NL1003283C2 - Modificatie van een polypeptide voor het vergroten van de elektro- transport-flux en toepassing daarvan als geneesmiddel. - Google Patents

Modificatie van een polypeptide voor het vergroten van de elektro- transport-flux en toepassing daarvan als geneesmiddel. Download PDF

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Publication number
NL1003283C2
NL1003283C2 NL1003283A NL1003283A NL1003283C2 NL 1003283 C2 NL1003283 C2 NL 1003283C2 NL 1003283 A NL1003283 A NL 1003283A NL 1003283 A NL1003283 A NL 1003283A NL 1003283 C2 NL1003283 C2 NL 1003283C2
Authority
NL
Netherlands
Prior art keywords
analog
polypeptide
gin
electrotransport
ala
Prior art date
Application number
NL1003283A
Other languages
English (en)
Dutch (nl)
Other versions
NL1003283A1 (nl
Inventor
Allen Holladay Leslie
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of NL1003283A1 publication Critical patent/NL1003283A1/xx
Application granted granted Critical
Publication of NL1003283C2 publication Critical patent/NL1003283C2/nl

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/53Colony-stimulating factor [CSF]
    • C07K14/535Granulocyte CSF; Granulocyte-macrophage CSF
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/60Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/635Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
  • Electrotherapy Devices (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
NL1003283A 1995-06-06 1996-06-06 Modificatie van een polypeptide voor het vergroten van de elektro- transport-flux en toepassing daarvan als geneesmiddel. NL1003283C2 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46661095A 1995-06-06 1995-06-06
US46661095 1995-06-06

Publications (2)

Publication Number Publication Date
NL1003283A1 NL1003283A1 (nl) 1996-12-09
NL1003283C2 true NL1003283C2 (nl) 1997-05-02

Family

ID=23852435

Family Applications (1)

Application Number Title Priority Date Filing Date
NL1003283A NL1003283C2 (nl) 1995-06-06 1996-06-06 Modificatie van een polypeptide voor het vergroten van de elektro- transport-flux en toepassing daarvan als geneesmiddel.

Country Status (12)

Country Link
US (2) US7324846B2 (fr)
JP (2) JP4354529B2 (fr)
AU (1) AU6590396A (fr)
BE (1) BE1009704A3 (fr)
BR (1) BR9609149A (fr)
CA (1) CA2220146A1 (fr)
DE (1) DE19681439T1 (fr)
FR (1) FR2735132B1 (fr)
GB (1) GB2317179B (fr)
IT (1) IT1285405B1 (fr)
NL (1) NL1003283C2 (fr)
WO (1) WO1996039422A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1285405B1 (it) * 1995-06-06 1998-06-03 Alza Corp Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto.
EP1222930B1 (fr) 1999-10-14 2006-11-02 Pola Chemical Industries Inc. Compositions d'electroporation
MXPA03002045A (es) * 2000-09-08 2003-07-24 Amgen Inc Composiciones analogas de factor estimulador de colonias de granulocitos y metodos para su elaboracion.
AU2003278766A1 (en) * 2002-09-04 2004-03-29 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
KR20050071498A (ko) * 2002-09-18 2005-07-07 상트르 오스피딸리에 드 루니버시떼 드 몬트리알 성장 호르몬 방출 호르몬 유사체
WO2006081279A2 (fr) 2005-01-25 2006-08-03 Microchips, Inc. Regulation de la liberation de medicament par la modification transitoire de microenvironnements locaux
EP2542574B1 (fr) 2010-03-04 2017-08-09 Pfenex Inc. Procédé pour la production de la protéine interféron recombinante soluble sans dénaturation
AU2011235210B2 (en) 2010-04-01 2015-07-16 Pfenex Inc. Methods for G-CSF production in a Pseudomonas host cell
KR102143482B1 (ko) 2011-11-30 2020-08-11 쓰리엠 이노베이티브 프로퍼티즈 컴파니 펩티드 치료제 및 아미노산을 포함하는 마이크로니들 장치, 이의 제조 및 사용 방법
ES3055185T3 (en) 2014-03-28 2026-02-10 Univ Duke Treatment of an estrogen receptor positive breast cancer using a selective estrogen receptor modulator
KR20250152679A (ko) 2015-04-29 2025-10-23 래디어스 파마슈티컬스, 인코포레이티드 암을 치료하는 방법
JP7481115B2 (ja) 2017-01-05 2024-05-10 ラジウス ファーマシューティカルズ,インコーポレイテッド Rad1901-2hclの多形性形態
MX2020013713A (es) 2018-07-04 2021-03-02 Radius Pharmaceuticals Inc Formas polimorficas de rad1901-2hcl.
EP3924328A1 (fr) 2019-02-12 2021-12-22 Radius Pharmaceuticals, Inc. Procédés et composés

