NO159654C - Analogifremgangsm te for fremstilling av terapeutisk aktive 2-guanidin-4-heteroaryltiazolderivater. - Google Patents

Analogifremgangsm te for fremstilling av terapeutisk aktive 2-guanidin-4-heteroaryltiazolderivater.

Info

Publication number: NO159654C
Authority: NO; Norway
Prior art keywords: heteroaryltiazold; guanidin; derivatives; preparation; therapeutic active
Prior art date: 1980-10-14

Application number

NO813442A

Other languages

English (en)

Norwegian (no)

Other versions

NO813442L (no

NO159654B (no

Inventor

John Lawrence Lamattina

Christopher Andrew Lipinski

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-10-14

Filing date

1981-10-13

Publication date

1989-01-25

1981-10-13 Application filed by Pfizer filed Critical Pfizer

1982-04-15 Publication of NO813442L publication Critical patent/NO813442L/no

1988-10-17 Publication of NO159654B publication Critical patent/NO159654B/no

1989-01-25 Publication of NO159654C publication Critical patent/NO159654C/no

Links

238000000034 method Methods 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO813442A 1980-10-14 1981-10-13 Analogifremgangsm te for fremstilling av terapeutisk aktive 2-guanidin-4-heteroaryltiazolderivater. NO159654C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US19623180A	1980-10-14	1980-10-14
US06/293,574 US4374843A (en)	1980-10-14	1981-08-20	2-Guanidino-4-heteroarylthiazoles

Publications (3)

Publication Number	Publication Date
NO813442L NO813442L (no)	1982-04-15
NO159654B NO159654B (no)	1988-10-17
NO159654C true NO159654C (no)	1989-01-25

Family

ID=26891753

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO813442A NO159654C (no)	1980-10-14	1981-10-13	Analogifremgangsm te for fremstilling av terapeutisk aktive 2-guanidin-4-heteroaryltiazolderivater.

Country Status (28)

