MEP10509A - Process for preparing n-alkyl naltrexone halides - Google Patents

Process for preparing n-alkyl naltrexone halides

Info

Publication number: MEP10509A
Authority: ME; Montenegro
Prior art keywords: carbonate; halides; preparing; reacting; reaction medium
Prior art date: 2006-09-21

Application number

MEP-105/09A

Other languages

Bosnian (bs)

English (en)

Inventor

Alain Dlubala

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-09-21

Filing date

2007-09-19

Publication date

2011-12-20

2007-09-19 Application filed filed Critical

2011-12-20 Publication of ME00613B publication Critical patent/ME00613B/me

2011-12-20 Publication of MEP10509A publication Critical patent/MEP10509A/xx

Links

238000004519 manufacturing process Methods 0.000 title 1
229960003086 naltrexone Drugs 0.000 title 1
IFGIYSGOEZJNBE-KNLJMPJLSA-N (4r,4as,7ar,12bs)-3-(cyclopropylmethyl)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-3-ium-7-one;bromide Chemical compound [Br-].C[N+]1([C@@H]2CC=3C4=C(C(=CC=3)O)O[C@@H]3[C@]4([C@@]2(O)CCC3=O)CC1)CC1CC1 IFGIYSGOEZJNBE-KNLJMPJLSA-N 0.000 abstract 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
239000012431 aqueous reaction media Substances 0.000 abstract 2
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 abstract 1
229910000024 caesium carbonate Inorganic materials 0.000 abstract 1
229910000019 calcium carbonate Inorganic materials 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
BDAGIHXWWSANSR-NJFSPNSNSA-N hydroxyformaldehyde Chemical compound O[14CH]=O BDAGIHXWWSANSR-NJFSPNSNSA-N 0.000 abstract 1
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 abstract 1
239000001095 magnesium carbonate Substances 0.000 abstract 1
229910000021 magnesium carbonate Inorganic materials 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 abstract 1
JVLBPIPGETUEET-GAAHOAFPSA-O methylnaltrexone Chemical compound C[N+]1([C@@H]2CC=3C4=C(C(=CC=3)O)O[C@@H]3[C@]4([C@@]2(O)CCC3=O)CC1)CC1CC1 JVLBPIPGETUEET-GAAHOAFPSA-O 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
229910000018 strontium carbonate Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

MEP-105/09A 2006-09-21 2007-09-19 Process for preparing n-alkyl naltrexone halides MEP10509A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0608286A FR2906252B1 (fr)	2006-09-21	2006-09-21	Procede de preparation d'halogenures de n-aklyl naltrexone
PCT/FR2007/001516 WO2008034973A1 (fr)	2006-09-21	2007-09-19	Procede de preparation d'halogenures de n-alkyl naltrexone

Publications (2)

Publication Number	Publication Date
ME00613B ME00613B (me)	2011-12-20
MEP10509A true MEP10509A (en)	2011-12-20

Family

ID=38016779

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-105/09A MEP10509A (en)	2006-09-21	2007-09-19	Process for preparing n-alkyl naltrexone halides

Country Status (35)

Country	Link
US (2)	US7645880B2 (pt)
EP (1)	EP2069362B1 (pt)
JP (1)	JP5214615B2 (pt)
KR (1)	KR101434693B1 (pt)
CN (2)	CN102225939A (pt)
AR (1)	AR062918A1 (pt)
AU (1)	AU2007298855B2 (pt)
BR (1)	BRPI0718440A2 (pt)
CA (1)	CA2663509C (pt)
CL (1)	CL2007002711A1 (pt)
CO (1)	CO6170362A2 (pt)
CR (1)	CR10660A (pt)
DO (1)	DOP2011000307A (pt)
EA (1)	EA015426B1 (pt)
ES (1)	ES2531093T3 (pt)
FR (1)	FR2906252B1 (pt)
GT (1)	GT200900060A (pt)
HN (1)	HN2009000503A (pt)
IL (1)	IL197402A (pt)
JO (1)	JO3023B1 (pt)
MA (1)	MA30793B1 (pt)
ME (1)	MEP10509A (pt)
MX (1)	MX2009003084A (pt)
MY (1)	MY148094A (pt)
NI (1)	NI200900035A (pt)
NO (1)	NO20091561L (pt)
NZ (1)	NZ575417A (pt)
PE (1)	PE20080867A1 (pt)
SV (1)	SV2009003192A (pt)
TN (1)	TN2009000080A1 (pt)
TW (1)	TWI465451B (pt)
UA (1)	UA96957C2 (pt)
UY (1)	UY30599A1 (pt)
WO (1)	WO2008034973A1 (pt)
ZA (1)	ZA200901846B (pt)

Families Citing this family (24)

