NO167920C - Analogifremgangsmaate til fremstilling av terapeutisk aktive tricykliske 1,4-azepinderivater - Google Patents

Analogifremgangsmaate til fremstilling av terapeutisk aktive tricykliske 1,4-azepinderivater

Info

Publication number: NO167920C
Authority: NO; Norway
Prior art keywords: lower alkoxy; integer; carbon; lower alkyl; diseases
Prior art date: 1987-12-18

Application number

NO885597A

Other languages

English (en)

Norwegian (no)

Other versions

NO167920B (no

NO885597L (no

NO885597D0 (no

Inventor

Armin Walser

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-18

Filing date

1988-12-16

Publication date

1991-12-27

1988-12-16 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1988-12-16 Publication of NO885597D0 publication Critical patent/NO885597D0/no

1989-06-19 Publication of NO885597L publication Critical patent/NO885597L/no

1991-09-16 Publication of NO167920B publication Critical patent/NO167920B/no

1991-12-27 Publication of NO167920C publication Critical patent/NO167920C/no

Links

230000001225 therapeutic effect Effects 0.000 title 1
125000003545 alkoxy group Chemical group 0.000 abstract 4
HVAUUPRFYPCOCA-AREMUKBSSA-N 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP([O-])(=O)OCC[N+](C)(C)C HVAUUPRFYPCOCA-AREMUKBSSA-N 0.000 abstract 3
108010003541 Platelet Activating Factor Proteins 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
229910052799 carbon Inorganic materials 0.000 abstract 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
125000004423 acyloxy group Chemical group 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
206010052779 Transplant rejections Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
208000026278 immune system disease Diseases 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000035939 shock Effects 0.000 abstract 1
206010040560 shock Diseases 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Immunology (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

NO885597A 1987-12-18 1988-12-16 Analogifremgangsmaate til fremstilling av terapeutisk aktive tricykliske 1,4-azepinderivater NO167920C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US13472687A	1987-12-18	1987-12-18
US22794888A	1988-08-03	1988-08-03

Publications (4)

Publication Number	Publication Date
NO885597D0 NO885597D0 (no)	1988-12-16
NO885597L NO885597L (no)	1989-06-19
NO167920B NO167920B (no)	1991-09-16
NO167920C true NO167920C (no)	1991-12-27

Family

ID=26832617

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO885597A NO167920C (no)	1987-12-18	1988-12-16	Analogifremgangsmaate til fremstilling av terapeutisk aktive tricykliske 1,4-azepinderivater

Country Status (21)

