MX2009005604A - Inhibidores espiro cetona de acetil-coa carboxilasa. - Google Patents

Inhibidores espiro cetona de acetil-coa carboxilasa.

Info

Publication number
MX2009005604A
MX2009005604A MX2009005604A MX2009005604A MX2009005604A MX 2009005604 A MX2009005604 A MX 2009005604A MX 2009005604 A MX2009005604 A MX 2009005604A MX 2009005604 A MX2009005604 A MX 2009005604A MX 2009005604 A MX2009005604 A MX 2009005604A
Authority
MX
Mexico
Prior art keywords
sup
spiroketone
acetyl
coa carboxylase
carboxylase inhibitors
Prior art date
Application number
MX2009005604A
Other languages
English (en)
Inventor
Jeffrey Wayne Corbett
Andrew Simon Bell
Richard Louis Elliott
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MX2009005604A publication Critical patent/MX2009005604A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/39—Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención proporciona compuestos de Fórmula (1) (ver fórmula (1)) o una sal farmacéuticamente aceptable de dichos compuestos, en la que R1, R2, R3, R4, R5, R6, R7, R8 y R9 son como se han descrito en este documento; composiciones farmacéuticas de los mismos; y el uso de los mismos en el tratamiento de mamíferos que padecen de la afección de sobrepeso.
MX2009005604A 2006-11-29 2007-11-16 Inhibidores espiro cetona de acetil-coa carboxilasa. MX2009005604A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86177906P 2006-11-29 2006-11-29
PCT/IB2007/003639 WO2008065508A1 (en) 2006-11-29 2007-11-16 Spiroketone acetyl-coa carboxylase inhibitors

Publications (1)

Publication Number Publication Date
MX2009005604A true MX2009005604A (es) 2009-06-08

Family

ID=39126209

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005604A MX2009005604A (es) 2006-11-29 2007-11-16 Inhibidores espiro cetona de acetil-coa carboxilasa.

Country Status (23)

Country Link
US (1) US20090270435A1 (es)
EP (1) EP2097420B1 (es)
JP (1) JP2010511035A (es)
KR (1) KR20090083956A (es)
CN (1) CN101541809A (es)
AP (1) AP2009004880A0 (es)
AT (1) ATE552262T1 (es)
AU (1) AU2007326950B2 (es)
BR (1) BRPI0721053A2 (es)
CA (1) CA2670422C (es)
CO (1) CO6180424A2 (es)
CR (1) CR10831A (es)
EA (1) EA200900613A1 (es)
EC (1) ECSP099371A (es)
IL (1) IL198779A0 (es)
MA (1) MA30932B1 (es)
MX (1) MX2009005604A (es)
NO (1) NO20091889L (es)
RS (1) RS20090249A (es)
SV (1) SV2009003281A (es)
TN (1) TN2009000204A1 (es)
WO (1) WO2008065508A1 (es)
ZA (1) ZA200903268B (es)

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Also Published As

Publication number Publication date
EP2097420A1 (en) 2009-09-09
AU2007326950A1 (en) 2008-06-05
BRPI0721053A2 (pt) 2014-07-29
CR10831A (es) 2009-06-18
CA2670422A1 (en) 2008-06-05
ATE552262T1 (de) 2012-04-15
MA30932B1 (fr) 2009-11-02
AP2009004880A0 (en) 2009-06-30
NO20091889L (no) 2009-06-17
WO2008065508A1 (en) 2008-06-05
SV2009003281A (es) 2010-08-17
CA2670422C (en) 2011-09-06
US20090270435A1 (en) 2009-10-29
TN2009000204A1 (fr) 2010-10-18
ZA200903268B (en) 2010-07-28
AU2007326950B2 (en) 2010-10-14
KR20090083956A (ko) 2009-08-04
RS20090249A (sr) 2010-06-30
EP2097420B1 (en) 2012-04-04
CO6180424A2 (es) 2010-07-19
JP2010511035A (ja) 2010-04-08
EA200900613A1 (ru) 2009-10-30
IL198779A0 (en) 2010-02-17
CN101541809A (zh) 2009-09-23
ECSP099371A (es) 2009-06-30

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