MX2013003227A - Nuevos analogos de piperazina con grupos heteroarilo sustituidos como antivirales de la influenza de espectro amplio. - Google Patents
Nuevos analogos de piperazina con grupos heteroarilo sustituidos como antivirales de la influenza de espectro amplio.Info
- Publication number
- MX2013003227A MX2013003227A MX2013003227A MX2013003227A MX2013003227A MX 2013003227 A MX2013003227 A MX 2013003227A MX 2013003227 A MX2013003227 A MX 2013003227A MX 2013003227 A MX2013003227 A MX 2013003227A MX 2013003227 A MX2013003227 A MX 2013003227A
- Authority
- MX
- Mexico
- Prior art keywords
- broad
- substituted heteroaryl
- heteroaryl groups
- novel piperazine
- spectrum influenza
- Prior art date
Links
- 125000001072 heteroaryl group Chemical group 0.000 title abstract 2
- 239000003443 antiviral agent Substances 0.000 title 1
- 229940121357 antivirals Drugs 0.000 title 1
- 206010022000 influenza Diseases 0.000 title 1
- 150000004885 piperazines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a un compuesto de la siguiente Fórmula (I), que incluye las sales farmacéuticamente aceptables del mismo: en donde Het es un heterociclo de 5 o 6 miebros con -N, -O, o -s adyacente al substituyente -Ar o adyacente al punto de fijación para el substituyente -Ar; Ar es arilo o heteroarilo; R es CH3, -CH2-F, -CHF2 o -CH=CH2; V es -H, -CH3 o =0; W es -NO2, -Cl, -Br, -CH2OH, o -CN; X es -Cl, -Br, -F, -CH3, -OCH3, o -CN; Y es -CH o -N; y Z es -CH o -N. Este compuesto es útil en las composiciones para la prevención y el tratamiento del virus de la influenza.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38718610P | 2010-09-28 | 2010-09-28 | |
| PCT/US2011/052965 WO2012044531A1 (en) | 2010-09-28 | 2011-09-23 | Novel piperazine analogs with substituted heteroaryl groups as broad-spectrum influenza antivirals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2013003227A true MX2013003227A (es) | 2013-05-31 |
Family
ID=44759794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013003227A MX2013003227A (es) | 2010-09-28 | 2011-09-23 | Nuevos analogos de piperazina con grupos heteroarilo sustituidos como antivirales de la influenza de espectro amplio. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20120245176A1 (es) |
| EP (1) | EP2621920B1 (es) |
| JP (1) | JP2013542201A (es) |
| CN (1) | CN103209977A (es) |
| BR (1) | BR112013007651A2 (es) |
| CA (1) | CA2812935A1 (es) |
| EA (1) | EA201390476A1 (es) |
| ES (1) | ES2564257T3 (es) |
| MX (1) | MX2013003227A (es) |
| WO (1) | WO2012044531A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101369584B1 (ko) | 2011-04-19 | 2014-03-06 | 일양약품주식회사 | 페닐-이속사졸 유도체 및 그의 제조방법 |
| CN102432555A (zh) * | 2011-09-09 | 2012-05-02 | 中国科学院广州生物医药与健康研究院 | 1,2,3-三氮唑-4（5）羧酰胺类化合物及其应用 |
| US9676734B2 (en) | 2012-05-18 | 2017-06-13 | Vironova Influenza Ab | Compounds and methods |
| WO2013171334A1 (en) * | 2012-05-18 | 2013-11-21 | Vironova Ab | Methanethione compounds having antiviral activity |
| CN104447625B (zh) * | 2013-09-16 | 2016-08-17 | 中国科学院广州生物医药与健康研究院 | 苯甲酰胺类化合物或其药学上可接受的盐及其应用 |
| WO2015196086A1 (en) * | 2014-06-20 | 2015-12-23 | The University of Montana, Missoula, MT | NOVEL INHIBITORS OF SYSTEM Xc(-) |
| CN107056762B (zh) * | 2016-12-22 | 2020-08-28 | 四川百利药业有限责任公司 | 一种用作抗流感病毒的双羰基类似物 |
| WO2021204923A1 (en) | 2020-04-09 | 2021-10-14 | Vironova Medical Ab | Antiviral agents |
| WO2021204924A1 (en) | 2020-04-09 | 2021-10-14 | Vironova Medical Ab | Compounds for use in the treatment of hypercytokinemia |
| CN118076585A (zh) * | 2021-07-23 | 2024-05-24 | 国家医疗保健研究所 | 革兰氏阴性菌外排泵抑制剂 |
| CN114507220B (zh) * | 2022-03-08 | 2023-01-10 | 中国医学科学院医药生物技术研究所 | 一种取代4-苯基-5-位官能团化的1,2,4-三唑类衍生物及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1242995C (zh) | 1999-05-21 | 2006-02-22 | 比奥维特罗姆股份公司 | 化合物,它们的用途和制备方法 |
| ATE417038T1 (de) * | 2001-06-15 | 2008-12-15 | Astellas Pharma Inc | Phenylpyridincarbonyl piperazinderivate |
| DE60304718T2 (de) | 2002-08-06 | 2007-04-26 | Astrazeneca Ab | Kondensierte pyridine und pyrimidine mit tie2 (tek) aktivität |
| WO2007002220A2 (en) | 2005-06-21 | 2007-01-04 | Bristol-Myers Squibb Company | Aminoacetamide acyl guanidines as beta-secretase inhibitors |
| AU2007267692B2 (en) | 2006-05-24 | 2012-06-14 | Eli Lilly And Company | Compounds and methods for modulating FXR |
| WO2009131957A2 (en) * | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, compositions and methods comprising oxadiazole derivatives |
| CN102596946B (zh) * | 2009-08-05 | 2015-06-17 | 港大科桥有限公司 | 抗病毒化合物及其制备和使用方法 |
| US9212177B2 (en) * | 2009-08-05 | 2015-12-15 | Versitech Limited | Antiviral compounds and methods of making and using thereof |
-
2011
- 2011-09-23 CA CA2812935A patent/CA2812935A1/en not_active Abandoned
- 2011-09-23 EA EA201390476A patent/EA201390476A1/ru unknown
- 2011-09-23 CN CN2011800566517A patent/CN103209977A/zh active Pending
- 2011-09-23 US US13/242,676 patent/US20120245176A1/en not_active Abandoned
- 2011-09-23 JP JP2013531678A patent/JP2013542201A/ja not_active Withdrawn
- 2011-09-23 ES ES11764930.1T patent/ES2564257T3/es active Active
- 2011-09-23 WO PCT/US2011/052965 patent/WO2012044531A1/en not_active Ceased
- 2011-09-23 EP EP11764930.1A patent/EP2621920B1/en not_active Not-in-force
- 2011-09-23 MX MX2013003227A patent/MX2013003227A/es not_active Application Discontinuation
- 2011-09-23 BR BR112013007651A patent/BR112013007651A2/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN103209977A (zh) | 2013-07-17 |
| EA201390476A1 (ru) | 2013-08-30 |
| BR112013007651A2 (pt) | 2019-09-24 |
| WO2012044531A1 (en) | 2012-04-05 |
| ES2564257T3 (es) | 2016-03-21 |
| EP2621920B1 (en) | 2016-01-27 |
| WO2012044531A8 (en) | 2012-08-09 |
| EP2621920A1 (en) | 2013-08-07 |
| US20120245176A1 (en) | 2012-09-27 |
| JP2013542201A (ja) | 2013-11-21 |
| CA2812935A1 (en) | 2012-04-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |