolidine et leurs utilisations en tant qu’agents therapeutiques
WO2007044085A2 (fr) 2005-05-19 2007-04-19 Xenon Pharmaceuticals Inc. Composes heteroaryle et leurs utilisations en tant qu'agents therapeutiques
WO2006125194A2 (fr) 2005-05-19 2006-11-23 Xenon Pharmaceuticals Inc. Derives de piperazine et leurs utilisations en tant qu'agents therapeutiques
US8541457B2 (en) 2005-06-03 2013-09-24 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors
WO2006130986A1 (fr) 2005-06-09 2006-12-14 Merck Frosst Canada Ltd. Derives d'azacyclohexane comme inhibiteurs de la stearoyl-coenzyme a delta-9 desaturase
JPWO2006137465A1 (ja) 2005-06-24 2009-01-22 塩野義製薬株式会社 含窒素複素環誘導体
CA2615045A1 (fr) 2005-07-20 2007-01-25 Merck Frosst Canada Ltd. Composes heteroaromatiques servant d'inhibiteurs d'une coenzyme stearoyle a delta-9 desaturase
EP1951731A4 (fr) 2005-11-15 2010-07-07 Merck Frosst Canada Ltd Dérivés d'azacyclohexane en tant qu'inhibiteurs de la stéaroyl-coenzyme a delta-9 désaturase
WO2007076055A2 (fr) 2005-12-22 2007-07-05 Entremed, Inc. Compositions et methodes comprenant l'utilisation d'antagonistes du recepteur active par des proteases
JP2009522287A (ja) 2005-12-29 2009-06-11 ナームローゼ・フエンノートチヤツプ・オルガノン 脂肪酸アミド加水分解酵素阻害剤
PE20071221A1 (es) 2006-04-11 2007-12-14 Arena Pharm Inc Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
WO2007136746A2 (fr) 2006-05-19 2007-11-29 Xenon Pharmaceuticals Inc. Composés macrocycliques et leurs utilisations en tant qu'agents thérapeutiques
CA2651700A1 (fr) 2006-05-22 2007-11-29 Merck Frosst Canada Ltd. Derives d'amines cycliques en tant qu'inhibiteurs de la stearoyl-coenzyme a delta-9-desaturase
RU2491285C2 (ru) 2006-06-05 2013-08-27 Новартис Аг Органические соединения
JP2009539884A (ja) 2006-06-12 2009-11-19 メルク フロスト カナダ リミテツド ステアロイル−コエンザイムａデルタ−９デサチュラーゼのインヒビターとしてのアゼチジン誘導体
US7754745B2 (en) 2006-06-13 2010-07-13 Merck Frosst Canada Ltd. Azacyclopentane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
US20080280891A1 (en) 2006-06-27 2008-11-13 Locus Pharmaceuticals, Inc. Anti-cancer agents and uses thereof
WO2008003753A1 (fr) 2006-07-07 2008-01-10 Biovitrum Ab (Publ) Analogues de pyrazolo [1,5-a] pyrimidine utilisables comme inhibiteurs de l'activité stéaroyl-coa désaturase (scd)
US8080659B2 (en) 2006-07-11 2011-12-20 Emory University CXCR4 antagonists including diazine and triazine structures for the treatment of medical disorders
WO2008008852A2 (fr) 2006-07-11 2008-01-17 Emory University Antagonistes de cxcr4 comprenant des hétéroatomes pour le traitement de troubles médicaux
WO2008008059A1 (fr) 2006-07-12 2008-01-17 Locus Pharmaceuticals, Inc. Agents anti-cancer et leurs utilisations
US20090318476A1 (en) 2006-08-09 2009-12-24 Merck Frosst Canada Ltd. Azacycloalkane Derivatives as Inhibitors of Stearoyl-Coenzyme a Delta-9 Desaturase
PE20110341A1 (es) 2006-08-15 2011-06-21 Novartis Ag COMPUESTOS HETEROCICLICOS QUE MODULAN LA ACTIVIDAD DE LA ESTEROIL-CoA-DESATURASA
WO2008024139A2 (fr) 2006-08-18 2008-02-28 N.V. Organon Inhibiteurs d'hydrolase des amides d'acides gras
