NO167920C - Analogifremgangsmaate til fremstilling av terapeutisk aktive tricykliske 1,4-azepinderivater - Google Patents

Analogifremgangsmaate til fremstilling av terapeutisk aktive tricykliske 1,4-azepinderivater

Info

Publication number
NO167920C
NO167920C NO885597A NO885597A NO167920C NO 167920 C NO167920 C NO 167920C NO 885597 A NO885597 A NO 885597A NO 885597 A NO885597 A NO 885597A NO 167920 C NO167920 C NO 167920C
Authority
NO
Norway
Prior art keywords
lower alkoxy
integer
carbon
lower alkyl
diseases
Prior art date
Application number
NO885597A
Other languages
English (en)
Norwegian (no)
Other versions
NO167920B (no
NO885597D0 (no
NO885597L (no
Inventor
Armin Walser
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO885597D0 publication Critical patent/NO885597D0/no
Publication of NO885597L publication Critical patent/NO885597L/no
Publication of NO167920B publication Critical patent/NO167920B/no
Publication of NO167920C publication Critical patent/NO167920C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
NO885597A 1987-12-18 1988-12-16 Analogifremgangsmaate til fremstilling av terapeutisk aktive tricykliske 1,4-azepinderivater NO167920C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13472687A 1987-12-18 1987-12-18
US22794888A 1988-08-03 1988-08-03

Publications (4)

Publication Number Publication Date
NO885597D0 NO885597D0 (no) 1988-12-16
NO885597L NO885597L (no) 1989-06-19
NO167920B NO167920B (no) 1991-09-16
NO167920C true NO167920C (no) 1991-12-27

Family

ID=26832617

Family Applications (1)

Application Number Title Priority Date Filing Date
NO885597A NO167920C (no) 1987-12-18 1988-12-16 Analogifremgangsmaate til fremstilling av terapeutisk aktive tricykliske 1,4-azepinderivater

Country Status (21)

