NL194332C - Werkwijze ter bereiding van L-5-(2-hydroxypropionylamino)-2,4,6- trijoodisoftaalzuur-bis-(1,3-dihydroxypropylamide). - Google Patents

Werkwijze ter bereiding van L-5-(2-hydroxypropionylamino)-2,4,6- trijoodisoftaalzuur-bis-(1,3-dihydroxypropylamide). Download PDF

Info

Publication number
NL194332C
NL194332C NL9500415A NL9500415A NL194332C NL 194332 C NL194332 C NL 194332C NL 9500415 A NL9500415 A NL 9500415A NL 9500415 A NL9500415 A NL 9500415A NL 194332 C NL194332 C NL 194332C
Authority
NL
Netherlands
Prior art keywords
solution
acid
column
resin
ira
Prior art date
Application number
NL9500415A
Other languages
English (en)
Dutch (nl)
Other versions
NL194332B (nl
NL9500415A (nl
Inventor
Vincenzo Cannata
Valeriano Merli
Claudio Dal Santo
Original Assignee
Bracco Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Int Bv filed Critical Bracco Int Bv
Publication of NL9500415A publication Critical patent/NL9500415A/nl
Publication of NL194332B publication Critical patent/NL194332B/xx
Application granted granted Critical
Publication of NL194332C publication Critical patent/NL194332C/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
NL9500415A 1994-03-03 1995-03-02 Werkwijze ter bereiding van L-5-(2-hydroxypropionylamino)-2,4,6- trijoodisoftaalzuur-bis-(1,3-dihydroxypropylamide). NL194332C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI940378A IT1274027B (it) 1994-03-03 1994-03-03 Processo per la preparazione e purificazione di mezzi di contrasto iodurati
ITMI940378 1994-03-03

Publications (3)

Publication Number Publication Date
NL9500415A NL9500415A (nl) 1995-10-02
NL194332B NL194332B (nl) 2001-09-03
NL194332C true NL194332C (nl) 2002-01-04

Family

ID=11368040

Family Applications (1)

Application Number Title Priority Date Filing Date
NL9500415A NL194332C (nl) 1994-03-03 1995-03-02 Werkwijze ter bereiding van L-5-(2-hydroxypropionylamino)-2,4,6- trijoodisoftaalzuur-bis-(1,3-dihydroxypropylamide).

Country Status (22)

Country Link
US (1) US5550287A (de)
JP (1) JP4143136B2 (de)
AT (1) AT405052B (de)
BE (1) BE1007938A3 (de)
CA (1) CA2143805C (de)
CH (1) CH689296A5 (de)
CZ (1) CZ287640B6 (de)
DE (1) DE19507294B4 (de)
DK (1) DK171530B1 (de)
ES (1) ES2105961B1 (de)
FI (1) FI950977L (de)
FR (1) FR2716881B1 (de)
GB (1) GB2287024B (de)
HU (1) HU216330B (de)
IE (1) IE950154A1 (de)
IL (1) IL112718A (de)
IT (1) IT1274027B (de)
NL (1) NL194332C (de)
NO (1) NO304112B1 (de)
PT (1) PT101665B (de)
SE (1) SE510124C2 (de)
ZA (1) ZA951748B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2929236A (en) * 1955-03-29 1960-03-22 Steward Construction Company Building wall construction
PT773925E (pt) * 1995-05-23 2000-05-31 Fructamine Spa Processo para a preparacao de um dicloreto de um acido dicarboxilico
PT101720A (pt) * 1995-06-08 1997-01-31 Hovione Sociedade Quimica S A Processo para a purificacao e cristalizacao de iopamidol
AU7707096A (en) * 1995-12-01 1997-06-27 Mallinckrodt Medical Imaging-Ireland Reversed phase chromatographic process
IT1283319B1 (it) * 1996-03-29 1998-04-16 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1289519B1 (it) * 1996-12-24 1998-10-15 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1292127B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la dissalazione di sostanze instabili a ph acidi
DE19736472C1 (de) * 1997-08-21 1999-04-22 Bernhard Dr Sixt Verfahren zum Herstellen von weitgehend nebenwirkungsfreien Kontrastmitteln
US6265610B1 (en) 1999-01-12 2001-07-24 The University Of North Carolina At Chapel Hill Contrast media for angiography
US6803485B2 (en) * 1999-02-26 2004-10-12 Bracco Imaging S.P.A. Process for the preparation of iopamidol
TWI288654B (en) * 2001-05-17 2007-10-21 Ind Tech Res Inst Process for the purification of water-soluble non-ionic contrast agents
US20110017673A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Endotoxin removal in contrast media
IT1403988B1 (it) * 2010-07-15 2013-11-08 Bracco Imaging Spa Processo per la preparazione di agenti di contrasto.
CN105705483B (zh) 2013-11-05 2018-09-04 伯拉考成像股份公司 碘帕醇的制备方法
CN115403481A (zh) * 2022-04-13 2022-11-29 江苏宇田医药有限公司 一种通过离子交换树脂纯化碘海醇的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4956989A (de) * 1972-10-09 1974-06-03
CH608189A5 (de) * 1974-12-13 1978-12-29 Savac Ag
IT1193211B (it) * 1979-08-09 1988-06-15 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
CA1327600C (en) * 1987-05-22 1994-03-08 Ernest Felder Process for the preparation of 5-acylamino-2,4,6- triiodo-or tribromo-benzoic acid derivatives and corresponding novel 5-acylamino-2,4,6-triiodo or tribromo-benzoic acid derivatives obtained by said process
JPH03244380A (ja) * 1990-02-23 1991-10-31 Asahi Chem Ind Co Ltd 精製酵素およびその製造方法
US5019371A (en) * 1990-11-21 1991-05-28 Mallinckrodt Medical, Inc. Novel x-ray contrast agents, compositions and methods
IT1248741B (it) * 1991-02-26 1995-01-26 Bracco Spa Processo di concentrazione e di purificazione di composti organici
IT1254991B (it) * 1992-06-24 1995-10-11 Chemi Spa Procedimento per la preparazione di glicerofosfolipidi
DE10204861B4 (de) * 2002-02-06 2004-01-29 Wacker Construction Equipment Ag Luftfederschlagwerk mit elektrodynamisch bewegtem Antriebskolben

