MA29543B1 - Procedes pour traiter un cancer pharmacoresistant - Google Patents

Procedes pour traiter un cancer pharmacoresistant

Info

Publication number
MA29543B1
MA29543B1 MA30468A MA30468A MA29543B1 MA 29543 B1 MA29543 B1 MA 29543B1 MA 30468 A MA30468 A MA 30468A MA 30468 A MA30468 A MA 30468A MA 29543 B1 MA29543 B1 MA 29543B1
Authority
MA
Morocco
Prior art keywords
resistant cancer
methods
compound
treating drug
salt
Prior art date
Application number
MA30468A
Other languages
English (en)
Inventor
Glenn C Michelson
Vivien W Chan
Carla C Heise
Marion Wiesmann
Timothy D Dawes
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA29543B1 publication Critical patent/MA29543B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE UN PROCÉDÉ POUR TRAITER UN CANCER PHARMACORÉSISTANT, QUI CONSISTE À ADMINISTRER À UN PATIENT QUI LE NÉCESSITE UN COMPOSÉ DE FORMULE (I), UN TAUTOMÈRE DE CE COMPOSÉ, UN SEL DE CE COMPOSÉ, UN SEL DUDIT TAUTOMÈRE OU UN MÉLANGE DE CEUX-CI OU UNE COMPOSITION PHARMACEUTIQUE COMPRENANT LEDIT COMPOSÉ, LEDIT TAUTOMÈRE, LEDIT SEL DU COMPOSÉ, LEDIT SEL DU TAUTOMÈRE OU LEDIT MÉLANGE. LE PATIENT EST UN PATIENT ATTEINT D'UN CANCER PHARMACORÉSISTANT ET LE COMPOSÉ DE FORMULE (I) EST TEL QUE DÉFINI DANS LA DEMANDE.
MA30468A 2005-05-13 2007-12-10 Procedes pour traiter un cancer pharmacoresistant MA29543B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68072205P 2005-05-13 2005-05-13

Publications (1)

Publication Number Publication Date
MA29543B1 true MA29543B1 (fr) 2008-06-02

Family

ID=37431829

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30468A MA29543B1 (fr) 2005-05-13 2007-12-10 Procedes pour traiter un cancer pharmacoresistant

Country Status (22)

Country Link
US (1) US8299081B2 (fr)
EP (1) EP1885187B1 (fr)
JP (2) JP5344910B2 (fr)
KR (1) KR101319122B1 (fr)
CN (1) CN101222850B (fr)
AU (1) AU2006247803B2 (fr)
BR (1) BRPI0610360A2 (fr)
CA (1) CA2608171C (fr)
DK (1) DK1885187T3 (fr)
ES (1) ES2440799T3 (fr)
IL (1) IL187327A (fr)
MA (1) MA29543B1 (fr)
MX (1) MX2007014206A (fr)
NO (1) NO20076425L (fr)
NZ (1) NZ564144A (fr)
PL (1) PL1885187T3 (fr)
PT (1) PT1885187E (fr)
RU (1) RU2426539C2 (fr)
SI (1) SI1885187T1 (fr)
TN (1) TNSN07419A1 (fr)
WO (1) WO2006124413A2 (fr)
ZA (1) ZA200709620B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101423513B (zh) * 2007-10-29 2013-03-27 中国医学科学院药物研究所 胺基嘧啶衍生物、及其制法和药物组合物与用途
PL2149372T3 (pl) 2008-07-31 2015-03-31 Univ Ulm Zastosowanie opioidów z grupy metadonu w leczeniu opornych pacjentów onkologicznych
US9095592B2 (en) * 2008-11-07 2015-08-04 The Research Foundation For The State University Of New York Bruton's tyrosine kinase as anti-cancer drug target
WO2010088701A1 (fr) * 2009-02-02 2010-08-05 Asurion Corporation Procédé d'intégration d'application dans un carnet d'adresses électronique
TWI410418B (zh) 2009-04-29 2013-10-01 Ind Tech Res Inst 氮雜薁化合物、藥學組合物與抑制一細胞中蛋白質激酶之活性的方法
JP2013525292A (ja) * 2010-04-16 2013-06-20 ノバルティス アーゲー 有機化合物の組合せ
MX2013013437A (es) * 2011-05-19 2013-12-06 Novartis Ag 4-amino-5-fluoro-3- [6- (4-metil-piperazin-1-il) -1h-bencimidazol-2-il] -1h-quinolin-2-ona parea usarse en el tratamiento de un carcinoma adenoide quistico.
WO2013063003A1 (fr) 2011-10-28 2013-05-02 Novartis Ag Méthode de traitement des tumeurs stromales gastro-intestinales
KR20140117457A (ko) * 2012-01-31 2014-10-07 노파르티스 아게 Rtk 억제제와 항에스트로겐의 조합물 및 암의 치료를 위한 그의 용도
RU2015104537A (ru) * 2012-07-11 2016-08-27 Новартис Аг Способы лечения стромальных опухолей желудочно-кишечного тракта
WO2014058785A1 (fr) 2012-10-10 2014-04-17 Novartis Ag Polythérapie
RU2547999C1 (ru) * 2013-10-28 2015-04-10 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ лечения аденогенного местно-распространенного рака нижнеампулярного отдела прямой кишки
WO2016123054A2 (fr) * 2015-01-26 2016-08-04 The University Of North Carolina At Chapel Hill Combinaisons de médicaments à base de kinase et leurs procédés d'utilisation
ES3033182T3 (en) * 2016-09-20 2025-07-31 Dana Farber Cancer Inst Inc Compositions and methods for identification, assessment, prevention, and treatment of aml using usp10 biomarkers and modulators

