NO158740C - Analogifremgangsmaate ved fremstilling av terapeutisk aktive 4-substituerte 2-azetidinonforbindelser. - Google Patents

Analogifremgangsmaate ved fremstilling av terapeutisk aktive 4-substituerte 2-azetidinonforbindelser.

Info

Publication number: NO158740C
Authority: NO; Norway
Prior art keywords: substituted; preparation; therapeutically active; azetidinone compounds; analogy procedure
Prior art date: 1983-03-25

Application number

NO841158A

Other languages

English (en)

Norwegian (no)

Other versions

NO841158L (no

NO158740B (no

Inventor

Toshinari Tamura

Hidenori Iwamoto

Makoto Yoshida

Minoru Yamamoto

Original Assignee

Yamanouchi Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-03-25

Filing date

1984-03-23

Publication date

1988-10-26

1983-03-25 Priority claimed from JP58048989A external-priority patent/JPS59225182A/ja

1983-11-25 Priority claimed from JP58221469A external-priority patent/JPS60115577A/ja

1983-11-25 Priority claimed from JP58221470A external-priority patent/JPS60115578A/ja

1984-03-23 Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd

1984-09-26 Publication of NO841158L publication Critical patent/NO841158L/no

1987-01-23 Priority to NO870289A priority Critical patent/NO167662C/no

1988-07-18 Publication of NO158740B publication Critical patent/NO158740B/no

1988-10-26 Publication of NO158740C publication Critical patent/NO158740C/no

Links

-1 4-SUBSTITUTED 2-AZETIDINONE COMPOUNDS Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO841158A 1983-03-25 1984-03-23 Analogifremgangsmaate ved fremstilling av terapeutisk aktive 4-substituerte 2-azetidinonforbindelser. NO158740C (no)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
NO870289A NO167662C (no)	1983-03-25	1987-01-23	4-substituerte-2-azetidinonforbindelser.

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP58048989A JPS59225182A (ja)	1983-03-25	1983-03-25	２−アゼチジノン−４−カルボン酸の誘導体
JP58221469A JPS60115577A (ja)	1983-11-25	1983-11-25	２−アゼチジノン−４−置換体
JP58221470A JPS60115578A (ja)	1983-11-25	1983-11-25	２−アゼチジノン−４−置換化合物

Publications (3)

Publication Number	Publication Date
NO841158L NO841158L (no)	1984-09-26
NO158740B NO158740B (no)	1988-07-18
NO158740C true NO158740C (no)	1988-10-26

Family

ID=27293483

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO841158A NO158740C (no)	1983-03-25	1984-03-23	Analogifremgangsmaate ved fremstilling av terapeutisk aktive 4-substituerte 2-azetidinonforbindelser.

Country Status (8)

