NO150800C - Analogifremgangsmaate ved fremstilling av terapeutisk aktive tricykliske forbindelser - Google Patents

Analogifremgangsmaate ved fremstilling av terapeutisk aktive tricykliske forbindelser

Info

Publication number
NO150800C
NO150800C NO782541A NO782541A NO150800C NO 150800 C NO150800 C NO 150800C NO 782541 A NO782541 A NO 782541A NO 782541 A NO782541 A NO 782541A NO 150800 C NO150800 C NO 150800C
Authority
NO
Norway
Prior art keywords
preparation
therapeutic active
tricyclic compounds
analogy procedure
active tricyclic
Prior art date
Application number
NO782541A
Other languages
English (en)
Norwegian (no)
Other versions
NO150800B (no
NO782541L (no
Inventor
Madhukar Subraya Chodnekar
Ado Kaiser
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO782541L publication Critical patent/NO782541L/no
Publication of NO150800B publication Critical patent/NO150800B/no
Publication of NO150800C publication Critical patent/NO150800C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO782541A 1977-07-25 1978-07-24 Analogifremgangsmaate ved fremstilling av terapeutisk aktive tricykliske forbindelser NO150800C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU77829 1977-07-25
CH577678 1978-05-26

Publications (3)

Publication Number Publication Date
NO782541L NO782541L (no) 1979-01-26
NO150800B NO150800B (no) 1984-09-10
NO150800C true NO150800C (no) 1984-12-27

Family

ID=25698353

Family Applications (1)

Application Number Title Priority Date Filing Date
NO782541A NO150800C (no) 1977-07-25 1978-07-24 Analogifremgangsmaate ved fremstilling av terapeutisk aktive tricykliske forbindelser

Country Status (29)

Country Link
US (1) US4256748A (de)
EP (1) EP0000718B1 (de)
JP (1) JPS5441894A (de)
AR (1) AR218500A1 (de)
AT (1) AT363479B (de)
AU (1) AU519688B2 (de)
BR (1) BR7804763A (de)
CA (1) CA1094555A (de)
CS (1) CS203014B2 (de)
DE (2) DE2861688D1 (de)
DK (1) DK144128C (de)
ES (2) ES471981A1 (de)
FI (1) FI63409C (de)
FR (1) FR2398748A1 (de)
GB (1) GB2001638B (de)
GR (1) GR72968B (de)
HU (1) HU177643B (de)
IE (1) IE47280B1 (de)
IL (1) IL55183A (de)
IT (1) IT1097337B (de)
MC (1) MC1199A1 (de)
MY (1) MY8500249A (de)
NL (1) NL7807507A (de)
NO (1) NO150800C (de)
NZ (1) NZ187921A (de)
PH (1) PH14642A (de)
PT (1) PT68342A (de)
SE (1) SE7808111L (de)
YU (1) YU177578A (de)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
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NL7807507A (nl) 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
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CA1131631A (en) * 1979-06-20 1982-09-14 Madhukar S. Chodnekar Quinazoline derivatives and pharmaceutical preparations
EP0029559A3 (de) * 1979-11-24 1981-09-30 Sandoz Ag 5,10 Dihydroimidazo (2,1-b) chinazoline, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4444768A (en) * 1980-03-04 1984-04-24 Ciba-Geigy Corporation Pyrimido[1,6-a]indoles, pharmaceutical preparations containing them, and methods of treating pain and inflammation with them
ZW16481A1 (en) * 1980-08-15 1982-03-10 Hoffmann La Roche Novel imidazoquinazoline derivatives
EP0054180A3 (de) * 1980-12-16 1982-12-01 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung eines Imidazochinazolinonderivates
JPS57178234U (de) * 1981-05-06 1982-11-11
US4455311A (en) * 1981-08-28 1984-06-19 Hoffmann-La Roche Inc. Imidazoquinazoline derivatives which inhibit the aggregation of blood platelets, inhibit gastric secretion or have activity on the circulatory system
US4551459A (en) * 1983-02-16 1985-11-05 Syntex (U.S.A.) Inc. Method of treating heart failure using (2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolinyl)oxyalkylamides
US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
US4663320A (en) * 1983-02-16 1987-05-05 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
JPS604186A (ja) * 1983-06-21 1985-01-10 Dai Ichi Seiyaku Co Ltd イミダゾキナゾリン化合物
JPS6028979A (ja) * 1983-07-14 1985-02-14 Dai Ichi Seiyaku Co Ltd イミダゾキナゾリン類化合物
CA1254557A (en) * 1984-02-15 1989-05-23 Michael C. Venuti (2-oxo-1,2,3,5-tetrahydroimidazo-(2,1-b) quinazolinyl) oxyalkylamides
US4783467A (en) * 1985-06-05 1988-11-08 Pfizer Inc. Tetrahydroimidazoquinazolinone inotropic agents
GB8514207D0 (en) * 1985-06-05 1985-07-10 Pfizer Ltd Cardiac stimulants
US4837239A (en) * 1985-08-23 1989-06-06 Syntex (U.S.A.) Inc. Cardiotonic phosphodiesterase inhibitors complexed with water soluble vitamins
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US5043327A (en) * 1989-07-18 1991-08-27 Janssen Pharmaceutica N.V. Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives, compositions and use
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
EP0597956A1 (de) * 1991-07-29 1994-05-25 Warner-Lambert Company Chinazolin-derivate als acetylcholinesterase-inhibitoren
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
JPH06167328A (ja) * 1992-05-26 1994-06-14 Mayekawa Mfg Co Ltd 氷厚測定装置
JP2003509478A (ja) * 1999-09-21 2003-03-11 エモリー・ユニバーシティ 血小板関連障害を処置する方法および組成物
US6388073B1 (en) * 2000-07-26 2002-05-14 Shire Us Inc. Method for the manufacture of anagrelide
AP2103A (en) * 2003-01-23 2010-02-08 Shire Holdings Ag A skin permeable form of an anagrelide and device therefore
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7700608B2 (en) 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
US8383637B2 (en) 2004-08-06 2013-02-26 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8436006B2 (en) * 2004-08-06 2013-05-07 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8426429B2 (en) 2004-08-06 2013-04-23 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
GB0623750D0 (en) * 2006-11-28 2007-01-10 Shire Llc Substituted quinazolines
US7910597B2 (en) 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
GB0808968D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0808947D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808951D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808948D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
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GB0808952D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808953D0 (en) * 2008-05-16 2008-06-25 Shire Llc substituted quinazolines
GB0810005D0 (en) * 2008-06-02 2008-07-09 Shire Llc Substituted quinazolines
ES2627848T3 (es) 2008-06-04 2017-07-31 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
GB0822970D0 (en) 2008-12-17 2009-01-21 Shire Llc Process for the preparation of anagrelide and analogues
GB201004495D0 (en) 2010-03-18 2010-05-05 Shire Llc Subtituted quinazolines
GB201004491D0 (en) 2010-03-18 2010-05-05 Shire Llc Quinazoline analogues
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
MX357121B (es) 2011-03-01 2018-06-27 Synergy Pharmaceuticals Inc Star Proceso de preparacion de agonistas c de guanilato ciclasa.
EP2958577A2 (de) 2013-02-25 2015-12-30 Synergy Pharmaceuticals Inc. Guanylat-cyclase-rezeptoragonisten zur verwendung bei der darmreinigung
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
EP2968439A2 (de) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Zusammensetzungen zur behandlung von magen-darm-störungen
PL3004138T3 (pl) 2013-06-05 2024-07-29 Bausch Health Ireland Limited Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie
CA2920856C (en) 2013-08-09 2026-03-03 Ardelyx, Inc. Ph modulating compounds for inhibiting gastrointestinal phosphate uptake
JP5935843B2 (ja) * 2014-08-08 2016-06-15 Ｊｆｅスチール株式会社 スポット溶接性に優れた冷延鋼板およびその製造方法
JP2022533251A (ja) 2019-05-21 2022-07-21 アルデリックス， インコーポレイテッド 患者において血清リン酸塩を低下させるための組み合わせ
EP4201403A1 (de) 2021-12-21 2023-06-28 Som Innovation Biotech, S.L. Verbindungen tirapazamin und quazinon zur verwendung bei der behandlung von gm2-gangliosidosen