Country	Link
US (1)	US4374843A (de)
EP (1)	EP0050458B1 (de)
KR (1)	KR850001858B1 (de)
AR (3)	AR228675A1 (de)
AT (1)	ATE11048T1 (de)
AU (2)	AU530589B2 (de)
CA (1)	CA1156239A (de)
CS (1)	CS231182B2 (de)
DD (4)	DD202293A5 (de)
DE (1)	DE3168067D1 (de)
DK (1)	DK453181A (de)
ES (4)	ES8301978A1 (de)
FI (1)	FI75821C (de)
GR (1)	GR75098B (de)
HK (1)	HK52387A (de)
HU (2)	HU191895B (de)
IE (1)	IE51642B1 (de)
IL (1)	IL64035A (de)
KE (1)	KE3707A (de)
MY (1)	MY8700512A (de)
NO (1)	NO159654C (de)
NZ (1)	NZ198629A (de)
PH (3)	PH17562A (de)
PL (3)	PL135331B1 (de)
PT (1)	PT73817B (de)
SG (1)	SG23487G (de)
SU (1)	SU1153829A3 (de)
YU (4)	YU42434B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4482723A (en) *	1983-04-11	1984-11-13	Pfizer Inc.	Process for preparation of 4-acetyl-2-substituted-imidazoles
US4435396A (en) *	1982-05-10	1984-03-06	Pfizer Inc.	Antiulcer 2-guanidino-4-(2-substituted-amino-4-imidazolyl)thiazoles and process therefor
AU542287B2 (en) *	1982-06-17	1985-02-14	Toyama Chemical Co. Ltd.	Process for producing 2-(2-aminothiazol-4-yl) glyoxylic acid derivative, it:s salt and intermediates therefor
EP0156644A1 (de) *	1984-04-02	1985-10-02	Pfizer Inc.	Verfahren und Zwischenprodukte für 4-Acetylimidazole
US4560690A (en) *	1984-04-30	1985-12-24	Pfizer Inc.	2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents
US4567179A (en) *	1984-10-11	1986-01-28	Pfizer, Inc.	Antiinflammatory salts of piroxicam
US4632993A (en) *	1984-10-11	1986-12-30	Pfizer Inc.	Process for making 2-guanidino-4-(2-methyl-4-imidazolyl) thiazole dihydrobromide
US4591595A (en) *	1984-10-11	1986-05-27	Pfizer Inc.	2-guanidino-4-(2-methyl-4-imidazolyl)thiazoles in the treatment of rheumatoid arthritis
WO1986003203A1 (fr) *	1984-11-22	1986-06-05	Yoshitomi Pharmaceutical Industries, Ltd.	Derives de thienylthiazole
US4814341A (en) *	1986-08-26	1989-03-21	Reiter Lawrence A	2-guanidino-4-(2-furyl) thiazoles as antiulcer agents
EP0259085B1 (de) *	1986-08-29	1991-08-21	Pfizer Inc.	2-Guanidino-4-aryl-thiazole für die Behandlung von peptischen Geschwüren
ATE106884T1 (de) *	1986-10-29	1994-06-15	Pfizer	Verfahren zur herstellung von 2-(1-pentyl-3- guanidino)-4-(2-methyl-4-imidazolyl)thiazol und dessen kristallinisches dihydrochlorid-trihydrat.
IL95548A0 (en) *	1989-09-15	1991-06-30	Fujisawa Pharmaceutical Co	Thiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same
WO1992016526A1 (en) *	1991-03-13	1992-10-01	Fujisawa Pharmaceutical Co., Ltd.	Thiazole derivatives
SI0928793T1 (en) *	1998-01-02	2002-10-31	F. Hoffmann-La Roche Ag	Thiazole derivatives
CN101287711A (zh) *	2005-08-23	2008-10-15	宇部兴产株式会社	1-取代-5-酰基咪唑化合物的制备方法
US9499533B2 (en)	2012-03-27	2016-11-22	Shionogi & Co., Ltd.	Aromatic 5-membered heterocyclic derivative having TRPV4-Inhibiting activity
KR20220119653A (ko)	2019-12-20	2022-08-30	테나야 테라퓨틱스, 인코포레이티드	플루오로알킬-옥사디아졸 및 이의 용도
WO2022034121A1 (en)	2020-08-11	2022-02-17	Université De Strasbourg	H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1516777A (fr) *	1966-08-02	1968-02-05	Innothera Lab Sa	Dérivés du thiazole ainsi que de la thiazolo [4,5-d] pyridazine et leur préparation
US3519637A (en) *	1966-12-06	1970-07-07	Hoffmann La Roche	1-(4-thiazolylmethyl)nitroimidazole derivatives
BE758146A (fr) *	1969-10-29	1971-04-28	Smith Kline French Lab	Derives de l'amidine
US3950353A (en) *	1971-03-09	1976-04-13	Smith Kline & French Laboratories Limited	Pharmacologically active thiourea and urea compounds
HU168776B (de) *	1973-11-09	1976-07-28
DE2614189A1 (de) *	1976-04-02	1977-10-20	Hoechst Ag	Therapeutisch wirksame ureido- und semicarbazido-derivate des tiazols und verfahren zu ihrer herstellung
NZ186965A (en) *	1977-04-20	1980-02-21	Ici Ltd	Guanidino derivatives and pharmaceutical compositions
JPS54132566A (en) *	1978-01-18	1979-10-15	Ici Ltd	Guanidine derivative*its manufacture and secretion controlling pharmaceutical composition containing it
EP0014057B1 (de) *	1979-01-18	1985-01-02	Imperial Chemical Industries Plc	Guanidin-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4220654A (en) *	1979-06-04	1980-09-02	Merck & Co., Inc.	Cyclic imidazole cyanoguanidines
AU518569B2 (en) *	1979-08-07	1981-10-08	Farmos-Yhtyma Oy	4-benzyl- and 4-benzoyl imidazole derivatives

