MEP48608A - Piperazine containing phosphonic acid compounds as inhibitors of serine proteases - Google Patents

Piperazine containing phosphonic acid compounds as inhibitors of serine proteases

Info

Publication number: MEP48608A
Authority: ME; Montenegro
Prior art keywords: phosphonic acid; acid compounds; inhibitors; serine proteases; containing phosphonic
Prior art date: 2003-04-16

Application number

MEP-486/08A

Other languages

Bosnian (bs)

English (en)

Inventor

Michael N Greco

Harold R Almond

Eugene Powell

Garavilla Lawrence De

Original Assignee

Ortho Mcneil Janssen Pharm

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-16

Filing date

2004-04-14

Publication date

2011-02-10

2004-04-14 Application filed by Ortho Mcneil Janssen Pharm filed Critical Ortho Mcneil Janssen Pharm

2011-02-10 Publication of MEP48608A publication Critical patent/MEP48608A/xx

Links

102000012479 Serine Proteases Human genes 0.000 title abstract 3
108010022999 Serine Proteases Proteins 0.000 title abstract 3
239000003112 inhibitor Substances 0.000 title abstract 2
150000003009 phosphonic acids Chemical class 0.000 title abstract 2
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 2
230000001404 mediated effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3882—Arylalkanephosphonic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

MEP-486/08A 2003-04-16 2004-04-14 Piperazine containing phosphonic acid compounds as inhibitors of serine proteases MEP48608A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10/414,782 US7459461B2 (en)	2001-10-19	2003-04-16	Phosphonic acid compounds as inhibitors of serine proteases
PCT/US2004/011490 WO2004094441A2 (en)	2003-04-16	2004-04-14	Piperazine containing phosphonic acid compounds as inhibitors of serine proteases

Publications (1)

Publication Number	Publication Date
MEP48608A true MEP48608A (en)	2011-02-10

Family

ID=33309497

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-486/08A MEP48608A (en)	2003-04-16	2004-04-14	Piperazine containing phosphonic acid compounds as inhibitors of serine proteases

Country Status (21)

Country	Link
US (17)	US7459461B2 (es)
EP (1)	EP1620446B1 (es)
JP (1)	JP4526534B2 (es)
KR (1)	KR101106574B1 (es)
CN (1)	CN100475824C (es)
AU (1)	AU2004232941B2 (es)
BR (1)	BRPI0409566A (es)
CA (1)	CA2523203C (es)
CR (1)	CR8046A (es)
EA (1)	EA200501463A1 (es)
EC (1)	ECSP056106A (es)
ES (1)	ES2399884T3 (es)
HR (1)	HRP20050899A2 (es)
ME (1)	MEP48608A (es)
MX (1)	MXPA05011218A (es)
NO (1)	NO20055396L (es)
NZ (1)	NZ543139A (es)
RS (1)	RS20050778A (es)
UA (1)	UA80869C2 (es)
WO (1)	WO2004094441A2 (es)
ZA (1)	ZA200509249B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7459461B2 (en) *	2001-10-19	2008-12-02	Ortho-Mcneil Pharmaceutical, Inc.	Phosphonic acid compounds as inhibitors of serine proteases
GB0224084D0 (en)	2002-10-16	2002-11-27	Glaxo Group Ltd	Novel compounds
GB0308333D0 (en) *	2003-04-10	2003-05-14	Glaxo Group Ltd	Novel compounds
US20060293298A1 (en) *	2003-04-10	2006-12-28	Bamford Mark J	Compounds
KR101326537B1 (ko) *	2006-11-30	2013-11-08	(주)아모레퍼시픽	카텝신 ｇ 발현 억제제 조성물
DK2205737T3 (da) *	2007-10-04	2013-05-21	Santaris Pharma As	Mikromirer
EP2058011A1 (en) *	2007-11-07	2009-05-13	Wittycell	Nkt cell activating gycolipids covalently bound antigens and/or drug
US8846660B2 (en)	2009-12-25	2014-09-30	Daiichi Sankyo Company, Ltd.	Seven-membered ring compound and pharmaceutical use therefor
US10744179B2 (en)	2014-09-18	2020-08-18	The Provost, Fellows, Foundation Scholars, & the Other Members of Board, of The College of the Holy	Method for treatment of inflammatory skin disorders with inhibitors of IL-36 proteolytic processing
US20260151410A1 (en) *	2022-05-30	2026-06-04	Scinnohub Pharmaceutical Co., Ltd	Tetrahydronaphthyridine Derivatives, Medicine Prepared Therefrom, and Applications Thereof in Preventing and Treating Adhesion-related Diseases

