MEP19008A - Imidazoquinoline derivatives as adenosine a3 receptor ligands - Google Patents

Imidazoquinoline derivatives as adenosine a3 receptor ligands

Info

Publication number: MEP19008A
Authority: ME; Montenegro
Prior art keywords: adenosine; receptor ligands; imidazoquinoline derivatives; imidazoquinoline; derivatives
Prior art date: 2002-11-15

Application number

MEP-190/08A

Other languages

Bosnian (bs)

English (en)

Croatian (hr)

Inventor

Peter Aranyi

Laszlo Balazs

Maria Balogh

Sandor Batori

Nagy Lajos T

Geza Timari

Kinga Boer

Zoltan Kapui

Endre Mikus

Katalin Gerber

Szeredi Judit Vargane

Katalin Urban-Szabo

Erzsebet Walcz

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-11-15

Filing date

2003-11-11

Publication date

2010-06-10

2003-11-11 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2010-06-10 Publication of MEP19008A publication Critical patent/MEP19008A/xx

Links

102000008161 Adenosine A3 Receptor Human genes 0.000 title abstract 2
108010060261 Adenosine A3 Receptor Proteins 0.000 title abstract 2
RHKWIGHJGOEUSM-UHFFFAOYSA-N 3h-imidazo[4,5-h]quinoline Chemical class C1=CN=C2C(N=CN3)=C3C=CC2=C1 RHKWIGHJGOEUSM-UHFFFAOYSA-N 0.000 title 1
239000003446 ligand Substances 0.000 title 1
239000005557 antagonist Substances 0.000 abstract 1
239000011230 binding agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P11/06—Antiasthmatics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Psychology (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Otolaryngology (AREA)

MEP-190/08A 2002-11-15 2003-11-11 Imidazoquinoline derivatives as adenosine a3 receptor ligands MEP19008A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
HU0203976A HUP0203976A3 (en)	2002-11-15	2002-11-15	Adenozine a3 receptors, process for their preparation and pharmaceutical compositions containing them
YUP-2005/0364A RS51320B (sr)	2002-11-15	2003-11-11	Derivati imidazohinolina kao veznici a3 receptora adenozina
PCT/HU2003/000095 WO2004046146A1 (fr)	2002-11-15	2003-11-11	Derives d'imidazoquinoline en tant que ligands recepteurs de l'adenosine a3

Publications (1)

Publication Number	Publication Date
MEP19008A true MEP19008A (en)	2010-06-10

Family

ID=90001561

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-190/08A MEP19008A (en)	2002-11-15	2003-11-11	Imidazoquinoline derivatives as adenosine a3 receptor ligands

Country Status (34)

