NO159653C - Analogifremgangsm te for fremstilling av terapeutisk aktive, sure indol-derivater. - Google Patents

Analogifremgangsm te for fremstilling av terapeutisk aktive, sure indol-derivater.

Info

Publication number: NO159653C
Authority: NO; Norway
Prior art keywords: carbon atoms; radical; substituted; compounds; amino group
Prior art date: 1984-12-10

Application number

NO854941A

Other languages

English (en)

Norwegian (no)

Other versions

NO159653B (no

NO854941L (no

Inventor

David T Connor

Paul C Unangst

S Russell Stabler

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-12-10

Filing date

1985-12-09

Publication date

1989-01-25

1985-12-09 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1986-06-11 Publication of NO854941L publication Critical patent/NO854941L/no

1988-10-17 Publication of NO159653B publication Critical patent/NO159653B/no

1989-01-25 Publication of NO159653C publication Critical patent/NO159653C/no

Links

SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 12
125000003277 amino group Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
BNJMRELGMDUDDB-UHFFFAOYSA-N $l^{1}-sulfanylbenzene Chemical compound [S]C1=CC=CC=C1 BNJMRELGMDUDDB-UHFFFAOYSA-N 0.000 abstract 2
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 2
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
125000004414 alkyl thio group Chemical group 0.000 abstract 2
-1 phenylsulphinyl radical Chemical class 0.000 abstract 2
150000003254 radicals Chemical class 0.000 abstract 2
125000003396 thiol group Chemical class [H]S* 0.000 abstract 2
SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
BQIKRTGTPBOIMK-UHFFFAOYSA-N [O]C[O] Chemical compound [O]C[O] BQIKRTGTPBOIMK-UHFFFAOYSA-N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Lubricants (AREA)
Cosmetics (AREA)

NO854941A 1984-12-10 1985-12-09 Analogifremgangsm te for fremstilling av terapeutisk aktive, sure indol-derivater. NO159653C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US68011684A	1984-12-10	1984-12-10
US06/788,111 US4675332A (en)	1984-12-10	1985-10-21	Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents

Publications (3)

Publication Number	Publication Date
NO854941L NO854941L (no)	1986-06-11
NO159653B NO159653B (no)	1988-10-17
NO159653C true NO159653C (no)	1989-01-25

Family

ID=27102395

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO854941A NO159653C (no)	1984-12-10	1985-12-09	Analogifremgangsm te for fremstilling av terapeutisk aktive, sure indol-derivater.

Country Status (18)

Country	Link
US (1)	US4675332A (fr)
EP (1)	EP0186367B1 (fr)
JP (1)	JPH0653736B2 (fr)
KR (1)	KR890000292B1 (fr)
CN (1)	CN1005974B (fr)
AT (1)	ATE86252T1 (fr)
AU (1)	AU576131B2 (fr)
CA (1)	CA1259317A (fr)
DE (1)	DE3587148T2 (fr)
DK (1)	DK174104B1 (fr)
ES (1)	ES8700252A1 (fr)
FI (1)	FI84719C (fr)
GR (1)	GR852948B (fr)
IE (1)	IE58554B1 (fr)
NO (1)	NO159653C (fr)
NZ (1)	NZ214480A (fr)
PH (1)	PH24075A (fr)
PT (1)	PT81637B (fr)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE64995B1 (en) *	1987-07-14	1995-09-20	Warner Lambert Co	Novel benzothiophenes having antiallergic activity and both novel and other selected benzothiophenes having activity for treating acute respiratory distress syndrome
IT1228893B (it) *	1989-02-24	1991-07-09	Valeas Spa	Derivati tetrazol ammidici di acidi alchenil eterociclici e loroimpiego come sostanze antiallergiche
LU87611A1 (fr) *	1989-10-20	1991-05-07	Oreal	Composition tinctoriale pour fibres keratiniques contenant des precurseurs de colorants par oxydation et des coupleurs amino indoliques,procedes de teinture mettant en oeuvre ces compositions et composes nouveaux
US5051442A (en) *	1990-04-25	1991-09-24	Merrell Dow Pharmaceuticals Inc.	3-indolyl thioacetate derivatives and NMDA receptor antagonistic use thereof
US5095031A (en) *	1990-08-20	1992-03-10	Abbott Laboratories	Indole derivatives which inhibit leukotriene biosynthesis
US5189054A (en) *	1990-11-02	1993-02-23	Merrell Dow Pharmaceuticals Inc.	3-amidoindolyl derivatives and pharmaceutical compositions thereof
AU641052B2 (en) *	1990-11-02	1993-09-09	Aventisub Ii Inc.	3-amidoindolyl derivatives
US5599774A (en) *	1992-01-22	1997-02-04	Imperial Chemical Industries Plc	N-arylindoles and their use as herbicides
US5395817A (en) *	1992-01-22	1995-03-07	Imperial Chemical Industries Plc	N-arylindoles and their use as herbicides
US5424329A (en) *	1993-08-18	1995-06-13	Warner-Lambert Company	Indole-2-carboxamides as inhibitors of cell adhesion
GB9716657D0 (en)	1997-08-07	1997-10-15	Zeneca Ltd	Chemical compounds
GB9803226D0 (en)	1998-02-17	1998-04-08	Zeneca Ltd	Chemical compounds
GB9902461D0 (en) *	1999-02-05	1999-03-24	Zeneca Ltd	Chemical compounds
GB9902459D0 (en) *	1999-02-05	1999-03-24	Zeneca Ltd	Chemical compounds
GB9902452D0 (en)	1999-02-05	1999-03-24	Zeneca Ltd	Chemical compounds
GB9902453D0 (en) *	1999-02-05	1999-03-24	Zeneca Ltd	Chemical compounds
GB9902455D0 (en) *	1999-02-05	1999-03-24	Zeneca Ltd	Chemical compounds
GB0000625D0 (en)	2000-01-13	2000-03-01	Zeneca Ltd	Chemical compounds
US6436965B1 (en)	2000-03-02	2002-08-20	Merck Frosst Canada & Co.	PDE IV inhibiting amides, compositions and methods of treatment
EP1314733A1 (fr) *	2001-11-22	2003-05-28	Aventis Pharma Deutschland GmbH	Indole-2-carboxamides comme inhibiteurs du facteur Xa
DE60328675D1 (de) *	2002-04-23	2009-09-17	Aventis Pharma Inc	3-(substitutierte amino)-1h-indole-2-carbonsäureester und 3-(substitutierte amino)-benzoäbüthiophen-2-carbonsäureester verbindungen als inhibitoren der interleukin-4 genexpression
GB0217920D0 (en)	2002-04-23	2002-09-11	Aventis Pharm Prod Inc	Interleukin-4 Gene Expression inhibitors
JP2006500355A (ja) *	2002-08-07	2006-01-05	イデニクス（ケイマン）リミテツド	Ｈｉｖ治療用の置換フェニルインドール類
EP1479677A1 (fr) *	2003-05-19	2004-11-24	Aventis Pharma Deutschland GmbH	Nouveaux derivés d'indole en tant qu'inhibiteurs du facteur xa
EP1644360A1 (fr) *	2003-06-05	2006-04-12	Warner-Lambert Company LLC	Indoles 3-substitues et leurs derives utilises comme agents therapeutiques
ATE428711T1 (de) *	2003-12-11	2009-05-15	Aventis Pharma Inc	Substituierte 1h-pyrroloä3,2-b, 3,2-c und 2,3- cüpyridin-2-carbonsäureamide und verwandte analoga als inhibitoren von caseinkinase-i- epsilon
ES2315877T3 (es)	2004-06-18	2009-04-01	Biolipox Ab	Indoles utiles en el tratamiento de inflamaciones.
CN101142185A (zh)	2005-01-19	2008-03-12	比奥里波克斯公司	用于炎症治疗的吲哚
AU2006249866B2 (en)	2005-05-26	2011-10-13	Aldeyra Therapeutics, Inc.	Compositions and methods of treating retinal disease
WO2011072141A1 (fr)	2009-12-11	2011-06-16	Neuron Systems, Inc.	Compositions et procédés pour le traitement de la dégénérescence maculaire
WO2012081893A2 (fr) *	2010-12-13	2012-06-21	한국화학연구원	Nouveau dérivé de 3-indolinone et composition le comprenant
AU2013361314A1 (en)	2012-12-20	2015-07-02	Aldeyra Therapeutics, Inc.	Peri-carbinols
CN117045653A (zh)	2013-01-23	2023-11-14	奥尔德拉医疗公司	与毒性醛相关的疾病和治疗
US10111862B2 (en)	2013-01-25	2018-10-30	Aldeyra Therapeutics, Inc.	Traps in the treatment of macular degeneration
US10550085B2 (en)	2015-08-21	2020-02-04	Aldeyra Therapeutics, Inc.	Deuterated compounds and uses thereof
CA3022665A1 (fr)	2016-05-09	2017-11-16	Aldeyra Therapeutics, Inc.	Polytherapie de troubles et de maladies inflammatoires oculaires
CA3054811A1 (fr)	2017-03-16	2018-09-20	Aldeyra Therapeutics, Inc.	Composes polymorphes et leurs utilisations
WO2019075136A1 (fr)	2017-10-10	2019-04-18	Aldeyra Therapeutics, Inc.	Traitement de troubles inflammatoires
WO2019199979A1 (fr)	2018-04-10	2019-10-17	The General Hospital Corporation	Composés antibactériens
AU2019319740A1 (en)	2018-08-06	2021-03-25	Aldeyra Therapeutics, Inc.	Polymorphic compounds and uses thereof
WO2020223717A1 (fr)	2019-05-02	2020-11-05	Aldeyra Therapeutics, Inc.	Procédé de préparation d'un piégeur d'aldéhyde et d'intermédiaires
JP2022530967A (ja)	2019-05-02	2022-07-05	アルデイラセラピューティクス，インコーポレイテッド	多形化合物およびその使用
CN112028815A (zh) *	2019-06-03	2020-12-04	中国药科大学	吲哚类衍生物及其医药用途
WO2021231792A1 (fr)	2020-05-13	2021-11-18	Aldeyra Therapeutics, Inc.	Formulations pharmaceutiques et leurs utilisations

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3417096A (en) *	1965-07-01	1968-12-17	Bristol Myers Co	Certain 5(1-benzoyl-3-indolylmethyl) tetrazoles
US4316904A (en) *	1978-06-05	1982-02-23	Brown Richard E	Indolopyrone tetrazoles and carboxamidotetrazoles having antiallergic activity
US4432986A (en) *	1979-06-18	1984-02-21	Riker Laboratories, Inc.	Tetrazoles bonded to certain polycyclic aromatic systems and anti-allergic use thereof
US4333943A (en) *	1980-04-24	1982-06-08	Miles Laboratories, Inc.	Ethyl 3-(3-indolyl)-3-(5-tetrazolyl) propionate compounds used as anti-hypertensive agents
DE3131527A1 (de) *	1981-08-08	1983-02-24	Kali-Chemie Pharma Gmbh, 3000 Hannover	1-phenyl-2-aminocarbonylindol-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
GB2111050B (en) *	1981-11-19	1985-09-11	Ciba Geigy Ag	N-substituted-2-pyridylindoles
US4567201A (en) *	1981-11-25	1986-01-28	Takeda Chemical Industries, Ltd.	Diphenoxypropane derivatives and compositions of antiasthmatic and antiinflammatory agents thereof
US4436746A (en) *	1982-09-30	1984-03-13	Ciba-Geigy Corporation	Thromboxane synthetase inhibitory N-substituted-2-(1-imidazolyl)indoles
US4536505A (en) *	1983-05-17	1985-08-20	Ciba-Geigy Corporation	Certain N-(pyridyl) indoles
US4511573A (en) *	1983-05-17	1985-04-16	Ciba-Geigy Corporation	3-Substituted-2-(heteroaryl) indoles
EP0146243A1 (fr) *	1983-10-31	1985-06-26	Merck Frosst Canada Inc.	Inhibiteurs de la lipoxygénase
US4581354A (en) *	1984-08-06	1986-04-08	Sterling Drug Inc.	3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, compositions and use
IE58555B1 (en) *	1984-12-10	1993-10-06	Warner Almbert Company	Novel benzothiophenes and benzofurans having antiallergy activity

1985
- 1985-10-21 US US06/788,111 patent/US4675332A/en not_active Expired - Lifetime
- 1985-11-13 IE IE284185A patent/IE58554B1/en not_active IP Right Cessation
- 1985-11-29 AU AU50508/85A patent/AU576131B2/en not_active Ceased
- 1985-12-04 FI FI854821A patent/FI84719C/fi not_active IP Right Cessation
- 1985-12-06 PH PH33140A patent/PH24075A/en unknown
- 1985-12-09 NZ NZ214480A patent/NZ214480A/en unknown
- 1985-12-09 DK DK198505688A patent/DK174104B1/da not_active IP Right Cessation
- 1985-12-09 JP JP60275227A patent/JPH0653736B2/ja not_active Expired - Fee Related
- 1985-12-09 NO NO854941A patent/NO159653C/no unknown
- 1985-12-09 GR GR852948A patent/GR852948B/el unknown
- 1985-12-10 AT AT85308948T patent/ATE86252T1/de not_active IP Right Cessation
- 1985-12-10 CA CA000497268A patent/CA1259317A/fr not_active Expired
- 1985-12-10 KR KR1019850009255A patent/KR890000292B1/ko not_active Expired
- 1985-12-10 ES ES549768A patent/ES8700252A1/es not_active Expired
- 1985-12-10 CN CN85109061.3A patent/CN1005974B/zh not_active Expired
- 1985-12-10 PT PT81637A patent/PT81637B/pt not_active IP Right Cessation
- 1985-12-10 DE DE8585308948T patent/DE3587148T2/de not_active Expired - Fee Related
- 1985-12-10 EP EP85308948A patent/EP0186367B1/fr not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU5050885A (en)	1986-06-19
IE58554B1 (en)	1993-10-06
FI854821A0 (fi)	1985-12-04
JPH0653736B2 (ja)	1994-07-20
JPS61191683A (ja)	1986-08-26
GR852948B (fr)	1986-04-11
ES549768A0 (es)	1986-04-16
NO159653B (no)	1988-10-17
DE3587148T2 (de)	1993-07-15
IE852841L (en)	1986-06-10
NO854941L (no)	1986-06-11
PT81637A (en)	1986-01-01
AU576131B2 (en)	1988-08-11
KR860004882A (ko)	1986-07-14
EP0186367B1 (fr)	1993-03-03
DK568885A (da)	1986-06-11
EP0186367A3 (en)	1988-01-07
PH24075A (en)	1990-03-05
PT81637B (pt)	1988-02-17
FI84719B (fi)	1991-09-30
CA1259317A (fr)	1989-09-12
DE3587148D1 (de)	1993-04-08
EP0186367A2 (fr)	1986-07-02
DK174104B1 (da)	2002-06-17
NZ214480A (en)	1988-05-30
FI854821A7 (fi)	1986-06-11
ATE86252T1 (de)	1993-03-15
US4675332A (en)	1987-06-23
KR890000292B1 (ko)	1989-03-13
FI84719C (fi)	1992-01-10
ES8700252A1 (es)	1986-10-16
CN1005974B (zh)	1989-12-06
CN85109061A (zh)	1987-01-21
DK568885D0 (da)	1985-12-09

Publication	Publication Date	Title
NO159653C (no)	1989-01-25	Analogifremgangsm te for fremstilling av terapeutisk aktive, sure indol-derivater.
ES539446A0 (es)	1986-06-01	Un procedimiento para preparar un derivado de dihidropiridazinona
AU549927B2 (en)	1986-02-20	2-oxindole-1-carboxamide derivatives
ES552044A0 (es)	1987-06-01	Un procedimiento para la preparacion de oxindol-carboxamidas triciclicas
AU586187B2 (en)	1989-07-06	7-``2-(dialkylamino)ethyl``-4-hydroxy-1, 3-benzimidazol-2- ones
NO169442C (no)	1992-06-24	Analogifremgangsmaate ved fremstilling av terapeutisk aktive prolinderivater og lignende forbindelser
DK96086A (da)	1986-09-05	8-thiotetrahydroquinolinderivater, deres fremstilling og anvendelse som laegemidler
NZ216741A (en)	1988-10-28	6-oxo-1,6-dihydropyridazines and pharmaceutical compositions
FR2598914B1 (fr)	1991-10-25	Composition prophylactique et curative pour l'arteriosclerose