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE633914A (es)	1962-06-22
US4511551A (en)	1982-11-18	1985-04-16	Unique Technologies, Incorporated	Method and composition for the detection of a precancerous or leukemic condition in mammals
AT380490B (de) *	1984-09-06	1986-05-26	Voest Alpine Ag	Vorrichtung zur gewinnung der fuehlbaren waerme von schuettfaehigem heissgut
JPS61151199A (ja) *	1984-12-26	1986-07-09	Otsuka Pharmaceut Factory Inc	カルボン酸アミド誘導体
US4704382A (en) *	1985-07-29	1987-11-03	G. D. Searle & Co.	Phenylpiperazine phosphonates
US4822780A (en) *	1987-07-08	1989-04-18	Otsuka Pharmaceutical Factory, Inc.	Carboxamide compounds
US5508273A (en)	1993-12-30	1996-04-16	Ortho Pharmaceutical Corporation	Substituted phosphonic acids and derivatives useful in treating bone wasting diseases
DK0871454T3 (da)	1995-07-17	2004-03-22	Cephalon Inc	Phosphorholdige inhibitorer af cystein- og serinprotease
US6080738A (en) *	1996-10-25	2000-06-27	Yoshitomi Pharmaceuticals Industries, Ltd.	Heterocyclic amide compounds and medicinal uses thereof
CN1160075C (zh) *	1998-03-11	2004-08-04	卫福有限公司	杂环酰胺化合物在制备IgE抗体产生抑制剂中的用途
BR0213961A (pt)	2001-10-19	2004-08-31	Ortho Mcneil Pharm Inc	Compostos de ácido fosfÈnico como inibidores de serina protease
US7459461B2 (en)	2001-10-19	2008-12-02	Ortho-Mcneil Pharmaceutical, Inc.	Phosphonic acid compounds as inhibitors of serine proteases
US20090143396A1 (en)	2005-10-12	2009-06-04	Malecha James W	Sulfonyl-Substituted Aryl Compounds as Modulators of Peroxisome Proliferator Activated Receptors

