MA55478A - Inhibiteurs bicycliques de hpk1 - Google Patents
Inhibiteurs bicycliques de hpk1Info
- Publication number
- MA55478A MA55478A MA055478A MA55478A MA55478A MA 55478 A MA55478 A MA 55478A MA 055478 A MA055478 A MA 055478A MA 55478 A MA55478 A MA 55478A MA 55478 A MA55478 A MA 55478A
- Authority
- MA
- Morocco
- Prior art keywords
- bicyclic
- hpk1 inhibitors
- hpk1
- inhibitors
- bicyclic hpk1
- Prior art date
Links
- 101001059991 Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 1 Proteins 0.000 title 1
- 102100028199 Mitogen-activated protein kinase kinase kinase kinase 1 Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962823712P | 2019-03-26 | 2019-03-26 | |
| EP19167828 | 2019-04-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA55478A true MA55478A (fr) | 2022-02-09 |
Family
ID=69845448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA055478A MA55478A (fr) | 2019-03-26 | 2020-03-24 | Inhibiteurs bicycliques de hpk1 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US12486264B2 (fr) |
| EP (1) | EP3947373B1 (fr) |
| AU (1) | AU2020249397C1 (fr) |
| CA (1) | CA3129772A1 (fr) |
| ES (1) | ES3031241T3 (fr) |
| MA (1) | MA55478A (fr) |
| TW (1) | TW202102500A (fr) |
| WO (1) | WO2020193512A1 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102658602B1 (ko) | 2018-10-31 | 2024-04-19 | 길리애드 사이언시즈, 인코포레이티드 | Hpk1 억제 활성을 갖는 치환된 6-아자벤즈이미다졸 화합물 |
| FI3873903T3 (fi) | 2018-10-31 | 2024-03-26 | Gilead Sciences Inc | Substituoituja 6-azabentsiimidatsoliyhdisteitä HPK1-inhibiittoreina |
| TWI826690B (zh) | 2019-05-23 | 2023-12-21 | 美商基利科學股份有限公司 | 經取代之烯吲哚酮化物及其用途 |
| WO2022184152A1 (fr) * | 2021-03-03 | 2022-09-09 | 劲方医药科技(上海)有限公司 | Composé hétérocyclique à six chaînons substitué par un cycle condensé, son procédé de préparation et son utilisation |
| AU2022272704A1 (en) * | 2021-05-11 | 2023-11-16 | Evopoint Biosciences Co., Ltd. | Nitrogen-containing heterocyclic compound |
| EP4373817B1 (fr) | 2021-07-20 | 2025-05-21 | Astrazeneca AB | Pyrazine-2-carboxamides substituées utilisées en tant qu'inhibiteurs de hpk1 pour le traitement du cancer |
| CN113861188B (zh) * | 2021-08-23 | 2023-02-28 | 杭州医学院 | 吡唑并[3,4-b]吡啶类衍生物及其制备方法和作为HPK1抑制剂的应用 |
| AU2022364646B2 (en) * | 2021-10-15 | 2025-10-09 | Lomond Therapeutics, Inc. | SUBSTITUTED 1H-PYRAZOLO [4,3-c] QUINOLINES, METHODS OF PREPARATION, AND USE THEREOF |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107206088A (zh) | 2014-12-05 | 2017-09-26 | 豪夫迈·罗氏有限公司 | 使用pd‑1轴拮抗剂和hpk1拮抗剂用于治疗癌症的方法和组合物 |
| JP6898868B2 (ja) | 2015-06-25 | 2021-07-07 | ユニバーシティー ヘルス ネットワーク | Ｈｐｋ１阻害剤およびそれを用いる方法 |
| TWI771319B (zh) * | 2016-09-09 | 2022-07-21 | 美商英塞特公司 | 吡唑并吡啶化合物及其用途 |
| US10280164B2 (en) | 2016-09-09 | 2019-05-07 | Incyte Corporation | Pyrazolopyridone compounds and uses thereof |
| WO2018049214A1 (fr) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Dérivés de pyrazolopyridine comme modulateurs de hpk1 et leurs utilisations pour le traitement du cancer |
| AR109595A1 (es) | 2016-09-09 | 2018-12-26 | Incyte Corp | Compuestos de pirazolopirimidina y usos de estos como inhibidores de hpk1 |
| WO2018081531A2 (fr) | 2016-10-28 | 2018-05-03 | Ariad Pharmaceuticals, Inc. | Méthodess d'activation de lymphocytes t humains |
| WO2018102366A1 (fr) | 2016-11-30 | 2018-06-07 | Ariad Pharmaceuticals, Inc. | Anilinopyrimidines en tant qu'inhibiteurs de kinase 1 progénitrices hématopoïétiques (hpk1) |
| CN110402248B (zh) | 2017-03-15 | 2023-01-06 | 豪夫迈·罗氏有限公司 | 作为hpk1抑制剂的氮杂吲哚类 |
| US10407424B2 (en) | 2017-03-30 | 2019-09-10 | Genentech, Inc. | Naphthyridines as inhibitors of HPK1 |
| MX2019010302A (es) | 2017-03-30 | 2019-11-21 | Hoffmann La Roche | Isoquinolinas como inhibidores de hpk1. |
| AU2018272986A1 (en) | 2017-05-26 | 2019-12-12 | Ichnos Sciences SA | Novel inhibitors of MAP4K1 |
| WO2018228923A1 (fr) | 2017-06-13 | 2018-12-20 | Bayer Pharma Aktiengesellschaft | Dérivés de pyrrolopyridine substitués utilisés en tant que modulateurs de map4k1 pour le traitement de maladies cancéreuses |
| CA3066859A1 (fr) | 2017-06-13 | 2018-12-20 | Bayer Pharma Aktiengesellschaft | Derives de pyrrolopyridine substitues |
| US20200246347A1 (en) | 2017-06-13 | 2020-08-06 | Bayer Pharma Aktiengesellschaft | Substituted Pyrrolopyridine-Derivatives |
| US10722495B2 (en) | 2017-09-08 | 2020-07-28 | Incyte Corporation | Cyanoindazole compounds and uses thereof |
-
2020
- 2020-03-24 TW TW109109736A patent/TW202102500A/zh unknown
- 2020-03-24 EP EP20711974.4A patent/EP3947373B1/fr active Active
- 2020-03-24 US US17/442,655 patent/US12486264B2/en active Active
- 2020-03-24 WO PCT/EP2020/058085 patent/WO2020193512A1/fr not_active Ceased
- 2020-03-24 MA MA055478A patent/MA55478A/fr unknown
- 2020-03-24 ES ES20711974T patent/ES3031241T3/es active Active
- 2020-03-24 AU AU2020249397A patent/AU2020249397C1/en not_active Expired - Fee Related
- 2020-03-24 CA CA3129772A patent/CA3129772A1/fr active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3947373C0 (fr) | 2025-05-14 |
| TW202102500A (zh) | 2021-01-16 |
| US12486264B2 (en) | 2025-12-02 |
| ES3031241T3 (en) | 2025-07-07 |
| AU2020249397A1 (en) | 2021-09-30 |
| US20220169644A1 (en) | 2022-06-02 |
| EP3947373A1 (fr) | 2022-02-09 |
| EP3947373B1 (fr) | 2025-05-14 |
| AU2020249397C1 (en) | 2025-08-07 |
| CA3129772A1 (fr) | 2020-10-01 |
| WO2020193512A1 (fr) | 2020-10-01 |
| AU2020249397B2 (en) | 2025-04-17 |
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