Country Link
EP (1) EP0320992B1 (fr)
JP (1) JPH0725762B2 (fr)
KR (1) KR890009932A (fr)
CN (1) CN1031057C (fr)
AT (1) ATE109148T1 (fr)
AU (1) AU612441B2 (fr)
CA (1) CA1327570C (fr)
CS (1) CS833288A2 (fr)
DE (1) DE3850866T2 (fr)
DK (1) DK704088A (fr)
ES (1) ES2056889T3 (fr)
FI (1) FI88799C (fr)
HU (1) HU204273B (fr)
IE (1) IE63762B1 (fr)
IL (1) IL88688A0 (fr)
MC (1) MC1999A1 (fr)
NO (1) NO167920C (fr)
NZ (1) NZ227341A (fr)
PT (1) PT89250B (fr)
RU (1) RU2094436C1 (fr)
YU (1) YU46991B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH30676A (en) * 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
JP2959598B2 (ja) * 1990-10-12 1999-10-06 吉富製薬株式会社 光学活性なチエノトリアゾロジアゼピン化合物
US5130315A (en) * 1991-01-10 1992-07-14 Raymond R. Wittekind 1-piperazinyl-2-butenes and -2-butynes
WO1994006802A1 (fr) * 1992-09-18 1994-03-31 Yoshitomi Pharmaceutical Industries, Ltd. Compose de thienodiazepine et son utilisation medicinale
US5302590A (en) * 1992-12-18 1994-04-12 Hoffmann-La Roche Inc. Compounds useful as dual antagonists of platelet activating factor and leukotriene D4
DE19839566C2 (de) * 1998-08-31 2002-01-17 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten in der Transplantationsmedizin
EP1925614A1 (fr) * 2002-03-28 2008-05-28 Wisys Technology Foundation, Inc. Agents anxiolytiques avec effets ataxiques et sédatifs réduits
DE60319812T2 (de) * 2002-03-28 2009-04-23 Wisys Technology Foundation, Inc., Madison Angstlösende wirkstoffe mit verminderten beruhigenden und ataktischen nebenwirkungen
US7618958B2 (en) 2004-06-30 2009-11-17 Wisys Technology Foundation, Inc. Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects
BRPI0513811A (pt) * 2004-07-27 2008-07-15 Gilead Sciences Inc imidazo [4,5-d] pirimidinas, seus usos e processos de preparação
CN101014345A (zh) * 2004-09-09 2007-08-08 默克公司 三环酰苯胺螺环内酰胺cgrp受体拮抗剂
US7750010B2 (en) * 2004-09-13 2010-07-06 Merck Sharp & Dohme Corp. Tricyclic anilide spirohydantion CGRP receptor antagonists
KR100858262B1 (ko) * 2004-10-13 2008-09-11 에프. 호프만-라 로슈 아게 Ｃｄｋ2 및 혈관신생에 대한 저해제로서 유용하고, 유방암,대장암, 폐암 및 전립선암의 치료용으로 유용한이중치환된 피라졸로벤조디아제핀
JP5844358B2 (ja) * 2010-06-22 2016-01-13 グラクソスミスクライン エルエルシー ベンゾトリアゾロジアゼピン化合物を含むブロモドメイン阻害剤
WO2012075456A1 (fr) 2010-12-02 2012-06-07 Constellation Pharmaceuticals Inhibiteurs de bromodomaines et leurs utilisations
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
US9422292B2 (en) 2011-05-04 2016-08-23 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
UA110640C2 (uk) 2011-05-05 2016-01-25 Янссен Фармацевтика Нв ПРОТИГРИБКОВІ 5,6-ДИГІДРО-4Н-ПІРОЛО[1,2-a][1,4]БЕНЗОДІАЗЕПІНИ ТА 6Н-ПІРОЛО[1,2-a][1,4]БЕНЗОДІАЗЕПІНИ, ЯКІ ЗАМІЩЕНІ ГЕТЕРОЦИКЛІЧНИМИ ПОХІДНИМИ
WO2012174487A2 (fr) 2011-06-17 2012-12-20 Constellation Pharmaceuticals, Inc. Inhibiteurs à bromodomaine et leurs utilisations
US9624244B2 (en) 2012-06-06 2017-04-18 Constellation Pharmaceuticals, Inc. Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
CN105492428A (zh) * 2013-05-01 2016-04-13 中央研究院 治疗β-地中海贫血和镰状细胞病的方法和组合物
CN103694253A (zh) * 2013-11-04 2014-04-02 湖南华腾制药有限公司 一种噻吩并三唑并[4,3-a][1,4]二氮杂卓类化合物的制备方法
PL3157928T3 (pl) 2014-06-20 2019-07-31 Constellation Pharmaceuticals, Inc. Krystaliczne postacie 2-((4S)-6-(4-chlorofenylo)-1-metylo-4H-benzo[ c]izoksazolo-[4,5-e]azepin-4-ylo)acetamidu
WO2018083051A1 (fr) * 2016-11-01 2018-05-11 F. Hoffmann-La Roche Ag 1,3-dihydro -1,4-benzodiazépine-2-thiones pour le traitement de maladies liées au snc
CA3200710A1 (fr) * 2020-11-16 2022-05-19 Boehringer Ingelheim International Gmbh Derives de cyclopentathiophene carboxamide utiles en tant qu'antagonistes du recepteur du facteur d'activation des plaquettes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3435973A1 (de) * 1984-10-01 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
DE3778559D1 (de) * 1986-01-21 1992-06-04 Boehringer Ingelheim Kg Thieno-1,4-diazepine.
DE3610848A1 (de) * 1986-04-01 1987-10-15 Boehringer Ingelheim Kg Neue 1,4-diazepine
EP0315698B1 (fr) * 1987-05-28 1993-03-03 Yoshitomi Pharmaceutical Industries, Ltd. Composes a base de thieno(triazolo)diazepine et applications medicales de ces composes

Also Published As

Publication number Publication date
AU612441B2 (en) 1991-07-11
KR890009932A (ko) 1989-08-05
JPH01197484A (ja) 1989-08-09
EP0320992B1 (fr) 1994-07-27
DE3850866T2 (de) 1994-12-08
FI88799B (fi) 1993-03-31
HU204273B (en) 1991-12-30
RU2094436C1 (ru) 1997-10-27
NO167920B (no) 1991-09-16
CS833288A2 (en) 1990-10-12
IL88688A0 (en) 1989-07-31
FI885820A7 (fi) 1989-06-19
EP0320992A2 (fr) 1989-06-21
JPH0725762B2 (ja) 1995-03-22
DK704088A (da) 1989-06-19
YU46991B (sh) 1994-11-15
FI88799C (fi) 1993-07-12
FI885820A0 (fi) 1988-12-16
YU228088A (en) 1990-06-30
ATE109148T1 (de) 1994-08-15
PT89250A (pt) 1989-12-29
CN1034722A (zh) 1989-08-16
CN1031057C (zh) 1996-02-21
DE3850866D1 (de) 1994-09-01
NZ227341A (en) 1992-01-29
IE883758L (en) 1989-06-18
NO885597D0 (no) 1988-12-16
IE63762B1 (en) 1995-06-14
PT89250B (pt) 1993-07-30
AU2698988A (en) 1989-06-29
NO885597L (no) 1989-06-19
EP0320992A3 (fr) 1991-01-09
HUT50823A (en) 1990-03-28
MC1999A1 (fr) 1990-01-26
CA1327570C (fr) 1994-03-08
ES2056889T3 (es) 1994-10-16
DK704088D0 (da) 1988-12-16

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