MA70477B1 - Composés amido hétéroaromatiques utiles dans le traitement de maladies hépatiques - Google Patents

Composés amido hétéroaromatiques utiles dans le traitement de maladies hépatiques

Info

Publication number
MA70477B1
MA70477B1 MA70477A MA70477A MA70477B1 MA 70477 B1 MA70477 B1 MA 70477B1 MA 70477 A MA70477 A MA 70477A MA 70477 A MA70477 A MA 70477A MA 70477 B1 MA70477 B1 MA 70477B1
Authority
MA
Morocco
Prior art keywords
treatment
amido
hetero
liver diseases
compounds useful
Prior art date
Application number
MA70477A
Other languages
English (en)
Inventor
Daniel Tor Pettersen
Erik Lars MALMERBERG
Tord Bertil Inghardt
Jan Åke LINDBERG
Jens Peter BRANDT
Björn Erik Anton HOLM
Stéphanie Marcelle GUERET
Nidhal SELMI
Jon Paul JANET
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MA70477B1 publication Critical patent/MA70477B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention concerne des composés de formule (I) : et des sels pharmaceutiquement acceptables de ceux-ci, des procédés et des intermédiaires utilisés pour leur préparation, des compositions pharmaceutiques les contenant et leur utilisation dans le traitement de maladies telles que les maladies hépatiques.
MA70477A 2022-05-19 2023-05-18 Composés amido hétéroaromatiques utiles dans le traitement de maladies hépatiques MA70477B1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202263364976P 2022-05-19 2022-05-19
US202263367843P 2022-07-07 2022-07-07
US202263383982P 2022-11-16 2022-11-16
EP23727858.5A EP4514782B1 (fr) 2022-05-19 2023-05-18 Composés amido hétéroaromatiques utiles dans le traitement de maladies hépatiques
PCT/EP2023/063424 WO2023222850A1 (fr) 2022-05-19 2023-05-18 Composés amido hétéroaromatiques utiles dans le traitement de maladies hépatiques

Publications (1)

Publication Number Publication Date
MA70477B1 true MA70477B1 (fr) 2025-12-31

Family

ID=86646721

Family Applications (1)

Application Number Title Priority Date Filing Date
MA70477A MA70477B1 (fr) 2022-05-19 2023-05-18 Composés amido hétéroaromatiques utiles dans le traitement de maladies hépatiques

Country Status (28)

Country Link
US (3) US20230373983A1 (fr)
EP (2) EP4635494A3 (fr)
JP (2) JP7770594B2 (fr)
KR (1) KR102963549B1 (fr)
CN (1) CN119173506A (fr)
AU (1) AU2023274003B2 (fr)
CA (1) CA3256765A1 (fr)
CL (1) CL2024003495A1 (fr)
CO (1) CO2024017138A2 (fr)
CR (1) CR20240536A (fr)
DK (1) DK4514782T3 (fr)
DO (1) DOP2024000239A (fr)
ES (1) ES3057934T3 (fr)
FI (1) FI4514782T3 (fr)
HR (1) HRP20251564T1 (fr)
IL (1) IL316898A (fr)
LT (1) LT4514782T (fr)
MA (1) MA70477B1 (fr)
MX (1) MX2024014315A (fr)
PE (1) PE20250791A1 (fr)
PL (1) PL4514782T3 (fr)
PT (1) PT4514782T (fr)
RS (1) RS67515B1 (fr)
SI (1) SI4514782T1 (fr)
SM (1) SMT202500465T1 (fr)
TW (1) TWI919070B (fr)
UY (1) UY40282A (fr)
WO (1) WO2023222850A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025104697A1 (fr) 2023-11-16 2025-05-22 Astrazeneca Ab Inhibiteurs de la 17-bêta-hydroxystéroïde déshydrogénase 13 hétéroaromatiques
WO2025104564A1 (fr) * 2023-11-16 2025-05-22 Astrazeneca Ab Forme cristalline d'un composé amido hétéroaromatique
KR20260113258A (ko) * 2023-11-16 2026-07-21 아스트라제네카 아베 우라실 화합물

