NL7706051A - Werkwijze ter bereiding van een farmaceutisch preparaat. - Google Patents

Werkwijze ter bereiding van een farmaceutisch preparaat.

Info

Publication number
NL7706051A
NL7706051A NL7706051A NL7706051A NL7706051A NL 7706051 A NL7706051 A NL 7706051A NL 7706051 A NL7706051 A NL 7706051A NL 7706051 A NL7706051 A NL 7706051A NL 7706051 A NL7706051 A NL 7706051A
Authority
NL
Netherlands
Prior art keywords
preparing
pharmaceutical preparation
pharmaceutical
preparation
Prior art date
Application number
NL7706051A
Other languages
English (en)
Dutch (nl)
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of NL7706051A publication Critical patent/NL7706051A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
NL7706051A 1976-06-03 1977-06-02 Werkwijze ter bereiding van een farmaceutisch preparaat. NL7706051A (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/692,589 US4065573A (en) 1976-06-03 1976-06-03 4-Amino-4-phenylcyclohexanone ketal compositions and process of use

Publications (1)

Publication Number Publication Date
NL7706051A true NL7706051A (nl) 1977-12-06

Family

ID=24781200

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7706051A NL7706051A (nl) 1976-06-03 1977-06-02 Werkwijze ter bereiding van een farmaceutisch preparaat.

Country Status (13)