Country	Link
EP (1)	EP0320992B1 (cs)
JP (1)	JPH0725762B2 (cs)
KR (1)	KR890009932A (cs)
CN (1)	CN1031057C (cs)
AT (1)	ATE109148T1 (cs)
AU (1)	AU612441B2 (cs)
CA (1)	CA1327570C (cs)
CS (1)	CS833288A2 (cs)
DE (1)	DE3850866T2 (cs)
DK (1)	DK704088A (cs)
ES (1)	ES2056889T3 (cs)
FI (1)	FI88799C (cs)
HU (1)	HU204273B (cs)
IE (1)	IE63762B1 (cs)
IL (1)	IL88688A0 (cs)
MC (1)	MC1999A1 (cs)
NO (1)	NO167920C (cs)
NZ (1)	NZ227341A (cs)
PT (1)	PT89250B (cs)
RU (1)	RU2094436C1 (cs)
YU (1)	YU46991B (cs)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
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PH30676A (en) *	1986-07-22	1997-09-16	Boehringer Ingelhein Kg	Hetrazepine compounds which have useful pharmaceutical utility
JP2959598B2 (ja) *	1990-10-12	1999-10-06	吉富製薬株式会社	光学活性なチエノトリアゾロジアゼピン化合物
US5130315A (en) *	1991-01-10	1992-07-14	Raymond R. Wittekind	1-piperazinyl-2-butenes and -2-butynes
WO1994006802A1 (fr) *	1992-09-18	1994-03-31	Yoshitomi Pharmaceutical Industries, Ltd.	Compose de thienodiazepine et son utilisation medicinale
US5302590A (en) *	1992-12-18	1994-04-12	Hoffmann-La Roche Inc.	Compounds useful as dual antagonists of platelet activating factor and leukotriene D4
DE19839566C2 (de) *	1998-08-31	2002-01-17	Fumapharm Ag Muri	Verwendung von Fumarsäurederivaten in der Transplantationsmedizin
EP1925614A1 (en) *	2002-03-28	2008-05-28	Wisys Technology Foundation, Inc.	Anxiolytic agents with reduced sedative and ataxic effects
BR0308918A (pt)	2002-03-28	2005-01-04	Wisys Technology Found Inc	Agentes ansiolìticos com efeitos sedativos e atáxicos reduzidos
CA2570185A1 (en)	2004-06-30	2006-01-12	Wisys Technology Foundation Inc.	Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects
BRPI0513811A (pt) *	2004-07-27	2008-07-15	Gilead Sciences Inc	imidazo [4,5-d] pirimidinas, seus usos e processos de preparação
JP2008512456A (ja) *	2004-09-09	2008-04-24	メルクエンドカムパニーインコーポレーテッド	三環式アニリドスピロラクタムｃｇｒｐ受容体拮抗薬
ATE518852T1 (de) *	2004-09-13	2011-08-15	Merck Sharp & Dohme	Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten
DK1802625T3 (da) *	2004-10-13	2008-09-01	Hoffmann La Roche	Disubstituerede pyrazolobenzodiazepiner der er nyttige som inhibitorer af CDK2 og angiogenese og til behandling af bryst-, tyktarms-, lunge- og prostatacancer
ES2526671T3 (es) *	2010-06-22	2015-01-14	Glaxosmithkline Llc	Compuestos de benzotriazoldiazepina inhibidores de bromodominios
AR084070A1 (es)	2010-12-02	2013-04-17	Constellation Pharmaceuticals Inc	Inhibidores del bromodominio y usos de los mismos
US9249161B2 (en)	2010-12-02	2016-02-02	Constellation Pharmaceuticals, Inc.	Bromodomain inhibitors and uses thereof
EP2705039B1 (en)	2011-05-04	2017-07-26	Constellation Pharmaceuticals, Inc.	Bromodomain inhibitors and uses thereof
UA110640C2 (uk) *	2011-05-05	2016-01-25	Янссен Фармацевтика Нв	ПРОТИГРИБКОВІ 5,6-ДИГІДРО-4Н-ПІРОЛО[1,2-a][1,4]БЕНЗОДІАЗЕПІНИ ТА 6Н-ПІРОЛО[1,2-a][1,4]БЕНЗОДІАЗЕПІНИ, ЯКІ ЗАМІЩЕНІ ГЕТЕРОЦИКЛІЧНИМИ ПОХІДНИМИ
US9328117B2 (en)	2011-06-17	2016-05-03	Constellation Pharmaceuticals, Inc.	Bromodomain inhibitors and uses thereof
US9624244B2 (en)	2012-06-06	2017-04-18	Constellation Pharmaceuticals, Inc.	Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof
TWI602820B (zh)	2012-06-06	2017-10-21	星宿藥物公司	溴域抑制劑及其用途
WO2014179567A2 (en) *	2013-05-01	2014-11-06	Academia Sinica	Methods and compositions for treating beta-thalassemia and sickle cell disease
CN103694253A (zh) *	2013-11-04	2014-04-02	湖南华腾制药有限公司	一种噻吩并三唑并[4,3-a][1,4]二氮杂卓类化合物的制备方法
PL3157928T3 (pl)	2014-06-20	2019-07-31	Constellation Pharmaceuticals, Inc.	Krystaliczne postacie 2-((4S)-6-(4-chlorofenylo)-1-metylo-4H-benzo[ c]izoksazolo-[4,5-e]azepin-4-ylo)acetamidu
JP7139323B2 (ja) *	2016-11-01	2022-09-20	エフ．ホフマン－ラロシュアーゲー	Ｃｎｓ関連疾患を処置するための１，３－ジヒドロ－１，４－ベンゾジアゼピン－２－チオン
CR20230211A (es) *	2020-11-16	2023-07-13	Boehringer Ingelheim Int	Derivados de ciclopentatiofen carboxamida como antagonistas del receptor del factor de activación de plaquetas