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Publication number	Priority date	Publication date	Assignee	Title
MX2009010550A (es)	2007-03-29	2009-12-14	Progenics Pharm Inc	Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas.
WO2008138383A1 (de) *	2007-05-16	2008-11-20	Cilag Ag	Verfahren zur herstellung von n-methylnaltrexonbromid
WO2009009292A2 (en) *	2007-07-11	2009-01-15	Mallinckrodt Inc.	Crystalline forms of naltrexone methobromide
EP2019105A1 (en) *	2007-07-19	2009-01-28	Siegfried Ltd.	Process for the preparation of quaternary n-alkyl morphine or morphinane alkaloid derivatives
CN102227433B (zh) *	2008-09-30	2015-01-07	马林克罗特有限公司	烷基化吗啡喃衍生物的仲胺基团的方法
CN102325777B (zh) *	2009-02-23	2015-08-12	马林克罗特公司	(+)-吗啡喃*n-氧化物及其制备方法
JP5784507B2 (ja) *	2009-02-23	2015-09-24	マリンクロッドエルエルシー	（＋）−モルフィナニウム第四級塩およびその生成方法
US8563724B2 (en) *	2009-02-23	2013-10-22	Mallinckrodt Llc	(+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8946419B2 (en)	2009-02-23	2015-02-03	Mallinckrodt Llc	(+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
AU2010239059B2 (en)	2009-04-24	2016-06-09	Brock University	Processes for the preparation of morphinane and morphinone compounds
US8829020B2 (en)	2009-07-16	2014-09-09	Mallinckrodt Llc	Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CN101845047B (zh) *	2009-12-31	2011-12-07	南京臣功制药有限公司	一种溴甲基纳曲酮的制备方法
JO3209B1 (ar) *	2010-11-05	2018-03-08	H Lundbeck As	طريقة لتصنيع نالتريكسون
US8580963B2 (en)	2010-11-05	2013-11-12	H. Lundbeck A/S	Method for the manufacturing of naltrexone
AU2011325563B2 (en)	2010-11-05	2015-08-20	H. Lundbeck A/S	Method for the manufacturing of naltrexone
US9029543B2 (en)	2011-04-05	2015-05-12	Alkermes, Inc.	Process for the synthesis of quaternary amine compounds
KR20140063763A (ko)	2011-09-08	2014-05-27	말린크로트 엘엘씨	중간체를 단리하지 않는 알칼로이드의 제조 방법
CN103172640A (zh) *	2011-12-22	2013-06-26	天津康鸿医药科技发展有限公司	一种(r)-n-溴甲基纳曲酮的制备方法以及纳曲酮衍生物
US20140155608A1 (en)	2012-05-03	2014-06-05	H. Lundbeck A/S	Method for the manufacturing of naltrexone
CN105985348B (zh) *	2015-02-12	2019-02-01	正大天晴药业集团股份有限公司	一种溴甲基纳曲酮的制备方法
CN106317064B (zh) *	2015-06-30	2018-06-19	北大方正集团有限公司	溴甲纳曲酮的制备方法
KR102201609B1 (ko) *	2019-04-19	2021-01-12	연성정밀화학(주)	날데메딘의 제조방법
CN111777617B (zh) *	2020-07-10	2025-06-06	华润三九医药股份有限公司	一种溴甲纳曲酮的精制方法
CA3194746A1 (en)	2020-10-06	2022-04-14	Tien-Li Lee	Oral delayed burst formulation of low-dose naltrexone or naloxone used for\|treating fibromyalgia and long covid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4176186A (en) *	1978-07-28	1979-11-27	Boehringer Ingelheim Gmbh	Quaternary derivatives of noroxymorphone which relieve intestinal immobility
US7285665B2 (en) *	2002-11-08	2007-10-23	Mallinckrodt Inc.	Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
AR057325A1 (es) *	2005-05-25	2007-11-28	Progenics Pharm Inc	Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos

2006
- 2006-09-21 FR FR0608286A patent/FR2906252B1/fr not_active Expired - Fee Related
2007
- 2007-09-19 NZ NZ575417A patent/NZ575417A/en not_active IP Right Cessation
- 2007-09-19 EA EA200970307A patent/EA015426B1/ru not_active IP Right Cessation
- 2007-09-19 CN CN2011101080743A patent/CN102225939A/zh active Pending
- 2007-09-19 AU AU2007298855A patent/AU2007298855B2/en not_active Ceased
- 2007-09-19 EP EP07848250.2A patent/EP2069362B1/fr active Active
- 2007-09-19 ES ES07848250T patent/ES2531093T3/es active Active
- 2007-09-19 CA CA2663509A patent/CA2663509C/fr not_active Expired - Fee Related
- 2007-09-19 KR KR1020097005731A patent/KR101434693B1/ko not_active Expired - Fee Related
- 2007-09-19 ZA ZA200901846A patent/ZA200901846B/xx unknown
- 2007-09-19 JP JP2009528751A patent/JP5214615B2/ja not_active Expired - Fee Related
- 2007-09-19 CN CN2007800350747A patent/CN101516892B/zh not_active Expired - Fee Related
- 2007-09-19 WO PCT/FR2007/001516 patent/WO2008034973A1/fr not_active Ceased
- 2007-09-19 UA UAA200903924A patent/UA96957C2/ru unknown
- 2007-09-19 BR BRPI0718440-9A2A patent/BRPI0718440A2/pt not_active IP Right Cessation
- 2007-09-19 MY MYPI20091158A patent/MY148094A/en unknown
- 2007-09-19 TW TW096134967A patent/TWI465451B/zh not_active IP Right Cessation
- 2007-09-19 MX MX2009003084A patent/MX2009003084A/es active IP Right Grant
- 2007-09-19 ME MEP-105/09A patent/MEP10509A/xx unknown
- 2007-09-20 PE PE2007001269A patent/PE20080867A1/es not_active Application Discontinuation
- 2007-09-20 JO JOP/2007/0399A patent/JO3023B1/ar active
- 2007-09-20 CL CL200702711A patent/CL2007002711A1/es unknown
- 2007-09-20 AR ARP070104157A patent/AR062918A1/es unknown
- 2007-09-20 UY UY30599A patent/UY30599A1/es not_active Application Discontinuation
2008
- 2008-03-17 US US12/049,607 patent/US7645880B2/en not_active Expired - Fee Related
2009
- 2009-03-04 IL IL197402A patent/IL197402A/en not_active IP Right Cessation
- 2009-03-10 TN TN2009000080A patent/TN2009000080A1/fr unknown
- 2009-03-11 CR CR10660A patent/CR10660A/es unknown
- 2009-03-12 GT GT200900060A patent/GT200900060A/es unknown
- 2009-03-18 HN HN2009000503A patent/HN2009000503A/es unknown
- 2009-03-19 SV SV2009003192A patent/SV2009003192A/es active IP Right Grant
- 2009-03-19 NI NI200900035A patent/NI200900035A/es unknown
- 2009-03-19 CO CO09028774A patent/CO6170362A2/es active IP Right Grant
- 2009-04-16 MA MA31789A patent/MA30793B1/fr unknown
- 2009-04-20 NO NO20091561A patent/NO20091561L/no not_active Application Discontinuation
- 2009-11-25 US US12/625,649 patent/US8288547B2/en not_active Expired - Fee Related
2011
- 2011-10-07 DO DO2011000307A patent/DOP2011000307A/es unknown

Also Published As

Publication number	Publication date
JP2010504308A (ja)	2010-02-12
FR2906252A1 (fr)	2008-03-28
MY148094A (en)	2013-02-28
WO2008034973A1 (fr)	2008-03-27
ZA200901846B (en)	2010-07-28
US20080214817A1 (en)	2008-09-04
IL197402A0 (en)	2009-12-24
EA015426B1 (ru)	2011-08-30
DOP2011000307A (es)	2011-10-31
US8288547B2 (en)	2012-10-16
CA2663509C (fr)	2014-03-18
UA96957C2 (ru)	2011-12-26
EP2069362B1 (fr)	2014-07-09
AU2007298855B2 (en)	2012-09-13
MA30793B1 (fr)	2009-10-01
CN101516892B (zh)	2012-06-20
US20100145051A1 (en)	2010-06-10
US7645880B2 (en)	2010-01-12
IL197402A (en)	2012-12-31
EA200970307A1 (ru)	2009-12-30
ES2531093T3 (es)	2015-03-10
BRPI0718440A2 (pt)	2013-11-19
ME00613B (me)	2011-12-20
CN101516892A (zh)	2009-08-26
PE20080867A1 (es)	2008-08-22
CL2007002711A1 (es)	2008-04-18
GT200900060A (es)	2011-01-04
NZ575417A (en)	2011-09-30
MX2009003084A (es)	2009-04-02
FR2906252B1 (fr)	2008-11-28
TW200821314A (en)	2008-05-16
KR101434693B1 (ko)	2014-08-27
JO3023B1 (ar)	2016-09-05
NI200900035A (es)	2010-01-26
KR20090057031A (ko)	2009-06-03
UY30599A1 (es)	2008-05-02
JP5214615B2 (ja)	2013-06-19
TN2009000080A1 (en)	2010-08-19
TWI465451B (zh)	2014-12-21
SV2009003192A (es)	2009-10-27
CO6170362A2 (es)	2010-06-18
NO20091561L (no)	2009-06-16
CA2663509A1 (fr)	2008-03-27
AR062918A1 (es)	2008-12-17
EP2069362A1 (fr)	2009-06-17
AU2007298855A1 (en)	2008-03-27
CN102225939A (zh)	2011-10-26
HK1135389A1 (en)	2010-06-04
HN2009000503A (es)	2011-03-02
CR10660A (es)	2009-06-24

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