1981
- 1981-08-20 US US06/293,574 patent/US4374843A/en not_active Expired - Fee Related
- 1981-10-12 IL IL64035A patent/IL64035A/xx unknown
- 1981-10-12 AT AT81304724T patent/ATE11048T1/de not_active IP Right Cessation
- 1981-10-12 DE DE8181304724T patent/DE3168067D1/de not_active Expired
- 1981-10-12 EP EP81304724A patent/EP0050458B1/de not_active Expired
- 1981-10-12 IE IE2384/81A patent/IE51642B1/en unknown
- 1981-10-13 CS CS817500A patent/CS231182B2/cs unknown
- 1981-10-13 CA CA000387744A patent/CA1156239A/en not_active Expired
- 1981-10-13 FI FI813177A patent/FI75821C/fi not_active IP Right Cessation
- 1981-10-13 KR KR1019810003857A patent/KR850001858B1/ko not_active Expired
- 1981-10-13 SU SU813344744A patent/SU1153829A3/ru active
- 1981-10-13 HU HU833918A patent/HU191895B/hu not_active IP Right Cessation
- 1981-10-13 PH PH26341A patent/PH17562A/en unknown
- 1981-10-13 ES ES506216A patent/ES8301978A1/es not_active Expired
- 1981-10-13 DK DK453181A patent/DK453181A/da not_active Application Discontinuation
- 1981-10-13 NO NO813442A patent/NO159654C/no unknown
- 1981-10-13 NZ NZ198629A patent/NZ198629A/en unknown
- 1981-10-13 YU YU2464/81A patent/YU42434B/xx unknown
- 1981-10-13 HU HU812951A patent/HU186788B/hu not_active IP Right Cessation
- 1981-10-13 GR GR66268A patent/GR75098B/el unknown
- 1981-10-13 AU AU76287/81A patent/AU530589B2/en not_active Ceased
- 1981-10-14 DD DD81234080A patent/DD202293A5/de not_active IP Right Cessation
- 1981-10-14 PT PT73817A patent/PT73817B/pt unknown
- 1981-10-14 PL PL1981241644A patent/PL135331B1/pl unknown
- 1981-10-14 PL PL1981233430A patent/PL134491B1/pl unknown
- 1981-10-14 PL PL1981241643A patent/PL133712B1/pl unknown
- 1981-10-14 DD DD81248821A patent/DD207719A5/de not_active IP Right Cessation
- 1981-10-14 DD DD81248822A patent/DD207913A5/de not_active IP Right Cessation
- 1981-10-14 DD DD81248820A patent/DD207718A5/de not_active IP Right Cessation
1982
- 1982-08-20 ES ES515157A patent/ES515157A0/es active Granted
- 1982-08-20 ES ES515159A patent/ES515159A0/es active Granted
- 1982-08-20 ES ES515158A patent/ES515158A0/es active Granted
- 1982-08-27 AR AR290463A patent/AR228675A1/es active
- 1982-08-27 AR AR290461A patent/AR229703A1/es active
- 1982-08-27 AR AR290462A patent/AR228674A1/es active
1983
- 1983-04-06 PH PH28740A patent/PH18467A/en unknown
- 1983-04-06 PH PH28741A patent/PH17856A/en unknown
- 1983-05-12 YU YU1051/83A patent/YU42076B/xx unknown
- 1983-05-12 YU YU1053/83A patent/YU42078B/xx unknown
- 1983-05-12 YU YU1052/83A patent/YU42077B/xx unknown
1984
- 1984-08-17 AU AU32062/84A patent/AU548992B2/en not_active Ceased
1987
- 1987-03-09 SG SG234/87A patent/SG23487G/en unknown
- 1987-03-20 KE KE3707A patent/KE3707A/xx unknown
- 1987-07-09 HK HK523/87A patent/HK52387A/xx unknown
- 1987-12-30 MY MY512/87A patent/MY8700512A/xx unknown

Also Published As

Publication number	Publication date
DD207718A5 (de)	1984-03-14
ES506216A0 (es)	1982-12-16
DK453181A (da)	1982-04-15
ES8306750A1 (es)	1983-06-01
US4374843A (en)	1983-02-22
YU42434B (en)	1988-08-31
PH17856A (en)	1985-01-09
ES8306751A1 (es)	1983-06-01
IL64035A (en)	1986-01-31
YU105383A (en)	1983-10-31
IE812384L (en)	1982-04-14
YU105183A (en)	1983-10-31
AR228675A1 (es)	1983-03-30
CS750081A2 (en)	1984-02-13
FI813177L (fi)	1982-04-15
KR850001858B1 (ko)	1985-12-28
DE3168067D1 (en)	1985-02-14
PL133712B1 (en)	1985-06-29
DD207719A5 (de)	1984-03-14
PL241643A1 (en)	1983-11-21
NO813442L (no)	1982-04-15
HK52387A (en)	1987-07-17
SU1153829A3 (ru)	1985-04-30
PH17562A (en)	1984-10-01
AU530589B2 (en)	1983-07-21
CA1156239A (en)	1983-11-01
AR228674A1 (es)	1983-03-30
AR229703A1 (es)	1983-10-31
ES8301978A1 (es)	1982-12-16
PL233430A1 (en)	1983-11-21
ES8306749A1 (es)	1983-06-01
CS231182B2 (en)	1984-10-15
GR75098B (de)	1984-07-13
DD202293A5 (de)	1983-09-07
SG23487G (en)	1987-07-10
AU7628781A (en)	1982-04-22
YU42078B (en)	1988-04-30
ATE11048T1 (de)	1985-01-15
NZ198629A (en)	1985-02-28
PT73817B (en)	1983-11-07
PL241644A1 (en)	1983-11-21
FI75821B (fi)	1988-04-29
YU105283A (en)	1983-10-31
MY8700512A (en)	1987-12-31
YU246481A (en)	1983-10-31
AU548992B2 (en)	1986-01-09
HU186788B (en)	1985-09-30
ES515157A0 (es)	1983-06-01
IE51642B1 (en)	1987-01-21
DD207913A5 (de)	1984-03-21
PL134491B1 (en)	1985-08-31
NO159654B (no)	1988-10-17
IL64035A0 (en)	1982-01-31
EP0050458B1 (de)	1985-01-02
ES515158A0 (es)	1983-06-01
FI75821C (fi)	1988-08-08
KR830007638A (ko)	1983-11-04
ES515159A0 (es)	1983-06-01
YU42076B (en)	1988-04-30
YU42077B (en)	1988-04-30
EP0050458A2 (de)	1982-04-28
EP0050458A3 (en)	1982-09-01
PT73817A (en)	1981-11-01
PH18467A (en)	1985-07-18
KE3707A (en)	1987-04-03
AU3206284A (en)	1984-11-29
PL135331B1 (en)	1985-10-31
HU191895B (en)	1987-04-28