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1030415A (zh) 1987-02-20 1989-01-18 山之内制药株式会社 饱和的杂环碳酰胺衍生物和它的制备方法
JPH0696532B2 (ja) 1988-08-11 1994-11-30 山之内製薬株式会社 血小板活性化因子拮抗剤
CN1691944A (zh) 2002-08-09 2005-11-02 阿斯利康(瑞典)有限公司 作为代谢型谷氨酸受体－5调节剂的噁二唑
WO2004014881A2 (fr) 2002-08-09 2004-02-19 Astra Zeneca Ab Nouveaux composes
AU2003264018A1 (en) 2002-08-09 2004-02-25 Astrazeneca Ab Compounds having an activity at metabotropic glutamate receptors
WO2005077368A2 (fr) 2004-02-03 2005-08-25 Astrazeneca Ab Nouveau traitement du reflux gastro-oesophagien pathologique iii
WO2005077345A1 (fr) 2004-02-03 2005-08-25 Astrazeneca Ab Composes pour le traitement de la maladie du reflux gastro-oesophagien
WO2005077373A2 (fr) 2004-02-03 2005-08-25 Astrazeneca Ab Nouveau traitement du reflux gastro-oesophagien pathologique ii
US7585881B2 (en) 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
PE20060285A1 (es) 2004-03-30 2006-05-08 Aventis Pharma Inc Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp)
EA200901573A1 (ru) 2007-05-22 2010-04-30 Ачиллион Фармасьютикалз, Инк. Гетероарилзамещенные тиазолы
EP2002834A1 (fr) * 2007-06-13 2008-12-17 Bayer Schering Pharma Aktiengesellschaft Aryle/hétarylamides en tant que modulateurs du récepteur EP2
BRPI0907844B8 (pt) 2008-02-22 2021-05-25 Radius Health Inc compostos e método para modular um receptor de andrógeno, processos de preparação e composição farmacêutica dos mesmos e seus usos
WO2009126782A1 (fr) 2008-04-11 2009-10-15 High Point Pharmaceuticals, Llc Ligands du récepteur h<sb>3</sb> de l'histamine
US20090318429A1 (en) 2008-04-28 2009-12-24 Institute For Oneworld Health Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives
US20100144733A1 (en) 2008-04-28 2010-06-10 Institute For Oneworld Health Compounds, compositions and methods comprising heteroaromatic derivatives
EP2350067A2 (fr) 2008-10-16 2011-08-03 Schering Corporation Dérivés de pyrrolidine, de pipéridine et de pipérazine et leurs méthodes d'utilisation
EP2550266B1 (fr) 2010-03-24 2018-05-09 Amitech Therapeutics Solutions, Inc. Composés hétérocycliques utiles pour l'inhibition de la kinase
KR101559883B1 (ko) 2013-10-30 2015-10-13 동국대학교 산학협력단 2-아미노치환 옥사디아졸 유도체, 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물
WO2015090579A1 (fr) 2013-12-18 2015-06-25 Grünenthal GmbH Carboxamides à base de pyrazolyle servant d'inhibiteurs de canal crac
US20170290337A1 (en) 2014-09-24 2017-10-12 Syngenta Participations Ag Herbicidal Pyridino-/Pyrimidino-Thiazoles
JP2017538676A (ja) 2014-11-05 2017-12-28 ザ ユニバーシティ オブ カンザス ミトコンドリア透過性遷移孔（ｍｔＰＴＰ）の小分子阻害剤
WO2016172631A2 (fr) 2015-04-24 2016-10-27 President And Fellows Of Harvard College Inhibiteurs sélectifs de substrats d'enzyme dégradant l'insuline (ide) et utilisations associées
WO2017161028A1 (fr) 2016-03-16 2017-09-21 Kura Oncology, Inc. Inhibiteurs substitués de ménine-mll et méthodes d'utilisation
