MA63501B1 - Dérivés d'urée pouvant être utilisés pour traiter le cancer - Google Patents

Dérivés d'urée pouvant être utilisés pour traiter le cancer

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Publication number
MA63501B1
MA63501B1 MA63501A MA63501A MA63501B1 MA 63501 B1 MA63501 B1 MA 63501B1 MA 63501 A MA63501 A MA 63501A MA 63501 A MA63501 A MA 63501A MA 63501 B1 MA63501 B1 MA 63501B1
Authority
MA
Morocco
Prior art keywords
cancer treatment
urea derivatives
disorder
disease
formula
Prior art date
Application number
MA63501A
Other languages
English (en)
Other versions
MA63501A1 (fr
Inventor
Maxwell David Cummings
JR. David St. Jean
Original Assignee
Scorpion Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scorpion Therapeutics, Inc. filed Critical Scorpion Therapeutics, Inc.
Publication of MA63501A1 publication Critical patent/MA63501A1/fr
Publication of MA63501B1 publication Critical patent/MA63501B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Compounds Of Iron (AREA)

Abstract

La présente divulgation concerne des composés de formule (I), de formule (II), et des sels pharmaceutiquement acceptables de ceux-ci, qui inhibent l'isoforme alpha de phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K). Ces entités chimiques sont utiles, par exemple, pour traiter une affection, une maladie ou un trouble dans lesquels une activation accrue (par exemple, excessive) de PI3Ka contribue à la pathologie et/ou aux symptômes et/ou à la progression de l'affection, de la maladie ou du trouble (par exemple, un cancer) chez un sujet (par exemple, un être humain). Cette divulgation concerne également des compositions contenant lesdites entités, ainsi que des procédés d'utilisation et de fabrication de celles-ci.
MA63501A 2021-06-14 2022-06-13 Dérivés d'urée pouvant être utilisés pour traiter le cancer MA63501B1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202163210370P 2021-06-14 2021-06-14
US202163228351P 2021-08-02 2021-08-02
US202163288909P 2021-12-13 2021-12-13
US202263316017P 2022-03-03 2022-03-03
US202263319236P 2022-03-11 2022-03-11
US202263348261P 2022-06-02 2022-06-02
PCT/US2022/033255 WO2022265993A1 (fr) 2021-06-14 2022-06-13 Dérivés d'urée pouvant être utilisés pour traiter le cancer

Publications (2)

Publication Number Publication Date
MA63501A1 MA63501A1 (fr) 2024-03-29
MA63501B1 true MA63501B1 (fr) 2024-07-31

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MA63501A MA63501B1 (fr) 2021-06-14 2022-06-13 Dérivés d'urée pouvant être utilisés pour traiter le cancer

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US (5) US20240300939A1 (fr)
EP (1) EP4334298B1 (fr)
JP (2) JP7728367B2 (fr)
KR (1) KR20240035395A (fr)
AU (1) AU2022292554A1 (fr)
CA (1) CA3220039A1 (fr)
CL (1) CL2023003691A1 (fr)
CO (1) CO2023017150A2 (fr)
CR (1) CR20230576A (fr)
DK (1) DK4334298T3 (fr)
DO (1) DOP2023000271A (fr)
EC (1) ECSP23093675A (fr)
FI (1) FI4334298T3 (fr)
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Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20230576A (es) 2021-06-14 2024-04-05 Scorpion Therapeutics Inc Derivados de la urea que pueden ser utilizados para tratar el cáncer