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US580883A (en) * 1897-04-20 Logging-sled
US3663606A (en) 1966-06-21 1972-05-16 Mitsui Toatsu Chemicals Organic imino-compounds
DE2363459A1 (de) 1973-12-20 1975-06-26 Basf Ag Neue fluoreszierende chinolinverbindungen
US4659657A (en) 1982-12-24 1987-04-21 Bayer Aktiengesellschaft Chromogenic and fluorogenic esters for photometric or fluorimetric determination of phosphatases or sulphatases
DE3248043A1 (de) 1982-12-24 1984-06-28 Bayer Ag, 5090 Leverkusen Fluorogene phosphorsaeureester, verfahren zu deren herstellung sowie verfahren und mittel zum nachweis und zur fluorometrischen bestimmung von phosphaten
DE3634066A1 (de) 1986-10-07 1988-04-21 Boehringer Mannheim Gmbh Neue 5-alkylbenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel
US5073492A (en) 1987-01-09 1991-12-17 The Johns Hopkins University Synergistic composition for endothelial cell growth
JPH07121937B2 (ja) 1987-03-18 1995-12-25 大塚製薬株式会社 カルボスチリル誘導体
JPH0699497B2 (ja) 1987-04-16 1994-12-07 富士写真フイルム株式会社 光重合性組成物
GB8709448D0 (en) 1987-04-21 1987-05-28 Pfizer Ltd Heterobicyclic quinoline derivatives
JPH02229165A (ja) 1989-03-02 1990-09-11 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
DE3932953A1 (de) 1989-10-03 1991-04-11 Boehringer Mannheim Gmbh Neue 2-bicyclo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5151360A (en) 1990-12-31 1992-09-29 Biomembrane Institute Effect of n,n,n-trimethylsphingosine on protein kinase-c activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation
GB9107742D0 (en) 1991-04-11 1991-05-29 Rhone Poulenc Agriculture New compositions of matter
GB9108369D0 (en) 1991-04-18 1991-06-05 Rhone Poulenc Agriculture Compositions of matter
GB9108547D0 (en) 1991-04-22 1991-06-05 Fujisawa Pharmaceutical Co Quinoline derivatives
USRE37650E1 (en) 1991-05-10 2002-04-09 Aventis Pharmacetical Products, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5710158A (en) 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5480883A (en) 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
CA2102780C (fr) 1991-05-10 2007-01-09 Alfred P. Spada Composes de type bis-monoaryle, aryle bicyclique et (ou) heteroaryle inhibant l'activite de tyrosine kinase des recepteurs de l'egf et (ou) du pdgf
US5856115A (en) 1991-05-24 1999-01-05 Fred Hutchinson Cancer Research Center Assay for identification therapeutic agents
WO1993017715A1 (fr) 1992-03-05 1993-09-16 Board Of Regents, The University Of Texas System Agents diagnostiques et/ou therapeutiques cibles sur des cellules endotheliales neovasculaires
JP3142378B2 (ja) 1992-06-22 2001-03-07 ティーディーケイ株式会社 有機ｅｌ素子
HUT69922A (en) 1992-09-02 1995-09-28 Isis Pharmaceuticals Inc Oligonucleotide modification of cell adhesion
US5330992A (en) * 1992-10-23 1994-07-19 Sterling Winthrop Inc. 1-cyclopropyl-4-pyridyl-quinolinones
SE9203318D0 (sv) 1992-11-06 1992-11-06 Kabi Pharmacia Ab Novel 3,3-diphenylpropylamines, their use and preparation
US5981569A (en) 1992-11-13 1999-11-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Substituted phenylacrylonitrile compounds and compositions thereof for the treatment of disease
US5763441A (en) 1992-11-13 1998-06-09 Sugen, Inc. Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis
US5792771A (en) 1992-11-13 1998-08-11 Sugen, Inc. Quinazoline compounds and compositions thereof for the treatment of disease
JPH0743896A (ja) 1993-07-28 1995-02-14 Toyobo Co Ltd 光重合性組成物
US5498608A (en) 1994-01-07 1996-03-12 Salix Pharmaceuticals Use of 2-hydroxy-5-phenylazobenzoic acid derivatives as colon cancer chemopreventative and chemotherapeutic agents
WO1995018801A1 (fr) 1994-01-08 1995-07-13 Rhone-Poulenc Agriculture Ltd. Derives de quinoline-3-carboxylate benzimidazoyle, leurs intermediaires ainsi que leur utilisation en tant qu'herbicides
JPH0829973A (ja) 1994-07-11 1996-02-02 Toyobo Co Ltd 光重合性組成物
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
JP3441246B2 (ja) 1995-06-07 2003-08-25 富士写真フイルム株式会社 光重合性組成物
GB9514265D0 (en) 1995-07-13 1995-09-13 Wellcome Found Hetrocyclic compounds
JP2000501736A (ja) 1995-12-12 2000-02-15 メルク エンド カンパニー インコーポレーテッド ロサルタンの新用途
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
US6010711A (en) 1996-01-26 2000-01-04 University Of Rochester Methods, articles and compositions for the pharmacologic inhibition of bone resorption with phosphodiesterase inhibitors
