NL8601981A - Afgifteinrichting voor het in beheerste snelheid toedienen van een heilzaam middel. - Google Patents

Afgifteinrichting voor het in beheerste snelheid toedienen van een heilzaam middel. Download PDF

Info

Publication number: NL8601981A
Authority: NL; Netherlands
Prior art keywords: composition; wall; cellulose; dispensing device; compartment
Prior art date: 1985-08-08

Application number

NL8601981A

Other languages

English (en)

Dutch (nl)

Original Assignee

Alza Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-08-08

Filing date

1986-08-01

Publication date

1987-03-02

1986-08-01 Application filed by Alza Corp filed Critical Alza Corp

1987-03-02 Publication of NL8601981A publication Critical patent/NL8601981A/nl

Links

239000000203 mixture Substances 0.000 claims description 164
239000003795 chemical substances by application Substances 0.000 claims description 120
230000009286 beneficial effect Effects 0.000 claims description 87
239000007788 liquid Substances 0.000 claims description 40
229920000642 polymer Polymers 0.000 claims description 36
229920002678 cellulose Polymers 0.000 claims description 34
239000011148 porous material Substances 0.000 claims description 34
239000000463 material Substances 0.000 claims description 31
-1 fatty acid ester Chemical class 0.000 claims description 29
239000001913 cellulose Substances 0.000 claims description 28
241001465754 Metazoa Species 0.000 claims description 24
229920002301 cellulose acetate Polymers 0.000 claims description 20
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229920006217 cellulose acetate butyrate Polymers 0.000 claims description 10
AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 claims description 9
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FSVJFNAIGNNGKK-UHFFFAOYSA-N 2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one Chemical compound C1C(C2=CC=CC=C2CC2)N2C(=O)CN1C(=O)C1CCCCC1 FSVJFNAIGNNGKK-UHFFFAOYSA-N 0.000 claims description 2
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JNMRHUJNCSQMMB-UHFFFAOYSA-N sulfathiazole Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CS1 JNMRHUJNCSQMMB-UHFFFAOYSA-N 0.000 claims description 2
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239000012229 microporous material Substances 0.000 description 14
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GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 6
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QZWHWHNCPFEXLL-UHFFFAOYSA-N propan-2-yl n-[2-(1,3-thiazol-4-yl)-3h-benzimidazol-5-yl]carbamate Chemical compound N1C2=CC(NC(=O)OC(C)C)=CC=C2N=C1C1=CSC=N1 QZWHWHNCPFEXLL-UHFFFAOYSA-N 0.000 description 1
239000003380 propellant Substances 0.000 description 1
AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 1
239000000473 propyl gallate Substances 0.000 description 1
235000010388 propyl gallate Nutrition 0.000 description 1
229940075579 propyl gallate Drugs 0.000 description 1
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108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
230000003236 psychic effect Effects 0.000 description 1
MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
210000000664 rectum Anatomy 0.000 description 1
230000001846 repelling effect Effects 0.000 description 1
230000031070 response to heat Effects 0.000 description 1
238000001223 reverse osmosis Methods 0.000 description 1
238000012552 review Methods 0.000 description 1
YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
229960001860 salicylate Drugs 0.000 description 1
235000019378 salinomycin Nutrition 0.000 description 1
229960001548 salinomycin Drugs 0.000 description 1
235000003441 saturated fatty acids Nutrition 0.000 description 1
150000004671 saturated fatty acids Chemical class 0.000 description 1
239000012047 saturated solution Substances 0.000 description 1
CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
239000011669 selenium Substances 0.000 description 1
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235000011649 selenium Nutrition 0.000 description 1
229940091258 selenium supplement Drugs 0.000 description 1
229920002379 silicone rubber Polymers 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000017550 sodium carbonate Nutrition 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
235000011083 sodium citrates Nutrition 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
239000011697 sodium iodate Substances 0.000 description 1
235000015281 sodium iodate Nutrition 0.000 description 1
229940032753 sodium iodate Drugs 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 description 1
238000007711 solidification Methods 0.000 description 1
230000008023 solidification Effects 0.000 description 1
239000001570 sorbitan monopalmitate Substances 0.000 description 1