Country	Link
US (3)	US4564609A (fr)
EP (1)	EP0123444B1 (fr)
KR (3)	KR870000357B1 (fr)
CA (1)	CA1256650A (fr)
DE (1)	DE3476399D1 (fr)
DK (1)	DK164684A (fr)
ES (4)	ES530960A0 (fr)
NO (1)	NO158740C (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
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US4719207A (en) *	1984-06-25	1988-01-12	Yamanouchi Pharmaceutical Co., Ltd.	CNS active substituted azetidinone compounds
JPS6253994A (ja)	1985-05-09	1987-03-09	Yamanouchi Pharmaceut Co Ltd	１−置換シリル−４−オキソ−２−アゼチジンカルボン酸低級アルキルエステル
ZA868957B (en) *	1985-12-06	1987-07-29	Yamanouchi Pharma Co Ltd	Crystals of nalpha-(((s)-4-oxo-2-azetidinyl)carbonyl)-l-histidyl-l-prolinamide and process for producing the crystals
US5686420A (en) *	1987-06-05	1997-11-11	Georgetown University	Thyrotropin-releasing hormone analogs and method of use
US5151497A (en) *	1989-02-21	1992-09-29	Japan Tobacco Inc.	Histidyl peptide derivatives
DK437289D0 (da) *	1989-09-04	1989-09-04	Hans Bundgaard	Prodrug derivatives of thyrotropin-releasing hormone (trh)
IT1249728B (it) *	1991-11-06	1995-03-09	Sigma Tau Ind Farmaceuti	Derivati delle prolinammide quali attivatori della memoria e dei processi di apprendimento e composizioni farmaceutiche che li contengono
JP2001524132A (ja) *	1997-05-09	2001-11-27	スミスクライン・ビーチャム・コーポレイション	ＣｏＡ−ＩＴのベータ−ラクタム阻害剤
US20020151502A1 (en) *	1997-10-09	2002-10-17	Albert Sattin	Tri-peptides for neurological and neurobehavior applications
US7202279B1 (en) *	1998-02-11	2007-04-10	Georgetown University	Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders
JP4812225B2 (ja) *	2000-07-11	2011-11-09	塩野義製薬株式会社	生理活性ペプチド含有腸溶性製剤
KR100557268B1 (ko)	2000-08-31	2006-03-07	시오노기세이야쿠가부시키가이샤	파킨슨씨병 치료제
US6982251B2 (en) *	2000-12-20	2006-01-03	Schering Corporation	Substituted 2-azetidinones useful as hypocholesterolemic agents
SK9502003A3 (en) *	2001-01-26	2003-12-02	Schering Corp	Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions
PT1385548E (pt) *	2001-01-26	2007-08-24	Schering Corp	Combinações de um inibidor ou de inibidores de absorção de esteróis com agente (s) para o tratamento de doenças vasculares
WO2002058733A2 (fr) *	2001-01-26	2002-08-01	Schering Corporation	Combinaisons de chelateur(s) des acides biliaires et d'inhibiteur(s) d'absorption des sterols, et traitements pour troubles vasculaires
AR035533A1 (es) *	2001-01-26	2004-06-02	Schering Corp	Uso de por lo menos un inhibidor de la absorcion de los esteroles o sus sales, solvatos, prodrogas farmaceuticamente aceptables o mezclas de los mismos para la preparacion de un medicamento para el tratamiento de la sitosterolemia, composiciones farmaceuticas, el uso de dichas composiciones para la
US20060287254A1 (en) *	2001-01-26	2006-12-21	Schering Corporation	Use of substituted azetidinone compounds for the treatment of sitosterolemia
IL156445A0 (en) *	2001-01-26	2004-01-04	Schering Corp	Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications
US7071181B2 (en) *	2001-01-26	2006-07-04	Schering Corporation	Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
WO2002058685A2 (fr) *	2001-01-26	2002-08-01	Schering Corporation	Combinaisons d'acide nicotinique et de derives de ce dernier, inhibiteur(s) d'absorption de sterols et traitements de conditions vasculaires
ES2275007T3 (es) *	2001-05-25	2007-06-01	Schering Corporation	Uso de derivados de azetidinona sustitudos en el tratamiento de la enfermedad de alzeimer.
US20030119808A1 (en) *	2001-09-21	2003-06-26	Schering Corporation	Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
HUP0401501A3 (en) *	2001-09-21	2012-02-28	Schering Corp	Treating or preventing vascular inflammation using pharmaceutical compositions containing sterol absorption inhibitor(s)
US7056906B2 (en) *	2001-09-21	2006-06-06	Schering Corporation	Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US7053080B2 (en) *	2001-09-21	2006-05-30	Schering Corporation	Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
MXPA04002573A (es) *	2001-09-21	2004-06-18	Schering Corp	Tratamiento de xantoma con derivados de azetidinona como inhibidores de la absorcion de esterol.
WO2004043457A1 (fr) *	2002-11-06	2004-05-27	Schering Corporation	Inhibiteurs d'absorption de cholesterol pour le traitement de troubles auto-immuns
CA2517572C (fr) *	2003-03-07	2011-12-13	Schering Corporation	Composes d'azetidinone substitues, leurs formulations et leur utilisation pour traiter l'hypercholesterolemie
JP2006519869A (ja) *	2003-03-07	2006-08-31	シェーリング　コーポレイション	置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用
EP1601668B1 (fr) *	2003-03-07	2008-08-27	Schering Corporation	Composes d'azetidinone substitues, leurs formulations et utilisations en vue du traitement de l'hypercholesterolemie
US7459442B2 (en) *	2003-03-07	2008-12-02	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP2007510659A (ja) *	2003-11-05	2007-04-26	シェーリング　コーポレイション	脂質調節剤および置換アゼチジノンの組み合わせならびに血管状態の処置
US7462595B2 (en) *	2004-09-17	2008-12-09	Prange Jr Arthur Jergen	Methods for treating cancer-related fatigue
KR101137503B1 (ko) *	2009-07-14	2012-04-20	웰이앤씨 주식회사	고분자 고체 지지체를 이용한 히스티딜-프롤린아미드 유도체의 제조 방법
RU2652187C2 (ru) *	2013-08-16	2018-04-25	ЛОС АЛАМОС НЭШНЛ СЕКЬЮРИТИ, ЭлЭлСи	Композиции и способы для улучшения продуктивности растений

