MC1390A1 - Derives de pyrazolopyridazine,procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

Derives de pyrazolopyridazine,procede pour leur preparation et compositions pharmaceutiques les contenant

Info

Publication number: MC1390A1
Authority: MC; Monaco
Prior art keywords: group; formula; aryl; compound; lower alkyl
Prior art date: 1980-06-13

Application number

MC811520A

Other languages

English (en)

French (fr)

Inventor

Christopher J Moody

Cedric H Hassal

Geoffrey Lawton

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-06-13

Filing date

1981-06-12

Publication date

1982-04-27

1981-06-12 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1982-04-27 Publication of MC1390A1 publication Critical patent/MC1390A1/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

MC811520A 1980-06-13 1981-06-12 Derives de pyrazolopyridazine,procede pour leur preparation et compositions pharmaceutiques les contenant MC1390A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8019342		1980-06-13
GB8107621		1981-03-11

Publications (1)

Publication Number	Publication Date
MC1390A1 true MC1390A1 (fr)	1982-04-27

Family

ID=26275850

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MC811520A MC1390A1 (fr)	1980-06-13	1981-06-12	Derives de pyrazolopyridazine,procede pour leur preparation et compositions pharmaceutiques les contenant

Country Status (10)

Country	Link
US (2)	US4399136A (da)
EP (1)	EP0042100A1 (da)
AU (1)	AU7138281A (da)
DK (1)	DK249581A (da)
ES (1)	ES502994A0 (da)
FI (1)	FI811834A7 (da)
GR (1)	GR74580B (da)
MC (1)	MC1390A1 (da)
NO (1)	NO812007L (da)
PT (1)	PT73186B (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2128984B (en) *	1982-05-12	1985-05-22	Hoffmann La Roche	Diaza-bicyclic compounds
ZA833214B (en) *	1982-05-12	1983-12-28	Hoffmann La Roche	Bicyclic compounds
US4692438A (en) *	1984-08-24	1987-09-08	Hoffmann-La Roche Inc.	Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
ZW11586A1 (en) *	1985-07-01	1987-12-30	Hoffmann La Roche	Bicyclic compounds
US5430145A (en) *	1990-10-18	1995-07-04	Merrell Dow Pharmaceuticals Inc.	Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) *	1990-12-21	1994-05-03	Merrell Dow Pharmaceuticals Inc.	Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
BR9205752A (pt) *	1991-03-19	1994-11-08	Ciba Geigy Ag	Novos compostos herbicidamente, acaricidamente e inseticidamente ativos
ATE155143T1 (de) *	1991-09-27	1997-07-15	Merrell Pharma Inc	2-substituierte indan-2-mercaptoacetylamid- verbindungen mit enkephalinase und ace- hemmwirkung
US5457196A (en) *	1991-09-27	1995-10-10	Merrell Dow Pharmaceuticals Inc.	2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
US5455242A (en) *	1991-09-27	1995-10-03	Merrell Dow Pharmaceuticals Inc.	Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
DE69317764T2 (de) *	1992-02-14	1998-07-30	Merrell Pharmaceuticals Inc., Cincinnati, Ohio	Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung
ATE182892T1 (de) *	1992-05-15	1999-08-15	Merrell Pharma Inc	Mercaptoacetylamide von pyridazo(1,2-a>(1,2>- diazepin -derivaten als eukephalinase und ace- inhibitoren
US5420271A (en) *	1992-08-24	1995-05-30	Merrell Dow Pharmaceuticals, Inc.	2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
PT669936E (pt) *	1992-10-30	2001-04-30	Merrell Pharma Inc	Derivados de lactama biciclica de mercaptoacetilamida uteis como inibidores de encefalinase e de ace
GB9223739D0 (en) *	1992-11-12	1992-12-23	Univ London	Process for the preparation of (3r) and (3s) piperazic acid derivatives
JP3561753B2 (ja) *	1994-02-14	2004-09-02	メレルファーマスーティカルズインコーポレーテッド	エンケファリナーゼ及びａｃｅの阻害剤として有用な、新規な２−置換インダン−２−メルカプトアセチルアミドジスルフィド誘導体類
CA2183313C (en) *	1994-02-14	2001-01-02	Gary A. Flynn	Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
US5530013A (en) *	1994-02-14	1996-06-25	American Home Products Corporation	Venlafaxine in the inducement of cognition enhancement
PT750631E (pt) *	1994-02-14	2000-07-31	Merrell Pharma Inc	Novos derivados de dissulfureto de mercapto-aacetilamido-1,3,4,5-tetra-hidro-benzo¬c)azepin-3-ona uteis como inibidores de encefalinase e ace
JP3596778B2 (ja) *	1994-02-14	2004-12-02	メレルファーマスーティカルズインコーポレーテッド	エンケファリナーゼ及びａｃｅの阻害剤として有用な、新規なメルカプトアセチルアミドジスルフィド誘導体類
US5484783A (en) *	1994-03-24	1996-01-16	Merrell Dow Pharmaceuticals Inc.	Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
ATE246927T1 (de) *	1994-03-24	2003-08-15	Merrell Pharma Inc	Cholesterin senkende mercaptoacetylamiddisulfidderivate
PT751783E (pt) *	1994-03-24	2000-05-31	Merrell Pharma Inc	Derivados aminoacetilmercapto hipocolesterolemicos antiateroscleroticos e hipotrigliceridemicos
US5552400A (en) *	1994-06-08	1996-09-03	Sterling Winthrop Inc.	Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors
TW448172B (en) *	1996-03-08	2001-08-01	Pharmacia & Upjohn Co Llc	Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation
US7253169B2 (en)	1999-11-12	2007-08-07	Gliamed, Inc.	Aza compounds, pharmaceutical compositions and methods of use
US6417189B1 (en)	1999-11-12	2002-07-09	Gpi Nil Holdings, Inc.	AZA compounds, pharmaceutical compositions and methods of use
GB0119305D0 (en)	2001-04-12	2001-10-03	Aventis Pharma Gmbh	Mercaptoacetylamide derivatives,a process for their preparation and their use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL60617A0 (en) *	1979-07-23	1980-09-16	Sparamedica Ag	Triazolopyridazine derivative,their preparation and pharmaceutical compositions containing them
EP0025941B1 (de) *	1979-09-19	1983-05-04	F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft	Pyridazopyridazinderivate, Verfahren zu deren Herstellung und Arzneimittel enthaltend solche Pyridazopyridazinderivate

