NO174152C - Analogifremgangsmåte for fremstilling av N-substituerte aminoalkandifosfonsyrer - Google Patents

Analogifremgangsmåte for fremstilling av N-substituerte aminoalkandifosfonsyrer

Info

Publication number: NO174152C
Authority: NO; Norway
Prior art keywords: aminoalkandiphosphonic; acids; substituted; preparation; formula
Prior art date: 1989-03-08

Application number

NO901077A

Other languages

English (en)

Norwegian (no)

Other versions

NO901077L (no

NO901077D0 (no

NO174152B (no

Inventor

Knut A Jaeggi

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-08

Filing date

1990-03-07

Publication date

1994-03-23

1990-03-07 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1990-03-07 Publication of NO901077D0 publication Critical patent/NO901077D0/no

1990-09-10 Publication of NO901077L publication Critical patent/NO901077L/no

1993-12-13 Publication of NO174152B publication Critical patent/NO174152B/no

1994-03-23 Publication of NO174152C publication Critical patent/NO174152C/no

Links

239000002253 acid Substances 0.000 title 1
150000007513 acids Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
101100490437 Mus musculus Acvrl1 gene Proteins 0.000 abstract 1
230000003913 calcium metabolism Effects 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
230000004060 metabolic process Effects 0.000 abstract 1
125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 abstract 1
230000000865 phosphorylative effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000004149 thio group Chemical group *S* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Rheumatology (AREA)
Biochemistry (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Epoxy Compounds (AREA)

NO901077A 1989-03-08 1990-03-07 Analogifremgangsmåte for fremstilling av N-substituerte aminoalkandifosfonsyrer NO174152C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH86689		1989-03-08

Publications (4)

Publication Number	Publication Date
NO901077D0 NO901077D0 (no)	1990-03-07
NO901077L NO901077L (no)	1990-09-10
NO174152B NO174152B (no)	1993-12-13
NO174152C true NO174152C (no)	1994-03-23

Family

ID=4197009

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO901077A NO174152C (no)	1989-03-08	1990-03-07	Analogifremgangsmåte for fremstilling av N-substituerte aminoalkandifosfonsyrer

Country Status (21)

Country	Link
US (1)	US5036058A (ja)
EP (1)	EP0387194B1 (ja)
JP (1)	JPH02279689A (ja)
KR (1)	KR900014413A (ja)
AT (1)	ATE117308T1 (ja)
AU (1)	AU629298B2 (ja)
CA (1)	CA2011586A1 (ja)
DD (1)	DD297824A5 (ja)
DE (1)	DE59008275D1 (ja)
DK (1)	DK0387194T3 (ja)
ES (1)	ES2067010T3 (ja)
FI (1)	FI95264C (ja)
HU (1)	HU206120B (ja)
IE (1)	IE64984B1 (ja)
IL (1)	IL93586A (ja)
MX (1)	MX19785A (ja)
NO (1)	NO174152C (ja)
NZ (1)	NZ232805A (ja)
PH (1)	PH26923A (ja)
PT (1)	PT93353B (ja)
ZA (1)	ZA901742B (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4015715A1 (de) *	1990-05-16	1991-11-21	Bayer Ag	Neuartige oligophosphate mit antiviraler wirkung
IE912115A1 (en) *	1990-06-25	1992-01-01	Takeda Chemical Industries Ltd	Bisphosphonic acid derivatives, their production and use
US5159108A (en) *	1990-09-18	1992-10-27	Merck & Co., Inc.	Process for preparing an antihypercalcemic agent
EP0491374B1 (en) *	1990-12-19	1996-01-31	Takeda Chemical Industries, Ltd.	Bisphosphonic acid derivatives, their production and use
IT1244698B (it) *	1991-02-01	1994-08-08	Gentili Ist Spa	Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale
ES2096061T3 (es) *	1991-08-27	1997-03-01	Ciba Geigy Ag	Acidos aminometanodifosfonicos n-substituidos.
EP0541037A3 (en) *	1991-11-06	1997-02-26	Takeda Chemical Industries Ltd	Squalene synthetase inhibitory composition and use thereof
US5283057A (en) *	1992-04-24	1994-02-01	The Procter & Gamble Company	Risedronate in oral compositions
JP2006176499A (ja) *	2004-11-25	2006-07-06	Nippon Seibutsu Seizai:Kk	眼疾患治療剤
FR2926081B1 (fr) *	2008-01-03	2010-02-19	Univ Nantes	Derives d'acide hydroxy-bisphosphonique comme vecteur ciblant le tissu osseux
FR2973378B1 (fr) *	2011-03-28	2013-10-04	Atlanthera	Derives d'acide hydroxybisphosphonique bifonctionnels

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3203308A1 (de) *	1982-01-27	1983-07-28	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
FR2531088B1 (fr) *	1982-07-29	1987-08-28	Sanofi Sa	Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
GB8419489D0 (en) *	1984-07-31	1984-09-05	Leo Pharm Prod Ltd	Chemical compounds
US4639338A (en) *	1984-08-06	1987-01-27	Ciba-Geigy Corporation	Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
IL77243A (en) *	1984-12-21	1996-11-14	Procter & Gamble	Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
IT1187828B (it) *	1985-05-24	1987-12-23	Gentili Ist Spa	Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi
EP0243173B1 (en) *	1986-04-24	1991-06-26	Fujisawa Pharmaceutical Co., Ltd.	New diphosphonic acid compounds, processes for the preparation thereof and pharmaceutical composition comprising the same
DE3623397A1 (de) *	1986-07-11	1988-01-14	Boehringer Mannheim Gmbh	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
GB8618259D0 (en) *	1986-07-25	1986-09-03	Leo Pharm Prod Ltd	Pharmaceutical compositions
EP0272208B1 (de) *	1986-11-21	1991-06-12	Ciba-Geigy Ag	Aromatisch substituierte Azacyclo-alkylalkandiphosphonsäuren
US4933472A (en) *	1988-04-08	1990-06-12	Yamanouchi Pharmaceutical Co., Ltd.	Substituted aminomethylenebis(phosphonic acid) derivatives

