MA57399B1 - Inhibition de l'intégrine humaine alpha4beta7 - Google Patents

Inhibition de l'intégrine humaine alpha4beta7

Info

Publication number
MA57399B1
MA57399B1 MA57399A MA57399A MA57399B1 MA 57399 B1 MA57399 B1 MA 57399B1 MA 57399 A MA57399 A MA 57399A MA 57399 A MA57399 A MA 57399A MA 57399 B1 MA57399 B1 MA 57399B1
Authority
MA
Morocco
Prior art keywords
integrin
inhibition
human
diseases
treat
Prior art date
Application number
MA57399A
Other languages
English (en)
Inventor
Bruce N. Rogers
Robert Zahler
Fu-Yang Lin
Cheng Zhong
Eugene Hickey
Tyler DAY
Byungchan Kim
Matthew G. Bursavich
Dan CUI
James E. Dowling
Kristopher N. Hahn
Bryce A. Harrison
Blaise S. LIPPA
Dawn M. Troast
Kyle D. Konze
Aleksey I. Gerasyuto
Salma RAFI
Evelyne HOUANG
Original Assignee
Morphic Therapeutic, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphic Therapeutic, Inc. filed Critical Morphic Therapeutic, Inc.
Publication of MA57399B1 publication Critical patent/MA57399B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Radio Relay Systems (AREA)
  • Air Conditioning Control Device (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention concerne des petites molécules antagonistes de l'intégrine α4β7 et des procédés d'utilisation de celles-ci pour traiter un certain nombre de maladies et de pathologies.
MA57399A 2019-10-16 2020-10-16 Inhibition de l'intégrine humaine alpha4beta7 MA57399B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962916062P 2019-10-16 2019-10-16
PCT/US2020/055986 WO2021076890A1 (fr) 2019-10-16 2020-10-16 INHIBITION DE L'INTÉGRINE HUMAINE α4β7
EP20875989.4A EP4045039B1 (fr) 2019-10-16 2020-10-16 Inhibition de l'intégrine humaine alpha4beta7

Publications (1)

Publication Number Publication Date
MA57399B1 true MA57399B1 (fr) 2025-06-30

Family

ID=73198501

Family Applications (1)

Application Number Title Priority Date Filing Date
MA57399A MA57399B1 (fr) 2019-10-16 2020-10-16 Inhibition de l'intégrine humaine alpha4beta7

Country Status (37)

Country Link
US (3) US11104661B1 (fr)
EP (3) EP4045039B1 (fr)
JP (7) JP7437490B2 (fr)
KR (2) KR20220102669A (fr)
CN (3) CN119192137A (fr)
AR (1) AR120244A1 (fr)
AU (2) AU2020366435A1 (fr)
BR (1) BR112022007284A2 (fr)
CA (1) CA3154269A1 (fr)
CL (1) CL2022000959A1 (fr)
CO (1) CO2022005759A2 (fr)
CR (1) CR20220205A (fr)
CU (1) CU20220027A7 (fr)
DK (1) DK4045039T3 (fr)
DO (2) DOP2022000081A (fr)
EC (1) ECSP22038978A (fr)
ES (1) ES3035561T3 (fr)
FI (1) FI4045039T3 (fr)
HR (1) HRP20250749T1 (fr)
HU (1) HUE071814T2 (fr)
IL (2) IL319053A (fr)
LT (1) LT4045039T (fr)
MA (1) MA57399B1 (fr)
MD (1) MD4045039T2 (fr)
MX (1) MX2022004406A (fr)
PE (1) PE20221829A1 (fr)
PH (1) PH12022550886A1 (fr)
PL (1) PL4045039T3 (fr)
PT (1) PT4045039T (fr)
PY (1) PY2065718A (fr)
RS (1) RS66976B1 (fr)
SI (1) SI4045039T1 (fr)
TW (7) TWI775182B (fr)
UA (1) UA130059C2 (fr)
UY (1) UY38926A (fr)
WO (3) WO2021076902A1 (fr)
ZA (2) ZA202203872B (fr)

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EP3773573B1 (fr) 2018-04-12 2026-03-18 Morphic Therapeutic, Inc. Antagonistes de l'intégrine humaine (alpha4) (beta7)
FI3873884T3 (fi) 2018-10-30 2025-02-24 Gilead Sciences Inc 3-(kinolin-8-yyli)-1,4-dihydropyrido[3,4-d]pyrimidiini-2,4-dionijohdannaisia alfa-4-beta-7-integriinin estäjinä tulehdussairauksien hoidossa
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WO2021030438A1 (fr) 2019-08-14 2021-02-18 Gilead Sciences, Inc. Composés pour l'inhibition de l'intégrine alpha 4 bêta 7
TWI775182B (zh) 2019-10-16 2022-08-21 美商莫菲克醫療股份有限公司 抑制人類整合素αβ
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IL292296A (en) 2022-06-01
CL2022000959A1 (es) 2023-04-28
WO2021076890A4 (fr) 2021-06-10
FI4045039T3 (fi) 2025-06-20
JP7702004B2 (ja) 2025-07-02
US20240174632A1 (en) 2024-05-30
MX2022004406A (es) 2022-08-25
LT4045039T (lt) 2025-08-11
JP7437495B2 (ja) 2024-02-22
SI4045039T1 (sl) 2025-07-31
WO2022081983A1 (fr) 2022-04-21
JP2024116230A (ja) 2024-08-27
DK4045039T3 (da) 2025-06-30
EP4045039A1 (fr) 2022-08-24
DOP2022000081A (es) 2022-07-31
PY2065718A (es) 2023-01-17
BR112022007284A2 (pt) 2022-07-05
CN115087444B (zh) 2024-09-17
TWI840047B (zh) 2024-04-21
TW202500558A (zh) 2025-01-01
TWI775182B (zh) 2022-08-21
ES3035561T3 (en) 2025-09-04
JP2022548809A (ja) 2022-11-22
TWI802477B (zh) 2023-05-11
UA130059C2 (uk) 2025-10-29
EP4045039B1 (fr) 2025-04-23
TW202126624A (zh) 2021-07-16
JP2023500437A (ja) 2023-01-06
IL319053A (en) 2025-04-01
IL292296B1 (en) 2025-03-01
TW202244040A (zh) 2022-11-16
JP7717202B2 (ja) 2025-08-01
EP4045039A4 (fr) 2023-12-13
DOP2025000034A (es) 2025-04-08
TWI791304B (zh) 2023-02-01
CN116783161A (zh) 2023-09-19
KR20220102669A (ko) 2022-07-20
PH12022550886A1 (en) 2023-05-03
WO2021076902A1 (fr) 2021-04-22
ZA202303992B (en) 2024-06-26
CN119192137A (zh) 2024-12-27
JP2024054296A (ja) 2024-04-16
EP4228634A4 (fr) 2024-12-18
JP7500785B2 (ja) 2024-06-17
HUE071814T2 (hu) 2025-09-28
TW202500559A (zh) 2025-01-01
EP4559525A3 (fr) 2025-08-20
TWI888065B (zh) 2025-06-21
JP7209116B2 (ja) 2023-01-19
US11104661B1 (en) 2021-08-31
HRP20250749T1 (hr) 2025-08-15
CU20220027A7 (es) 2022-12-12
ECSP22038978A (es) 2022-06-30
AR120244A1 (es) 2022-02-09
TW202332675A (zh) 2023-08-16
ZA202203872B (en) 2024-01-31
JP7437490B2 (ja) 2024-02-22
CN115087444A (zh) 2022-09-20
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