235000011071 sorbitan monopalmitate Nutrition 0.000 description 1
229940031953 sorbitan monopalmitate Drugs 0.000 description 1
238000005507 spraying Methods 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
239000000021 stimulant Substances 0.000 description 1
229960005322 streptomycin Drugs 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 description 1
229960000894 sulindac Drugs 0.000 description 1
239000013589 supplement Substances 0.000 description 1
230000008961 swelling Effects 0.000 description 1
230000001975 sympathomimetic effect Effects 0.000 description 1
229940064707 sympathomimetics Drugs 0.000 description 1
229920001059 synthetic polymer Polymers 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
230000008685 targeting Effects 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
OKUCEQDKBKYEJY-UHFFFAOYSA-N tert-butyl 3-(methylamino)pyrrolidine-1-carboxylate Chemical compound CNC1CCN(C(=O)OC(C)(C)C)C1 OKUCEQDKBKYEJY-UHFFFAOYSA-N 0.000 description 1
WUBVEMGCQRSBBT-UHFFFAOYSA-N tert-butyl 4-(trifluoromethylsulfonyloxy)-3,6-dihydro-2h-pyridine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(OS(=O)(=O)C(F)(F)F)=CC1 WUBVEMGCQRSBBT-UHFFFAOYSA-N 0.000 description 1
229960004989 tetracycline hydrochloride Drugs 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
229960000278 theophylline Drugs 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
239000004308 thiabendazole Substances 0.000 description 1
235000010296 thiabendazole Nutrition 0.000 description 1
229960004546 thiabendazole Drugs 0.000 description 1
WJCNZQLZVWNLKY-UHFFFAOYSA-N thiabendazole Chemical compound S1C=NC(C=2NC3=CC=CC=C3N=2)=C1 WJCNZQLZVWNLKY-UHFFFAOYSA-N 0.000 description 1
XCTYLCDETUVOIP-UHFFFAOYSA-N thiethylperazine Chemical compound C12=CC(SCC)=CC=C2SC2=CC=CC=C2N1CCCN1CCN(C)CC1 XCTYLCDETUVOIP-UHFFFAOYSA-N 0.000 description 1
229960004869 thiethylperazine Drugs 0.000 description 1
239000010409 thin film Substances 0.000 description 1
229960004605 timolol Drugs 0.000 description 1
OUDSBRTVNLOZBN-UHFFFAOYSA-N tolazamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1CCCCCC1 OUDSBRTVNLOZBN-UHFFFAOYSA-N 0.000 description 1
229960002277 tolazamide Drugs 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
239000003204 tranquilizing agent Substances 0.000 description 1
230000002936 tranquilizing effect Effects 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
238000012546 transfer Methods 0.000 description 1
229910052723 transition metal Inorganic materials 0.000 description 1
GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
229960005294 triamcinolone Drugs 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
PVNIQBQSYATKKL-UHFFFAOYSA-N tripalmitin Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC PVNIQBQSYATKKL-UHFFFAOYSA-N 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
229910000406 trisodium phosphate Inorganic materials 0.000 description 1
235000019801 trisodium phosphate Nutrition 0.000 description 1
210000004291 uterus Anatomy 0.000 description 1
229960005486 vaccine Drugs 0.000 description 1
210000001215 vagina Anatomy 0.000 description 1
229940102566 valproate Drugs 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
229960002726 vincamine Drugs 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
KAKZBPTYRLMSJV-UHFFFAOYSA-N vinyl-ethylene Natural products C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 1
235000019373 virginiamycin Nutrition 0.000 description 1
229960003842 virginiamycin Drugs 0.000 description 1
150000003710 vitamin D derivatives Chemical class 0.000 description 1
229940045997 vitamin a Drugs 0.000 description 1
229940046008 vitamin d Drugs 0.000 description 1
150000003722 vitamin derivatives Chemical class 0.000 description 1
238000005406 washing Methods 0.000 description 1
229920003169 water-soluble polymer Polymers 0.000 description 1
NAWDYIZEMPQZHO-UHFFFAOYSA-N ytterbium Chemical compound [Yb] NAWDYIZEMPQZHO-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0068—Rumen, e.g. rumen bolus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Medicinal Preparation (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)
External Artificial Organs (AREA)

NL8601981A 1985-08-08 1986-08-01 Afgifteinrichting voor het in beheerste snelheid toedienen van een heilzaam middel. NL8601981A (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US76349385		1985-08-08
US06/763,493 US4684524A (en)	1984-03-19	1985-08-08	Rate controlled dispenser for administering beneficial agent

Publications (1)

Publication Number	Publication Date
NL8601981A true NL8601981A (nl)	1987-03-02

Family

ID=25067977

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8601981A NL8601981A (nl)	1985-08-08	1986-08-01	Afgifteinrichting voor het in beheerste snelheid toedienen van een heilzaam middel.

