NO177672C - Analogifremgangsmåte for fremstilling av terapeutisk aktive, N-substituerte azaheterocykliske karboksylsyrer og estere derav - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktive, N-substituerte azaheterocykliske karboksylsyrer og estere derav

Info

Publication number: NO177672C
Authority: NO; Norway
Prior art keywords: esters; carboxylic acids; preparation; therapeutically active; substituted
Prior art date: 1988-12-19

Application number

NO895093A

Other languages

English (en)

Norwegian (no)

Other versions

NO895093D0 (no

NO177672B (no

NO895093L (no

Inventor

Lars Jacob Stray Knutsen

Anker Steen Joergensen

Knud Erik Andersen

Ursula Sonnewald

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-19

Filing date

1989-12-18

Publication date

1995-11-01

1989-12-18 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1989-12-18 Publication of NO895093D0 publication Critical patent/NO895093D0/no

1990-06-20 Publication of NO895093L publication Critical patent/NO895093L/no

1995-07-24 Publication of NO177672B publication Critical patent/NO177672B/no

1995-11-01 Publication of NO177672C publication Critical patent/NO177672C/no

Links

150000001735 carboxylic acids Chemical class 0.000 title abstract 2
150000002148 esters Chemical class 0.000 title abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000001397 3-pyrrolyl group Chemical group [H]N1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000001033 ether group Chemical group 0.000 abstract 1
229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
230000000946 synaptic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Cephalosporin Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)
Pyrrole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Bipolar Transistors (AREA)

NO895093A 1988-12-19 1989-12-18 Analogifremgangsmåte for fremstilling av terapeutisk aktive, N-substituerte azaheterocykliske karboksylsyrer og estere derav NO177672C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK704488A DK704488D0 (da)	1988-12-19	1988-12-19	Nye n-substituerede azaheterocykliske carboxylsyrer

Publications (4)

Publication Number	Publication Date
NO895093D0 NO895093D0 (no)	1989-12-18
NO895093L NO895093L (no)	1990-06-20
NO177672B NO177672B (no)	1995-07-24
NO177672C true NO177672C (no)	1995-11-01

Family

ID=8149197

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO895093A NO177672C (no)	1988-12-19	1989-12-18	Analogifremgangsmåte for fremstilling av terapeutisk aktive, N-substituerte azaheterocykliske karboksylsyrer og estere derav

Country Status (16)

