MY140442A - A new process for the preparation of epothilone derivatives - Google Patents

A new process for the preparation of epothilone derivatives

Info

Publication number: MY140442A
Authority: MY; Malaysia
Prior art keywords: preparation; epothilone derivatives; new process; unsubstituted; synthesis
Prior art date: 2002-09-13

Application number

MYPI20033494A

Other languages

English (en)

Inventor

Guido Koch

Olivier Loiseleur

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-13

Filing date

2003-09-13

Publication date

2009-12-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9944042&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MY140442(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-09-13 Application filed by Novartis Ag filed Critical Novartis Ag

2009-12-31 Publication of MY140442A publication Critical patent/MY140442A/en

Links

150000003883 epothilone derivatives Chemical class 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 2
238000003786 synthesis reaction Methods 0.000 abstract 2
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical class C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
150000003254 radicals Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Tropical Medicine & Parasitology (AREA)
Neurosurgery (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)

MYPI20033494A 2002-09-13 2003-09-13 A new process for the preparation of epothilone derivatives MY140442A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0221312.2A GB0221312D0 (en)	2002-09-13	2002-09-13	Organic compounds

Publications (1)

Publication Number	Publication Date
MY140442A true MY140442A (en)	2009-12-31

Family

ID=9944042

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MYPI20033494A MY140442A (en)	2002-09-13	2003-09-13	A new process for the preparation of epothilone derivatives

Country Status (29)

Country	Link
US (1)	US7470792B2 (de)
EP (1)	EP1539768B1 (de)
JP (1)	JP4628102B2 (de)
KR (1)	KR20050042500A (de)
CN (1)	CN100522968C (de)
AR (1)	AR041231A1 (de)
AT (1)	ATE373663T1 (de)
AU (2)	AU2003267349B2 (de)
BR (1)	BR0314263A (de)
CA (1)	CA2497119C (de)
CY (1)	CY1107794T1 (de)
DE (1)	DE60316456T2 (de)
DK (1)	DK1539768T3 (de)
EC (1)	ECSP055652A (de)
ES (1)	ES2290489T3 (de)
GB (1)	GB0221312D0 (de)
IL (1)	IL166829A (de)
MX (1)	MXPA05002785A (de)
MY (1)	MY140442A (de)
NO (1)	NO20051794L (de)
NZ (1)	NZ538612A (de)
PE (1)	PE20050052A1 (de)
PL (1)	PL375039A1 (de)
PT (1)	PT1539768E (de)
RU (2)	RU2404985C2 (de)
SG (1)	SG155770A1 (de)
TW (1)	TWI289563B (de)
WO (1)	WO2004024735A2 (de)
ZA (1)	ZA200501008B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4579351B2 (ja)	1996-12-03	2010-11-10	スローン−ケッタリングインスティトュートフォアキャンサーリサーチ	エポチロンの合成とその中間体及びその類似物並びにその使用
PT1506203E (pt)	2002-08-23	2007-04-30	Sloan Kettering Inst Cancer	Síntese de epotilonas, seus intermediários, seus análogos e suas utilizações
US6921769B2 (en)	2002-08-23	2005-07-26	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
US7649006B2 (en)	2002-08-23	2010-01-19	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
CA2799202C (en)	2010-05-18	2016-07-05	Cerulean Pharma Inc.	Compositions and methods for treatment of autoimmune and other diseases

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0923583A1 (de) *	1996-08-30	1999-06-23	Novartis AG	Verfahren zur herstellung von epothilonen und zwischenprodukte innerhalb des verfahrens
US6441186B1 (en) *	1996-12-13	2002-08-27	The Scripps Research Institute	Epothilone analogs
US6380394B1 (en) *	1996-12-13	2002-04-30	The Scripps Research Institute	Epothilone analogs
DE19880193D2 (de) *	1997-02-25	2000-08-24	Biotechnolog Forschung Gmbh	Seitenkettenmodifizierte Epothilone
US6498257B1 (en) *	1998-04-21	2002-12-24	Bristol-Myers Squibb Company	2,3-olefinic epothilone derivatives
GB9810659D0 (en) *	1998-05-18	1998-07-15	Ciba Geigy Ag	Organic compounds
BR9916833A (pt) *	1998-12-22	2001-09-25	Novartis Ag	Derivados de epotilona e seu uso como agentes antitumor
EP1226142A2 (de) *	1999-07-22	2002-07-31	Schering Aktiengesellschaft	Verfahren zur herstellung von epothiolon-b und derivaten davon, sowie von zwischenprodukten für dieses verfahren
US6593115B2 (en) *	2000-03-24	2003-07-15	Bristol-Myers Squibb Co.	Preparation of epothilone intermediates
JP2005500974A (ja) *	2000-10-13	2005-01-13	ザユニバーシテイオブミシシッピー	エポシロン類及び関連類似体の合成
WO2004012735A2 (en) *	2002-07-31	2004-02-12	Schering Ag	New effector conjugates, process for their production and their pharmaceutical use