Country Status (14)

Country	Link
US (1)	US4684524A (de)
JP (1)	JPH0759497B2 (de)
AU (3)	AU590308B2 (de)
BE (1)	BE905255A (de)
BR (1)	BR8603756A (de)
CA (1)	CA1265966A (de)
DE (1)	DE3626103C2 (de)
ES (1)	ES8802113A1 (de)
FR (1)	FR2585951B1 (de)
GB (1)	GB2178660B (de)
IT (1)	IT1195819B (de)
NL (1)	NL8601981A (de)
NZ (1)	NZ217024A (de)
ZA (1)	ZA865982B (de)

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US4034756A (en) *	1971-01-13	1977-07-12	Alza Corporation	Osmotically driven fluid dispenser
US3732865A (en) *	1971-01-13	1973-05-15	Alza Corp	Osmotic dispenser
SE376851B (de) *	1971-01-13	1975-06-16	Alza Corp
US3760804A (en) *	1971-01-13	1973-09-25	Alza Corp	Improved osmotic dispenser employing magnesium sulphate and magnesium chloride
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US3845770A (en) *	1972-06-05	1974-11-05	Alza Corp	Osmatic dispensing device for releasing beneficial agent
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US3995632A (en) *	1973-05-04	1976-12-07	Alza Corporation	Osmotic dispenser
US4178361A (en) *	1973-09-10	1979-12-11	Union Corporation	Sustained release pharmaceutical composition
GB1478759A (en) *	1974-11-18	1977-07-06	Alza Corp	Process for forming outlet passageways in pills using a laser
DE2729068A1 (de) *	1977-06-28	1979-01-11	Rainer Dr Med Liedtke	Verfahren zur freisetzungssteuerung von arzneimitteln aus kapseln
US4196187A (en) *	1977-09-02	1980-04-01	Eastman Kodak Company	Rumen-stable pellets
US4199569A (en) *	1977-10-03	1980-04-22	Merck & Co., Inc.	Selective hydrogenation products of C-076 compounds and derivatives thereof
US4200098A (en) *	1978-10-23	1980-04-29	Alza Corporation	Osmotic system with distribution zone for dispensing beneficial agent
US4285987A (en) *	1978-10-23	1981-08-25	Alza Corporation	Process for manufacturing device with dispersion zone
FI63335B (fi) *	1979-02-02	1983-02-28	Orion Yhtymae Oy	Foerfarande foer framstaellning av tabletter med foerdroejd loslighet av effektaemne
US4235236A (en) *	1979-02-12	1980-11-25	Alza Corporation	Device for dispensing drug by combined diffusional and osmotic operations
US4320759A (en) *	1980-04-28	1982-03-23	Alza Corporation	Dispenser with diffuser
US4389397A (en) *	1980-08-04	1983-06-21	Merck & Co., Inc.	Solubilization of ivermectin in water
AU591171B2 (en) *	1983-11-02	1989-11-30	Alza Corporation	Dispenser for delivering thermo-responsive composition
US4595583A (en) *	1984-03-19	1986-06-17	Alza Corporation	Delivery system controlled administration of beneficial agent to ruminants
FR2565102B1 (fr) *	1984-06-05	1987-03-20	Paris Sud Universite	Microcapsules biodegradables a base de serumalbumine, leur preparation et leur application a la liberation in situ de medicuments
JPH0641406A (ja) *	1992-07-23	1994-02-15	Teijin Ltd	難燃性ポリエステル樹脂組成物