IL316619A (en) * 2022-05-10 2024-12-01 Relay Therapeutics Inc PI3Kα inhibitors and methods of using them
EP4598919A1 (fr) * 2022-10-07 2025-08-13 Scorpion Therapeutics, Inc. Méthodes de traitement du cancer
IL320537A (en) * 2022-10-31 2025-06-01 Scorpion Therapeutics Inc Combination therapy for treating cancer
WO2024097721A1 (fr) 2022-11-02 2024-05-10 Petra Pharma Corporation Ciblage de poches allostériques et orthostériques de phosphoinositide 3-kinase (pi3k) pour le traitement d'une maladie
WO2024199430A1 (fr) * 2023-03-31 2024-10-03 长春金赛药业有限责任公司 COMPOSÉ INHIBITEUR DE PI3Kα, COMPOSITION PHARMACEUTIQUE ET LEUR UTILISATION
WO2024222894A1 (fr) * 2023-04-27 2024-10-31 Laekna Pharmaceutical Ningbo Co., Ltd. Composés de benzofurane et leur utilisation en tant qu'inhibiteurs de pi3k alpha
KR20260005985A (ko) 2023-05-05 2026-01-12 일라이 릴리 앤드 캄파니 Er+ 유방암을 갖는 대상체에서 중추 신경계 (cns) 전이를 치료 및 예방하는 데 사용하기 위한 임루네스트란트 또는 그의 염
WO2025002179A1 (fr) * 2023-06-27 2025-01-02 Laekna Pharmaceutical Ningbo Co., Ltd. Dérivés de n-[1-(2-benzofuranyl)-méthyl]-urée hétérotricycliques utilisés en tant qu'inhibiteurs de pi3k alpha pour le traitement du cancer
AU2024323620A1 (en) 2023-08-15 2026-02-19 Scorpion Therapeutics, Inc. Crystalline forms of a pi3k inhibitor and uses of same
KR20260052982A (ko) 2023-08-15 2026-04-20 스코르피온 테라퓨틱스, 인코퍼레이티드 Pi3k 억제제의 제조 방법
CN120623163A (zh) * 2024-03-11 2025-09-12 长春金赛药业有限责任公司 PI3Kα抑制剂化合物、药物组合物及其应用
WO2025231327A1 (fr) * 2024-05-03 2025-11-06 Scorpion Therapeutics, Inc. Agents de dégradation de pi3k et leurs procédés d'utilisation
TW202547511A (zh) 2024-05-30 2025-12-16 大陸商來凱製藥（寧波）有限公司 雜芳基化合物及其用作ＰＩ３Ｋα抑制劑之用途
WO2025264581A1 (fr) * 2024-06-17 2025-12-26 Leapfrog Bio, Inc. Inhibiteurs de p110 pour le traitement du cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004108709A1 (fr) * 2003-06-05 2004-12-16 Warner-Lambert Company Llc Benzofurancarboxamides de tetrazole actifs par rapport aux p13k, utiles comme agents therapeutiques

Family Cites Families (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820834A (en) 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
US4735941A (en) 1986-12-23 1988-04-05 Merck & Co., Inc. 1,4-benzodiazepines with 5- and 6-membered heterocyclic rings, useful as gastrointestinal and CNS agents
EP0304223A3 (fr) 1987-08-17 1990-10-24 Merck & Co. Inc. Bêta-carbolines comme antagonists de la cholecy-stokinine et de la gastrine
US5166151A (en) 1988-03-25 1992-11-24 Merck & Co., Inc. 2-Benzazepines with 5- and 6-membered heterocyclic rings, compositions and medical methods of use thereof
US5032604A (en) 1989-12-08 1991-07-16 Merck & Co., Inc. Class III antiarrhythmic agents
CA2032427A1 (fr) 1989-12-18 1991-06-19 Mark G. Bock Analogues de benzodiazepines
CA2032226A1 (fr) 1989-12-18 1991-06-19 Mark G. Bock Analogues de la benzodiazepine
US5324726A (en) 1989-12-18 1994-06-28 Merck & Co., Inc. Benzodiazepine analogs
US5041453A (en) 1990-05-30 1991-08-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4
US5095031A (en) 1990-08-20 1992-03-10 Abbott Laboratories Indole derivatives which inhibit leukotriene biosynthesis
CA2056809A1 (fr) 1990-12-07 1992-06-08 Mark G. Bock Analogues de la benzodiazepine
US5185331A (en) 1991-05-14 1993-02-09 Merck & Co., Inc. Triazolobenzodiazepines
CA2068500A1 (fr) 1991-05-14 1992-11-15 Roger M. Freidinger 1,4-benzodiazepines comportant des heterocycles a 5 et 6 chainons
US5206237A (en) 1991-05-14 1993-04-27 Merck & Co., Inc. Benzodiazepine analogs
US5210082A (en) 1991-05-16 1993-05-11 Merck & Co., Inc. 2-benzazepines with 5- and 6-membered heterocyclic rings to treat pain and anxiety disorders
CA2071092A1 (fr) 1991-06-14 1992-12-15 Roger M. Freidinger 1,4-benzodiazepines avec heterocycles a 5 chainons
EP0523845A3 (en) 1991-06-14 1993-11-18 Merck & Co Inc New benzodiazepine analogs
US5177071A (en) 1991-06-17 1993-01-05 Merck & Co., Inc. 1,4-benzodiazepines with 6-membered heterocyclic rings to treat panic and anxiety disorder
MY110227A (en) 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
GB9117852D0 (en) 1991-08-19 1991-10-09 Merck Sharp & Dohme Therapeutic agents
US6323212B1 (en) 1992-01-23 2001-11-27 Toray Industries, Inc. Morphinan derivative and its pharmaceutical applications
EP0642498A1 (fr) 1992-05-28 1995-03-15 Pfizer Inc. NOUVEAU DERIVES $i(N)-ARYLE ET DE $i(N)-HETEROARYLUREE EN TANT QU'INHIBITEURS DE L'ACYLCOENZIME A: CHOLESTEROL ACYLTRANSFERASE (ACAT)
WO1994008962A1 (fr) 1992-10-14 1994-04-28 Merck & Co., Inc. Antagonistes des recepteurs du fibrinogene
EP0663401B1 (fr) 1993-07-23 2000-06-07 Toray Industries, Inc. Derive de morphinane et application medicale
AU674613B2 (en) 1993-09-28 1997-01-02 Otsuka Pharmaceutical Co., Ltd. Quinoxaline derivative as antidiabetic agent
GB9408577D0 (en) 1994-04-29 1994-06-22 Fujisawa Pharmaceutical Co New compound
FR2725985B1 (fr) 1994-10-21 1996-11-15 Adir Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2734814B1 (fr) 1995-05-31 1997-07-04 Adir Nouveaux composes alkoxy-aryles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JPH11513684A (ja) 1995-10-19 1999-11-24 メルク エンド カンパニー インコーポレーテッド １６−置換−６−アザ−ステロイド５α−レダクターゼ阻害剤
US5821261A (en) 1995-12-08 1998-10-13 Merck & Co., Inc. Substituted saturated aza heterocycles as inhibitors of nitric oxide synthase
ATE359076T1 (de) 1996-11-25 2007-05-15 Toray Industries Mittel gegen juckreiz
WO1998049150A1 (fr) 1997-04-25 1998-11-05 Takeda Chemical Industries, Ltd. Derives de triazine, production de ces produits et composition agrochimique
US6372755B2 (en) 1997-07-11 2002-04-16 Toray Industries, Inc. Stable medicinal compositions containing 4,5-epoxymorphinan derivatives
WO1999005146A1 (fr) 1997-07-25 1999-02-04 Toray Industries, Inc. Remedes contre l'hyponatremie
JP4359711B2 (ja) 1997-09-02 2009-11-04 東レ株式会社 薬物依存症治療薬
FR2778662B1 (fr) 1998-05-12 2000-06-16 Adir Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO1999059586A1 (fr) 1998-05-19 1999-11-25 Regents Of The University Of California Derives de thiazolidine et d'oxazolidine pour le traitement d'infarctus du myocarde aigus et pour l'inhibition de l'apoptose des cardiomyocytes
JP2000053572A (ja) 1998-08-11 2000-02-22 Toray Ind Inc ＯＲＬ１（ｏｐｉｏｉｄ ｏｒｐｈａｎ）受容体拮抗薬
JP2003524598A (ja) 1998-09-04 2003-08-19 アルタナ ファルマ アクチエンゲゼルシャフト 新規ピラノセン
ES2211172T3 (es) 1998-09-25 2004-07-01 Astrazeneca Ab Derivados de benzamida y su utilizacion como inhibidores de citoquinas.