2002
- 2002-09-13 GB GBGB0221312.2A patent/GB0221312D0/en not_active Ceased
2003
- 2003-09-11 PE PE2003000922A patent/PE20050052A1/es not_active Application Discontinuation
- 2003-09-11 AR ARP030103290A patent/AR041231A1/es active IP Right Grant
- 2003-09-12 DK DK03748015T patent/DK1539768T3/da active
- 2003-09-12 RU RU2008129613/04A patent/RU2404985C2/ru not_active IP Right Cessation
- 2003-09-12 KR KR1020057004237A patent/KR20050042500A/ko not_active Ceased
- 2003-09-12 AU AU2003267349A patent/AU2003267349B2/en not_active Ceased
- 2003-09-12 EP EP03748015A patent/EP1539768B1/de not_active Expired - Lifetime
- 2003-09-12 JP JP2004535499A patent/JP4628102B2/ja not_active Expired - Fee Related
- 2003-09-12 NZ NZ538612A patent/NZ538612A/en not_active IP Right Cessation
- 2003-09-12 CA CA2497119A patent/CA2497119C/en not_active Expired - Fee Related
- 2003-09-12 PT PT03748015T patent/PT1539768E/pt unknown
- 2003-09-12 CN CNB038215837A patent/CN100522968C/zh not_active Expired - Fee Related
- 2003-09-12 PL PL03375039A patent/PL375039A1/xx not_active Application Discontinuation
- 2003-09-12 AT AT03748015T patent/ATE373663T1/de active
- 2003-09-12 TW TW092125250A patent/TWI289563B/zh not_active IP Right Cessation
- 2003-09-12 DE DE60316456T patent/DE60316456T2/de not_active Expired - Lifetime
- 2003-09-12 ES ES03748015T patent/ES2290489T3/es not_active Expired - Lifetime
- 2003-09-12 RU RU2005110925/04A patent/RU2343155C2/ru not_active IP Right Cessation
- 2003-09-12 US US10/526,283 patent/US7470792B2/en not_active Expired - Fee Related
- 2003-09-12 MX MXPA05002785A patent/MXPA05002785A/es active IP Right Grant
- 2003-09-12 BR BR0314263-9A patent/BR0314263A/pt not_active IP Right Cessation
- 2003-09-12 SG SG200701814-6A patent/SG155770A1/en unknown
- 2003-09-12 WO PCT/EP2003/010171 patent/WO2004024735A2/en not_active Ceased
- 2003-09-13 MY MYPI20033494A patent/MY140442A/en unknown
2005
- 2005-02-03 ZA ZA200501008A patent/ZA200501008B/xx unknown
- 2005-02-10 IL IL166829A patent/IL166829A/en not_active IP Right Cessation
- 2005-03-09 EC EC2005005652A patent/ECSP055652A/es unknown
- 2005-04-12 NO NO20051794A patent/NO20051794L/no not_active Application Discontinuation
2007
- 2007-11-08 CY CY20071101447T patent/CY1107794T1/el unknown
2008
- 2008-08-01 AU AU2008203451A patent/AU2008203451A1/en not_active Abandoned