1990
- 1990-02-14 PH PH40050A patent/PH26923A/en unknown
- 1990-02-16 US US07/481,482 patent/US5036058A/en not_active Expired - Fee Related
- 1990-02-16 AU AU49884/90A patent/AU629298B2/en not_active Ceased
- 1990-02-27 DE DE59008275T patent/DE59008275D1/de not_active Expired - Fee Related
- 1990-02-27 DK DK90810150.4T patent/DK0387194T3/da active
- 1990-02-27 AT AT90810150T patent/ATE117308T1/de not_active IP Right Cessation
- 1990-02-27 EP EP90810150A patent/EP0387194B1/de not_active Expired - Lifetime
- 1990-02-27 ES ES90810150T patent/ES2067010T3/es not_active Expired - Lifetime
- 1990-03-01 IL IL9358690A patent/IL93586A/en not_active IP Right Cessation
- 1990-03-05 FI FI901103A patent/FI95264C/fi not_active IP Right Cessation
- 1990-03-06 KR KR1019900002896A patent/KR900014413A/ko not_active Ceased
- 1990-03-06 NZ NZ232805A patent/NZ232805A/en unknown
- 1990-03-06 MX MX19785A patent/MX19785A/es unknown
- 1990-03-06 DD DD90338447A patent/DD297824A5/de unknown
- 1990-03-06 CA CA002011586A patent/CA2011586A1/en not_active Abandoned
- 1990-03-06 PT PT93353A patent/PT93353B/pt not_active IP Right Cessation
- 1990-03-07 HU HU901348A patent/HU206120B/hu not_active IP Right Cessation
- 1990-03-07 NO NO901077A patent/NO174152C/no unknown
- 1990-03-07 ZA ZA901742A patent/ZA901742B/xx unknown
- 1990-03-07 IE IE80990A patent/IE64984B1/en not_active IP Right Cessation
- 1990-03-08 JP JP2055163A patent/JPH02279689A/ja active Pending

Also Published As

Publication number	Publication date
FI95264B (fi)	1995-09-29
AU629298B2 (en)	1992-10-01
IL93586A0 (en)	1990-12-23
NO901077L (no)	1990-09-10
AU4988490A (en)	1990-09-13
PH26923A (en)	1992-12-03
DD297824A5 (de)	1992-01-23
US5036058A (en)	1991-07-30
HU901348D0 (en)	1990-05-28
KR900014413A (ko)	1990-10-23
FI901103A0 (fi)	1990-03-05
FI95264C (fi)	1996-01-10
IL93586A (en)	1995-06-29
HU206120B (en)	1992-08-28
MX19785A (es)	1994-03-31
PT93353A (pt)	1990-11-07
DK0387194T3 (da)	1995-03-20
HUT53112A (en)	1990-09-28
NZ232805A (en)	1992-06-25
NO901077D0 (no)	1990-03-07
ZA901742B (en)	1990-10-31
IE900809L (en)	1990-09-08
NO174152B (no)	1993-12-13
ES2067010T3 (es)	1995-03-16
EP0387194A1 (de)	1990-09-12
PT93353B (pt)	1996-02-29
ATE117308T1 (de)	1995-02-15
DE59008275D1 (de)	1995-03-02
CA2011586A1 (en)	1990-09-08
JPH02279689A (ja)	1990-11-15
EP0387194B1 (de)	1995-01-18
IE64984B1 (en)	1995-09-20

Publication	Publication Date	Title
AU629298B2 (en)	1992-10-01	N-substituted aminoalkanediphosphonic acids
PT99134A (pt)	1992-08-31	Processo para a preparacao de derivados da piperazina
TW198039B (ja)	1993-01-11
NO912462L (no)	1991-12-27	Fremstilling og anvendelse av bisfosfonsyrederivater.
ES8303279A1 (es)	1983-02-01	"procedimiento para preparar nuevos derivados de acidos fenil-alifatico-carboxilicos".
YU47723B (sh)	1996-01-08	Postupak za dobivanje derivata 2-imino-3-heterocikloalkilbenzotiazolina
GB2019843A (en)	1979-11-07	N-Alkenylmoranoline derivatives
EP0309261A3 (en)	1990-06-13	Butenoic acid amides, their salts, pharmaceutical compositions containing them and process for preparing same
DE3060236D1 (en)	1982-04-29	Thiazole derivatives, their preparation and medicaments containing them
SE8301785L (sv)	1984-06-04	Sett att framstella 2-tiofen-ettiksyraderivat och mellanprodukter erforderliga for deras framstellning
FI884177A0 (fi)	1988-09-12	Foerfarande foer framstaellning av l-aminsyror.
IT1244649B (it)	1994-08-08	Procedimento per il trattamento di substrati com composti aromatici contenenti gruppi solfo, composizioni contenenti tali composti e loro preparazione
SE7714526L (sv)	1978-07-01	Sett att framstella 2-amino-cyklopent-1-en-1-tiokarbonyl-disulfider