JPWO2008023720A1 (ja) 2006-08-23 2010-01-14 アステラス製薬株式会社 ウレア化合物又はその塩
AU2007288245A1 (en) 2006-08-24 2008-02-28 Novartis Ag 2- (pyrazin-2-yl) -thiazole and 2- (1h-pyrazol-3-yl) -thiazole derivatives as well as related compounds as stearoyl-CoA desaturase (SCD) inhibitors for the treatment of metabolic, cardiovascular and other disorders
WO2008029266A1 (fr) 2006-09-08 2008-03-13 Glenmark Pharmaceuticals S.A. Inhibiteurs de la stéaroyl coa désaturase
JP5351025B2 (ja) 2006-09-22 2013-11-27 ノバルティス アーゲー ヘテロ環式有機化合物
US7893066B2 (en) 2006-10-05 2011-02-22 Gilead Palo Alto, Inc. Pyridol[2,3-B]pyrazinones for use as stearoyl CoA desaturase inhibitors
KR20090057416A (ko) 2006-10-05 2009-06-05 씨브이 쎄러퓨틱스, 인코포레이티드 스테아로일 ＣｏＡ 탈포화효소 억제제로서 사용하기 위한, 바이시클릭 질소 함유 헤테로시클릭 화합물
US20090325956A1 (en) 2006-10-13 2009-12-31 Takahiko Taniguchi Aromatic amine derivative and use thereof
WO2008046226A1 (fr) 2006-10-20 2008-04-24 Merck Frosst Canada Ltd. Dérivés d'azacycloalcane en tant qu'inhibiteurs de la stéaroyl-coenzyme A delta-9 désaturase
WO2008057280A1 (fr) 2006-10-27 2008-05-15 Amgen Inc. Composés à cycles multiples et procédés d'utilisation
WO2008056687A1 (fr) 2006-11-09 2008-05-15 Daiichi Sankyo Company, Limited Nouveau dérivé de spiropipéridine
KR20090083477A (ko) 2006-11-20 2009-08-03 그렌마크 파머수티칼스 에스. 아. 스테아로일-ＣｏＡ 불포화효소 저해제인 아세틸렌 유도체
EP2102165A2 (fr) 2006-11-24 2009-09-23 AC Immune S.A. Derivés n-(méthyl)-1h-pyrazol-3-amine, n-(methyl)-pyridine-2-amine and n-(methyl)-thiazol-2-amine pour le traitement de maladies associés avec proteins amyloid ou similairs, comme p.e. alzheimer
CN101589039B (zh) 2006-12-01 2012-09-05 默克弗罗斯特加拿大有限公司 作为硬脂酰辅酶a △-9去饱和酶抑制剂的氮杂环烷衍生物
TW200826936A (en) 2006-12-01 2008-07-01 Merck Frosst Canada Ltd Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
CN101562977A (zh) 2006-12-15 2009-10-21 艾博特公司 新的二唑化合物
MX2009006728A (es) 2006-12-20 2009-09-09 Novartis Ag Heterociclos de 5 miembros 2-sustituidos como inhibidores de scd.
GB0625604D0 (en) 2006-12-21 2007-01-31 Smithkline Beecham Corp Compounds
GB0625605D0 (en) 2006-12-21 2007-01-31 Smithkline Beecham Corp Compounds
GB0625594D0 (en) 2006-12-21 2007-01-31 Smithkline Beecham Corp Compounds
AU2007336781C1 (en) 2006-12-21 2014-10-09 Sloan-Kettering Institute For Cancer Research Pyridazinones and furan-containing compounds
GB0625654D0 (en) 2006-12-21 2007-01-31 Smithkline Beecham Corp Compounds
AR064965A1 (es) 2007-01-26 2009-05-06 Merck Frosst Canada Inc Derivados de azacicloalcanos como inhibidores de estearoil - coenzima a delta -9 desaturasa
WO2008096746A1 (fr) 2007-02-06 2008-08-14 Takeda Pharmaceutical Company Limited Composé spiro et son utilisation
WO2008104524A1 (fr) 2007-02-28 2008-09-04 Smithkline Beecham Corporation Dérivés de thiadiazole, inhibiteurs de stéoryl-coa désaturase
CN101801972A (zh) 2007-03-28 2010-08-11 英诺瓦西亚公司 作为硬脂酰-辅酶a去饱和酶抑制剂的吡唑并[1,5-a]嘧啶
WO2008120744A1 (fr) 2007-03-30 2008-10-09 Japan Tobacco Inc. Composé d'amide cyclique à cinq chaînons et son utilisation
WO2008123469A1 (fr) 2007-03-30 2008-10-16 Japan Tobacco Inc. Composé amide à six chaînons et son utilisation