1985
- 1985-08-08 US US06/763,493 patent/US4684524A/en not_active Expired - Lifetime
1986
- 1986-06-20 ES ES556375A patent/ES8802113A1/es not_active Expired
- 1986-07-30 GB GB8618568A patent/GB2178660B/en not_active Expired
- 1986-07-30 NZ NZ217024A patent/NZ217024A/xx unknown
- 1986-07-31 JP JP61181189A patent/JPH0759497B2/ja not_active Expired - Fee Related
- 1986-08-01 DE DE3626103A patent/DE3626103C2/de not_active Expired - Lifetime
- 1986-08-01 AU AU60780/86A patent/AU590308B2/en not_active Expired
- 1986-08-01 NL NL8601981A patent/NL8601981A/nl unknown
- 1986-08-06 FR FR868611371A patent/FR2585951B1/fr not_active Expired
- 1986-08-06 BR BR8603756A patent/BR8603756A/pt not_active IP Right Cessation
- 1986-08-07 CA CA000515469A patent/CA1265966A/en not_active Expired - Lifetime
- 1986-08-08 IT IT67646/86A patent/IT1195819B/it active
- 1986-08-08 BE BE0/217033A patent/BE905255A/fr not_active IP Right Cessation
- 1986-08-08 ZA ZA865982A patent/ZA865982B/xx unknown
1991
- 1991-11-14 AU AU87886/91A patent/AU8788691A/en not_active Abandoned
- 1991-12-16 AU AU89738/91A patent/AU654515B2/en not_active Ceased

Also Published As

Publication number	Publication date
JPH0759497B2 (ja)	1995-06-28
FR2585951A1 (fr)	1987-02-13
FR2585951B1 (fr)	1989-03-03
ES8802113A1 (es)	1988-04-01
BE905255A (fr)	1986-12-01
AU8788691A (en)	1992-01-16
DE3626103A1 (de)	1987-02-12
GB2178660B (en)	1989-09-06
BR8603756A (pt)	1987-03-10
IT1195819B (it)	1988-10-27
AU8973891A (en)	1992-02-13
AU590308B2 (en)	1989-11-02
JPS6239519A (ja)	1987-02-20
GB2178660A (en)	1987-02-18
GB8618568D0 (en)	1986-09-10
AU6078086A (en)	1987-02-12
AU654515B2 (en)	1994-11-10
ZA865982B (en)	1987-04-29
DE3626103C2 (de)	1998-02-19
CA1265966A (en)	1990-02-20
ES556375A0 (es)	1988-04-01
US4684524A (en)	1987-08-04
NZ217024A (en)	1989-07-27
IT8667646A0 (it)	1986-08-08

Publication	Publication Date	Title
NL8601981A (nl)	1987-03-02	Afgifteinrichting voor het in beheerste snelheid toedienen van een heilzaam middel.
CA1244738A (en)	1988-11-15	Controlled release device for administering beneficial agent to recipient
US5000957A (en)	1991-03-19	Dispenser comprising hydrophilic osmopolymer
US4772474A (en)	1988-09-20	Dispenser with internal arrangement of lamina means for dispensing beneficial agent
US4624945A (en)	1986-11-25	Dispensing system with means for increasing delivery of beneficial agent from the system
US4576604A (en)	1986-03-18	Osmotic system with instant drug availability
CA1252362A (en)	1989-04-11	Ruminant dispensing device
US4844984A (en)	1989-07-04	Dispensing system with means for increasing delivery of beneficial agent from the system
US4673405A (en)	1987-06-16	Osmotic system with instant drug availability
US4612186A (en)	1986-09-16	Method for establishing blood levels of biocide in animals
US4717566A (en)	1988-01-05	Dosage system and method of using same
JPH0155242B2 (de)	1989-11-22
US4717568A (en)	1988-01-05	Laminar arrangement for increasing delivery of beneficial agent from dispenser
JP2002532406A (ja)	2002-10-02	複合コーティングによる液体充填ゼラチンカプセルの放出制御システムへの変換
US4717718A (en)	1988-01-05	Device for the controlled delivery of a beneficial agent
US4883667A (en)	1989-11-28	Process for forming dispensing device
US4729793A (en)	1988-03-08	Composition for manufacturing wall of dispensing device
JPH0137367B2 (de)	1989-08-07
US4871544A (en)	1989-10-03	Ruminant dispensing device
US4927633A (en)	1990-05-22	Dispenser for delivering drug to livestock
US5098425A (en)	1992-03-24	Method of administering a ruminant dispensing device comprising density member dispersed in hydrogel member
US4966767A (en)	1990-10-30	Ruminant dispensing device comprising agent displacement member