2003
- 2003-04-16 US US10/414,782 patent/US7459461B2/en not_active Expired - Fee Related
2004
- 2004-04-14 MX MXPA05011218A patent/MXPA05011218A/es unknown
- 2004-04-14 CA CA2523203A patent/CA2523203C/en not_active Expired - Fee Related
- 2004-04-14 BR BRPI0409566-9A patent/BRPI0409566A/pt not_active IP Right Cessation
- 2004-04-14 NZ NZ543139A patent/NZ543139A/en unknown
- 2004-04-14 JP JP2006510026A patent/JP4526534B2/ja not_active Expired - Fee Related
- 2004-04-14 EP EP04759852A patent/EP1620446B1/en not_active Expired - Lifetime
- 2004-04-14 UA UAA200509837A patent/UA80869C2/xx unknown
- 2004-04-14 KR KR1020057019811A patent/KR101106574B1/ko not_active Expired - Fee Related
- 2004-04-14 HR HR20050899A patent/HRP20050899A2/xx not_active Application Discontinuation
- 2004-04-14 ME MEP-486/08A patent/MEP48608A/xx unknown
- 2004-04-14 CN CNB2004800165009A patent/CN100475824C/zh not_active Expired - Fee Related
- 2004-04-14 AU AU2004232941A patent/AU2004232941B2/en not_active Ceased
- 2004-04-14 ES ES04759852T patent/ES2399884T3/es not_active Expired - Lifetime
- 2004-04-14 EA EA200501463A patent/EA200501463A1/ru unknown
- 2004-04-14 WO PCT/US2004/011490 patent/WO2004094441A2/en not_active Ceased
- 2004-04-14 RS YUP-2005/0778A patent/RS20050778A/sr unknown
2005
- 2005-10-14 CR CR8046A patent/CR8046A/es not_active Application Discontinuation
- 2005-10-14 EC EC2005006106A patent/ECSP056106A/es unknown
- 2005-11-15 ZA ZA200509249A patent/ZA200509249B/en unknown
- 2005-11-15 NO NO20055396A patent/NO20055396L/no not_active Application Discontinuation
2008
- 2008-10-24 US US12/289,000 patent/US20090118504A1/en not_active Abandoned
- 2008-10-24 US US12/288,992 patent/US20090124581A1/en not_active Abandoned
- 2008-10-24 US US12/288,999 patent/US20090118234A1/en not_active Abandoned
- 2008-10-24 US US12/288,998 patent/US8198440B2/en not_active Expired - Fee Related
- 2008-10-24 US US12/288,941 patent/US8178673B2/en not_active Expired - Fee Related
- 2008-10-24 US US12/290,028 patent/US8247599B2/en not_active Expired - Fee Related
- 2008-10-24 US US12/288,920 patent/US8394804B2/en not_active Expired - Fee Related
- 2008-10-24 US US12/288,993 patent/US20090137528A1/en not_active Abandoned
- 2008-10-24 US US12/290,027 patent/US20090131671A1/en not_active Abandoned
2010
- 2010-12-20 US US12/973,013 patent/US8207338B2/en not_active Expired - Fee Related
- 2010-12-20 US US12/972,848 patent/US8461195B2/en not_active Expired - Fee Related
- 2010-12-20 US US12/972,744 patent/US8304430B2/en not_active Expired - Fee Related
- 2010-12-20 US US12/972,891 patent/US8212039B2/en not_active Expired - Fee Related
2012
- 2012-05-15 US US13/471,876 patent/US8497373B2/en not_active Expired - Fee Related
- 2012-07-17 US US13/550,963 patent/US8609888B2/en not_active Expired - Fee Related
2013
- 2013-06-19 US US13/921,476 patent/US8703957B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US8609888B2 (en)	2013-12-17
EP1620446B1 (en)	2012-10-24
KR101106574B1 (ko)	2012-01-19
US20090124581A1 (en)	2009-05-14
US20090118508A1 (en)	2009-05-07
ECSP056106A (es)	2006-03-01
RS20050778A (sr)	2008-04-04
US20130281407A1 (en)	2013-10-24
US8394804B2 (en)	2013-03-12
US8212039B2 (en)	2012-07-03
NO20055396D0 (no)	2005-11-15
US20110092457A1 (en)	2011-04-21
US20090143336A1 (en)	2009-06-04
US8178673B2 (en)	2012-05-15
US20090118504A1 (en)	2009-05-07
EP1620446A2 (en)	2006-02-01
US20090118234A1 (en)	2009-05-07
ZA200509249B (en)	2007-01-31
KR20060006929A (ko)	2006-01-20
CN100475824C (zh)	2009-04-08
HRP20050899A2 (en)	2006-09-30
US20040082544A1 (en)	2004-04-29
US20110092705A1 (en)	2011-04-21
US20090137528A1 (en)	2009-05-28
US20090131371A1 (en)	2009-05-21
US8497373B2 (en)	2013-07-30
NZ543139A (en)	2009-02-28
US8198440B2 (en)	2012-06-12
US20090118235A1 (en)	2009-05-07
CA2523203A1 (en)	2004-11-04
US8207338B2 (en)	2012-06-26
US8703957B2 (en)	2014-04-22
US8461195B2 (en)	2013-06-11
CN1832950A (zh)	2006-09-13
US8304430B2 (en)	2012-11-06
AU2004232941B2 (en)	2011-07-28
US20110086819A1 (en)	2011-04-14
JP4526534B2 (ja)	2010-08-18
BRPI0409566A (pt)	2006-04-18
US7459461B2 (en)	2008-12-02
WO2004094441A3 (en)	2005-10-13
WO2004094441A2 (en)	2004-11-04
MXPA05011218A (es)	2006-07-06
CR8046A (es)	2009-01-16
US20110319363A1 (en)	2011-12-29
NO20055396L (no)	2006-01-04
AU2004232941A1 (en)	2004-11-04
UA80869C2 (en)	2007-11-12
US20090131671A1 (en)	2009-05-21
US20120283221A1 (en)	2012-11-08
ES2399884T3 (es)	2013-04-04
JP2006523705A (ja)	2006-10-19
CA2523203C (en)	2013-06-11
US8247599B2 (en)	2012-08-21
US20120238528A1 (en)	2012-09-20
EA200501463A1 (ru)	2006-08-25