WO2008120759A1 (fr) 2007-03-30 2008-10-09 Japan Tobacco Inc. Composé d'urée et son utilisation
EP2131844A1 (fr) 2007-04-09 2009-12-16 CV Therapeutics Inc. Dérivés de ptéridinone destinés à être utilisés comme des inhibiteurs de stéaroyl-coa désaturase
US20080255161A1 (en) 2007-04-11 2008-10-16 Dmitry Koltun 3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS
WO2008128335A1 (fr) 2007-04-20 2008-10-30 Merck Frosst Canada Ltd. Nouveaux composés hétéroaromatiques comme inhibiteurs de la stéaroyl-coenzyme a delta-9 désaturase
WO2008139845A1 (fr) 2007-04-24 2008-11-20 Daiichi Sankyo Company, Limited Nouveau dérivé amide
AU2008253512A1 (en) 2007-05-23 2008-11-27 Merck Frosst Canada Ltd. Bicyclic heteroaromatic compounds as inhibitors of stearoyl-coenzyme A delta-9 desaturase
US7842696B2 (en) 2007-06-21 2010-11-30 Forest Laboratories Holdings Limited Piperazine derivatives as inhibitors of stearoyl-CoA desaturase
JP2009019013A (ja) 2007-07-12 2009-01-29 Daiichi Sankyo Co Ltd 新規ヘテロアリールピペリジン誘導体
GB0714129D0 (en) 2007-07-19 2007-08-29 Smithkline Beecham Corp compounds
AU2008280784A1 (en) 2007-07-20 2009-01-29 Merck Frosst Canada Ltd Bicyclic heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
GB0715055D0 (en) 2007-08-02 2007-09-12 Smithkline Beecham Corp Compounds
WO2009019566A1 (fr) 2007-08-08 2009-02-12 Pfizer Inc. Dérivé phénoxy-pyrrolidine et son utilisation, et compositions associées
MX2010001745A (es) 2007-08-14 2010-03-10 Bayer Schering Pharma Ag Imidazoles fusionados para el tratamiento del cancer.
WO2009037542A2 (fr) 2007-09-20 2009-03-26 Glenmark Pharmaceuticals, S.A. Composés spirocycliques en tant qu'inhibiteurs de stéaroyle coa désaturase
AU2008302570B2 (en) 2007-09-20 2012-05-31 Irm Llc Compounds and compositions as modulators of GPR119 activity
GB0721419D0 (en) 2007-10-31 2007-12-12 Smithkline Beecham Corp Compounds
GB0722077D0 (en) 2007-11-09 2007-12-19 Smithkline Beecham Corp Compounds
GB0722075D0 (en) 2007-11-09 2007-12-19 Smithkline Beecham Corp Compounds
WO2009070533A1 (fr) 2007-11-29 2009-06-04 Complegen, Inc. Procédés d'inhibition de stéaroyle-coa désaturase
WO2009073973A1 (fr) 2007-12-11 2009-06-18 Merck Frosst Canada Ltd. Nouveaux composés hétéroaromatiques en tant qu'inhibiteurs de la coenzyme stéaroyle a delta-9 désaturase
AU2008334705B2 (en) 2007-12-11 2011-06-16 F. Hoffmann-La Roche Ag Inhibitors of stearoyl-CoA desaturase
US8642660B2 (en) 2007-12-21 2014-02-04 The University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2009086440A1 (fr) 2007-12-28 2009-07-09 Wisconsin Alumni Research Foundation Dérivés d'analogues de vitamine d 2-méthylène-20-méthyl-19,24,25,26,27-pentanor
PE20091473A1 (es) 2008-02-20 2009-10-23 Novartis Ag Heterociclos como inhibidores de esteaoril-coa desaturasa
CN106432213A (zh) 2008-02-28 2017-02-22 沃泰克斯药物股份有限公司 作为cftr调节剂的杂芳基衍生物
KR20110005248A (ko) 2008-03-20 2011-01-17 포레스트 래보러토리즈 홀딩스 리미티드 스테아로일-ｃｏａ 탈포화효소의 억제제로서의 신규한 피페라진 유도체
MX2010010241A (es) 2008-03-20 2010-12-06 Forest Lab Holdings Ltd Derivados de piperidina novedosos como inhibidores de estearoil-coa desaturasa.
