MX2009005803A - Derivados de estradiol de 6-alcoxialquilo y metodos de uso. - Google Patents

Derivados de estradiol de 6-alcoxialquilo y metodos de uso.

Info

Publication number
MX2009005803A
MX2009005803A MX2009005803A MX2009005803A MX2009005803A MX 2009005803 A MX2009005803 A MX 2009005803A MX 2009005803 A MX2009005803 A MX 2009005803A MX 2009005803 A MX2009005803 A MX 2009005803A MX 2009005803 A MX2009005803 A MX 2009005803A
Authority
MX
Mexico
Prior art keywords
symbol
methods
bond
estradiol derivatives
double bond
Prior art date
Application number
MX2009005803A
Other languages
English (en)
Other versions
MX342437B (es
Inventor
James Yarger
Original Assignee
Endece Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endece Llc filed Critical Endece Llc
Publication of MX2009005803A publication Critical patent/MX2009005803A/es
Publication of MX342437B publication Critical patent/MX342437B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un compuesto que tiene una estructura en donde R1, R2, R3, R4, R5, R6, R7 y R9 son hidrógenos independientes, C1, a C6 son alquilo o alquilo sustituido, halógeno, sulfato o partículas de glucuronida y el símbolo ---- representa o bien una ligadura simple o bien una doble y, cuando el símbolo ---- es una ligadura doble y forma un grupo aceto en posición 3 o 17, ningún R7 o R6 está presente, respectivamente. El símbolo --- representa la presencia o ausencia de una ligadura en posición 10 y el símbolo (ver símbolo) representa cualquier tipo de ligadura independientemente de la esteroquímica. La invención también comprende enanciómeros, otros isómeros estereoquímicos, hidratos, solvatos, tautómeros y las sales correspondientes farmacéuticamente aceptables.
MX2009005803A 2006-11-30 2007-11-29 Derivados de estradiol de 6-alcoxialquilo y metodos de uso. MX342437B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86798006P 2006-11-30 2006-11-30
PCT/US2007/085913 WO2008067450A2 (en) 2006-11-30 2007-11-29 6-alkoxyalkyl estradiol derivatives and methods of use

Publications (2)

Publication Number Publication Date
MX2009005803A true MX2009005803A (es) 2009-08-26
MX342437B MX342437B (es) 2016-09-29

Family

ID=39468717

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005803A MX342437B (es) 2006-11-30 2007-11-29 Derivados de estradiol de 6-alcoxialquilo y metodos de uso.

Country Status (11)

Country Link
EP (1) EP2099460B1 (es)
JP (1) JP5290189B2 (es)
KR (1) KR101499266B1 (es)
CN (1) CN101594874B (es)
AU (1) AU2007325092B2 (es)
BR (1) BRPI0721050A2 (es)
CA (1) CA2670773C (es)
DK (1) DK2099460T3 (es)
ES (1) ES2604079T3 (es)
MX (1) MX342437B (es)
WO (1) WO2008067450A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10174070B2 (en) * 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
MX343059B (es) * 2010-09-14 2016-10-24 Endece Llc Derivados de desmetil-estradiol sustituido en 6 como agonistas de er-beta selectivos.
CN106420767A (zh) * 2011-03-21 2017-02-22 安德斯有限责任公司 用于神经轴突的髓鞘再生的6‑取代的雌二醇衍生物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3377363A (en) 1966-04-13 1968-04-09 Abbott Lab delta5(10)-6-hydroxymethyl-estrene compounds
DD258820A1 (de) * 1986-06-13 1988-08-03 Adw Ddr Verfahren zur herstellung von 6beta-hydroxy-methyl-androsta-1,4-dien-3,17-dion
US5504074A (en) * 1993-08-06 1996-04-02 Children's Medical Center Corporation Estrogenic compounds as anti-angiogenic agents
DE19633349A1 (de) 1996-08-19 1998-02-26 Sigma Tau Ind Farmaceuti Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten
IT1317031B1 (it) 2000-05-17 2003-05-26 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi.
ATE548375T1 (de) * 2004-01-16 2012-03-15 Cedarburg Pharmaceuticals Inc Exemestan und zwischenprodukte davon und verfahren zu dessen herstellung
US7419972B2 (en) * 2004-07-02 2008-09-02 Schering Ag 2-substituted estra-1,3,5(10)-trien-17-ones as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
CN101312743A (zh) * 2005-09-30 2008-11-26 安德西有限公司 (s)-6-甲基氧杂烷基依西美坦化合物及相关使用方法
TWI392682B (zh) * 2006-04-13 2013-04-11 Sigma Tau Ind Farmaceuti 作為心血管疾病的治療藥物之雄甾烷和雄甾烯的胺基衍生物

Also Published As

Publication number Publication date
EP2099460A4 (en) 2010-03-24
JP2010511625A (ja) 2010-04-15
WO2008067450A3 (en) 2008-07-17
ES2604079T3 (es) 2017-03-02
CA2670773C (en) 2013-01-22
AU2007325092A1 (en) 2008-06-05
KR20090101914A (ko) 2009-09-29
CN101594874B (zh) 2017-02-08
BRPI0721050A2 (pt) 2014-07-29
DK2099460T3 (da) 2017-01-02
CN101594874A (zh) 2009-12-02
AU2007325092B2 (en) 2013-04-11
WO2008067450A2 (en) 2008-06-05
EP2099460A2 (en) 2009-09-16
EP2099460B1 (en) 2016-09-07
CA2670773A1 (en) 2008-06-05
JP5290189B2 (ja) 2013-09-18
MX342437B (es) 2016-09-29
KR101499266B1 (ko) 2015-03-05

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