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3435973A1 (de) *	1984-10-01	1986-04-10	Boehringer Ingelheim KG, 6507 Ingelheim	Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
DE3778559D1 (de) *	1986-01-21	1992-06-04	Boehringer Ingelheim Kg	Thieno-1,4-diazepine.
DE3610848A1 (de) *	1986-04-01	1987-10-15	Boehringer Ingelheim Kg	Neue 1,4-diazepine
EP0315698B1 (en) *	1987-05-28	1993-03-03	Yoshitomi Pharmaceutical Industries, Ltd.	Thieno(triazolo)diazepine compounds and medicinal application of the same

1988
- 1988-12-06 MC MC882021A patent/MC1999A1/fr unknown
- 1988-12-15 CS CS888332A patent/CS833288A2/cs unknown
- 1988-12-15 NZ NZ227341A patent/NZ227341A/en unknown
- 1988-12-15 CA CA000585981A patent/CA1327570C/en not_active Expired - Fee Related
- 1988-12-15 IL IL88688A patent/IL88688A0/xx unknown
- 1988-12-16 AT AT88121165T patent/ATE109148T1/de not_active IP Right Cessation
- 1988-12-16 EP EP88121165A patent/EP0320992B1/en not_active Expired - Lifetime
- 1988-12-16 IE IE375888A patent/IE63762B1/en not_active IP Right Cessation
- 1988-12-16 HU HU886449A patent/HU204273B/hu not_active IP Right Cessation
- 1988-12-16 AU AU26989/88A patent/AU612441B2/en not_active Ceased
- 1988-12-16 YU YU228088A patent/YU46991B/sh unknown
- 1988-12-16 ES ES88121165T patent/ES2056889T3/es not_active Expired - Lifetime
- 1988-12-16 PT PT89250A patent/PT89250B/pt not_active IP Right Cessation
- 1988-12-16 FI FI885820A patent/FI88799C/fi not_active IP Right Cessation
- 1988-12-16 NO NO885597A patent/NO167920C/no unknown
- 1988-12-16 DE DE3850866T patent/DE3850866T2/de not_active Expired - Fee Related
- 1988-12-16 JP JP63316555A patent/JPH0725762B2/ja not_active Expired - Lifetime
- 1988-12-16 DK DK704088A patent/DK704088A/da not_active Application Discontinuation
- 1988-12-17 KR KR1019880016887A patent/KR890009932A/ko not_active Ceased
- 1988-12-17 CN CN88108697A patent/CN1031057C/zh not_active Expired - Fee Related
1992
- 1992-01-31 RU SU925010684A patent/RU2094436C1/ru active