EP2615085B1 (fr) 2008-03-31 2015-08-26 Vertex Pharmaceuticals Incorporated Dérivés de pyridyle en tant que modulateur du CFTR
WO2009124259A1 (fr) 2008-04-04 2009-10-08 Cv Therapeutics, Inc. Dérivés de pyrrolotriazinone pouvant être utilisés à titre d'inhibiteurs de stéaroyl-coa désaturase
WO2009137201A1 (fr) 2008-04-04 2009-11-12 Cv Therapeutics, Inc. Dérivés de triazolopyridinone destinés à être utilisés comme inhibiteurs de la stéaroyl-coa désaturase
EP2278976A1 (fr) 2008-04-07 2011-02-02 Gilead Sciences, Inc. Dérivés de 2h-benzo[b][1,4]oxazin-3(4h)-one à utiliser comme inhibiteurs de la stéaroyl-coa désaturase
CA2720654A1 (fr) 2008-04-22 2009-10-29 Merck Frosst Canada Ltd. Nouveaux composes heteroaromatiques substitues en tant qu'inhibiteurs de la stearoyl-coenzyme a delta-9 desaturase
GB0810913D0 (en) 2008-06-13 2008-07-23 Smithkline Beecham Corp Comppounds
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
US8822513B2 (en) 2010-03-01 2014-09-02 Gtx, Inc. Compounds for treatment of cancer
MX2010014572A (es) 2008-06-27 2011-03-24 Novartis Ag Compuestos organicos.
TWI434842B (zh) 2008-07-14 2014-04-21 Astellas Pharma Inc Azole compounds
FR2933979B1 (fr) 2008-07-15 2012-08-24 Pf Medicament Derives de triazines et uraciles, leur preparation et leur application en therapeutique humaine
WO2010007482A2 (fr) 2008-07-16 2010-01-21 Glenmark Pharmaceuticals S.A. Dérivés de thiazole en tant qu’inhibiteurs de stéaroyl-coa désaturase
GB0813740D0 (en) 2008-07-28 2008-09-03 Angeletti P Ist Richerche Biologica Therapeutic compounds
JP2010043052A (ja) 2008-08-18 2010-02-25 Mitsubishi Chemicals Corp カロテノイド類の分離方法
WO2010022055A2 (fr) 2008-08-20 2010-02-25 Amgen Inc. Inhibiteurs de canaux sodiques sensibles au potentiel
CA2735794A1 (fr) 2008-09-08 2010-03-11 Merck Frosst Canada Ltd. Composes heteroaromatiques utilises en tant qu'inhibiteurs de la stearoyle-coenzyme a delta-9 desaturase
US8673917B2 (en) 2008-09-09 2014-03-18 Sanofi 2-heteroaryl-pyrrolo [3,4-C]pyrrole derivatives, and use thereof as SCD inhibitors
WO2010039186A2 (fr) 2008-09-23 2010-04-08 Renovis, Inc. Composés utiles en tant que modulateurs de la faah et leurs utilisations
WO2010035052A1 (fr) 2008-09-25 2010-04-01 Glenmark Pharmaceuticals, S.A. Inhibiteurs de la stéaroyl-coa désaturase 1 sélective de tissu et analyse de criblage à base de cellule pour leur identification
WO2010037225A1 (fr) 2008-10-02 2010-04-08 Merck Frosst Canada Ltd. Composés hétéroaromatiques en tant qu'inhibiteurs de la stéaroyl-coenzyme a delta-9 désaturase
WO2010045371A1 (fr) 2008-10-15 2010-04-22 Gilead Palo Alto, Inc. Composés pyrido- et pyrimido (1, 2-a) pyrimidine utiles comme inhibiteurs de la stéaroyl-coa-désaturase
JP2012505881A (ja) 2008-10-15 2012-03-08 ギリアード サイエンシーズ， インコーポレイテッド ステアロイル−ＣｏＡデサチュラーゼの阻害剤として使用するための３−ヒドロキナゾリン−４−オン誘導体
WO2010045374A1 (fr) 2008-10-15 2010-04-22 Gilead Palo Alto, Inc. Dérivés de 3-hydroquinazoline-4-1 à utiliser comme inhibiteurs de la stéaroyl-coa-désaturase
EP2350054A4 (fr) 2008-10-17 2012-03-28 Merck Canada Inc Dérivés d'azétidine comme inhibiteurs de la stéaroyl-coenzyme a delta-9 désaturase
WO2010048149A2 (fr) 2008-10-20 2010-04-29 Kalypsys, Inc. Modulateurs hétérocycliques de gpr119 pour le traitement d'une maladie
GB0821307D0 (en) 2008-11-21 2008-12-31 Summit Corp Plc Compounds for treatment of duchenne muscular dystrophy
EP2192196A1 (fr) 2008-11-27 2010-06-02 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Prédiction de susceptibilités physiologiques associées au métabotype de lipide