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3959248A (en) *	1974-04-03	1976-05-25	Merck & Co., Inc.	Analogs of thyrotropin-releasing hormone
GB1523598A (en) *	1975-03-08	1978-09-06	Reckitt & Colmann Prod Ltd	Tripeptides
US4271164A (en) *	1979-04-16	1981-06-02	Warner-Lambert Company	6-Substituted-arylpyrido[2,3-d]pyrimidin-7-amines and derivatives
HU180926B (en) *	1979-06-28	1983-05-30	Richter Gedeon Vegyeszet	Process for preparing trh analogues,tripeptide amides infectives on the central nerve sysrhem
US4328134A (en) *	1980-05-06	1982-05-04	Schally Andrew Victor	Anorexigenic peptides
US4426378A (en) *	1981-04-09	1984-01-17	The United States Of America As Represented By The Secretary Of The Army	Thyrotropin releasing hormone in therapy of shock and as a central nervous system stimulant

1984
- 1984-03-15 CA CA000449641A patent/CA1256650A/fr not_active Expired
- 1984-03-23 US US06/592,866 patent/US4564609A/en not_active Expired - Fee Related
- 1984-03-23 ES ES530960A patent/ES530960A0/es active Granted
- 1984-03-23 KR KR1019840001506A patent/KR870000357B1/ko not_active Expired
- 1984-03-23 DK DK164684A patent/DK164684A/da not_active Application Discontinuation
- 1984-03-23 NO NO841158A patent/NO158740C/no unknown
- 1984-03-26 DE DE8484302016T patent/DE3476399D1/de not_active Expired
- 1984-03-26 EP EP84302016A patent/EP0123444B1/fr not_active Expired
1985
- 1985-06-14 ES ES85544234A patent/ES8604209A1/es not_active Expired
- 1985-06-14 ES ES544235A patent/ES8604208A1/es not_active Expired
- 1985-06-14 ES ES544236A patent/ES8604136A1/es not_active Expired
- 1985-10-07 US US06/785,169 patent/US4636567A/en not_active Expired - Fee Related
- 1985-10-07 US US06/785,168 patent/US4610821A/en not_active Expired - Fee Related
1987
- 1987-01-20 KR KR1019870000408A patent/KR890002104B1/ko not_active Expired
- 1987-01-20 KR KR1019870000409A patent/KR890002105B1/ko not_active Expired

Also Published As

Publication number	Publication date
EP0123444B1 (fr)	1989-01-25
KR880009549A (ko)	1988-09-15
ES8604209A1 (es)	1986-01-16
DE3476399D1 (en)	1989-03-02
KR870000357B1 (ko)	1987-03-05
ES544236A0 (es)	1986-01-16
DK164684A (da)	1984-09-26
ES544235A0 (es)	1986-01-16
US4564609A (en)	1986-01-14
KR840008021A (ko)	1984-12-12
ES8600279A1 (es)	1985-10-01
NO841158L (no)	1984-09-26
ES8604208A1 (es)	1986-01-16
EP0123444A1 (fr)	1984-10-31
ES8604136A1 (es)	1986-01-16
KR890002104B1 (ko)	1989-06-19
ES544234A0 (es)	1986-01-16
US4636567A (en)	1987-01-13
DK164684D0 (da)	1984-03-23
US4610821A (en)	1986-09-09
ES530960A0 (es)	1985-10-01
CA1256650A (fr)	1989-06-27
NO158740B (no)	1988-07-18
KR890002105B1 (ko)	1989-06-19
KR880009550A (ko)	1988-09-15

