JOP20200054A1 - عوامل RNAi وتركيبات لتثبيط تعبير صَميمُ البروتينِ الشَّحْمِيّ C-III (APOC3) - Google Patents

عوامل RNAi وتركيبات لتثبيط تعبير صَميمُ البروتينِ الشَّحْمِيّ C-III (APOC3)

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Publication number
JOP20200054A1
JOP20200054A1 JOP/2020/0054A JOP20200054A JOP20200054A1 JO P20200054 A1 JOP20200054 A1 JO P20200054A1 JO P20200054 A JOP20200054 A JO P20200054A JO P20200054 A1 JOP20200054 A1 JO P20200054A1
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Jordan
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apoc3
rnai agents
iii
compositions
apolipoprotein
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JOP/2020/0054A
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English (en)
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So Wong
Tao Pei
Steven Kanner
Zhen Li
Rui Zhu
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Arrowhead Pharmaceuticals Inc
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Publication of JOP20200054A1 publication Critical patent/JOP20200054A1/ar

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Abstract

يتعلق الكشف الحالي بعوامل RNAi، على سبيل المثال، عوامل RNAi مزدوجة الشريط، القادرة على التعبير عن C جين تثبيط صَميمُ البروتينِ الشَّحْمِيّ -III (أيضا تسمى APOC3، apoC-III، APOC-III، و APO C-III)، و التركيبات التي تتضمن عوامل APOC3 RNAi. قد تقترن عوامل APOC3 RNAi التي تم وصفها هنا بليجندات مستهدفة، بما في ذلك الليجندات التي تتضمن N - أسيتيل- جالاكتوزامين، لتسهيل التسليم للخلايا، بما في ذلك الخلايا الكبدية. تم وصف أيضا التركيبات الصيدلية التي تتضمن واحدة او اكثر من عوامل APOC3 RNAi، اختياريا مع واحد أو اكثر من المواد العلاجية الإضافية. يوفر استلام عوامل APOC3 RNAi داخل جسم الكائن الحي لتثبيط التعبير الجيني ل APOC3، و يمكن ان ينتج عنه مستويات أقل من الدهون الثلاثية و/ أو الكوليستيرول في الشخص. يمكن أن تستخدم عوامل APOC3 RNAi في طرق علاج الأمراض والاضطرابات المتعلقة بـ APOC3، بما في ذلك ارتفاع الدهون الثلاثية في الدم، وأمراض القلب والأوعية الدموية، وغيرها من الاضطرابات والأمراض ذات الصلة بالتمثيل الغذائي.
JOP/2020/0054A 2017-09-11 2018-09-10 عوامل RNAi وتركيبات لتثبيط تعبير صَميمُ البروتينِ الشَّحْمِيّ C-III (APOC3) JOP20200054A1 (ar)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762556818P 2017-09-11 2017-09-11
US201862643927P 2018-03-16 2018-03-16
US201862720434P 2018-08-21 2018-08-21
PCT/US2018/050248 WO2019051402A1 (en) 2017-09-11 2018-09-10 RNA INTERFERENCE AGENTS AND COMPOSITIONS FOR INHIBITING THE EXPRESSION OF APOLIPOPROTEIN C-III (APOC3)

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JOP20200054A1 true JOP20200054A1 (ar) 2020-03-10

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EP (1) EP3681516A4 (ar)
JP (4) JP7438103B2 (ar)
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