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4628043A (en) * 1983-04-26 1986-12-09 The Salk Institute For Biological Studies Hypothalamic GRF agonists
WO1993025197A1 (fr) * 1992-06-12 1993-12-23 Affymax Technologies N.V. Compositions et procedes destines a ameliorer la liberation et l'acheminement de medicaments
EP0643981A1 (fr) * 1993-09-22 1995-03-22 Takeda Chemical Industries, Ltd. Electrode concrétée pour iontophorèse
WO1995011988A1 (fr) * 1993-10-25 1995-05-04 Affymax Technologies N.V. Composes a activite de parathormone et vecteurs d'adn recombine les codant
EP0667355A1 (fr) * 1994-02-10 1995-08-16 Hoechst Aktiengesellschaft Dérivé de l'hirudine et leur méthode de fabrication

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4250878A (en) 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
US4431739A (en) 1979-11-05 1984-02-14 Genentech, Inc. Transformant bacterial culture capable of expressing heterologous protein
US4383529A (en) 1980-11-03 1983-05-17 Wescor, Inc. Iontophoretic electrode device, method and gel insert
US4528190A (en) * 1983-10-25 1985-07-09 The Salk Institute For Biological Studies GRF Analogs IV
US4631211A (en) 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US4722726A (en) 1986-02-12 1988-02-02 Key Pharmaceuticals, Inc. Method and apparatus for iontophoretic drug delivery
US5250022A (en) 1990-09-25 1993-10-05 Rutgers, The State University Of New Jersey Iontotherapeutic devices, reservoir electrode devices therefore, process and unit dose
AU609769B2 (en) 1987-02-10 1991-05-09 Drug Delivery Systems Inc. Electrolytic transdermal delivery of proteins
US5013653A (en) 1987-03-20 1991-05-07 Creative Biomolecules, Inc. Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
EP0429842B1 (fr) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Dispositif d'administration transcutanée de médicaments à base de protéine ou de peptide
GB9107846D0 (en) * 1990-04-30 1991-05-29 Ici Plc Polypeptides
DK10191D0 (da) 1991-01-22 1991-01-22 Novo Nordisk As Hidtil ukendte peptider
CA2087087C (fr) 1992-01-22 2000-07-18 Burton H. Sage, Jr. Molecules pour administration par ionophorese
DK0676973T3 (da) * 1992-12-31 1998-03-02 Alza Corp Elektrotransportsystem med bøjeligt organ
DE69430575T2 (de) * 1993-06-08 2002-10-02 Hisamitsu Pharmaceutical Co., Inc. Iontophoretisches system
IT1285405B1 (it) * 1995-06-06 1998-06-03 Alza Corp Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4628043A (en) * 1983-04-26 1986-12-09 The Salk Institute For Biological Studies Hypothalamic GRF agonists
WO1993025197A1 (fr) * 1992-06-12 1993-12-23 Affymax Technologies N.V. Compositions et procedes destines a ameliorer la liberation et l'acheminement de medicaments
EP0643981A1 (fr) * 1993-09-22 1995-03-22 Takeda Chemical Industries, Ltd. Electrode concrétée pour iontophorèse
WO1995011988A1 (fr) * 1993-10-25 1995-05-04 Affymax Technologies N.V. Composes a activite de parathormone et vecteurs d'adn recombine les codant
EP0667355A1 (fr) * 1994-02-10 1995-08-16 Hoechst Aktiengesellschaft Dérivé de l'hirudine et leur méthode de fabrication

Also Published As

Publication number Publication date
JPH11507341A (ja) 1999-06-29
GB2317179B (en) 1999-07-28
CA2220146A1 (fr) 1996-12-12
US7324846B2 (en) 2008-01-29
FR2735132A1 (fr) 1996-12-13
US20090275877A1 (en) 2009-11-05
US20020107505A1 (en) 2002-08-08
BE1009704A3 (fr) 1997-07-01
ITTO960496A1 (it) 1997-12-05
FR2735132B1 (fr) 1998-04-24
JP2009149639A (ja) 2009-07-09
ITTO960496A0 (it) 1996-06-05
DE19681439T1 (de) 1998-07-23
GB2317179A (en) 1998-03-18
IT1285405B1 (it) 1998-06-03
WO1996039422A2 (fr) 1996-12-12
JP4354529B2 (ja) 2009-10-28
IE960413A1 (en) 1996-12-11
BR9609149A (pt) 1999-02-23
WO1996039422A3 (fr) 1997-03-06
AU6590396A (en) 1996-12-24
NL1003283A1 (nl) 1996-12-09
GB9725981D0 (en) 1998-02-04

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