Country	Link
US (2)	US7419977B2 (fr)
EP (1)	EP1560828B9 (fr)
JP (1)	JP4533148B2 (fr)
KR (1)	KR20050088291A (fr)
CN (1)	CN1332960C (fr)
AR (1)	AR041968A1 (fr)
AT (1)	ATE325123T1 (fr)
AU (1)	AU2003282263B2 (fr)
BR (1)	BR0316355A (fr)
CA (1)	CA2505910C (fr)
CO (1)	CO5690577A2 (fr)
CY (1)	CY1105180T1 (fr)
DE (1)	DE60305058T2 (fr)
DK (1)	DK1560828T3 (fr)
EA (1)	EA007595B1 (fr)
ES (1)	ES2263039T3 (fr)
HR (1)	HRP20050540A2 (fr)
HU (1)	HUP0203976A3 (fr)
IL (1)	IL168516A (fr)
IS (1)	IS2456B (fr)
MA (1)	MA27501A1 (fr)
ME (1)	MEP19008A (fr)
MX (1)	MXPA05005198A (fr)
NO (1)	NO20052866D0 (fr)
NZ (1)	NZ540029A (fr)
PL (1)	PL376837A1 (fr)
PT (1)	PT1560828E (fr)
RS (1)	RS51320B (fr)
SI (1)	SI1560828T1 (fr)
TN (1)	TNSN05133A1 (fr)
TW (1)	TWI248934B (fr)
UA (1)	UA78889C2 (fr)
WO (1)	WO2004046146A1 (fr)
ZA (1)	ZA200503807B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUP0105406A3 (en) *	2001-12-21	2003-12-29	Sanofi Aventis	Imidazo[1,2-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates
HUP0203976A3 (en) *	2002-11-15	2004-08-30	Sanofi Aventis	Adenozine a3 receptors, process for their preparation and pharmaceutical compositions containing them
HUP0400812A2 (en) *	2004-04-19	2006-02-28	Sanofi Aventis	Crystalline forms of 2-amino-3-cyano-quinoline derivatives, process for their preparation and pharmaceutical compositions containing them
GT200600381A (es)	2005-08-25	2007-03-28		Compuestos organicos
US20090088403A1 (en) *	2007-05-07	2009-04-02	Randy Blakely	A3 adenosine receptors as targets for the modulation of central serotonergic signaling
HUP0700395A2 (en) *	2007-06-07	2009-03-02	Sanofi Aventis	Substituted [1,2,4] triazolo [1,5-a] quinolines, process for their preparation, pharmaceutical compositions thereof, and intermediates
US9199102B2 (en)	2009-07-21	2015-12-01	Oradin Pharmaceutical Ltd.	A3 adenosine receptor ligands for modulation of pigmentation
BR122021012629B1 (pt)	2013-02-01	2022-06-07	Wellstat Therapeutics Corporation	Compostos de amina, composição compreendendo os referidos compostos e usos dos mesmos
KR101820909B1 (ko) *	2017-07-07	2018-01-23	퓨쳐메디신 주식회사	아데노신 유도체를 포함하는 만성신장질환 예방 및 치료용 약학적 조성물
WO2019055877A1 (fr)	2017-09-15	2019-03-21	Forma Therapeutics, Inc.	Compositions de tétrahydroimidazo quinoléine utilisées en tant qu'inhibiteurs de cbp/p300
IL279734B2 (en)	2018-06-29	2024-11-01	Forma Therapeutics Inc	Inhibiting creb binding protein (cbp)
EP3937936A4 (fr) *	2019-03-15	2022-12-28	Forma Therapeutics, Inc.	Inhibition de la protéine de liaison à un élément sensible à l'amp cyclique (creb)
TW202102494A (zh)	2019-03-15	2021-01-16	美商弗瑪治療公司	抑制環amp-反應元件-結合蛋白(creb)
US11801243B2 (en)	2020-09-23	2023-10-31	Forma Therapeutics, Inc.	Bromodomain inhibitors for androgen receptor-driven cancers
US11795168B2 (en)	2020-09-23	2023-10-24	Forma Therapeutics, Inc.	Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP)
BR112023011284A2 (pt)	2020-12-09	2024-02-06	Wellstat Therapeutics Corp	Composto de imidazoquinolina com atividade anti-inflamatória, antifúngica, antiparasítica e antineoplásica

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4075343A (en) *	1976-09-13	1978-02-21	Pfizer Inc.	Anti-allergenic 5-alkoxyimidazo[1,2-A]quinoline-2-carboxylic acids and derivatives thereof
GB1596652A (en) *	1977-01-20	1981-08-26	Roussel Lab Ltd	Imidazo (1,2-a) quinoline-2-carboxylic acid and derivatives
SE441449B (sv)	1979-02-09	1985-10-07	Roussel Uclaf	Heterocykliska derivat och farmaceutiska kompositioner innehallande dessa derivat
FR2448541A1 (fr)	1979-02-09	1980-09-05	Roussel Uclaf	Nouveaux derives de l'oxoimidazoquinoxaline et leurs sels, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
US4644002A (en)	1979-02-09	1987-02-17	Roussel Uclaf	Imidazo[2,1-C]quinolines, useful as antiallergic agents
CA2336967C (fr)	1998-07-10	2010-06-29	The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Antagonistes du recepteur de l'adenosine a3
US6448253B1 (en) *	1998-09-16	2002-09-10	King Pharmaceuticals Research And Development, Inc.	Adenosine A3 receptor modulators
JP4077198B2 (ja) *	1999-09-28	2008-04-16	株式会社大塚製薬工場	トリアゾロプリン誘導体、該誘導体を含有する医薬組成物およびアデノシンａ３受容体親和剤
US7160890B2 (en) *	1999-12-02	2007-01-09	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A3 receptor and uses thereof
BR0115847A (pt) *	2000-12-01	2004-02-25	Osi Pharm Inc	Compostos especìficos para receptor para adenosina a1, a2a, e a3 e usos dos mesmos
EP1390349B1 (fr)	2001-05-31	2012-07-25	Sanofi	Derives d'aminoquinoline et d'aminopyrridine et leur utilisation comme ligands d'adenosine a3
HUP0105407A3 (en) *	2001-12-21	2004-04-28	Sanofi Aventis	Triazolo[1,5-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates
HUP0105406A3 (en)	2001-12-21	2003-12-29	Sanofi Aventis	Imidazo[1,2-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates
HUP0203976A3 (en) *	2002-11-15	2004-08-30	Sanofi Aventis	Adenozine a3 receptors, process for their preparation and pharmaceutical compositions containing them