Also Published As

Publication number	Publication date
AU612441B2 (en)	1991-07-11
HUT50823A (en)	1990-03-28
FI88799B (fi)	1993-03-31
FI885820A0 (fi)	1988-12-16
NO167920B (no)	1991-09-16
NO885597L (no)	1989-06-19
FI885820A7 (fi)	1989-06-19
NZ227341A (en)	1992-01-29
MC1999A1 (fr)	1990-01-26
KR890009932A (ko)	1989-08-05
ATE109148T1 (de)	1994-08-15
IE883758L (en)	1989-06-18
IL88688A0 (en)	1989-07-31
JPH01197484A (ja)	1989-08-09
YU46991B (sh)	1994-11-15
CN1031057C (zh)	1996-02-21
HU204273B (en)	1991-12-30
CN1034722A (zh)	1989-08-16
NO885597D0 (no)	1988-12-16
EP0320992A3 (en)	1991-01-09
DE3850866T2 (de)	1994-12-08
DK704088D0 (da)	1988-12-16
FI88799C (fi)	1993-07-12
JPH0725762B2 (ja)	1995-03-22
CA1327570C (en)	1994-03-08
PT89250B (pt)	1993-07-30
RU2094436C1 (ru)	1997-10-27
EP0320992B1 (en)	1994-07-27
AU2698988A (en)	1989-06-29
YU228088A (en)	1990-06-30
ES2056889T3 (es)	1994-10-16
PT89250A (pt)	1989-12-29
EP0320992A2 (en)	1989-06-21
IE63762B1 (en)	1995-06-14
CS833288A2 (en)	1990-10-12
DK704088A (da)	1989-06-19
DE3850866D1 (de)	1994-09-01

Publication	Publication Date	Title
DE3850866D1 (de)	1994-09-01	Triazolodiazepinderivate.
DK586588D0 (da)	1988-10-21	Terapeutiske heterocycliske forbindelser
CA2084193A1 (en)	1991-12-02	3-amino-2-aryl quinuclidines
RU96103653A (ru)	1998-05-10	Бициклические тетрагидропиразолопиридины
ATE45736T1 (de)	1989-09-15	Benzofuran- und benzothiophen-derivate, ihre verwendung zur hemmung der leukotrien-biosynthese bei saeugetieren und diese derivate enthaltende pharmazeutische zusammensetzungen.
FI810250L (fi)	1981-08-14	Foerfarande foer framstaellning av nya terapeutiskt aktiva heterocykliska foereningar
DE3855325D1 (de)	1996-07-04	Oxothiolane und Derivate, diese enthaltende pharmazeutische Zubereitungen und ihre Verwendung als Arzneimittel
ES8300762A1 (es)	1982-11-01	Un procedimiento para la preparacion de benzamidas.
ES8606337A1 (es)	1986-04-16	Un procedimiento para preparar nuevas benzamidas con actividada antagonista de 5-ht.
NO881835D0 (no)	1988-04-27	Fremgangsmaate for fremstilling av terapeutisk aktive bicykliske forbindelser.
DE69106902D1 (de)	1995-03-09	Imidazopyridazine, ihre Herstellung und Verwendung.
SE7704615L (sv)	1977-10-31	Sett att framstella nya 1,4-bensodioxanderivat
HUT50176A (en)	1989-12-28	Process for production of derivatives of heterocyclic lactane and medical compositions containing them as active substance
JPS6429367A (en)	1989-01-31	2-amino-5-hydroxy-4-pyrimidone
FI810103L (fi)	1981-07-17	Nya 2,3-dihydro-imidazo /1,2-b/ pyridazinderivat foerfarande foer deras framstaellning och deras terapeutiska anvaendning
IT1207255B (it)	1989-05-17	Derivati 1,2,4-triazolici, un procedimento per la loro produzione, il loro uso come agenti antiriproduttivi e le composizioni farmaceutiche che li contengono.
DE69219219D1 (de)	1997-05-28	Verwendung von 3-Pyridazinone zur Verringerung der Blutplätchenzahl
HUT53089A (en)	1990-09-28	Process for producing cyclic guanidine derivatives of calcium-antagonistic activity and pharmaceutical compositions containing them
ATE19881T1 (de)	1986-06-15	Tropyl- und pseudotropylalkylbenzoate und ihre verwendung in der behandlung von migraene.
FI874107A7 (fi)	1987-09-21	Foerfarande foer framstaellning av terapeutiskt anvaendbara piperidinderivat.