Publication	Publication Date	Title
EA200901124A1 (ru)	2010-04-30	Соединения формулы (i) в качестве ингибиторов серинпротеазы
EA200801530A1 (ru)	2008-12-30	Аналоги арилпропионамида, арилакриламида, арилпропинамида или арилметилмочевины в качестве фактор xia ингибиторов
NO990855L (no)	1999-04-23	Substituerte sykliske amin-metallprotease-inhibitorer
NO20073098L (no)	2007-07-19	Substituerte biarylforbindelser som faktor XIa-Inhibitorer
NO20081467L (no)	2008-05-15	Inhibitorer av sennproteaser
EA200100815A1 (ru)	2002-08-29	Пептидильные гетероциклические кетоны, применимые в качестве ингибиторов триптазы
EA200802054A1 (ru)	2009-04-28	Ингибиторы фермента
NO20061627L (no)	2006-04-10	Haloalkyl inneholdende forbindelser som cysteinproteaseinhibitorer
ATE309264T1 (de)	2005-11-15	Peptidyl-2-amino-1hydroxyalkansulfonsäuren als cystein-protease-inhibitoren
ATE538651T1 (de)	2012-01-15	Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit
EA200970349A1 (ru)	2010-02-26	Ингибиторы металлопротеазы гетероциклического происхождения
EA200601358A1 (ru)	2007-02-27	Новые ингибиторы химазы
ECSP077269A (es)	2007-03-29	Ácidos de oxazolo - naftilo como moduladores del ácidos de oxazolo - naftilo como moduladores del inhibidor del activador de plasminógeno tipo 1 (pai-1)
MX2021015324A (es)	2022-04-06	Inhibidores heteroaromaticos de las proteinasas de astacina.
ATE461697T1 (de)	2010-04-15	Phospholipidderivate von valproinsäure und ihre kombinationen
UY26155A1 (es)	2000-12-29	Aril y heteroaril pirazinonas policiclicas sustituidas útiles para la inhibición selectiva de la cascada de coagulación.
HRP20050899A2 (en)	2006-09-30	Novel phosphonic acid compounds as inhibitors of serine proteases
MEP48708A (en)	2011-02-10	Phosphonic acid compounds as inhibitors of serine proteases
EA201001823A1 (ru)	2011-06-30	Новые гетероциклические карбоксамиды для применения в качестве ингибиторов тромбина
NO20080661L (no)	2008-03-04	Nye cystein-protease-inhibitorer og deres terapeutiske anvendelser
MX2023011012A (es)	2023-09-28	Compuestos farmaceuticos como inhibidores de proteasa 19 especifica de ubiquitina (usp19).
AR039937A1 (es)	2005-03-09	Derivados de azetidina como inhibidores de tripsina proteasas
EA200900510A1 (ru)	2009-08-28	Дифторосодержащие соединения в качестве ингибиторов цистеиновых протеаз
BRPI0513267A (pt)	2008-05-06	variantes melhoradas de aprotinina
MX2007011739A (es)	2008-03-14	Compuestos que contienen sulfonilo como inhibidores de cisteina proteasa.