2002
- 2002-11-15 HU HU0203976A patent/HUP0203976A3/hu unknown
2003
- 2003-11-11 PT PT03773882T patent/PT1560828E/pt unknown
- 2003-11-11 DK DK03773882T patent/DK1560828T3/da active
- 2003-11-11 AU AU2003282263A patent/AU2003282263B2/en not_active Ceased
- 2003-11-11 SI SI200330299T patent/SI1560828T1/sl unknown
- 2003-11-11 EA EA200500830A patent/EA007595B1/ru unknown
- 2003-11-11 MX MXPA05005198A patent/MXPA05005198A/es active IP Right Grant
- 2003-11-11 RS YUP-2005/0364A patent/RS51320B/sr unknown
- 2003-11-11 BR BR0316355-5A patent/BR0316355A/pt not_active IP Right Cessation
- 2003-11-11 WO PCT/HU2003/000095 patent/WO2004046146A1/fr not_active Ceased
- 2003-11-11 KR KR1020057008683A patent/KR20050088291A/ko not_active Abandoned
- 2003-11-11 EP EP03773882A patent/EP1560828B9/fr not_active Expired - Lifetime
- 2003-11-11 HR HR20050540A patent/HRP20050540A2/xx not_active Application Discontinuation
- 2003-11-11 CA CA2505910A patent/CA2505910C/fr not_active Expired - Fee Related
- 2003-11-11 DE DE60305058T patent/DE60305058T2/de not_active Expired - Lifetime
- 2003-11-11 JP JP2004552920A patent/JP4533148B2/ja not_active Expired - Fee Related
- 2003-11-11 CN CNB2003801062293A patent/CN1332960C/zh not_active Expired - Fee Related
- 2003-11-11 PL PL376837A patent/PL376837A1/pl not_active Application Discontinuation
- 2003-11-11 AT AT03773882T patent/ATE325123T1/de active
- 2003-11-11 UA UAA200505875A patent/UA78889C2/uk unknown
- 2003-11-11 NZ NZ540029A patent/NZ540029A/en not_active IP Right Cessation
- 2003-11-11 ES ES03773882T patent/ES2263039T3/es not_active Expired - Lifetime
- 2003-11-11 ME MEP-190/08A patent/MEP19008A/xx unknown
- 2003-11-14 TW TW092131901A patent/TWI248934B/zh not_active IP Right Cessation
- 2003-11-14 AR ARP030104200A patent/AR041968A1/es unknown
2005
- 2005-05-10 TN TNP2005000133A patent/TNSN05133A1/en unknown
- 2005-05-10 IL IL168516A patent/IL168516A/en not_active IP Right Cessation
- 2005-05-11 ZA ZA200503807A patent/ZA200503807B/en unknown
- 2005-05-16 US US11/130,429 patent/US7419977B2/en not_active Expired - Fee Related
- 2005-05-31 IS IS7874A patent/IS2456B/is unknown
- 2005-06-13 NO NO20052866A patent/NO20052866D0/no not_active Application Discontinuation
- 2005-06-13 MA MA28334A patent/MA27501A1/fr unknown
- 2005-06-14 CO CO05057645A patent/CO5690577A2/es not_active Application Discontinuation
2006
- 2006-07-28 CY CY20061101054T patent/CY1105180T1/el unknown
2008
- 2008-06-17 US US12/140,512 patent/US7709489B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IS2456B (is)	2008-11-15
AU2003282263A1 (en)	2004-06-15
MXPA05005198A (es)	2005-08-18
CN1332960C (zh)	2007-08-22
PT1560828E (pt)	2006-08-31
IS7874A (is)	2005-05-31
NO20052866L (no)	2005-06-13
JP2006515572A (ja)	2006-06-01
IL168516A (en)	2011-05-31
CO5690577A2 (es)	2006-10-31
MA27501A1 (fr)	2005-08-01
ATE325123T1 (de)	2006-06-15
JP4533148B2 (ja)	2010-09-01
EA200500830A1 (ru)	2005-10-27
TNSN05133A1 (en)	2007-05-14
CY1105180T1 (el)	2010-03-03
ES2263039T3 (es)	2006-12-01
US7419977B2 (en)	2008-09-02
TW200413369A (en)	2004-08-01
EA007595B1 (ru)	2006-12-29
SI1560828T1 (sl)	2006-08-31
ZA200503807B (en)	2006-08-30
US20050234056A1 (en)	2005-10-20
HRP20050540A2 (en)	2005-08-31
US7709489B2 (en)	2010-05-04
RS51320B (sr)	2010-12-31
RS20050364A (sr)	2007-08-03
HUP0203976A3 (en)	2004-08-30
NZ540029A (en)	2007-01-26
DK1560828T3 (da)	2006-09-04
CN1726213A (zh)	2006-01-25
CA2505910A1 (fr)	2004-06-03
KR20050088291A (ko)	2005-09-05
TWI248934B (en)	2006-02-11
EP1560828B1 (fr)	2006-05-03
DE60305058D1 (de)	2006-06-08
WO2004046146A1 (fr)	2004-06-03
CA2505910C (fr)	2010-07-13
HU0203976D0 (en)	2003-01-28
PL376837A1 (pl)	2006-01-09
UA78889C2 (en)	2007-04-25
EP1560828A1 (fr)	2005-08-10
AU2003282263B2 (en)	2009-05-14
HUP0203976A2 (hu)	2004-07-28
NO20052866D0 (no)	2005-06-13
BR0316355A (pt)	2005-09-27
DE60305058T2 (de)	2006-12-14
US20080255110A1 (en)	2008-10-16
EP1560828B9 (fr)	2007-02-14
HK1077819A1 (en)	2006-02-24
AR041968A1 (es)	2005-06-01