WO2018112077A1 (fr) 2016-12-13 2018-06-21 Centaurus Therapeutics Inhibiteurs de dihydrocéramide désaturase pour le traitement de maladies
KR102736865B1 (ko) 2017-06-21 2024-12-03 샤이 테라퓨틱스 엘엘씨 암, 염증성 질환, 신경발달질환 및 섬유증 질환의 치료를 위하여 Ras 수퍼패밀리와 상호작용하는 화합물
WO2019036562A1 (fr) * 2017-08-18 2019-02-21 Saint Louis University Agonistes inverses d'err
GB201801226D0 (en) 2018-01-25 2018-03-14 Redx Pharma Plc Modulators of Rho-associated protein kinase
CN112566636A (zh) 2018-04-25 2021-03-26 优曼尼蒂治疗公司 化合物及其用途
JP2021536458A (ja) 2018-09-04 2021-12-27 マジェンタ セラピューティクス インコーポレイテッドMagenta Therapeutics, Inc. アリール炭化水素レセプター・アンタゴニスト及び使用方法
EP3919489A4 (fr) 2019-01-31 2022-10-12 The National Institutes of Pharmaceutical R&D Co., Ltd Composés cycliques aromatiques ou cycliques hétéroaromatiques, procédé de préparation correspondant et utilisation médicale associée
MA56457A (fr) 2019-07-02 2022-05-11 Regeneron Pharma Modulateurs de hsd17b13 et leurs procédés d'utilisation
WO2021050555A1 (fr) 2019-09-10 2021-03-18 X-Chem, Inc. Compositions et leurs utilisations
WO2021138450A1 (fr) 2019-12-30 2021-07-08 Buto Corporation Nouveaux bloqueurs de shc à petites molécules pour le traitement d'une maladie hépatique et d'une maladie métabolique
WO2021211974A1 (fr) 2020-04-18 2021-10-21 Inipharm, Inc. Composés et utilisations de ceux-ci
CA3179059A1 (fr) * 2020-06-09 2021-12-16 Anima Biotech Inc. Inhibiteurs de traduction du collagene 1 et leurs procedes d'utilisation
JP2023537271A (ja) 2020-07-24 2023-08-31 イニファーム，インク． チオフェンｈｓｄ１７ｂ１３阻害剤とその使用
CN116194440A (zh) 2020-07-24 2023-05-30 伊尼制药公司 喹唑啉酮hsd17b13抑制剂及其用途
WO2022040324A1 (fr) 2020-08-18 2022-02-24 Metrea Biosciences, Inc. COMPOSÉS ET PROCÉDÉS DE MODULATION DE LA 17β-ΗYDROXYSTÉROÏDE DÉSHYDROGÉNASE DE TYPE 13
EP4221701A1 (fr) 2020-09-30 2023-08-09 FL2022-001, Inc. Inhibiteurs de hsd17b13 et leurs utilisations
MX2023003677A (es) 2020-09-30 2023-06-22 Fl2022 001 Inc Inhibidores de hidroxiesteroide 17beta- deshidrogenasa 13 (hsd17b13) y usos de estos.
US20240083861A1 (en) 2020-09-30 2024-03-14 Fl2022-001, Inc. Hsd17b13 inhibitors and uses thereof
CN116670118B (zh) 2020-11-13 2026-02-06 伊尼制药公司 二氯苯酚hsd17b13抑制剂及其用途
WO2022149617A1 (fr) 2021-01-06 2022-07-14 中外製薬株式会社 Banque de composés
TWI884348B (zh) 2021-01-06 2025-05-21 日商中外製藥股份有限公司 酸性官能基的烷基化方法
US12617772B2 (en) 2021-04-05 2026-05-05 Inipharm, Inc. Hydroxypyridine HSD17B13 inhibitors and uses thereof
EP4319872A4 (fr) 2021-04-05 2025-03-12 Inipharm, Inc. Inhibiteurs d'hsd17b13 de type thiazole/isothiazole et leurs utilisations
WO2022226349A1 (fr) 2021-04-22 2022-10-27 Essa Pharma, Inc. Modulateurs du récepteur des androgènes et leurs procédés d'utilisation
KR20240016327A (ko) 2021-06-01 2024-02-06 신젠타 크롭 프로텍션 아게 살미생물 테트라하이드로이소퀴놀린 유도체
EP4469451A4 (fr) 2022-01-26 2025-12-24 Inipharm Inc Inhibiteurs thiazoles 2-substitués de hsd17b13 et utilisations associées

