ECSP20017905A - AGENTES DE iARN Y COMPOSICIONES PARA INHIBIR LA EXPRESIÓN DE LA APOLIPOPROTEÍNA C-III (APOC3) - Google Patents

AGENTES DE iARN Y COMPOSICIONES PARA INHIBIR LA EXPRESIÓN DE LA APOLIPOPROTEÍNA C-III (APOC3)

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Publication number
ECSP20017905A
ECSP20017905A ECSENADI202017905A ECDI202017905A ECSP20017905A EC SP20017905 A ECSP20017905 A EC SP20017905A EC SENADI202017905 A ECSENADI202017905 A EC SENADI202017905A EC DI202017905 A ECDI202017905 A EC DI202017905A EC SP20017905 A ECSP20017905 A EC SP20017905A
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EC
Ecuador
Prior art keywords
apoc3
irna agents
iii
expression
compositions
Prior art date
Application number
ECSENADI202017905A
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English (en)
Inventor
So Wong
Steven Kanner
Zhen Li
Tao Pei
Rui Zhu
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Arrowhead Pharmaceuticals Inc
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Publication date
Application filed by Arrowhead Pharmaceuticals Inc filed Critical Arrowhead Pharmaceuticals Inc
Publication of ECSP20017905A publication Critical patent/ECSP20017905A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07H3/02—Monosaccharides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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Abstract

La presente descripción se refiere a agentes de iARN, por ejemplo, agentes de iARN de cadena doble, capaces de inhibir la expresión del gen de la Apolipoproteína C-III (también denominada APOC3, apoC-III, APOC-III, y APO C-III), y composiciones que incluyen agentes de iARN de APOC3. Los agentes de iARN de APOC3 descritos en la presente pueden estar conjugados con ligandos diana, que incluyen ligandos que incluyen N-acetil-galactosamina, para facilitar la administración a células, que incluyen a hepatocitos. También se describen las composiciones farmacéuticas que incluyen uno o más agentes de iARN de APOC3, opcionalmente con uno o más productos terapéuticos adicionales. La administración de los agentes de iARN de APOC3 in vivo proporciona la inhibición de la expresión del gen APOC3, y puede dar como resultado niveles de triglicéridos y/o niveles de colesterol reducidos en el sujeto. Los agentes de iARN de APOC3 se pueden usar en métodos de tratamiento de enfermedades y trastornos relacionados con APOC3 que incluyen hipertrigliceridemia, enfermedad cardiovascular, y otros trastornos y enfermedades metabólicos relacionados.
ECSENADI202017905A 2017-09-11 2020-03-11 AGENTES DE iARN Y COMPOSICIONES PARA INHIBIR LA EXPRESIÓN DE LA APOLIPOPROTEÍNA C-III (APOC3) ECSP20017905A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762556818P 2017-09-11 2017-09-11
US201862643927P 2018-03-16 2018-03-16
US201862720434P 2018-08-21 2018-08-21

Publications (1)

Publication Number Publication Date
ECSP20017905A true ECSP20017905A (es) 2020-06-30

Family

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ECSENADI202017905A ECSP20017905A (es) 2017-09-11 2020-03-11 AGENTES DE iARN Y COMPOSICIONES PARA INHIBIR LA EXPRESIÓN DE LA APOLIPOPROTEÍNA C-III (APOC3)

Country Status (24)

Country Link
US (5) US10597657B2 (es)
EP (1) EP3681516A4 (es)
JP (4) JP7438103B2 (es)
KR (2) KR20240161202A (es)
CN (2) CN118879696A (es)
AU (2) AU2018329190B2 (es)
BR (1) BR112020002413A2 (es)
CA (1) CA3074303A1 (es)
CL (2) CL2020000593A1 (es)
CO (1) CO2020002586A2 (es)
CR (1) CR20200108A (es)
EC (1) ECSP20017905A (es)
IL (2) IL273172B1 (es)
JO (1) JOP20200054A1 (es)
MX (1) MX2020002648A (es)
MY (1) MY202025A (es)
PE (1) PE20201283A1 (es)
PH (1) PH12020500332A1 (es)
SG (1) SG11201912178VA (es)
TN (1) TN2020000039A1 (es)
TW (2) TW202415389A (es)
UY (1) UY37871A (es)
WO (1) WO2019051402A1 (es)
ZA (1) ZA202100806B (es)

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