Also Published As

Publication number	Publication date
RU2008129613A (ru)	2010-01-27
JP4628102B2 (ja)	2011-02-09
CN1681824A (zh)	2005-10-12
DK1539768T3 (da)	2008-01-07
CN100522968C (zh)	2009-08-05
ES2290489T3 (es)	2008-02-16
RU2343155C2 (ru)	2009-01-10
GB0221312D0 (en)	2002-10-23
US20060106073A1 (en)	2006-05-18
AU2003267349B2 (en)	2008-05-01
US7470792B2 (en)	2008-12-30
NO20051794D0 (no)	2005-04-12
HK1078853A1 (en)	2006-03-24
DE60316456T2 (de)	2008-06-19
PE20050052A1 (es)	2005-03-28
NZ538612A (en)	2008-01-31
KR20050042500A (ko)	2005-05-09
ECSP055652A (es)	2005-05-30
RU2404985C2 (ru)	2010-11-27
JP2006511469A (ja)	2006-04-06
ZA200501008B (en)	2006-12-27
EP1539768B1 (de)	2007-09-19
TWI289563B (en)	2007-11-11
AU2003267349A1 (en)	2004-04-30
AR041231A1 (es)	2005-05-11
EP1539768A2 (de)	2005-06-15
CA2497119C (en)	2011-08-02
PT1539768E (pt)	2007-12-17
CY1107794T1 (el)	2013-06-19
WO2004024735A2 (en)	2004-03-25
NO20051794L (no)	2005-04-12
TW200413388A (en)	2004-08-01
WO2004024735A3 (en)	2004-07-22
RU2005110925A (ru)	2006-01-20
SG155770A1 (en)	2009-10-29
ATE373663T1 (de)	2007-10-15
CA2497119A1 (en)	2004-03-25
MXPA05002785A (es)	2005-06-03
PL375039A1 (en)	2005-11-14
AU2008203451A1 (en)	2008-08-21
DE60316456D1 (de)	2007-10-31
IL166829A (en)	2011-01-31
BR0314263A (pt)	2005-07-05

Publication	Publication Date	Title
CO5611127A2 (es)	2006-02-28	Derivados de indolilmaleimida
TW200510441A (en)	2005-03-16	Novel compounds
ATE353870T1 (de)	2007-03-15	Dibenzylaminverbindung und deren medizinische verwendung
AR047339A1 (es)	2006-01-18	Derivados de difenilazetidona.proceso de obtencion.
HUP0401649A2 (hu)	2004-11-29	Benzoxazin-, benzotiazinszármazékok és gyógyszerkészítményeik
NO20071112L (no)	2007-02-27	Nye heterosykliske karboksylsyreamidderivater
WO2002064567A3 (en)	2003-11-06	Substituted carboxamides as inhibitors of factor xa
ATE268751T1 (de)	2004-06-15	Biphenylamidin-derivate
MY140442A (en)	2009-12-31	A new process for the preparation of epothilone derivatives
EA200000484A1 (ru)	2000-10-30	Способ получения производных тиазолидиндиона
SE9703379D0 (sv)	1997-09-18	New compounds
TW200510361A (en)	2005-03-16	Process of preparating 3-acylaminobenzofuran-2-carboxylic acid derivatives
HU0100146D0 (en)	2001-03-28	3-(1-hydroxy-pentylidene)-5-nitro-3h-benzofuran-2-one, process for the preparation thereof and use thereof
DK1559714T3 (da)	2008-03-25	Fremgangsmåde til fremstilling af 2-alkyl-3-aminothiophenderivater og 3-aminothiophenderivater
YU74201A (sh)	2004-05-12	Nova sinteza prstena piperazina
AU1589695A (en)	1995-08-21	Bicyclic amino group-substituted pyridonecarboxylic acid derivatives, esters thereof and salts thereof, and bicyclic amines useful as intermediates thereof
FI955933A0 (fi)	1995-12-11	Abeo-ergoliinijohdannaiset 5HT1A-ligandeina
JPS6479155A (en)	1989-03-24	Diphenylpyridine compound
AU7332996A (en)	1997-05-07	Therapeutics for thrombocytopenia
AU2639999A (en)	1999-09-15	Intermediate compounds in the synthesis of the a ring moiety of 2-substituted vitamin d derivatives
EP1403252A4 (de)	2004-10-13	Neue butadienderivate, verfahren zu deren herstellung und zwischenprodukte zu deren synthese
DE60124831D1 (de)	2007-01-11	Ein verfahren zur herstellung substituierter alkylamin-derivate
AU7313300A (en)	2001-04-17	Process for the preparation of oxazole derivatives