Also Published As

Publication number Publication date
TWI919070B (zh) 2026-03-21
CN119173506A (zh) 2024-12-20
JP7770594B2 (ja) 2025-11-14
CL2024003495A1 (es) 2025-04-04
MX2024014315A (es) 2024-12-06
HRP20251564T1 (hr) 2026-01-30
JP2025516080A (ja) 2025-05-26
SI4514782T1 (sl) 2026-02-27
EP4514782B1 (fr) 2025-09-10
AU2023274003A1 (en) 2025-01-02
AU2023274003B2 (en) 2026-01-29
IL316898A (en) 2025-01-01
KR102963549B1 (ko) 2026-05-14
DK4514782T3 (da) 2025-12-15
CR20240536A (es) 2025-01-29
PL4514782T3 (pl) 2026-02-23
LT4514782T (lt) 2025-12-29
RS67515B1 (sr) 2025-12-31
DOP2024000239A (es) 2024-12-30
FI4514782T3 (fi) 2025-12-10
SMT202500465T1 (it) 2026-01-12
US20230373983A1 (en) 2023-11-23
WO2023222850A1 (fr) 2023-11-23
UY40282A (es) 2023-11-15
PE20250791A1 (es) 2025-03-14
US20250011311A1 (en) 2025-01-09
EP4635494A2 (fr) 2025-10-22
TW202411224A (zh) 2024-03-16
ES3057934T3 (en) 2026-03-05
JP2026021479A (ja) 2026-02-10
US12291524B2 (en) 2025-05-06
KR20250016177A (ko) 2025-02-03
US20260159508A1 (en) 2026-06-11
PT4514782T (pt) 2025-12-15
EP4514782A1 (fr) 2025-03-05
CO2024017138A2 (es) 2025-03-06
CA3256765A1 (fr) 2023-11-23
EP4635494A3 (fr) 2025-12-31

Similar Documents

Publication Publication Date Title
MA67365B1 (fr) Dérivés de benzisoxazole sulfonamide
MA28747B1 (fr) Dérivés de pyridine
MA29926B1 (fr) Derives de pyrazine
TN2009000138A1 (fr) Biaryl-ether-urees
MA58498B1 (fr) Agonistes hétérocycliques de glp-1
MA56883B1 (fr) Dérivés de 2-hydroxycycloalcane-1-carbamoyle
MA59968B1 (fr) Composés de cyclobutyle dihydroquinoléine sulfonamide
MA31419B1 (fr) Derives de pyridine
MA54608B1 (fr) Inhibiteurs aza-hétérobicycliques de mat2a et procédés d&#39;utilisation pour le traitement du cancer
MA27774A1 (fr) Inhibiteurs de phosphatidylinositol 3-kinase
MA54653B1 (fr) Modulateurs du récepteur de cxcr7 pipéridine
MA30403B1 (fr) Derives d&#39;acides cycloalkylamines et leurs compositions pharmaceutiques
TN2010000230A1 (fr) Agonistes nouveaux des recepteurs de glucocorticoides
MA27808A1 (fr) Derives de quinoleine utilises en tant qu&#39;inhibiteurs de la phosphodiesterase
MA27801A1 (fr) Nouveaux composes heterocycliques pour le traitement des affections inflammatoires et allergiques, leur procede de preparation et compositions pharmaceutiques les contenant
MA38138A1 (fr) Dérivés inédits de quinolone
MA37762A1 (fr) Composés n-aryltriazole utilisés comme antagonistes de lpar
MA31761B1 (fr) Nouveaux inhibiteurs de seh et leur utilisation
MA37764A1 (fr) Composés n-alkyltriazole utilisés comme antagonistes de lpar
MA27990A1 (fr) Derives de piperazine pour le traitement d&#39;infections par le vih
MA30232B1 (fr) Inhibiteurs de kinase bases sur l&#39;hydantoine
MA49956B1 (fr) Composés de pyrimidine utilisés en tant qu&#39;inhibiteurs de kinase jak
MA27095A1 (fr) Formes de sels de e-2 -methoxy-n-(3-(4-(3-methyl-pyridine-3-yloxy)-phenylamino)-quinazoline-6-yl)-allyl)-acetamide, leur preparation et leur utilisation contre le cancer
MA30696B1 (fr) Derives de l&#39;acide (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetique
MA33533B1 (fr) Compositions pharmaceutiques pour le traitement du cancer et d&#39;autres maladies ou troubles