Publication	Publication Date	Title
BR0016396A (pt)	2002-08-20	Novos antagonistas do receptor p2x7 para uso no tratamento de doenças inflamatórias, imunes ou cardiovasculares
HRP20080664A2 (hr)	2009-05-31	Supstituirani piridinski herbicidi
DK1337518T3 (da)	2009-10-19	Piperazinylpyrazinforbindelser som antagonister for serotonin-5-HT2-receptoren
UY28623A1 (es)	2005-06-30	Derivados de pirazol y usos de los mismos
MY144903A (en)	2011-11-30	Pyrrolopyridine derivatives and their use as crth2 antagonists
ATE450533T1 (de)	2009-12-15	Carboxamidderivate
TR200200795T2 (tr)	2002-07-22	5-HT1B antagonistleri olarak piperazin türevleri
MXPA06000921A (es)	2006-03-30	Derivados de benzamidazoles como inhibidores de mek.
PL1756086T3 (pl)	2008-11-28	Pirydyn-4-ylo-etynylo-imidazole i pirazole jako antagoniści receptora mGlu5
ATE346067T1 (de)	2006-12-15	Carbolinderivate
MXPA05005198A (es)	2005-08-18	Derivados de imidazoquinolina, como ligandos del receptor a3 de adenosina.
NZ552137A (en)	2009-08-28	New 4-benzylidene-piperidin derivatives
IS7507A (is)	2004-10-15	Ný efnasambönd
MXPA04006113A (es)	2005-06-08	Derivados de triazoloquinolina utiles como ligandos receptores de adenosina.
WO2004067703A3 (fr)	2004-11-04	Antagonistes 5ht7 et agonistes inverses
MXPA05010651A (es)	2005-12-12	Compuestos de pirazol.
MXPA05010650A (es)	2005-12-12	Pirazoles sustituidos.
ATE338043T1 (de)	2006-09-15	5-methoxy-8-aryl- 1,2,4ötriazolo 1,5-aöpyridine derivative als adenosin-rezeptor antagonisten
TNSN04105A1 (en)	2006-06-01	Imidazoquinoline derivatives
ATE246174T1 (de)	2003-08-15	Tosylprolin-derivate als thymidylat-synthase inhibitoren
CO5540291A2 (es)	2005-07-29	Benzamidoacetonitrilos y su uso como antiparasitarios
IL173629A0 (en)	2006-07-05	Imidazo(4,5-b) pyridine derivatives and pharmaceutical compositions containing the same
NO20060603L (no)	2006-02-07	Fremgangsmate for fremstillingen av fenyltetrazolderivater
NO20004075L (no)	2000-08-15	Substituerte pyrimidin-2-yloksy-karboksylsyrederivater, fremstilling av disse og deres anvendelse som endotelin- antagonister
IS8034A (is)	2005-09-16	Imídasó[4,5-B]kínólínafleiður og notkun þeirra sem NO-myndunarhemla