Country Link
US (1) US4065573A (fr)
JP (1) JPS5318546A (fr)
AU (1) AU511781B2 (fr)
BE (1) BE855405A (fr)
CA (1) CA1093553A (fr)
CH (6) CH641177A5 (fr)
DE (1) DE2723937A1 (fr)
ES (1) ES459429A1 (fr)
FR (1) FR2354992A1 (fr)
GB (2) GB1561206A (fr)
IL (1) IL52131A (fr)
NL (1) NL7706051A (fr)
ZA (1) ZA772819B (fr)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4180584A (en) * 1976-06-03 1979-12-25 The Upjohn Company 4-Pyrrolidino-cyclohexanone ketals
US4460604A (en) * 1976-06-03 1984-07-17 The Upjohn Company 4-Amino-4-aryl-cyclohexanones
US4115589A (en) * 1977-05-17 1978-09-19 The Upjohn Company Compounds, compositions and method of use
US4212878A (en) * 1978-01-26 1980-07-15 The Upjohn Company Phenylacetamide derivative analgesics
US4260606A (en) * 1979-07-19 1981-04-07 A. H. Robins Company, Inc. 3-Methyleneazetidine derivatives
US4346101A (en) * 1980-12-08 1982-08-24 The Upjohn Company Benzamide derivative analgesics
US4466977A (en) * 1981-04-09 1984-08-21 The Upjohn Company N-[2-Amino(oxy- or thia- group-substituted-cycloaliphatic)]benzeneacetamides and -benzamide analgesics
US4360531A (en) * 1981-04-09 1982-11-23 The Upjohn Company Substituted cycloalkanes
US4359476A (en) * 1981-04-09 1982-11-16 The Upjohn Company Adjacently substituted cycloalkane-amide analgesics
US4460600A (en) * 1981-04-09 1984-07-17 The Upjohn Company Adjacently substituted ketal derivatives of cycloalkane-amide analgesics
US4438130A (en) 1981-11-12 1984-03-20 The Upjohn Company Analgesic 1-oxa-, aza- and thia-spirocyclic compounds
US4508911A (en) * 1982-06-21 1985-04-02 The Upjohn Company Amine intermediates for analgesic compounds
US4598088A (en) * 1983-05-18 1986-07-01 The Upjohn Company 2-pyrrolyl-cycloalkyl-amide analgesics
ZA842753B (en) * 1983-05-18 1984-11-28 Upjohn Co 2-dihydropyrrolyl-cycloalkyl-amide analgesics
US4560767A (en) * 1983-06-17 1985-12-24 The Upjohn Company N-(2-amino-cycloalkenyl)benzeneacetamide and -benzamide analgesics and tritiated kappa agonists therefrom
US4588591A (en) * 1984-05-25 1986-05-13 The Upjohn Company Analgesic 2-oxa-spirocyclic compounds
US4632935A (en) * 1984-05-30 1986-12-30 The Upjohn Company Omega-(hydroxy-, ether and ester)-alkyl-2-amino-cycloalkyl- and cycloalkenyl amides as analgesics
US4737493A (en) * 1985-07-01 1988-04-12 Warner-Lambert Company 7-((substituted)amino)-8-((substituted)carbonyl)-methylamino)-1-oxaspiro(4,5)decanes as analgesic agents
US5985880A (en) * 1996-06-05 1999-11-16 Delta Pharmaceuticals Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
GR920100520A (el) * 1992-11-26 1994-07-29 Smithkline Beecham Corp Ενώσεις.
GR920100521A (el) * 1992-11-26 1994-07-29 Smithkline Beecham Corp Ενώσεις.
GR920100523A (el) * 1992-11-26 1994-07-29 Smithkline Beecham Corp Ενώσεις.
DE9320479U1 (de) * 1993-06-25 1994-08-25 Claas Saulgau Gmbh, 88348 Saulgau Frei schwenkbare Nachlaufräder für landwirtschaftliche Arbeitsmaschinen, insbesondere Kreiselheumaschinen
US6013827A (en) * 1994-03-11 2000-01-11 Smithkline Beecham Corporation Compounds
US5646151A (en) * 1996-03-08 1997-07-08 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5688955A (en) * 1996-03-08 1997-11-18 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
USRE38133E1 (en) * 1996-03-08 2003-06-03 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5763445A (en) * 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6057323A (en) * 1996-03-08 2000-05-02 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6750216B2 (en) * 1996-03-08 2004-06-15 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US6303611B1 (en) 1996-03-08 2001-10-16 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
GB0012240D0 (en) * 2000-05-19 2000-07-12 Merck Sharp & Dohme Therapeutic agents
JP4735915B2 (ja) * 2001-03-30 2011-07-27 Ｄｉｃ株式会社 ジオンモノアセタール類の製造方法
DE10123163A1 (de) * 2001-05-09 2003-01-16 Gruenenthal Gmbh Substituierte Cyclohexan-1,4-diaminderivate
PE20030320A1 (es) * 2001-07-17 2003-04-03 Gruenenthal Chemie Derivados sustituidos de 4-aminociclohexanol
US6852713B2 (en) * 2003-04-16 2005-02-08 Adolor Corporation Lactam derivatives and methods of their use
US6992193B2 (en) 2003-06-10 2006-01-31 Adolor Corporation Sulfonylamino phenylacetamide derivatives and methods of their use
US7034051B2 (en) * 2003-08-28 2006-04-25 Adolor Corporation Fused bicyclic carboxamide derivatives and methods of their use
US7160902B2 (en) * 2003-11-14 2007-01-09 Adolor Corporation Amide derivatives and methods of their use
US20070203111A1 (en) * 2006-01-06 2007-08-30 Sepracor Inc. Cycloalkylamines as monoamine reuptake inhibitors
DE102006033114A1 (de) 2006-07-18 2008-01-24 Grünenthal GmbH Spirocyclische Azaindol-Derivate
JP5529843B2 (ja) 2008-03-27 2014-06-25 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 置換シクロヘキシルジアミン
EP2280941B1 (fr) * 2008-03-27 2015-05-06 Grünenthal GmbH Dérivés de (hétéro-)aryl-cyclohexane
ES2464102T3 (es) 2008-03-27 2014-05-30 Grünenthal GmbH Derivados de 4-aminociclohexano sustituidos
ES2375543T3 (es) * 2008-03-27 2012-03-01 Grünenthal GmbH Derivados de espiro(5.5)undecano.
CN102046591B (zh) * 2008-03-27 2014-12-03 格吕伦塔尔有限公司 羟甲基环己胺
AU2009228647B2 (en) * 2008-03-27 2013-07-04 Grunenthal Gmbh Substituted spirocyclic cyclohexane derivatives
RU2421213C1 (ru) * 2010-02-24 2011-06-20 Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) Применение 2-гидрокси-3-метил-6-(1-метилэтенил)циклогекс-3-енона в качестве анальгезирующего средства
US8602341B2 (en) * 2010-11-24 2013-12-10 Lincoln Global, Inc. Multi-spool adapter
CN115190815B (zh) 2019-12-26 2024-06-18 吉尔伽美什制药公司 芳基环己基胺衍生物及其在精神障碍的治疗中的用途
KR20230124103A (ko) 2020-02-18 2023-08-24 길가메쉬 파마슈티컬스, 인코포레이티드 기분 장애 치료에 사용되기 위한 특이적 트립타민
US12129234B1 (en) 2023-08-03 2024-10-29 Gilgamesh Pharmaceuticals, Inc. Crystalline salts of N-ethyl-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine
US12157722B1 (en) 2023-08-03 2024-12-03 Gilgamesh Pharmaceuticals, Inc. Crystalline hydrochloride salts of N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901920A (en) * 1974-04-19 1975-08-26 Sterling Drug Inc 1,5-dioxaspiro(5.5)+0 undecanes

Also Published As

Publication number Publication date
BE855405A (fr) 1977-12-05
IL52131A0 (en) 1977-07-31
ZA772819B (en) 1978-07-26
CH641177A5 (de) 1984-02-15
CH638806A5 (de) 1983-10-14
US4065573A (en) 1977-12-27
AU511781B2 (en) 1980-09-04
DE2723937A1 (de) 1977-12-15
GB1561205A (en) 1980-02-13
IL52131A (en) 1984-01-31
CH638802A5 (de) 1983-10-14
CH638775A5 (de) 1983-10-14
CH638803A5 (de) 1983-10-14
FR2354992A1 (fr) 1978-01-13
JPS5318546A (en) 1978-02-20
GB1561206A (en) 1980-02-13
CA1093553A (fr) 1981-01-13
AU2542577A (en) 1978-11-30
CH638513A5 (de) 1983-09-30
ES459429A1 (es) 1978-11-16

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Legal Events

Date Code Title Description
BV The patent application has lapsed