DK3619199T3 - Fremstilling af 2-([1,2,3]triazol-2-yl)-benzoesyrederivater - Google Patents

Fremstilling af 2-([1,2,3]triazol-2-yl)-benzoesyrederivater Download PDF

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Publication number
DK3619199T3
DK3619199T3 DK18722948.9T DK18722948T DK3619199T3 DK 3619199 T3 DK3619199 T3 DK 3619199T3 DK 18722948 T DK18722948 T DK 18722948T DK 3619199 T3 DK3619199 T3 DK 3619199T3
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DK
Denmark
Prior art keywords
triazol
preparation
benzoic acid
acid derivatives
derivatives
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Application number
DK18722948.9T
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English (en)
Inventor
Patric Dörrwächter
Gunther Schmidt
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of DK3619199T3 publication Critical patent/DK3619199T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/70—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the iron group metals or copper
    • B01J23/72—Copper
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK18722948.9T 2017-05-03 2018-05-02 Fremstilling af 2-([1,2,3]triazol-2-yl)-benzoesyrederivater DK3619199T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2017060451 2017-05-03
PCT/EP2018/061172 WO2018202689A1 (en) 2017-05-03 2018-05-02 Preparation of 2-([1,2,3]triazol-2-yl)-benzoic acid derivatives

Publications (1)

Publication Number Publication Date
DK3619199T3 true DK3619199T3 (da) 2021-09-27

Family

ID=62116854

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18722948.9T DK3619199T3 (da) 2017-05-03 2018-05-02 Fremstilling af 2-([1,2,3]triazol-2-yl)-benzoesyrederivater

Country Status (20)

Country Link
US (1) US11124488B2 (da)
EP (1) EP3619199B1 (da)
JP (1) JP7182562B2 (da)
KR (1) KR102582197B1 (da)
CN (1) CN110612291B (da)
CA (1) CA3059394C (da)
CY (1) CY1124777T1 (da)
DK (1) DK3619199T3 (da)
ES (1) ES2892161T3 (da)
HR (1) HRP20211304T1 (da)
HU (1) HUE055904T2 (da)
IL (1) IL270274B (da)
LT (1) LT3619199T (da)
MX (1) MX392154B (da)
PL (1) PL3619199T3 (da)
PT (1) PT3619199T (da)
RS (1) RS62357B1 (da)
SI (1) SI3619199T1 (da)
TW (1) TWI756418B (da)
WO (1) WO2018202689A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230134935A1 (en) 2020-04-19 2023-05-04 Idorsia Pharmaceuticals Ltd Medical use of daridorexant
AR129309A1 (es) 2022-05-13 2024-08-07 Idorsia Pharmaceuticals Ltd Derivados de hidrazina-n-carboxamida cíclica sustituida con tiazoloaril-metilo
CN118724879B (zh) * 2023-12-19 2025-02-11 南京知和医药科技有限公司 一种氘代稠环化合物及其制备方法与用途
ES3038762A1 (es) * 2024-04-12 2025-10-14 Moehs Iberica Sl Procedimiento de síntesis de ácido 5-metoxi-2-(2H-1,2,3-triazol-2yl)benzoico, sal sódica de dicho ácido como intermedio de síntesis y uso del ácido o de su sal en la preparación de daridorexant y ciertos intermedios en la síntesis del mismo