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1645917A1 (de) 1962-10-26 1970-09-24 American Home Prod Verfahren zur Herstellung von 5-Aryl-3-acyloxy-1,2-dihydro-3H-1,4-benzodiazepin-2-onen
GB1037375A (en) * 1964-08-07 1966-07-27 Hoffmann La Roche A process for the manufacture of benzodiazepine derivatives
BE794964A (fr) 1972-02-04 1973-08-02 Bristol Myers Co Nouveaux agents hypotenseurs et procede pour les preparer
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
US3983119A (en) * 1974-11-06 1976-09-28 Bristol-Myers Company Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones
US3988340A (en) * 1975-01-23 1976-10-26 Bristol-Myers Company 6-Alkoxymethyl-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones and 7-alkoxymethyl-6-[H]-1,2,3,4-tetrahydropyrimido[2,1-b]quinazolin-2-ones
NL7807507A (nl) 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.

Also Published As

Publication number Publication date
YU177578A (en) 1983-01-21
IT7826019A0 (it) 1978-07-24
BR7804763A (pt) 1979-04-10
MC1199A1 (fr) 1979-03-19
EP0000718B1 (de) 1982-03-24
AU519688B2 (en) 1981-12-17
DK144128B (da) 1981-12-14
ATA535178A (de) 1981-01-15
IE781478L (en) 1979-01-25
NZ187921A (en) 1981-03-16
IE47280B1 (en) 1984-02-08
EP0000718A3 (en) 1979-06-13
IL55183A (en) 1981-11-30
PT68342A (en) 1978-08-01
GB2001638B (en) 1982-02-10
NO150800B (no) 1984-09-10
FI782248A7 (fi) 1979-01-26
CA1094555A (en) 1981-01-27
GR72968B (de) 1984-01-20
FR2398748A1 (fr) 1979-02-23
IL55183A0 (en) 1978-09-29
AT363479B (de) 1981-08-10
SE7808111L (sv) 1979-01-26
ES476955A1 (es) 1979-10-16
DK328978A (da) 1979-01-26
US4256748A (en) 1981-03-17
FI63409B (fi) 1983-02-28
NO782541L (no) 1979-01-26
IT1097337B (it) 1985-08-31
DK144128C (da) 1982-05-17
CS203014B2 (en) 1981-02-27
ES471981A1 (es) 1979-10-16
NL7807507A (nl) 1979-01-29
FR2398748B1 (de) 1981-09-04
EP0000718A2 (de) 1979-02-21
HU177643B (en) 1981-11-28
DE2861688D1 (en) 1982-04-29
PH14642A (en) 1981-10-12
GB2001638A (en) 1979-02-07
AR218500A1 (es) 1980-06-13
AU3812778A (en) 1980-01-24
FI63409C (fi) 1983-06-10
JPS5441894A (en) 1979-04-03
MY8500249A (en) 1985-12-31
DE2832138A1 (de) 1979-02-08

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