Country	Link
US (1)	US5071859A (fr)
EP (1)	EP0374801B1 (fr)
JP (1)	JP2848534B2 (fr)
AT (1)	ATE150455T1 (fr)
AU (1)	AU634992B2 (fr)
CA (1)	CA2005919C (fr)
DE (1)	DE68927875T2 (fr)
DK (1)	DK704488D0 (fr)
ES (1)	ES2099067T3 (fr)
FI (1)	FI93951C (fr)
GR (1)	GR3023379T3 (fr)
IL (1)	IL92652A0 (fr)
NO (1)	NO177672C (fr)
NZ (1)	NZ231836A (fr)
PT (1)	PT92628B (fr)
ZA (1)	ZA899736B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4910312A (en) *	1985-11-08	1990-03-20	Warner-Lambert Company	Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof
DE3609699A1 (de) *	1986-03-20	1987-09-24	Schering Ag	5- oder 6-substituierte-(beta)-carbolin-3-carbonsaeureester
US5214054A (en) *	1988-05-18	1993-05-25	Novo Nordisk A/S	Azacyclic carboxylic acid derivatives and their preparation and use
FR2653123B1 (fr) *	1989-10-17	1992-01-17	Roussel Uclaf	Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
DK588189D0 (da) *	1989-11-22	1989-11-22	Novo Nordisk As	Nye heterocykliske carboxylsyrer
DE4017211A1 (de) *	1990-05-29	1991-12-05	Merck Patent Gmbh	Oxazolidinone
DK181190D0 (da) *	1990-07-30	1990-07-30	Lundbeck & Co As H	3-aryl-indol- eller 3-aryl-indazolderivater
DE4117904A1 (de) *	1991-05-31	1992-12-03	Basf Ag	Substituierte n-phenylpiperidine
DK93791D0 (da) *	1991-05-17	1991-05-17	Novo Nordisk As	Nye heterocykliske carboxylsyrer
EP0535496A1 (fr) *	1991-09-25	1993-04-07	Hoechst-Roussel Pharmaceuticals Incorporated	(1-Indanon-2-yl)méthylpipéridines, produits intermédiaires et procédé pour leur préparation et leur utilisation comme médicaments
EP0543780A3 (en) *	1991-11-21	1993-09-01	Ciba-Geigy Ag	Novel aminoalkanephosphinic acids and their salts
US5807872A (en) *	1992-12-16	1998-09-15	Schering Corporation	Imidazoylalkyl substituted with a six membered nitrogen containing heterocyclic ring
US5463074A (en) *	1991-12-18	1995-10-31	Schering Corporation	Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring
US5932596A (en) *	1991-12-18	1999-08-03	Schering Corporation	Imidazoylalkyl substituted with a six membered nitrogen containing nitrogen containing heterocyclic ring
US5633250A (en) *	1991-12-18	1997-05-27	Schering Corporation	Imidazoylalkyl substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms
GB9127306D0 (en) *	1991-12-23	1992-02-19	Boots Co Plc	Therapeutic agents
US5284957A (en) *	1992-09-03	1994-02-08	Eli Lilly And Company	Excitatory amino acid receptor antagonists
US5286733A (en) *	1992-11-20	1994-02-15	Sterling Winthrop Inc.	Substituted 3-piperidinealkanoates and alkanones and compositions and method of use thereof
US5580877A (en) *	1994-04-25	1996-12-03	Merck Sharp & Dohme Ltd.	Pyrazolo-quinoline derivatives for treating cerebral ischemia
US5962449A (en)	1995-04-07	1999-10-05	Novo Nordisk A/S	Tricyclic compounds in treating hyperalgesic conditions and NIDDM
FR2735476B1 (fr) *	1995-06-14	1997-07-18	Rhone Poulenc Rorer Sa	Nouvelle application de derives du pyrrole
US5747523A (en) *	1996-01-24	1998-05-05	Guilford Pharmaceuticals Inc.	Substituted ethyl α,α-diarylmethyl ether derivatives
AU1506499A (en) *	1997-12-12	1999-07-05	Toyama Chemical Co. Ltd.	Alkyl ether derivatives or salts thereof and calcium antagonists containing the same
DE19840611A1 (de) *	1998-09-05	2000-03-09	Klaus Wanner	GABA-uptake-Inhibitoren mit Pyrrolidinstruktur
US7026335B2 (en) *	2002-04-30	2006-04-11	The Procter & Gamble Co.	Melanocortin receptor ligands
US20040010010A1 (en) *	2002-04-30	2004-01-15	Ebetino Frank Hallock	Melanocortin receptor ligands
EP4175635B1 (fr) *	2020-07-02	2026-03-25	Sea Pharmaceuticals LLC	Compositions pharmaceutiques d'acide 6-(2-(2h-tétrazol-5-yl)éthyl)-6-fluorodécahydroisoquinoléine-3-carboxylique et de dérivés esters de celui-ci

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU552050B2 (en) *	1981-05-26	1986-05-22	Smithkline Beckman Corporation	N-substituted azeheterocyclic carboxylic acids and their esters
US4383999A (en) *	1981-05-26	1983-05-17	Smithkline Beckman Corporation	Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters
US4514414A (en) *	1982-10-25	1985-04-30	Smithkline Beckman Corporation	N-Substituted pyrrolidineacetic acids and their esters
FI83957C (fi) *	1984-09-28	1991-09-25	Byk Gulden Lomberg Chem Fab	Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara diarylfoereningar.
DK288385D0 (da) *	1985-06-26	1985-06-26	Novo Industri As	Aminosyrederivater
FI864246A7 (fi) *	1985-11-08	1987-05-09	Warner Lambert Co	N-substituerade 3-piperidin- eller 3-pyridinkarboxylsyror samt deras derivat.
US4910312A (en) *	1985-11-08	1990-03-20	Warner-Lambert Company	Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof
DE3787657T2 (de) *	1986-01-07	1994-02-03	Novo Ind A S Bagsvaerd	Aminosäure-Derivate.
DK270488D0 (da) *	1988-05-18	1988-05-18	Novo Industri As	Hidtil ukendte o-substituerede ketoximer