DE19610723A1 (de) 1996-03-19 1997-09-25 Bayer Ag Elektrolumineszierende Anordnungen unter Verwendung von Blendsystemen
US5942385A (en) 1996-03-21 1999-08-24 Sugen, Inc. Method for molecular diagnosis of tumor angiogenesis and metastasis
JP4373497B2 (ja) 1996-06-19 2009-11-25 ローン−プーラン・ロレ・リミテツド 置換されたアザビシクロ化合物、ならびにｔｎｆおよびサイクリックａｍｐホスホジエステラーゼ産生の阻害剤としてのそれらの使用
US6111110A (en) 1996-10-30 2000-08-29 Eli Lilly And Company Synthesis of benzo[f]quinolinones
US6245760B1 (en) 1997-05-28 2001-06-12 Aventis Pharmaceuticals Products, Inc Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
GB9716557D0 (en) * 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
DE19756235A1 (de) * 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide
EP1086705A4 (fr) 1998-05-20 2002-02-06 Kyowa Hakko Kogyo Kk Inhibiteurs de l'activite du facteur de croissance endothelial vasculaire (vegf)
US6174912B1 (en) 1998-08-21 2001-01-16 Dupont Pharmaceuticals Company Nitrogen substituted imidazo[4,5-C]pyrazoles as corticotropin releasing hormone antagonists
DE19841985A1 (de) 1998-09-03 2000-03-09 Schering Ag Dialkylsulfonsäure- und Dialkylcarbonsäure-Derivate
US20030087854A1 (en) 2001-09-10 2003-05-08 Isis Pharmaceuticals Inc. Antisense modulation of fibroblast growth factor receptor 3 expression
JP4707240B2 (ja) 1999-05-05 2011-06-22 アベンティス・フアーマ・リミテッド 細胞接着調節剤としての尿素
KR100298572B1 (ko) 1999-08-19 2001-09-22 박찬구 카바아닐라이드로부터 4-니트로디페닐아민과 4-니트로소디페닐아민의 제조방법
JP2003512353A (ja) 1999-10-19 2003-04-02 メルク エンド カムパニー インコーポレーテッド チロシンキナーゼ阻害剤
KR100681724B1 (ko) 1999-10-19 2007-02-28 머크 앤드 캄파니 인코포레이티드 티로신 키나제 억제제 및 이를 포함하는 약제학적 조성물
US6420382B2 (en) 2000-02-25 2002-07-16 Merck & Co., Inc. Tyrosine kinase inhibitors
US6313138B1 (en) 2000-02-25 2001-11-06 Merck & Co., Inc. Tyrosine kinase inhibitors
RU2274442C2 (ru) 2000-03-07 2006-04-20 Раш-Презбитериан-Ст. Лук'С Медикал Сентер Композиции и способы улавливания и инактивации патогенных микроорганизмов и сперматозоидов
AU2001284413A1 (en) 2000-08-30 2002-03-13 Sankyo Company Limited Medicinal compositions for preventing or treating heart failure
EP1351946A2 (fr) 2000-09-01 2003-10-15 Icos Corporation Substances potentialisant un traitement anticancereux et methodes a cet effet
JP4341949B2 (ja) * 2000-09-01 2009-10-14 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド アザ複素環式誘導体およびその治療的使用
US20030028018A1 (en) 2000-09-11 2003-02-06 Chiron Coporation Quinolinone derivatives
JP4361727B2 (ja) 2000-09-11 2009-11-11 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド チロシンキナーゼインヒビターとしてのキノリノン誘導体
US7064215B2 (en) * 2001-07-03 2006-06-20 Chiron Corporation Indazole benzimidazole compounds
US6476068B1 (en) * 2001-12-06 2002-11-05 Pharmacia Italia, S.P.A. Platinum derivative pharmaceutical formulations
US20030159702A1 (en) 2002-01-21 2003-08-28 Lindell Katarina E.A. Formulation and use manufacture thereof
US7323479B2 (en) * 2002-05-17 2008-01-29 Celgene Corporation Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline
US20050256157A1 (en) 2002-08-23 2005-11-17 Chiron Corporation Combination therapy with CHK1 inhibitors
US7825132B2 (en) 2002-08-23 2010-11-02 Novartis Vaccines And Diagnostics, Inc. Inhibition of FGFR3 and treatment of multiple myeloma
CA2496164C (fr) 2002-08-23 2010-11-09 Chiron Corporation Quinolinones de benzimidazole et leurs utilisations
CA2501932C (fr) 2002-11-13 2014-03-11 Chiron Corporation Utilisation des quinolinones de benzimidazole pour le traitement du cancer
WO2004073631A2 (fr) * 2003-02-14 2004-09-02 Combinatorx, Incorporated Polytherapie pour le traitement de neoplasmes
US6774327B1 (en) 2003-09-24 2004-08-10 Agilent Technologies, Inc. Hermetic seals for electronic components
MXPA06004199A (es) * 2003-10-17 2006-06-28 Novo Nordisk As Terapia en combinacion.
TWI347940B (en) 2003-11-07 2011-09-01 Novartis Ag Methods for synthesizing quinolinone compounds
WO2005082340A2 (fr) * 2004-02-20 2005-09-09 Chiron Corporation Modulation de processus inflammatoires et metastatiques
US20060183750A1 (en) * 2005-01-27 2006-08-17 Chiron Corporation Treatment of metastasized tumors
US20060261307A1 (en) * 2005-05-18 2006-11-23 Black D J Water Activated Organic Scavenger
US20080025946A1 (en) 2006-07-13 2008-01-31 Sivakumar Pallavur V Interleukin 21 and tyrosine kinase inhibitor combination therapy
AU2007277144B2 (en) 2006-07-28 2012-01-19 Novartis Ag Use of melanoma inhibitory activity (MIA) protein as an early indicator for therapeutic response in melanoma

