MX340997B - Dicetonas e hidroxicetonas como activadores de la trayectoria de señalizacion de catenina. - Google Patents

Dicetonas e hidroxicetonas como activadores de la trayectoria de señalizacion de catenina.

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Publication number
MX340997B
MX340997B MX2013001940A MX2013001940A MX340997B MX 340997 B MX340997 B MX 340997B MX 2013001940 A MX2013001940 A MX 2013001940A MX 2013001940 A MX2013001940 A MX 2013001940A MX 340997 B MX340997 B MX 340997B
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MX
Mexico
Prior art keywords
disease
diseases
diketones
hydroxyketones
bone
Prior art date
Application number
MX2013001940A
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English (en)
Other versions
MX2013001940A (es
Inventor
Kumar Kc Sunil
Mark Wallace David
Hood John
F Barroga Charlene
Original Assignee
Samumed Llc
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Publication date
Application filed by Samumed Llc filed Critical Samumed Llc
Publication of MX2013001940A publication Critical patent/MX2013001940A/es
Publication of MX340997B publication Critical patent/MX340997B/es

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    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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Abstract

La presente invención describe ß-dicetonas, ?-dicetonas o ?-hidroxicetonas o análogos de las mismas, que activan la señalización de Wnt/p-catenina y de esta manera tratan o evitan enfermedades relacionadas con la transducción de señal, tales como osteoporosis y osteoartropatía; osteogénesis imperfecta, defectos óseos, fracturas de hueso, enfermedad periodontal, otosclerosis, sanación de heridas, defectos cráneo-facial, enfermedad ósea oncolítica, daños cerebrales traumáticos relacionados con la diferenciación y desarrollo del sistema nervioso central, que comprende enfermedad de Parkinson, apoplejías, enfermedad cerebral isquémica, epilepsia, enfermedad de Alzheimer, depresión, trastorno bipolar, esquizofrenia; enfermedades del ojo tales como degeneración macular relacionada con la edad, edema macular diabético o retinitis pigmentosa y enfermedades relacionadas con diferenciación y crecimiento de célula madre, que comprende pérdida del cabello, enfermedades relacionadas con hematopoyesis y enfermedades relacionadas con regeneración de tejido.
MX2013001940A 2010-08-18 2011-08-17 Dicetonas e hidroxicetonas como activadores de la trayectoria de señalizacion de catenina. MX340997B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37468710P 2010-08-18 2010-08-18
US201061427974P 2010-12-29 2010-12-29
PCT/US2011/048086 WO2012024404A1 (en) 2010-08-18 2011-08-17 Diketones and hydroxyketones as catenin signaling pathway activators

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MX2013001940A MX2013001940A (es) 2013-06-28
MX340997B true MX340997B (es) 2016-08-03

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MX2016010036A MX354133B (es) 2010-08-18 2011-08-17 Dicetonas e hidroxicetonas como activadores de la trayectoria de señalizacion de catenina.

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HR (2) HRP20180196T1 (es)
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PL (2) PL2605652T3 (es)
PT (2) PT2605652T (es)
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RU (2) RU2592694C2 (es)
SI (2) SI3311666T1 (es)
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Families Citing this family (14)

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Publication number Priority date Publication date Assignee Title
BRPI0914772A2 (pt) 2008-06-25 2015-10-20 Envivo Pharmaceuticals Inc compostos heterocíclicos 1,2-dissubstituídos
CN105125547A (zh) 2009-05-07 2015-12-09 费瑞姆医药有限公司 苯氧基甲基杂环化合物
CN105037355B (zh) 2009-08-10 2017-06-06 萨穆梅德有限公司 Wnt信号传导途径的吲唑抑制剂及其治疗用途
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