US20100160323A1 (en) 2008-12-23 2010-06-24 Alexander Bischoff NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE
JP5597210B2 (ja) 2009-02-17 2014-10-01 メルク カナダ インコーポレイテッド ステアロイル−補酵素ａデルタ−９デサチュラーゼの阻害剤として有用な新規スピロ化合物
AU2010215041A1 (en) 2009-02-23 2011-07-28 Merck Canada Inc. Heterocyclic derivatives as inhibitors of stearoyl-coenzyme A delta-9 desaturase
LT2403499T (lt) 2009-03-02 2020-01-10 Stemsynergy Therapeutics, Inc. Būdai ir kompozicijos, skirti panaudoti vėžio gydymui ir wnt sąlygotų poveikių ląstelėje sumažinimui
WO2010108268A1 (fr) 2009-03-23 2010-09-30 Merck Frosst Canada Ltd. Composés hétérocycliques inhibiteurs de la stéaroyl-coenzyme a delta-9 désaturase
EP2414366A1 (fr) 2009-04-01 2012-02-08 Novartis AG Dérivés spiro pour la modulation de la stéaroyl-coa désaturase
CA2768577A1 (fr) 2009-07-23 2011-01-27 Schering Corporation Composes d?oxazepine benzofusionnes en tant qu?inhibiteurs de la coenzyme-stearoyle a delta-9 desaturase
WO2011011506A1 (fr) 2009-07-23 2011-01-27 Schering Corporation Composés oxazépine spirocyclique en tant qu'inhibiteurs de la stéaroyl-coenzyme a delta-9 désaturase
US8383643B2 (en) 2009-07-28 2013-02-26 Merck Canada Inc. Spiro compounds useful as inhibitors of stearoyl-coenzyme A delta-9 desaturase
FR2948939B1 (fr) 2009-08-05 2013-03-22 Pf Medicament Derives de 2h pyridazin-3-ones, leur preparation et leur application en therapeutique humaine
WO2011025690A1 (fr) 2009-08-27 2011-03-03 Merck Sharp & Dohme Corp. Nouveaux agonistes de récepteurs adrénergiques bêta 3 dérivés de pyrrolidine
US8304551B2 (en) 2009-09-01 2012-11-06 Catabasis Pharmaceuticals, Inc. Fatty acid niacin conjugates and their uses
US20130012709A1 (en) 2009-09-10 2013-01-10 Centre National De La Recherche Scientifique NOVEL INHIBITORS OF STEAROYL-CoA-DESATURASE-1 AND THEIR USES
SG178869A1 (en) 2009-10-01 2012-04-27 Novartis Ag Pyrazole derivatives which modulate stearoyl-coa desaturase
WO2011047481A1 (fr) 2009-10-23 2011-04-28 Merck Frosst Canada Ltd. Nouveaux composés spiro utiles en tant qu'inhibiteurs de stéaroyl-coenzyme a delta-9 désaturase
US8563539B2 (en) 2009-12-23 2013-10-22 Jasco Pharmaceuticals, LLC Aminopyrimidine kinase inhibitors
EP3064204A1 (fr) 2010-03-01 2016-09-07 GTx, Inc. Composes pour le traitement du cancer
US8796254B2 (en) 2010-03-31 2014-08-05 Rigel Pharmaceuticals, Inc. Methods for using carboxamide, sulfonamide and amine compounds
FR2958935B1 (fr) 2010-04-19 2012-06-22 Pf Medicament Derives d'heterocycles azotes, leur preparation et leur application en therapeutique humaine
EP2582681A1 (fr) 2010-06-17 2013-04-24 Novartis AG Dérivés de 1,3 dihydro-benzoimidazol-2-ylidène-amine à substitution pipéridinyle
US20130259830A1 (en) 2010-07-12 2013-10-03 Ironwood Pharmaceuticals, Inc. Crth2 modulators
WO2012016133A2 (fr) 2010-07-29 2012-02-02 President And Fellows Of Harvard College Inhibiteurs de la ros1 kinase pour le traitement de glioblastome et d'autres cancers déficients en p53
CA2806341C (fr) 2010-07-29 2020-03-24 Rigel Pharmaceuticals, Inc. Composes heterocycliques d'activation de l'ampk et procedes d'utilisation de ceux-ci
SI2616465T1 (sl) 2010-09-13 2016-02-29 Novartis Ag Triazin-oksadiazoli
US20130225618A1 (en) 2010-10-04 2013-08-29 Kowa Co., Ltd. Agent for inhibiting expression of lipid metabolism related mrna
GB201114389D0 (en) 2011-08-22 2011-10-05 Prosidion Ltd Novel compounds
AR083904A1 (es) 2010-11-18 2013-04-10 Prosidion Ltd Derivados de 1,4-pirrolidinas disustituidos y 3-il-aminas y sus usos en el tratamiento de desordenes metabolicos