1988
- 1988-12-19 DK DK704488A patent/DK704488D0/da not_active Application Discontinuation
1989
- 1989-12-12 IL IL92652A patent/IL92652A0/xx not_active IP Right Cessation
- 1989-12-14 US US07/450,805 patent/US5071859A/en not_active Expired - Fee Related
- 1989-12-18 AU AU46889/89A patent/AU634992B2/en not_active Ceased
- 1989-12-18 NO NO895093A patent/NO177672C/no unknown
- 1989-12-18 DE DE68927875T patent/DE68927875T2/de not_active Expired - Fee Related
- 1989-12-18 ES ES89123400T patent/ES2099067T3/es not_active Expired - Lifetime
- 1989-12-18 AT AT89123400T patent/ATE150455T1/de not_active IP Right Cessation
- 1989-12-18 NZ NZ231836A patent/NZ231836A/xx unknown
- 1989-12-18 EP EP89123400A patent/EP0374801B1/fr not_active Expired - Lifetime
- 1989-12-19 CA CA002005919A patent/CA2005919C/fr not_active Expired - Fee Related
- 1989-12-19 PT PT92628A patent/PT92628B/pt not_active IP Right Cessation
- 1989-12-19 JP JP1327463A patent/JP2848534B2/ja not_active Expired - Lifetime
- 1989-12-19 ZA ZA899736A patent/ZA899736B/xx unknown
- 1989-12-19 FI FI896084A patent/FI93951C/fi not_active IP Right Cessation
1997
- 1997-05-09 GR GR970401032T patent/GR3023379T3/el unknown

Also Published As

Publication number	Publication date
NZ231836A (en)	1992-11-25
DE68927875D1 (de)	1997-04-24
DK704488D0 (da)	1988-12-19
DE68927875T2 (de)	1997-06-26
FI93951C (fi)	1995-06-26
FI93951B (fi)	1995-03-15
EP0374801A2 (fr)	1990-06-27
NO895093D0 (no)	1989-12-18
ZA899736B (en)	1990-09-26
NO177672B (no)	1995-07-24
GR3023379T3 (en)	1997-08-29
EP0374801B1 (fr)	1997-03-19
US5071859A (en)	1991-12-10
CA2005919C (fr)	1997-01-07
EP0374801A3 (fr)	1991-08-07
CA2005919A1 (fr)	1990-06-19
JP2848534B2 (ja)	1999-01-20
NO895093L (no)	1990-06-20
AU4688989A (en)	1990-06-21
FI896084A0 (fi)	1989-12-19
JPH02223551A (ja)	1990-09-05
PT92628B (pt)	1995-09-12
PT92628A (pt)	1990-06-29
IL92652A0 (en)	1990-08-31
ATE150455T1 (de)	1997-04-15
AU634992B2 (en)	1993-03-11
ES2099067T3 (es)	1997-05-16

Publication	Publication Date	Title
NO177672C (no)	1995-11-01	Analogifremgangsmåte for fremstilling av terapeutisk aktive, N-substituerte azaheterocykliske karboksylsyrer og estere derav
FI98367B (fi)	1997-02-28	Menetelmä uusien terapeuttisesti käyttökelpoisten trisyklisten, typpipitoisten yhdisteiden valmistamiseksi
FR2701951B1 (fr)	1995-06-09	Nouveaux derives peptidiques de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
CS291391A3 (en)	1992-04-15	Dipeptide l-proline-l-ergininaldehyde derivative and a pharmaceutical comprising thereof
PL299559A1 (en)	1994-03-21	Cyclic inhibitor of cell conglutination
DE68911834D1 (de)	1994-02-10	Verfahren zur Herstellung von 7-substituierten Hept-6-en- und Heptansäuren und Derivaten davon.
AU631070B2 (en)	1992-11-12	Novel platelet-aggregation inhibitor
PL315052A1 (en)	1996-09-30	Condensed dihydropyridines, method of obtaining them, their application in producing pharmaceutic preparations and pharmaceutic preparations containing such compounds
PT73814A (fr)	1981-11-01	Procede pour la preparation de nouveaux hexapeptides
AU6306190A (en)	1991-01-31	Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis
PT89492A (pt)	1989-10-04	Processo de preparacao de novos derivados de tioformamida terapeuticamente activos
SG81900A1 (en)	2001-07-24	A method for making a, b-unsaturated-b-trifluoromethyl-carboxylates and related compounds
CA2073189A1 (fr)	1991-05-23	Acides azaheterocyclocarboxyliques a substituant en n, et composition pharmaceutique
FI885839A0 (fi)	1988-12-16	Foerfarande foer framstaellning av tioformamidderivat.
EP0802179A4 (fr)	2000-04-05	Derives d'ester d'amidinonaphtyle substitues
MY115877A (en)	2003-09-30	Cyclopeptolides
DE69626846D1 (de)	2003-04-24	Phosphonsäurederivate mit metallopeptidase inhibierender aktivität
DK639989A (da)	1990-08-21	Nye n-substituerede azaheterocykliske carboxylsyrer
WO1997029077A1 (fr)	1997-08-14	Derives amides substitues