MX2020003245A - Moleculas artificiales de acido nucleico. - Google Patents

Moleculas artificiales de acido nucleico.

Info

Publication number
MX2020003245A
MX2020003245A MX2020003245A MX2020003245A MX2020003245A MX 2020003245 A MX2020003245 A MX 2020003245A MX 2020003245 A MX2020003245 A MX 2020003245A MX 2020003245 A MX2020003245 A MX 2020003245A MX 2020003245 A MX2020003245 A MX 2020003245A
Authority
MX
Mexico
Prior art keywords
nucleic acid
utr
artificial nucleic
acid sequence
acid molecules
Prior art date
Application number
MX2020003245A
Other languages
English (en)
Inventor
Andreas Thess
Original Assignee
Curevac Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curevac Ag filed Critical Curevac Ag
Publication of MX2020003245A publication Critical patent/MX2020003245A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La invención se refiere a una molécula artificial de ácido nucleico que comprende al menos un marco de lectura abierto y al menos un elemento de región no traducida 3' (3'-UTR) que comprende una secuencia que se deriva de la 3'-UTR de un gen de proteína ribosómica. La invención se refiere adicionalmente al uso de tal molécula artificial de ácido nucleico en la terapia génica y/o vacunación genética. Adicionalmente, la invención se refiere al uso de un elemento 3'-UTR que comprende una secuencia de ácido nucleico que se deriva de la 3'-UTR de un gen de proteína ribosómica para mejorar, estabilizar y/o prolongar la expresión de proteínas de una secuencia de ácido nucleico que comprende tal elemento 3'-UTR.
MX2020003245A 2013-12-30 2016-06-27 Moleculas artificiales de acido nucleico. MX2020003245A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP2013003946 2013-12-30

Publications (1)

Publication Number Publication Date
MX2020003245A true MX2020003245A (es) 2020-07-20

Family

ID=49920310

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016008551A MX372790B (es) 2013-12-30 2014-12-30 Moleculas artificiales de acido nucleico.
MX2020003245A MX2020003245A (es) 2013-12-30 2016-06-27 Moleculas artificiales de acido nucleico.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2016008551A MX372790B (es) 2013-12-30 2014-12-30 Moleculas artificiales de acido nucleico.

Country Status (13)

Country Link
US (2) US10047375B2 (es)
JP (2) JP6704850B2 (es)
KR (1) KR102399799B1 (es)
CN (2) CN111304231A (es)
AU (1) AU2014375402B2 (es)
BR (1) BR112016014462A2 (es)
CA (1) CA2927862C (es)
DK (1) DK3090053T3 (es)
ES (1) ES2712092T3 (es)
MX (2) MX372790B (es)
RU (1) RU2717986C2 (es)
SG (2) SG11201603144QA (es)
WO (1) WO2015101414A2 (es)

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WO2015062738A1 (en) 2013-11-01 2015-05-07 Curevac Gmbh Modified rna with decreased immunostimulatory properties
SG11201604198YA (en) 2013-12-30 2016-07-28 Curevac Ag Methods for rna analysis
CA2927254C (en) 2013-12-30 2023-10-24 Curevac Ag Artificial nucleic acid molecules
CN111304231A (zh) * 2013-12-30 2020-06-19 库瑞瓦格股份公司 人工核酸分子
CA2935878C (en) 2014-03-12 2023-05-02 Curevac Ag Combination of vaccination and ox40 agonists
US10369216B2 (en) 2014-04-01 2019-08-06 Curevac Ag Polymeric carrier cargo complex for use as an immunostimulating agent or as an adjuvant
PT4023755T (pt) * 2014-12-12 2023-07-05 CureVac SE Moléculas de ácido nucleico artificiais para uma expressão melhorada de proteína

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