Also Published As

Publication number Publication date
DE19507294A1 (de) 1995-09-07
NL194332B (nl) 2001-09-03
HU216330B (hu) 1999-06-28
FI950977A7 (fi) 1995-09-04
DK21795A (da) 1995-09-04
PT101665A (pt) 1995-09-12
SE510124C2 (sv) 1999-04-19
SE9500752D0 (sv) 1995-03-02
FI950977L (fi) 1995-09-04
AT405052B (de) 1999-05-25
FR2716881A1 (fr) 1995-09-08
FR2716881B1 (fr) 1996-08-02
PT101665B (pt) 1999-01-29
GB9503893D0 (en) 1995-04-19
DK171530B1 (da) 1996-12-23
IL112718A (en) 1999-05-09
IT1274027B (it) 1997-07-14
IE950154A1 (en) 1995-09-06
HU9500645D0 (en) 1995-04-28
ITMI940378A1 (it) 1995-09-04
DE19507294B4 (de) 2005-12-15
ES2105961A1 (es) 1997-10-16
NO950814D0 (no) 1995-03-02
NO950814L (no) 1995-09-04
ZA951748B (en) 1995-12-08
BE1007938A3 (fr) 1995-11-21
CH689296A5 (it) 1999-02-15
HUT70401A (en) 1995-10-30
IL112718A0 (en) 1995-05-26
ATA36995A (de) 1998-09-15
GB2287024A (en) 1995-09-06
NO304112B1 (no) 1998-10-26
ITMI940378A0 (it) 1994-03-03
GB2287024B (en) 1998-07-08
NL9500415A (nl) 1995-10-02
JP4143136B2 (ja) 2008-09-03
CA2143805A1 (en) 1995-09-04
ES2105961B1 (es) 1998-07-01
FI950977A0 (fi) 1995-03-02
US5550287A (en) 1996-08-27
SE9500752L (sv) 1995-09-04
CZ56295A3 (en) 1995-11-15
JPH07278081A (ja) 1995-10-24
CZ287640B6 (en) 2001-01-17
CA2143805C (en) 2004-12-28

Similar Documents

Publication Publication Date Title
NL194332C (nl) Werkwijze ter bereiding van L-5-(2-hydroxypropionylamino)-2,4,6- trijoodisoftaalzuur-bis-(1,3-dihydroxypropylamide).
JP5775524B2 (ja) イオジキサノールの調製及び精製
US20090112022A1 (en) Preparation of iodixanol
DE60011396T2 (de) Verfahren zur herstellung von iopamidol
JP4018751B2 (ja) イオパミドールの調製中の中間体の精製方法
US5817861A (en) Process for the preparation of an intermediate useful in the synthesis of iodinated contrast media
EP0883597B1 (de) Verfahren zur reinigung eines aminoalkohols
CZ285258B6 (cs) Způsob čištění a krystalizace Iopamidolu
EP0973723B1 (de) Verfahren zur herstellung eines aminoalkohol
NL194271C (nl) Werkwijze voor de bereiding van de verbinding L-5-(2-acetoxy-propionylamino)-2,4,6-trijood-isoftaalzuur-bis-(1,3- -dihydropropylamide).
JPS6216497A (ja) シチジン―５′―ジリン酸コリン１水和物結晶の製造法

Legal Events

Date Code Title Description
BB A search report has been drawn up
BC A request for examination has been filed
CNR Transfer of rights (patent application after its laying open for public inspection)

Free format text: BRACCO INTERNATIONAL B.V.

SNR Assignments of patents or rights arising from examined patent applications

Owner name: BRACCO IMAGING S.P.A.

V4 Discontinued because of reaching the maximum lifetime of a patent

Effective date: 20150302