1981
- 1981-06-03 EP EP81104239A patent/EP0042100A1/de not_active Withdrawn
- 1981-06-04 DK DK249581A patent/DK249581A/da not_active Application Discontinuation
- 1981-06-05 AU AU71382/81A patent/AU7138281A/en not_active Abandoned
- 1981-06-10 US US06/272,351 patent/US4399136A/en not_active Expired - Fee Related
- 1981-06-12 NO NO812007A patent/NO812007L/no unknown
- 1981-06-12 PT PT73186A patent/PT73186B/pt unknown
- 1981-06-12 GR GR65228A patent/GR74580B/el unknown
- 1981-06-12 FI FI811834A patent/FI811834A7/fi not_active Application Discontinuation
- 1981-06-12 MC MC811520A patent/MC1390A1/fr unknown
- 1981-06-12 ES ES502994A patent/ES502994A0/es active Granted
1983
- 1983-04-25 US US06/488,508 patent/US4487929A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US4399136A (en)	1983-08-16
DK249581A (da)	1981-12-14
NO812007L (no)	1981-12-14
ES8207533A1 (es)	1982-10-01
GR74580B (da)	1984-06-29
US4487929A (en)	1984-12-11
FI811834L (fi)	1981-12-14
EP0042100A1 (de)	1981-12-23
PT73186B (en)	1983-04-26
ES502994A0 (es)	1982-10-01
AU7138281A (en)	1981-12-17
PT73186A (en)	1981-07-01
FI811834A7 (fi)	1981-12-14

Legal Events

Date	Code	Title	Description
1983-06-11	YP	Annual fee paid

Publication	Publication Date	Title
US4399136A (en)	1983-08-16	Pyrazolopyridazine antihypertensives
US4355040A (en)	1982-10-19	Hypotensive imidazole-5-acetic acid derivatives
US4762924A (en)	1988-08-09	Bicyclic compounds
EP0202164B1 (fr)	1989-02-08	Dérivés de (benzoyl-4 pipéridino)-2 phenyl-1 alcanols, leur préparation et leur application en thérapeutique
MC1515A1 (fr)	1984-02-10	Composes bicycliques
EP0210084A1 (fr)	1987-01-28	Amides, procédés pour leur préparation et médicaments les contenant
SI9111318A (en)	1997-10-31	Acetamide derivatives
EP0421861A1 (fr)	1991-04-10	Dérivés d'hydroxy-2 thiophène et furanne condensés avec un cycle azoté, leur procédé de préparation et leur application en thérapeutique
EP0429341A2 (fr)	1991-05-29	Dérivés hétérocycliques, leur préparation et les médicaments les contenant
EP0379441A1 (fr)	1990-07-25	Nouveaux dérivés du benzopyranne, leur preparation et les compositions pharmaceutiques qui les contiennent
KR20010101730A (ko)	2001-11-14	매트릭스 금속단백질분해효소 억제제로서의2,3,4,5-테트라하이드로-1에이치-[1,4]벤조디아제핀-3-하이드록삼산
EP0433149A2 (fr)	1991-06-19	Antagonistes de la sérotonine, leur préparation et les médicaments les contenant
EP0350403A1 (fr)	1990-01-10	Dérivés de (aza)naphtalènesultame, leurs procédés de préparation et les médicaments les contenant
MC1879A1 (fr)	1989-01-24	Derives de la pyridazodiazepine
MC1334A1 (fr)	1981-04-21	Derives de triazolopyridazine
EP0374040B1 (fr)	1993-03-24	Dérivés de l'imino-2 Benzothiazoline, leurs procédés de préparation et les médicaments les contenant
EP0118321B1 (fr)	1986-12-17	Nouveaux composés hétérocycliques, leur préparation et les médicaments qui les contiennent
CH630623A5 (fr)	1982-06-30	Procede de preparation de derives de l'acide propionique.
MC1347A1 (fr)	1981-06-22	Derives de pyridazopyridazine
CH662354A5 (fr)	1987-09-30	Derives de l'hydantoine, procede pour leur preparation et medicament contenant ces derives.
US4576954A (en)	1986-03-18	Anti-rheumatic 5-(substituted amino)-1,2-dithiol-3-one compounds and their use
MC1962A1 (fr)	1989-06-30	Derives du benzimidazole
MC2136A1 (fr)	1992-01-14	Compose heterocycliques
EP0530058A1 (fr)	1993-03-03	Dérivés de 1,2,4-thiadiazino(3,4-b)benzothiazole, leur préparation et médicaments les contenant
MC1755A1 (fr)	1987-04-24	Composes bicycliques