ATE302005T1 (de) 1998-12-18 2005-09-15 Bristol Myers Squibb Pharma Co N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren
CA2348740A1 (fr) 1998-12-23 2000-07-06 Ruth R. Wexler Inhibiteurs de la thrombine ou du facteur xa
IL145922A0 (en) 1999-04-28 2002-07-25 Aventis Pharma Gmbh Di-aryl acid derivatives as ppar receptor ligands
DE60039444D1 (de) 1999-08-24 2008-08-21 Toray Industries Heilmittel für neuropathischen schmerz und versuchstier-modelle des neuropathischen schmerzes
JP2001163784A (ja) 1999-12-06 2001-06-19 Toray Ind Inc 角膜または結膜用止痒剤
WO2001051456A2 (fr) 2000-01-13 2001-07-19 Tularik Inc. Agents antibacteriens
AU2001273040A1 (en) 2000-06-27 2002-01-08 Du Pont Pharmaceuticals Company Factor xa inhibitors
US6545152B1 (en) 2000-07-18 2003-04-08 Parker Hughes Institute R-isomers of nonnucleoside inhibitors
CA2442423C (fr) 2001-03-30 2009-11-03 Toray Industries, Inc. Medicament therapeutique contre la psychonevrose
EP1402899A4 (fr) 2001-05-08 2009-03-11 Toray Industries Remedes contre la sepsie
SE0101978D0 (sv) 2001-06-01 2001-06-01 Astrazeneca Ab New compounds
MY130373A (en) 2001-10-29 2007-06-29 Malesci Sas Linear basic compounds having nk-2 antagonist activity and formulations thereof
US7718663B2 (en) 2002-04-26 2010-05-18 Nippon Shinyaku Co., Ltd. Quinazoline derivatives and medicaments
EP1578429A4 (fr) 2002-05-22 2006-12-06 Smithkline Beecham Corp Inhibiteurs de proteases
CL2003001415A1 (es) 2002-07-12 2005-01-07 Janssen Pharmaceutica Nv Compuestos d derivados de naftil, quinolinil e isoquinolinil urea; composicion farmaceutica; y uso en el tratamiento y prevencion de condiciones de dolor y en el sibndrome del colon irritable y condiciones asociadas.
AU2003261756A1 (en) 2002-08-28 2004-03-29 Toray Industries, Inc. Acrylamide derivatives
JP2004083511A (ja) 2002-08-28 2004-03-18 Yamanouchi Pharmaceut Co Ltd アクリルアミド誘導体
WO2005004810A2 (fr) 2003-07-02 2005-01-20 Merck & Co., Inc. Derives arylsulfonamide
GB0324498D0 (en) 2003-07-21 2003-11-26 Aventis Pharma Inc Heterocyclic compounds as P2X7 ion channel blockers
CA2536253A1 (fr) 2003-08-20 2005-03-03 Vertex Pharmaceuticals Incorporated Composes d'aminofurazan utiles comme inhibiteurs de proteine-kinases
CA2542220A1 (fr) 2003-10-22 2005-05-06 Eli Lilly And Company Nouveaux antagonistes des recepteurs de l'hormone mch
KR20060115396A (ko) 2003-10-28 2006-11-08 버텍스 파마슈티칼스 인코포레이티드 이온 채널 조절인자로서 유용한 벤즈이미다졸
WO2005051938A1 (fr) 2003-11-20 2005-06-09 Eli Lilly And Company Modulateurs de recepteur de la vitamine d
UA89035C2 (ru) 2003-12-03 2009-12-25 Лео Фарма А/С Эфиры гидроксамовых кислот и их фармацевтическое применение
TW200600494A (en) 2004-03-08 2006-01-01 Chugai Pharmaceutical Co Ltd Bisphenyl compounds useful as vitamin d3 receptor agonists
JP2007535551A (ja) 2004-04-28 2007-12-06 バーテックス　ファーマシューティカルズ　インコーポレイテッド Ｒｏｃｋおよび他のプロテインキナーゼの阻害剤として有用な組成物
MX2007011234A (es) 2005-03-14 2007-11-12 Transtech Pharma Inc Derivados de benzazol, composiciones y metodos de uso en la forma de inhibidores de b-secretasa.
