NO153061C - Fremgangsmaate for fremstilling av et b30-threonininsulin - Google Patents
Fremgangsmaate for fremstilling av et b30-threonininsulinInfo
- Publication number
- NO153061C NO153061C NO801048A NO801048A NO153061C NO 153061 C NO153061 C NO 153061C NO 801048 A NO801048 A NO 801048A NO 801048 A NO801048 A NO 801048A NO 153061 C NO153061 C NO 153061C
- Authority
- NO
- Norway
- Prior art keywords
- threon
- insulin
- procedure
- preparation
- threon insulin
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO844636A NO163531C (no) | 1979-04-13 | 1984-11-21 | Beskyttet b30-thr(r1)(r2)-insulin egnet for fremstilling av et b30-threonininsulin. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4571079A JPS55138393A (en) | 1979-04-13 | 1979-04-13 | Semisynthesis of insulin |
| JP4571179A JPS55138391A (en) | 1979-04-13 | 1979-04-13 | New synthetic method of peptide derivative |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO801048L NO801048L (no) | 1980-10-14 |
| NO153061B NO153061B (no) | 1985-09-30 |
| NO153061C true NO153061C (no) | 1986-01-08 |
Family
ID=26385768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO801048A NO153061C (no) | 1979-04-13 | 1980-04-11 | Fremgangsmaate for fremstilling av et b30-threonininsulin |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0017938B1 (da) |
| DE (1) | DE3064479D1 (da) |
| DK (1) | DK146482C (da) |
| NO (1) | NO153061C (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK147437A (en) * | 1980-02-11 | 1900-01-01 | Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof | |
| DK319780A (da) * | 1980-07-24 | 1982-01-25 | Forenede Bryggerier As | Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner |
| DE3101382A1 (de) * | 1981-01-17 | 1982-09-02 | Hoechst Ag, 6000 Frankfurt | "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten" |
| DK353781A (da) * | 1981-08-10 | 1983-02-11 | Novo Industri As | Fremgangsmaade til fremstilling af insulinderivater |
| AU550062B2 (en) * | 1981-08-10 | 1986-02-27 | Nordisk Insulinlaboratorium | A process for the preparation of an insulin derivative |
| AU551174B2 (en) * | 1981-09-15 | 1986-04-17 | Nordisk Insulinlaboratorium | Enzymatic preparation of human insulin or b-30 esters thereof |
| DK149824C (da) * | 1982-01-22 | 1987-03-16 | Carlsberg Biotechnology Ltd | Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner |
| WO1983002772A1 (en) * | 1982-02-08 | 1983-08-18 | Robin Ewart Offord | An improved method for preparing human insulin from non-human insulin |
| DE3209184A1 (de) * | 1982-03-13 | 1983-09-15 | Hoechst Ag, 6230 Frankfurt | Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen |
| NL8201650A (nl) * | 1982-04-21 | 1983-11-16 | Akzo Nv | Semisynthetische bereiding van humane insuline. |
| DK182483A (da) * | 1982-04-23 | 1983-10-24 | Wako Pure Chem Ind Ltd | Fremgangsmaade til semi-syntese af humant insulin og alkalisk protease til anvendelse derved |
| DK55183D0 (da) * | 1983-02-09 | 1983-02-09 | Nordisk Insulinlab | Fremgangsmade til fremstilling af human insulin |
| DE3326472A1 (de) * | 1983-07-22 | 1985-02-14 | Hoechst Ag, 6230 Frankfurt | Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus |
| DE3333640A1 (de) * | 1983-09-17 | 1985-04-25 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung |
| DK119785D0 (da) * | 1985-03-15 | 1985-03-15 | Nordisk Gentofte | Insulinpraeparat |
| EP0294851A3 (de) * | 1987-06-12 | 1990-05-09 | Berlin-Chemie Ag | Verfahren zur Herstellung von Humaninsulin und seinen Derivaten |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3276961A (en) * | 1963-04-08 | 1966-10-04 | Squibb & Sons Inc | Process for preparing human insulin |
| NL7110277A (da) * | 1970-07-31 | 1972-02-02 | ||
| GB1426061A (en) * | 1972-12-28 | 1976-02-25 | Ici Ltd | Polypeptides |
| CH602599A5 (en) * | 1974-03-27 | 1978-07-31 | Ciba Geigy Ag | Insulin prodn. using different cysteine protecting groups |
| GB1465235A (en) * | 1975-04-29 | 1977-02-23 | Sagami Chem Res | Process for preparing peptides |
| US4116768A (en) * | 1975-04-29 | 1978-09-26 | (Zaidanhojin) Sagami Chemical Research Center | Process for producing a peptide |
-
1980
- 1980-04-11 NO NO801048A patent/NO153061C/no unknown
- 1980-04-11 DE DE8080101966T patent/DE3064479D1/de not_active Expired
- 1980-04-11 EP EP80101966A patent/EP0017938B1/en not_active Expired
- 1980-04-11 DK DK155680A patent/DK146482C/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO801048L (no) | 1980-10-14 |
| DK155680A (da) | 1980-10-14 |
| DK146482B (da) | 1983-10-17 |
| DK146482C (da) | 1986-10-06 |
| EP0017938B1 (en) | 1983-08-03 |
| DE3064479D1 (en) | 1983-09-08 |
| NO153061B (no) | 1985-09-30 |
| EP0017938A1 (en) | 1980-10-29 |
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