EP2455080A1 (fr) 2010-11-23 2012-05-23 Almirall, S.A. Agonistes de récepteur S1P1 à utiliser dans le traitement de la sclérose en plaques
EP2455081A1 (fr) 2010-11-23 2012-05-23 Almirall, S.A. Agonistes de récepteur S1P1 à utiliser dans le traitement de la maladie de Crohn
GB201021103D0 (en) 2010-12-13 2011-01-26 Univ Leuven Kath New compounds for the treatment of neurodegenerative diseases
JP5937102B2 (ja) 2010-12-14 2016-06-22 エレクトロフォレティクス リミテッド カゼインキナーゼ１デルタ（ｃｋ１デルタ）阻害剤
EP2651930B1 (fr) 2010-12-16 2015-10-28 Boehringer Ingelheim International GmbH Inhibiteurs biarylamide de production de leukotriènes
US8853213B2 (en) 2011-01-03 2014-10-07 Hanmi Pharm. Co., Ltd Bicyclic compound for modulating G protein-coupled receptors
US8822471B2 (en) 2011-03-14 2014-09-02 Boehringer Ingelheim International Gmbh Compounds, pharmaceutical compositions and uses thereof
JP2014513071A (ja) 2011-04-04 2014-05-29 シエナ ビオテク ソシエタ ペル アチオニ ウィント経路遮断薬
US20140057895A1 (en) 2011-06-07 2014-02-27 Kazuhiro Mizuno Indazole- and pyrrolopyridine-derivative and pharmaceutical use thereof
WO2012170931A2 (fr) 2011-06-10 2012-12-13 Calcimedica, Inc. Composés qui modulent le calcium intracellulaire
EP2726470B1 (fr) 2011-07-01 2015-04-29 reMynd NV Dérivés de 1,2,4-thiadiazol-5-ylpipérazine utiles dans le traitement de maladies neurodégénératives
US20150051206A1 (en) 2011-09-01 2015-02-19 Irm Llc Compounds and compositions as c-kit kinase inhibitors
EP2771337B1 (fr) 2011-09-27 2017-08-02 Novartis AG 3-(pyrimidin-4-yl)-oxazolidin-2-ones comme inhibiteurs d'idh mutante
MX2014004426A (es) 2011-10-15 2014-07-09 Genentech Inc Metodos de uso de antagonistas de scd1.
US9205085B2 (en) 2011-11-07 2015-12-08 Emory University Tricyclic amino containing compounds for treatment or prevention of symptoms associated with endocrine dysfunction
WO2013085954A1 (fr) 2011-12-06 2013-06-13 Janssen Pharmaceutica Nv Dérivés de pipéridinyl-carboxamide substitué utiles en tant qu'inhibiteurs de scd 1
WO2013085957A1 (fr) 2011-12-06 2013-06-13 Janssen Pharmaceutica Nv Dérivés de pipéridinyl-pyridazinyle substitué utiles comme inhibiteurs de scd 1
US8530461B2 (en) 2011-12-29 2013-09-10 Boehringer Ingelheim International Gmbh Azetidine derivatives
US20130225529A1 (en) 2012-02-27 2013-08-29 Basil Rigas Phospho-ester derivatives and uses thereof
WO2013134546A1 (fr) 2012-03-07 2013-09-12 Mayo Foundation For Medical Education And Research Procédés et matériaux pour traiter le cancer
CN104244962A (zh) 2012-04-23 2014-12-24 皮拉马尔企业有限公司 用于治疗代谢紊乱的组合物
WO2013170072A2 (fr) 2012-05-09 2013-11-14 Neurop, Inc. Composés pour le traitement de troubles neurologiques
JP6293127B2 (ja) 2012-05-22 2018-03-14 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミテッド 未分化細胞の選択的阻害剤
WO2014003153A1 (fr) 2012-06-28 2014-01-03 協和発酵キリン株式会社 Composé amide substitué
WO2014031928A2 (fr) 2012-08-24 2014-02-27 Philip Jones Modulateurs hétérocycliques de l'activité du facteur hif utilisés pour le traitement de maladies
WO2014057435A1 (fr) 2012-10-10 2014-04-17 Actelion Pharmaceuticals Ltd Antagonistes des récepteurs de l'orexine, qui sont des dérivés [ortho bi (hetero )aryl]-[2-(meta bi (hetero )aryl)-pyrrolidin-1-yl]-methanone
WO2014065860A1 (fr) 2012-10-24 2014-05-01 The General Hospital Corporation Composés 1,2,4,5-tétrazines fonctionnalisés destinés à être utilisés dans des réactions de couplage bioorthogonaux
KR20150091071A (ko) 2012-12-03 2015-08-07 에프. 호프만-라 로슈 아게 Scd1의 억제제로서의 치환된 이속사졸 아민 화합물