EP1704860B1 (fr) 2005-03-24 2010-10-27 Rottapharm S.P.A. Des dérivés de la benzamidine pour le traitement et la prophylaxie de la mucositis
WO2006133459A1 (fr) 2005-06-09 2006-12-14 Vertex Pharmaceuticals Incorporated Derives d'indane comme modulateurs de canaux ioniques
WO2007026720A1 (fr) 2005-08-31 2007-03-08 Taisho Pharmaceutical Co., Ltd. Derive de pyrazole a noyau condense
US7897766B2 (en) 2005-09-23 2011-03-01 Abbott Laboratories Amino-aza-adamantane derivatives and methods of use
ES2383090T3 (es) 2005-10-12 2012-06-18 Vertex Pharmaceuticals, Inc. Derivados de bifenilo como moduladores de los canales iónicos dependientes de voltaje
NZ593074A (en) 2005-12-21 2012-04-27 Vertex Pharma sulfonamide-pyrrolidone derivatives as Modulators of Ion Channels
US7790707B2 (en) 2006-03-21 2010-09-07 Epix Pharmaceuticals Inc. S1P receptor modulating compounds and use thereof
TW200815351A (en) 2006-05-02 2008-04-01 Astrazeneca Ab Novel compounds
EP2051964A4 (fr) 2006-07-28 2012-03-07 Univ Connecticut Inhibiteurs d'amide d'acide gras hydrolase
JP2010502618A (ja) 2006-08-31 2010-01-28 アリーナ ファーマシューティカルズ， インコーポレイテッド セロトニン５−ｈｔ２ａ受容体のモジュレータとしてのベンゾフラン誘導体
PE20080888A1 (es) 2006-10-18 2008-08-26 Novartis Ag COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE LA ACIL-TRANSFERASA DE ACIL-CoA-DIACIL-GLICEROL 1 (DGAT1)
WO2008133297A1 (fr) 2007-04-24 2008-11-06 Toray Industries, Inc. Agent thérapeutique ou prophylactique de la dyskinésie
JP5099127B2 (ja) 2007-04-26 2012-12-12 東レ株式会社 ４，５−エポキシモルヒナン誘導体を含有する安定な固形製剤
WO2008156573A1 (fr) 2007-06-12 2008-12-24 Provid Pharmaceuticals, Inc. Inhibiteurs de kinases, leurs compositions et procédés d'utilisation
CA2934114A1 (fr) 2007-06-12 2008-12-18 Achaogen, Inc. Agents antibacteriens
MX2010003660A (es) 2007-10-05 2010-08-10 Toray Industries Agente para aliviar problemas de la piel que comprende un derivado de morfinano o una sal de adicion de acido, farmacologicamente aceptable del mismo como ingrediente activo.
CN101412692B (zh) 2007-10-18 2012-10-17 中国科学院上海药物研究所 1-(3-氨基丙基)哌啶-4-氨基酰胺类化合物、其药物组合物及其制备方法和用途
WO2009089508A1 (fr) 2008-01-11 2009-07-16 The Regents Of The University Of California Activateurs de procaspases effectrices 3, 6 et 7
WO2009112445A1 (fr) 2008-03-10 2009-09-17 Novartis Ag Procédé d’accroissement de phosphatidyl-choline des cellules par l’inhibition de la dgat1
AU2009233711B2 (en) 2008-04-09 2015-02-12 Infinity Pharmaceuticals, Inc Inhibitors of fatty acid amide hydrolase
CN102083794A (zh) 2008-05-05 2011-06-01 安姆根有限公司 作为γ分泌酶调节剂的脲化合物
CA2734500A1 (fr) 2008-08-27 2010-03-11 Calcimedica Inc. Composes qui modulent le calcium intracellulaire
CN101712679B (zh) 2008-10-08 2013-04-10 中国科学院上海药物研究所 一种酰胺类化合物、其药物组合物及其制备方法和用途
CN102196811B (zh) 2008-10-24 2014-03-19 东丽株式会社 含有4,5-环氧基吗啡烷衍生物的稳定片剂
JP5535931B2 (ja) 2008-10-27 2014-07-02 武田薬品工業株式会社 二環性化合物
GB0821913D0 (en) 2008-12-02 2009-01-07 Price & Co Antibacterial compounds
EP2774927A1 (fr) 2008-12-03 2014-09-10 Presidio Pharmaceuticals, Inc. Inhibiteurs du virus de l'hépatite C de type NS5A
WO2010088574A1 (fr) 2009-01-30 2010-08-05 Sirtris Pharmaceuticals, Inc. Azabenzimidazoles et analogues apparentés en tant que modulateurs de la sirtuine
MX2011010132A (es) 2009-03-27 2011-10-14 Presidio Pharmaceuticals Inc Inhibidores de anillo fusionado de hepatitis c.
EP2470533A4 (fr) 2009-08-24 2013-01-23 Ascepion Pharmaceuticals Inc Composés d'urée contenant un groupe hétéroaryle 5,6-bicyclique
KR101781663B1 (ko) 2010-01-13 2017-09-25 템페로 파마슈티칼즈, 인크. 히스톤 데아세틸라제 효소를 억제하기 위한 화합물 및 이를 제조하는 방법
MX362830B (es) 2010-01-29 2019-02-14 Toray Industries Agente terapeutico o profilactico para enfermedades del tracto biliar.
JP2013536806A (ja) 2010-09-01 2013-09-26 アスセピオン ファーマスーティカル、インコーポレイテッド キナーゼ阻害剤としての重水素化複素環式化合物
WO2012050918A2 (fr) 2010-09-29 2012-04-19 Presidio Pharmaceutical, Inc. Inhibiteurs de l'hépatite c tricyliques à cycles fusionnés
ES2586655T3 (es) 2011-01-31 2016-10-18 Toray Industries, Inc. (-)-17-(ciclopropilmetil)-3,14beta-dihidroxi-4,5alfa-epoxi-6beta-[N-metil-trans-3-(3-furil)acrilamido]morfinano para su utilización en el tratamiento o prevención de la caquexia por cáncer
WO2012107475A1 (fr) 2011-02-10 2012-08-16 Syngenta Participations Ag Dérivés de pyrazole microbiocides
WO2012129562A2 (fr) 2011-03-24 2012-09-27 The Scripps Research Institute Composés et procédés pour l'induction de la chondrogenèse
US9282738B2 (en) 2011-07-11 2016-03-15 Wisconsin Alumni Research Foundation Antimicrobial compositions and methods of use thereof
WO2013009810A1 (fr) 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc. Méthodes de traitement
WO2013009830A1 (fr) 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc. Méthodes de traitement
CN104136429A (zh) 2011-12-23 2014-11-05 诺华股份有限公司 用于抑制bcl2与结合配偶体相互作用的化合物
EP2803662B1 (fr) 2012-01-13 2017-03-01 Nippon Chemiphar Co., Ltd. Antagoniste des récepteurs p2x4
DE102012103405A1 (de) 2012-04-18 2013-10-24 Heinrich-Pette-Institut Desoxyhypusin-Synthase-Inhibitoren
US20140200215A1 (en) 2013-01-15 2014-07-17 Intermune, Inc. Lysophosphatidic acid receptor antagonists