Also Published As

Publication number Publication date
NZ564144A (en) 2009-11-27
CN101222850A (zh) 2008-07-16
TNSN07419A1 (en) 2009-03-17
PT1885187E (pt) 2013-12-16
AU2006247803B2 (en) 2011-12-22
RU2007145932A (ru) 2009-06-20
HK1110477A1 (en) 2008-07-18
JP5344910B2 (ja) 2013-11-20
JP2008540543A (ja) 2008-11-20
KR20080033902A (ko) 2008-04-17
KR101319122B1 (ko) 2013-10-23
PL1885187T3 (pl) 2014-03-31
MX2007014206A (es) 2008-02-07
CN101222850B (zh) 2012-10-03
US20090215793A1 (en) 2009-08-27
RU2426539C2 (ru) 2011-08-20
WO2006124413A2 (fr) 2006-11-23
BRPI0610360A2 (pt) 2010-06-15
AU2006247803A1 (en) 2006-11-23
ES2440799T3 (es) 2014-01-30
EP1885187B1 (fr) 2013-09-25
WO2006124413A3 (fr) 2007-06-07
ZA200709620B (en) 2008-10-29
CA2608171C (fr) 2014-02-04
US8299081B2 (en) 2012-10-30
JP2013173787A (ja) 2013-09-05
SI1885187T1 (sl) 2013-12-31
IL187327A0 (en) 2008-04-13
CA2608171A1 (fr) 2006-11-23
EP1885187A4 (fr) 2009-05-13
NO20076425L (no) 2008-01-30
EP1885187A2 (fr) 2008-02-13
DK1885187T3 (da) 2013-12-09
IL187327A (en) 2015-05-31

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