Publication	Publication Date	Title
NO158740C (no)	1988-10-26	Analogifremgangsmaate ved fremstilling av terapeutisk aktive 4-substituerte 2-azetidinonforbindelser.
NO161065C (no)	1989-06-28	Analogifremgangsmaate ved fremstilling av terapeutisk aktive 2-azetidinoner.
NO160521C (no)	1989-04-26	Analogifremgangsmaate ved fremstilling av terapeutisk aktive 13alfa- alkylgonaner.
NO163691C (no)	1990-07-04	Analogifremgangsmaate for fremstilling av terapeutisk aktive n-acryl-piperazinalkanamider.
NO159089C (no)	1988-11-30	Analogifremgangsmaate ved fremstilling av terapeutisk aktive glutarimidderivater.
NO170977C (no)	1993-01-06	Analogifremgangsmaate for fremstilling av terapeutisk aktive aryl-piperazinyl-etyl (eller butyl)-heterocykliske forbindelser
NO158540C (no)	1988-09-28	Analogifremgangsmaate ved fremstilling av terapeutisk aktive 2-penem-forbindelser.
NO162858C (no)	1990-02-28	Analogifremgangsmaate ved fremstilling av terapeutisk aktive thiazolidinderivater.
NO152904C (no)	1985-12-11	Analogifremgangsmaate til fremstilling av farmakologisk virksomme heksapyranoseforbindelser.
NO158060C (no)	1988-07-06	Analogifremgangsmaate for fremstilling av terapeutisk aktive kinolonforbindelser.
NO166083C (no)	1991-05-29	Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyridazodiazepinderivater.
NO164472C (no)	1990-10-10	Analogifremgangsmaate ved fremstilling av terapeutisk aktive substituerte 2-(monokondenserte (3,4- og 5,6)-pyridylalkylensulfinyl)-benzimidazoler.
NO158534C (no)	1988-09-28	Analogifremgangsmaate ved fremstilling av terapeutisk aktive fenoksyalkylkarboksylsyrederivater.
NO153370C (no)	1986-03-05	Analogifremgangsmaate ved fremstilling av terapeutisk aktive, stabile s-adenosylmethionisalter.
NO165400C (no)	1991-02-06	Analogifremgangsmaate ved fremstilling av terapeutisk aktive cefemforbindelser.
NO165842C (no)	1991-04-17	Analogifremgangsmaate for fremstilling av terapeutisk aktive cefem-forbindelser.
NO157538C (no)	1988-04-06	Analogifremgangsmaate ved fremstilling av terapeutisk aktive benzothiazolsufonamidderivater.
NO161313C (no)	1989-08-02	Analogifremgangsmaate ved fremstilling av terapeutisk aktive fluorallylaminderivater.
NO158673C (no)	1988-10-19	Analogifremgangsmaate ved fremstilling av terapeutisk aktive azurenderivater.
NO156865B (no)	1987-08-31	Analogifremgangsmaate for fremstilling av terapeutisk virksomme imidazolderivater.
NO163330C (no)	1990-05-09	Analogifremgangsmaate ved fremstilling av terapeutisk aktive isokinolinderivater.
NO164415C (no)	1990-10-03	Analogifremgangsmaate ved fremstilling av terapeutisk aktive 5-acyl-2-(1h)-pyridinoner.
NO167923C (no)	1991-12-27	Analogifremgangsmaate for fremstilling av terapeutisk aktive peptidsubstituerte heterocykliske forbindelser
NO158376C (no)	1988-08-31	Analogifremgangsmaate for fremstilling av terapeutisk virksomme rooperolforbindelser.
NO163896C (no)	1990-08-08	Analogifremgangsmaate ved fremstilling av terapeutisk aktive spiro-(1,8)-nafthyridin-dioner.