AU2014369053B2 (en) 2013-12-20 2019-03-14 Institute For Drug Discovery, Llc Substituted amino triazoles, and methods using same
KR20150136294A (ko) 2014-05-27 2015-12-07 주식회사 레고켐 바이오사이언스 인자 ＸＩａ 억제 활성을 가지는 신규한 화합물
EP2993174A1 (fr) 2014-09-08 2016-03-09 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Dérivés de pyrazolopyridine et leur utilisation en thérapie
JP6217866B2 (ja) * 2014-10-24 2017-10-25 小野薬品工業株式会社 Ｋｃｎｑ２〜５チャネル活性化剤
WO2016172255A1 (fr) 2015-04-21 2016-10-27 Allgenesis Biotherapeutics, Inc. Composés et leur utilisation en tant qu'inhibiteurs de bace1
WO2017039318A1 (fr) 2015-09-01 2017-03-09 Kainos Medicine, Inc. Dérivés de benzimidazole pour des inhibiteurs de méthylation de l'adn
WO2017117447A1 (fr) 2015-12-31 2017-07-06 Karyopharm Therapeutics Inc. Composés multicycliques et leurs utilisations
EP3447045B9 (fr) * 2016-04-22 2021-07-21 ONO Pharmaceutical Co., Ltd. Dérivés 1-(1-hydroxy-2,3-dihydro-1h-indèn-5-yl)-urée et composés similaires en tant qu'activateurs des canaux kcnq 2-5 pour le traitement de la dysurie
EA201892460A1 (ru) 2016-05-04 2019-09-30 Би.Си.Ай. ФАРМА Производные аденина как ингибиторы протеинкиназ
WO2018165501A1 (fr) 2017-03-10 2018-09-13 Lycera Corporation INDOLYLE SULFONAMIDE ET COMPOSÉS APPARENTÉS DESTINÉS À ÊTRE UTILISÉS EN TANT QU'AGONISTES DE RORγ ET POUR LE TRAITEMENT DE MALADIES
EP3621962A4 (fr) 2017-05-10 2020-12-09 Forge Therapeutics, Inc. Composés antibactériens
WO2019111225A1 (fr) 2017-12-08 2019-06-13 Avaliv Therapeutics Composés et procédés destinés au traitement de la stéatohépatite non alcoolique
GB201809050D0 (en) 2018-06-01 2018-07-18 E Therapeutics Plc Modulators of tryptophan catabolism
US12226400B2 (en) 2018-07-31 2025-02-18 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Neuroprotective disruption of Kv2.1/syntaxin interaction by small molecules
CA3051422A1 (fr) 2018-08-09 2020-02-09 Kineta, Inc. Activateurs de la trajectoire du gene inductible par l`acide retinoique « rig-i » et procedes d`utilisation associes
EP3841221A4 (fr) 2018-08-23 2022-06-08 Memorial Sloan-Kettering Cancer Center Biomarqueurs pour déterminer la réactivité d'un cancer à des inhibiteurs de pi3k
JP7541483B2 (ja) 2018-09-03 2024-08-28 日本ケミファ株式会社 糖尿病性末梢神経障害のための医薬
CN111039942B (zh) 2018-10-12 2023-04-14 上海长森药业有限公司 含氮杂环类化合物，及其制备方法、药物组合物和应用
EP3953350A1 (fr) 2019-04-12 2022-02-16 The United States of America, as Represented by The Department of Health and Human Services Composés agonistes du récepteur d3; procédés de préparation; intermédiaires de ceux-ci; et leurs procédés d'utilisation
WO2020228649A1 (fr) 2019-05-10 2020-11-19 上海海雁医药科技有限公司 Dérivé de phénylpropénylpyridine substitué, son procédé de préparation et son utilisation médicale
CR20230576A (es) 2021-06-14 2024-04-05 Scorpion Therapeutics Inc Derivados de la urea que pueden ser utilizados para tratar el cáncer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004108709A1 (fr) * 2003-06-05 2004-12-16 Warner-Lambert Company Llc Benzofurancarboxamides de tetrazole actifs par rapport aux p13k, utiles comme agents therapeutiques

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US12084434B2 (en) 2024-09-10
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