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TW200823227A (en) 2006-09-29 2008-06-01 Actelion Pharmaceuticals Ltd 3-aza-bicyclo[3.1.0]hexane derivatives
PE20081229A1 (es) * 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
CL2007003827A1 (es) 2006-12-28 2008-09-26 Actelion Pharmaceuticals Ltd Compuestos derivados de n-(2-aza-biciclo(3.1.0)hex-3-ilmetil)amida; y su uso para prevenir o tratar la depresion, neurosis, esquizofrenia, ansiedad, adicciones, epilepsia, dolor, enfermedades cardiacas, entre otras.
ATE483707T1 (de) 2007-05-14 2010-10-15 Actelion Pharmaceuticals Ltd 2-cyclopropylthiazolderivate
WO2008150364A1 (en) 2007-05-23 2008-12-11 Merck & Co., Inc. Cyclopropyl pyrrolidine orexin receptor antagonists
WO2011050200A1 (en) 2009-10-23 2011-04-28 Janssen Pharmaceutica Nv Fused heterocyclic compounds as orexin receptor modulators
ES2585806T3 (es) 2009-10-23 2016-10-10 Janssen Pharmaceutica N.V. Octahidropirrolo [3,4-c] pirroles disustituidos como moduladores de receptores de orexina
WO2011050202A1 (en) 2009-10-23 2011-04-28 Janssen Pharmaceutica Nv Fused heterocyclic compounds as orexin receptor modulators
PH12013501206A1 (en) 2010-12-17 2018-04-11 Taisho Pharmaceutical Co Ltd Pyrazole derivative
WO2012085852A1 (en) 2010-12-22 2012-06-28 Actelion Pharmaceuticals Ltd 3,8-diaza-bicyclo[4.2.0]oct-8-yl amides
US9108959B2 (en) 2011-03-03 2015-08-18 Merck Sharp & Dohme Corp. Process for the preparation of an orexin receptor antagonist
US9586962B2 (en) 2011-04-20 2017-03-07 Janssen Pharmaceutica Nv Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators
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TWI565703B (zh) 2011-11-08 2017-01-11 艾克泰聯製藥有限公司 ２-（１，２，３-三唑-２-基）苯甲醯胺及３-（１，２，３-三唑-２-基）吡啶醯胺衍生物
EP2847343A4 (en) 2012-05-09 2016-04-06 Merck Sharp & Dohme METHOD FOR PRODUCING A INTERMEDIATE PRODUCT FOR AN OREXINE RECEPTOR ANTAGONIST
KR101689093B1 (ko) 2012-06-04 2016-12-22 액테리온 파마슈티칼 리미티드 벤즈이미다졸-프롤린 유도체
JP2014015452A (ja) 2012-06-15 2014-01-30 Taisho Pharmaceutical Co Ltd ピラゾール誘導体を含有する医薬
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TW201444821A (zh) 2013-03-13 2014-12-01 Janssen Pharmaceutica Nv 經取代之哌啶化合物及其作為食慾素受體調節劑之用途
TW201444849A (zh) 2013-03-13 2014-12-01 Janssen Pharmaceutica Nv 經取代的7-氮雜雙環類及其作為食慾激素受體調節劑之用途
HK1225731B (en) 2013-12-03 2017-09-15 Idorsia Pharmaceuticals Ltd Crystalline form of (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone and its use as orexin receptor antagonists
UA119151C2 (uk) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА
HRP20181710T1 (hr) 2013-12-04 2018-12-28 Idorsia Pharmaceuticals Ltd Uporaba derivata benzimidazol-prolina
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Also Published As

Publication number Publication date
CN110612291B (zh) 2024-02-13
IL270274B (en) 2022-08-01
WO2018202689A1 (en) 2018-11-08
CA3059394A1 (en) 2018-11-08
PT3619199T (pt) 2021-10-01
HUE055904T2 (hu) 2021-12-28
SI3619199T1 (sl) 2021-11-30
LT3619199T (lt) 2021-09-27
RS62357B1 (sr) 2021-10-29
EP3619199B1 (en) 2021-07-07
ES2892161T3 (es) 2022-02-02
US20210114997A1 (en) 2021-04-22
JP7182562B2 (ja) 2022-12-02
TW201843144A (zh) 2018-12-16
KR20200003097A (ko) 2020-01-08
KR102582197B1 (ko) 2023-09-22
PL3619199T3 (pl) 2021-12-20
EP3619199A1 (en) 2020-03-11
CA3059394C (en) 2023-09-12
CN110612291A (zh) 2019-12-24
TWI756418B (zh) 2022-03-01
US11124488B2 (en) 2021-09-21
IL270274A (da) 2019-12-31
MX2019012902A (es) 2019-12-16
HRP20211304T1 (hr) 2021-11-12
MX392154B (es) 2025-03-21
CY1124777T1 (el) 2022-11-25
JP2020518573A (ja) 2020-06-25

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