MX2019012902A - Preparacion de derivados de acido 2-([1,2,3]triazol-2-il)-benzoico . - Google Patents

Preparacion de derivados de acido 2-([1,2,3]triazol-2-il)-benzoico .

Info

Publication number
MX2019012902A
MX2019012902A MX2019012902A MX2019012902A MX2019012902A MX 2019012902 A MX2019012902 A MX 2019012902A MX 2019012902 A MX2019012902 A MX 2019012902A MX 2019012902 A MX2019012902 A MX 2019012902A MX 2019012902 A MX2019012902 A MX 2019012902A
Authority
MX
Mexico
Prior art keywords
triazol
preparation
benzoic acid
formula
derivatives
Prior art date
Application number
MX2019012902A
Other languages
English (en)
Other versions
MX392154B (es
Inventor
Dörrwächter Patric
Schmidt Gunther
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of MX2019012902A publication Critical patent/MX2019012902A/es
Publication of MX392154B publication Critical patent/MX392154B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/70—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the iron group metals or copper
    • B01J23/72—Copper
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a un proceso para la preparación de derivados de ácido 2-(2H-[1,2,3]triazol-2-iI)-benzoico particulares de la fórmula (I) (ver Fórmula) a ciertas formas cristalinas de sales de potasio de dichos derivados de ácido 2-(2H-[1,2,3]triazol-2-il)-benzoico de la fórmula (lK), a ciertas formas cristalinas de dichos derivados de ácido 2-(2H-[1,2,3]triazol-2-il)-benzoico de la fórmula (I) y a su uso en la preparación de farmacéuticos tales como (S)-(2-(5-cloro-4-metil-1H-benzo[d]imidazol-2-il)-2-metilpirrolid in-1-il)-(5-metoxi-2-(2H-1,2,3-triazol-2-il)fenil)metanona.
MX2019012902A 2017-05-03 2018-05-02 Preparacion de derivados de acido 2-([1,2,3]triazol-2-il)-benzoico. MX392154B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2017060451 2017-05-03
PCT/EP2018/061172 WO2018202689A1 (en) 2017-05-03 2018-05-02 Preparation of 2-([1,2,3]triazol-2-yl)-benzoic acid derivatives

Publications (2)

Publication Number Publication Date
MX2019012902A true MX2019012902A (es) 2019-12-16
MX392154B MX392154B (es) 2025-03-21

Family

ID=62116854

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019012902A MX392154B (es) 2017-05-03 2018-05-02 Preparacion de derivados de acido 2-([1,2,3]triazol-2-il)-benzoico.

Country Status (20)

Country Link
US (1) US11124488B2 (es)
EP (1) EP3619199B1 (es)
JP (1) JP7182562B2 (es)
KR (1) KR102582197B1 (es)
CN (1) CN110612291B (es)
CA (1) CA3059394C (es)
CY (1) CY1124777T1 (es)
DK (1) DK3619199T3 (es)
ES (1) ES2892161T3 (es)
HR (1) HRP20211304T1 (es)
HU (1) HUE055904T2 (es)
IL (1) IL270274B (es)
LT (1) LT3619199T (es)
MX (1) MX392154B (es)
PL (1) PL3619199T3 (es)
PT (1) PT3619199T (es)
RS (1) RS62357B1 (es)
SI (1) SI3619199T1 (es)
TW (1) TWI756418B (es)
WO (1) WO2018202689A1 (es)

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EP4138822A1 (en) 2020-04-19 2023-03-01 Idorsia Pharmaceuticals Ltd Medical use of daridorexant
AR129309A1 (es) 2022-05-13 2024-08-07 Idorsia Pharmaceuticals Ltd Derivados de hidrazina-n-carboxamida cíclica sustituida con tiazoloaril-metilo
CN117736193B (zh) * 2023-12-19 2024-07-23 南京知和医药科技有限公司 一种氘代稠环化合物及其制备方法与用途
ES3038762A1 (es) * 2024-04-12 2025-10-14 Moehs Iberica Sl Procedimiento de síntesis de ácido 5-metoxi-2-(2H-1,2,3-triazol-2yl)benzoico, sal sódica de dicho ácido como intermedio de síntesis y uso del ácido o de su sal en la preparación de daridorexant y ciertos intermedios en la síntesis del mismo

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JP2010504957A (ja) 2006-09-29 2010-02-18 アクテリオン ファーマシューティカルズ リミテッド ３−アザ−ビシクロ［３．１．０］ヘキサン誘導体
PE20081229A1 (es) * 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
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JP2014015452A (ja) 2012-06-15 2014-01-30 Taisho Pharmaceutical Co Ltd ピラゾール誘導体を含有する医薬
EA201500399A1 (ru) * 2012-10-10 2015-09-30 Актелион Фармасьютиклз Лтд. Антагонисты рецептора орексина, которые представляют собой производные [орто-би-(гетеро)арил]-[2-(мета-би-(гетеро)арил)пирролидин-1-ил]метанона
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TW201444849A (zh) * 2013-03-13 2014-12-01 Janssen Pharmaceutica Nv 經取代的7-氮雜雙環類及其作為食慾激素受體調節劑之用途
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UA119151C2 (uk) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА
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Also Published As

Publication number Publication date
CN110612291B (zh) 2024-02-13
CA3059394C (en) 2023-09-12
RS62357B1 (sr) 2021-10-29
CA3059394A1 (en) 2018-11-08
SI3619199T1 (sl) 2021-11-30
CY1124777T1 (el) 2022-11-25
EP3619199B1 (en) 2021-07-07
JP7182562B2 (ja) 2022-12-02
WO2018202689A1 (en) 2018-11-08
PL3619199T3 (pl) 2021-12-20
US11124488B2 (en) 2021-09-21
CN110612291A (zh) 2019-12-24
TWI756418B (zh) 2022-03-01
IL270274A (es) 2019-12-31
KR102582197B1 (ko) 2023-09-22
KR20200003097A (ko) 2020-01-08
JP2020518573A (ja) 2020-06-25
ES2892161T3 (es) 2022-02-02
IL270274B (en) 2022-08-01
HUE055904T2 (hu) 2021-12-28
HRP20211304T1 (hr) 2021-11-12
LT3619199T (lt) 2021-09-27
PT3619199T (pt) 2021-10-01
MX392154B (es) 2025-03-21
TW201843144A (zh) 2018-12-16
DK3619199T3 (da) 2021-09-27
US20210114997A1 (en) 2021-04-22
EP3619199A1 (en) 2020-03-11

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