BR112015007312A2 (pt) 2012-12-03 2017-08-08 Hoffmann La Roche composto, composição farmacêutica, utilização de um composto, método para o tratamento de câncer e invenção
JP2016028016A (ja) 2012-12-12 2016-02-25 大日本住友製薬株式会社 オキサジアゾール誘導体とその医薬用途
US9416102B2 (en) 2013-01-23 2016-08-16 Wisconsin Alumni Research Foundation (22E)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 analogs
TWI594975B (zh) 2013-04-24 2017-08-11 第一三共股份有限公司 二羧酸化合物
KR101524650B1 (ko) 2013-07-30 2015-06-03 경상대학교산학협력단 테트라하이드로이소퀴놀린 알칼로이드계 화합물 ｙｓ－５１ｓ를 포함하는 대사성 질환의 예방 및 치료용 조성물
KR20150015305A (ko) 2013-07-31 2015-02-10 안동대학교 산학협력단 주박 추출물을 유효성분으로 함유하는 비만의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품
WO2015048547A2 (fr) 2013-09-26 2015-04-02 Rigel Pharmaceuticals, Inc. Procédé d'utilisation de composés activant l'ampk et biomarqueurs de l'ampk
WO2015054658A1 (fr) 2013-10-11 2015-04-16 Sutro Biopharma, Inc. Acides aminés modifiés comprenant des groupes fonctionnels de tétrazine, procédés de préparation et procédés d'utilisation associés
CN104163794A (zh) 2013-10-17 2014-11-26 中国药科大学 2-氨基芳环类血管内皮生长因子受体(vegfr)抑制剂及其制备方法和用途
CN105916848B (zh) 2013-12-31 2018-01-09 山东轩竹医药科技有限公司 激酶抑制剂及其用途
WO2015113920A1 (fr) 2014-01-29 2015-08-06 Bayer Pharma Aktiengesellschaft Isothiazoles amino-substitués
GB201403969D0 (en) 2014-03-06 2014-04-23 Isis Innovation Compounds for use in controlling body fat
JPWO2015137385A1 (ja) 2014-03-12 2017-04-06 武田薬品工業株式会社 ピリダジン化合物
US10562869B2 (en) 2014-03-17 2020-02-18 Remynd Nv Oxadiazole compounds
WO2016022626A1 (fr) 2014-08-06 2016-02-11 Merck Sharp & Dohme Corp. Antagonistes hétérocycliques des récepteurs cgrp
WO2016022955A1 (fr) 2014-08-07 2016-02-11 Mayo Foundation For Medical Education And Research Composés et méthodes de traitement du cancer
KR101715449B1 (ko) 2014-08-13 2017-03-30 주식회사 큐리언트 염증성 질환 치료용 화합물
EP3191578B1 (fr) 2014-09-12 2020-11-04 Whitehead Institute for Biomedical Research Cellules exprimant l'apolipoprotéine e et leurs utilisations
SG11201702398UA (en) 2014-09-25 2017-04-27 Univ Notre Dame Du Lac Non-beta lactam antibiotics
EP3034500A1 (fr) 2014-12-17 2016-06-22 Genkyotex Sa Dérivés d'amido-thiazole en tant qu'inhibiteurs d'oxydase NADPH
CN105753814A (zh) 2015-01-01 2016-07-13 成都贝斯凯瑞生物科技有限公司 取代氮杂环衍生物及其应用
US20160223559A1 (en) 2015-02-02 2016-08-04 The Regents Of The University Of California Tetrazine-containing compounds and synthetic methods thereof
US10350192B2 (en) 2015-02-09 2019-07-16 National University Corporation Okayama University Lactate dehydrogenase inhibitor and antiepileptic drug containing the same
CN106146391A (zh) 2015-04-15 2016-11-23 中国科学院上海药物研究所 5-芳香炔基取代的苯甲酰胺类化合物及其制备方法、药物组合物和用途
CA3001857A1 (fr) 2015-10-14 2017-04-20 Aquinnah Pharmaceuticals, Inc. Composes, compositions et methodes d'utilisation contre des granules de stress
US20200262799A1 (en) 2015-11-30 2020-08-20 Universite De Bourgogne Process for preparing functionalized 1,2,4,5-tetrazine compounds
EP3394056B1 (fr) 2015-12-22 2021-04-14 Shy Therapeutics LLC Composés pour le traitement du cancer et de maladies inflammatoires
KR20190015748A (ko) 2016-06-08 2019-02-14 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 Atf4 경로 억제제로서의 화학적 화합물
US20190185567A1 (en) 2016-08-01 2019-06-20 Ignyta, Inc. Combinations for the treatment of cancer
MA46589A (fr) 2016-10-24 2019-08-28 Yumanity Therapeutics Inc Composés et utilisations de ces derniers
US11135207B2 (en) 2016-12-13 2021-10-05 Centaurus Therapeutics Inhibitors of dihydroceramide desaturase for treating disease
EP3566055B1 (fr) 2017-01-06 2025-03-12 Janssen Pharmaceutica NV Inhibiteurs de la scd pour le traitement de troubles neurologiques
ES3036483T3 (en) 2017-02-28 2025-09-19 Mayo Found Medical Education & Res Combinations for use in the treatment of cancer
WO2018161033A1 (fr) 2017-03-02 2018-09-07 Wright, Adrian Inhibiteurs ire1-alpha à petites molécules
EP3381908A1 (fr) 2017-03-27 2018-10-03 Leadiant Biosciences SA Dérivés de benzazole 2-(4-(4-(bromo-methoxybenzamido)benzylamino)phényl) et leur utilisation comme anti-héparanase
CN118021814A (zh) 2017-04-21 2024-05-14 Epizyme股份有限公司 用ehmt2抑制剂进行的组合疗法
WO2019018795A1 (fr) 2017-07-20 2019-01-24 Yumanity Therapeutics Composés et utilisations de ces composés
CA3083000A1 (fr) 2017-10-24 2019-05-02 Yumanity Therapeutics, Inc. Composes et utilisations de ces composes
WO2019123375A1 (fr) 2017-12-21 2019-06-27 Gliapharm Sa Compositions et méthodes de traitement de troubles neurologiques notamment des maladies de motoneurones
JP2021507945A (ja) 2017-12-21 2021-02-25 グリアファーム エスエー 認知症を含む神経障害のための組成物および治療方法
EP3737361A4 (fr) 2018-01-11 2021-08-25 Centaurus Therapeutics Inhibiteurs de la dihydrocéramide désaturase pour le traitement d'une maladie
WO2019173394A1 (fr) 2018-03-05 2019-09-12 Wylder Nation Foundation Compositions et procédés pour activer une signalisation à travers le récepteur cannabinoïde cb1 pour traiter et prévenir des maladies et des troubles caractérisés par une accumulation cellulaire anormale de sphingolipides tels que la sphingomyéline
ES3043183T3 (en) 2018-03-23 2025-11-25 Janssen Pharmaceutica Nv Compounds and uses thereof
US11243207B2 (en) 2018-03-29 2022-02-08 Mayo Foundation For Medical Education And Research Assessing and treating cancer
WO2019209948A1 (fr) 2018-04-25 2019-10-31 Yumanity Therapeutics, Inc. Composés et leurs utilisations
EP3784234A1 (fr) 2018-04-25 2021-03-03 Yumanity Therapeutics, Inc. Composés et leurs utilisations
BR112021001263A2 (pt) 2018-07-24 2021-04-27 Epizyme, Inc. compostos, seus usos, método para tratar câncer e método para modular uma atividade de smarca2
WO2020132378A2 (fr) 2018-12-22 2020-06-25 Gliapharm Sa Compositions et méthodes de traitement de troubles neurologiques comprenant la dépression
MX2021008903A (es) 2019-01-24 2021-11-04 Yumanity Therapeutics Inc Compuestos y usos de los mismos.
MA55385A (fr) 2019-03-22 2022-01-26 Yumanity Therapeutics Inc Composés et leurs utilisations
EP4054554A1 (fr) 2019-11-05 2022-09-14 Dermira, Inc Antagonistes de mrgprx2 pour le traitement de troubles inflammatoires
CA3159628A1 (fr) 2019-11-05 2021-05-14 Dermira, Inc. Antagonistes de mrgprx2 et leurs utilisations
EA202192047A1 (ru) 2019-11-13 2021-12-08 Юманити Терапьютикс, Инк. Соединения и их применение
TW202136238A (zh) 2020-01-06 2021-10-01 大陸商廣東東陽光藥業有限公司 RORγt抑制劑及其製備方法和用途
US11457994B2 (en) 2020-01-31 2022-10-04 American Sterilizer Company Surgical light head with beam spreading and adjustable power balancing

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US20250034124A1 (en) 2025-01-30
AU2020212034A1 (en) 2021-09-16
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CN113906019A (zh) 2022-01-07
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MX2024006768A (es) 2024-06-20
MX2024006769A (es) 2024-06-20
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BR112021014583A2 (pt) 2021-10-05
US20210139471A1 (en) 2021-05-13
IL285118A (en) 2021-09-30
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