MX2020002648A - Agentes de iarn y composiciones para inhibir la expresion de la apolipoproteina c-iii (apoc3). - Google Patents

Agentes de iarn y composiciones para inhibir la expresion de la apolipoproteina c-iii (apoc3).

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Publication number
MX2020002648A
MX2020002648A MX2020002648A MX2020002648A MX2020002648A MX 2020002648 A MX2020002648 A MX 2020002648A MX 2020002648 A MX2020002648 A MX 2020002648A MX 2020002648 A MX2020002648 A MX 2020002648A MX 2020002648 A MX2020002648 A MX 2020002648A
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Mexico
Prior art keywords
apoc3
rnai agents
iii
expression
apolipoprotein
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MX2020002648A
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English (en)
Inventor
So Wong
Steven Kanner
Tao Pei
Zhen Li
Rui Zhu
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Arrowhead Pharmaceuticals Inc
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Publication date
Application filed by Arrowhead Pharmaceuticals Inc filed Critical Arrowhead Pharmaceuticals Inc
Publication of MX2020002648A publication Critical patent/MX2020002648A/es

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Abstract

La presente descripción se refiere a agentes de iARN, por ejemplo, agentes de iARN de cadena doble, capaces de inhibir la expresión del gen de la Apolipoproteína C-III (también denominada APOC3, apoC-III, APOC-III, y APO C-III), y composiciones que incluyen agentes de iARN de APOC3. Los agentes de iARN de APOC3 descritos en la presente pueden estar conjugados con ligandos diana, que incluyen ligandos que incluyen N-acetil-galactosamina, para facilitar la administración a células, que incluyen a hepatocitos. También se describen las composiciones farmacéuticas que incluyen uno o más agentes de iARN de APOC3, opcionalmente con uno o más productos terapéuticos adicionales. La administración de los agentes de iARN de APOC3 in vivo proporciona la inhibición de la expresión del gen APOC3, y puede dar como resultado niveles de triglicéridos y/o niveles de colesterol reducidos en el sujeto. Los agentes de iARN de APOC3 se pueden usar en métodos de tratamiento de enfermedades y trastornos relacionados con APOC3 que incluyen hipertrigliceridemia, enfermedad cardiovascular, y otros trastornos y enfermedades metabólicos relacionados.
MX2020002648A 2017-09-11 2018-09-10 Agentes de iarn y composiciones para inhibir la expresion de la apolipoproteina c-iii (apoc3). MX2020002648A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762556818P 2017-09-11 2017-09-11
US201862643927P 2018-03-16 2018-03-16
US201862720434P 2018-08-21 2018-08-21
PCT/US2018/050248 WO2019051402A1 (en) 2017-09-11 2018-09-10 RNA INTERFERENCE AGENTS AND COMPOSITIONS FOR INHIBITING THE EXPRESSION OF APOLIPOPROTEIN C-III (APOC3)

Publications (1)

Publication Number Publication Date
MX2020002648A true MX2020002648A (es) 2020-07-22

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MX2020002648A MX2020002648A (es) 2017-09-11 2018-09-10 Agentes de iarn y composiciones para inhibir la expresion de la apolipoproteina c-iii (apoc3).
MX2025015219A MX2025015219A (es) 2017-09-11 2020-03-06 Agentes de iarn y composiciones para inhibir la expresion de la apolipoproteina c-iii (apoc3)

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MX2025015219A MX2025015219A (es) 2017-09-11 2020-03-06 Agentes de iarn y composiciones para inhibir la expresion de la apolipoproteina c-iii (apoc3)

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US (5) US10597657B2 (es)
EP (1) EP3681516A4 (es)
JP (4) JP7438103B2 (es)
KR (2) KR20240161202A (es)
CN (2) CN111107853B (es)
AU (2) AU2018329190B2 (es)
BR (1) BR112020002413A2 (es)
CA (1) CA3074303A1 (es)
CL (2) CL2020000593A1 (es)
CO (1) CO2020002586A2 (es)
CR (1) CR20200108A (es)
EC (1) ECSP20017905A (es)
IL (2) IL273172B2 (es)
JO (1) JOP20200054A1 (es)
MX (2) MX2020002648A (es)
MY (1) MY202025A (es)
NZ (1) NZ763172A (es)
PE (1) PE20201283A1 (es)
PH (1) PH12020500332A1 (es)
SG (1) SG11201912178VA (es)
TN (1) TN2020000039A1 (es)
TW (2) TWI811238B (es)
UY (1) UY37871A (es)
WO (1) WO2019051402A1 (es)
ZA (1) ZA202100806B (es)

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