Publication	Publication Date	Title
NO158099C (no)	1988-07-13	Analogifremgangsmaate for fremstilling av terapeutisk aktive karbostyrilderivater.
NO156864B (no)	1987-08-31	Analogifremgangsmaate for fremstilling av terapeutisk aktive piperinderivater.
NO159531C (no)	1989-01-11	Analogifremgangsmaate for fremstilling av farmasoeytisk aktive karbostyrilderivater.
NO162022C (no)	1989-10-25	Analogifremgangsmaate til fremstilling av terapeutisk aktive cefemderivater.
NO161117C (no)	1989-07-05	Analogifremgangsmaate for fremstilling av terapeutisk aktive cefalosporinderivater.
NO165239C (no)	1991-01-16	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-benzyl-aminoalkyl-pyrrolidinon-derivater.
NO166320C (no)	1991-07-03	Analogifremgangsmaate ved fremstilling av terapeutisk aktive tetrazolderivater.
NO165192C (no)	1991-01-09	Analogifremgangsmaate for fremstilling av terapeutisk aktive glyserolderivater.
NO152129C (no)	1985-08-07	Analogifremgangsmaate for fremstilling av terapeutisk aktive omega-cyan-1, omega-difenyl-azaalkanderivater
NO814136L (no)	1982-06-07	Analogifremgangsmaate for fremstilling av terapeutisk aktive 8-arylalkyl-3-fenyl-3-notropanol-derivater
NO156787C (no)	1987-11-25	Analogifremgangsmaate for fremstilling av terapeutisk aktive kinolonderivater.
NO158183C (no)	1988-07-27	Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazolylfenylamidiner.
NO161676C (no)	1989-09-13	Analogifremgangsm te til fremstilling av terapeutisk aktive mitosanderivater.
NO161562C (no)	1989-08-30	Analogifremgangsmaate for fremstilling av terapeutisk aktive ergolinderivater.
NO158941C (no)	1988-11-16	Analogifremgangsmaate for fremstilling av terapeutisk aktive 4-piperidino-kinazolinderivater.
NO160079C (no)	1989-03-08	Analogifremgangsmaate for fremstilling av terapeutisk aktive cefem-derivater.
NO155840C (no)	1987-06-10	Analogifremgangsmaate for fremstilling av terapeutisk aktive taurin-derivater.
NO158739C (no)	1988-10-26	Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-piperazinopyrimidinderivater.
NO160511C (no)	1989-04-26	Analogifremgangsmaate for fremstilling av terapeutisk aktive fenyl-cyklo-butanderivater.
NO160512C (no)	1989-04-26	Analogifremgangsmaate for fremstilling av terapeutisk aktive karbostyrilderivater.
NO813821L (no)	1982-05-13	Analogifremgangsmaate for fremstilling av terapeutisk aktive indolinon-derivater
NO168478C (no)	1992-02-26	Analogifremgangsmaate for fremstilling av terapeutisk aktive vinylthioacetamido-oxacefalosporinderivater.
NO154052C (no)	1986-07-16	Analogifremgangsmaate for fremstilling av terapeutisk aktive kinolon-derivater.
NO160001C (no)	1989-03-01	Analogifremgangsm te for fremstilling av terapeutisk aktive spiro-3-hetero-azolon-derivater.
NO811360L (no)	1981-10-26	Fremgangsmaate for fremstilling av terapeutisk aktivt hydratisert picotamid.